ライフサイエンスコーパス: co-stimulatory

1 Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo.

2 LIGHT has potent, CD28-independent co-stimulatory activity leading to T-cell growth and sec

3 self-antigens involves a complex network of co-stimulatory and co-inhibitory molecules.

4 In this review, we will focus on the role of co-stimulatory and co-inhibitory pathways in two systemi

5 major component of which is a large array of co-stimulatory and co-inhibitory pathways that modulate

6 critically impacted by the constellation of co-stimulatory and co-inhibitory receptors expressed on

7 these superfamilies but potentially between co-stimulatory and co-inhibitory receptors.

8 revealed coexpression of multiple additional co-stimulatory and co-inhibitory receptors.

9 Signals transmitted by T cell, co-stimulatory and cytokine receptors control Thp lineag

10 function and the dynamic integration of the co-stimulatory and T-cell receptor signals are just begi

11 The co-stimulatory antigen CD28 has been shown to bind to se

12 of high-dose bone marrow transplantation and co-stimulatory blockade can thus achieve allogeneic bone

13 Co-stimulatory blockade has been shown to prolong allogr

14 als conditioned with anti-CD4, anti-CD8, and co-stimulatory blockade in addition to lethal irradiatio

15 transfusion (DST) can synergize with T cell co-stimulatory blockade in inducing tolerance in several

16 ction and Tg graft loss following CD40:CD40L co-stimulatory blockade in this model provides opportuni

17 een shown to overcome tolerance induction by co-stimulatory blockade or regulatory T cells.

18 -alpha responses and impaired the ability of co-stimulatory blockade to extend allograft survival.

19 alpha in the graft recipient synergized with co-stimulatory blockade to induce tolerance.

20 Unexpectedly, though, co-stimulatory blockade with anti-CD154 or CTLA4-Ig indu

21 ects and with tolerogenic potential, such as co-stimulatory blockade, would be a great improvement if

22 Abatacept, a co-stimulatory blocker, and rituximab, a B cell depletin

23 cell antigen receptor and, thus, function as co-stimulatory, but not direct stimulatory, molecules.

24 e crystal structure of the human CTLA-4/B7-1 co-stimulatory complex at 3.0 A resolution.

25 s are amplified by coligation of BCR and the co-stimulatory complex, and several self Ags targeted in

26 amplification of STAT3 phosphorylation under co-stimulatory conditions.

27 tion pathway can impact greatly not only the co-stimulatory context in which the antigen is presented

28 xtensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resis

29 Here is reported a co-stimulatory effect of angiotensin II (AngII) by showi

30 B7-1 is one of the co-stimulatory factors which plays an important role in

31 gs support a substantially revised model for co-stimulatory function in the primary GC response, with

32 acking isoforms, which may down-regulate the co-stimulatory function of dectin-1.

33 T cells and macrophages can be altered with co-stimulatory inhibitors, but may not be a significant

34 -4, is an important mediator of adhesive and co-stimulatory interactions that govern cutaneous immune

35 cytokines but partially dependent on direct co-stimulatory interactions via ICOSL-ICOS.

36 rapeutic interventions targeting ICOS.ICOS-L co-stimulatory interactions.

37 around the concept that CD86 is the initial co-stimulatory ligand based on its more abundant and ear

38 Recent studies identified ICAM-1 as a co-stimulatory ligand that binds to lymphocyte function

39 nflammatory mediator release is modulated by co-stimulatory ligands (CD80 and CD86) expressed by the

40 Neither cell population was positive for the co-stimulatory markers CD40, CD80 and CD86, but both dem

41 promoted BMDC maturation and upregulation of co-stimulatory markers, including CD40, CD86, and MHC-II

42 In particular, targeting co-stimulatory members of the tumor necrosis factor rece

43 drugs in development are those targeting the co-stimulatory modulation, cytokines and the B and T cel

44 Interactions between inducible co-stimulatory molecule (ICOS) and ICOS-ligand (ICOS-L)

45 The inducible co-stimulatory molecule (ICOS) is a CD28 homologue impli

46 The inducible co-stimulatory molecule (ICOS), a third member of the CD

47 y (Treg) cells with high levels of inducible co-stimulatory molecule (ICOS).

48 ation of MHC class I and II antigens and the co-stimulatory molecule B7 suggests increased immunogeni

49 6 and IL-8, as well as the expression of the co-stimulatory molecule B7.1, which is required for the

50 eD-dependent depletion of surface MHCII, the co-stimulatory molecule B7.2, and suppression of T cell

51 face receptor Slamf1 functions not only as a co-stimulatory molecule but also as a microbial sensor o

52 The co-stimulatory molecule CD28 is essential for activation

53 on signals delivered through the TCR and the co-stimulatory molecule CD28.

54 IL-36alpha increased the expression of the co-stimulatory molecule CD40 and enhanced the ability of

55 production, showed robust expression of the co-stimulatory molecule CD40L, and promoted the developm

56 the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are cha

57 ed significantly higher MHC class II and the co-stimulatory molecule CD80 compared to Tetherin KO DCs

58 henotypically mature as they up-regulate the co-stimulatory molecule CD86 from intracellular storages

59 otein ligand (GITRL) is a recently described co-stimulatory molecule expressed by antigen-presenting

60 Co-stimulatory molecule expression (CD40, 80, 86, and I-

61 assessed by cytokine production (ELISA) and co-stimulatory molecule expression (flow cytometry).

62 We demonstrate that the increased co-stimulatory molecule expression (MHC II and CD86) and

63 transplantation to study the role of MHC and co-stimulatory molecule expression on DST cells in media

64 no interleukin (IL)-12p35 mRNA, low surface co-stimulatory molecule expression, and CCR transcripts,

65 ntigen presentation through up-regulation of co-stimulatory molecule expression, and promote survival

66 Loss of Nrf2 results in increased co-stimulatory molecule expression, enhanced T cell stim

67 n (PSA) and containing transgenes for T-cell co-stimulatory molecule expression, including CD80.

68 ficantly inhibit BMDC maturation by reducing co-stimulatory molecule expression.

69 allele diminishes the expression of CD40, a co-stimulatory molecule for T cell polarization.

70 tein ligand (GITRL), a ligand for the T cell co-stimulatory molecule GITR, is expressed by keratinocy

71 To investigate the roles of B7-1 and/or B7-2 co-stimulatory molecule in the development of graft arte

72 The clustering state of the co-stimulatory molecule lymphocyte function-associated a

73 CD27 is a co-stimulatory molecule of T cells, and inherited CD27 d

74 up-regulated the expression of the negative co-stimulatory molecule PD-L1, and this can be prevented

75 Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the nega

76 , detected by NLDC-145 antibody and the CD80 co-stimulatory molecule, as well as Ia antigen on exposu

77 The co-stimulatory molecule, CD86, which is critical for DC/

78 h its cellular receptor 1 (HAVCR1), a T-cell co-stimulatory molecule, inhibits the function of Treg c

79 lpha4beta1 (CD49d) which, as well as being a co-stimulatory molecule, is required for CLL cells to un

80 press GITRL, and that through this important co-stimulatory molecule, they have the potential to infl

81 s major histocompatibility complex (MHC) and co-stimulatory molecules and are recognized and killed b

82 ed into chemokine-producing DCs that express co-stimulatory molecules and can prime naive T cells.

83 Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct t

84 immune response depends on the expression of co-stimulatory molecules and cytokines by antigen-presen

85 y, the improved understanding of the role of co-stimulatory molecules and cytokines IL-10 and IL-2 in

86 rrelation, DCs up-regulate the expression of co-stimulatory molecules and cytokines.

87 intrinsic effect leading to up-regulation of co-stimulatory molecules and subsequent T cell activatio

88 10, which in turn can downregulate important co-stimulatory molecules and the cytokines IL-12 and IFN

89 rd, activation of TLRs induces expression of co-stimulatory molecules and the release of cytokines th

90 ibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical

91 quire surface expression of MHC class II and co-stimulatory molecules as well as T-cell stimulatory a

92 The induction of CTL effectors requires co-stimulatory molecules B7-1 and/or B7-2 on host antige

93 MHC-II+ macrophages and cells expressing the co-stimulatory molecules B7-2 and CD40, as well as IgM +

94 cells, we investigated the expression of the co-stimulatory molecules BB-1, B7-1 (CD80) B7-2 (CD86) a

95 5(+) cells with reduced up-regulation of the co-stimulatory molecules CD80, CD86, and CD68.

96 Blocking CD28, CD154 (CD40L), or both co-stimulatory molecules has been efficacious in prevent

97 potently induced expression of cytokines and co-stimulatory molecules HLA-DR and CD86 in human newbor

98 recently strengthened by the upregulation of co-stimulatory molecules ICOS/ICOS-L and PD-L1.

99 n terms of up-regulation of MHC class II and co-stimulatory molecules in the absence and presence of

100 gs indicate distinct roles for B7-1 and B7-2 co-stimulatory molecules in the development of GAD, pote

101 ocytosis is downregulated, the expression of co-stimulatory molecules is enhanced, and newly formed i

102 ajor histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (AP

103 The interaction of co-stimulatory molecules on T cells with B7 molecules on

104 We also analyzed expression of different co-stimulatory molecules on virus-specific CD8+ and fork

105 expressed significantly higher levels of the co-stimulatory molecules OX40 (37.2% of FOXP3+ cell popu

106 The co-stimulatory molecules SLAMF3 and SLAMF6 have been imp

107 n several pathways of regulation of ILC2s by co-stimulatory molecules such as ICOS, regulatory T cell

108 Therefore, we hypothesized that co-stimulatory molecules that preferentially bind CD28 o

109 equires signals from the T cell receptor and co-stimulatory molecules to license effector functions o

110 he allograft response, and blocking positive co-stimulatory molecules with active delivery of inhibit

111 in a multi-step process involving cytokines, co-stimulatory molecules, and a variety of antigen-prese

112 ires signals from the T cell receptor (TCR), co-stimulatory molecules, and cytokines.

113 ules, including the T-cell receptor complex, co-stimulatory molecules, and integrins unrelated to LFA

114 s to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cel

115 s, regulation of MHC expression, activity of co-stimulatory molecules, and the signalling cascades ac

116 t sizes, the use of adjuvants, cytokines and co-stimulatory molecules, epitope enhancement and the st

117 ich are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the

118 ity in function, which is not seen for other co-stimulatory molecules, is responsible for the unique

119 ption factors, c-Maf and NFIL3, and negative co-stimulatory molecules, LAG-3, TIGIT, PD-1 and TIM-3,

120 ure and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and

121 during viral infections, by manipulation of co-stimulatory molecules, or in the development of tumor

122 associated with higher expression levels of co-stimulatory molecules, PD-L1, IL-6, TNF-alpha, and IL

123 synapse', including integrins, cadherins and co-stimulatory molecules, reveal in detail the molecular

124 ed with lipopolysaccharide do not upregulate co-stimulatory molecules, secrete greatly diminished amo

125 In contrast to wild-type CD80, the evolved co-stimulatory molecules, termed CD28-binding protein (C

126 on of relevant peptide epitopes, addition of co-stimulatory molecules, the development of novel vehic

127 class II family, cytokines, chemokines, and co-stimulatory molecules, was significantly altered in t

128 f dendritic cell (DC) maturation markers and co-stimulatory molecules.

129 tory cytokines, as well as adhesion cell and co-stimulatory molecules.

130 -inducible expression of CD40, CD80 and CD86 co-stimulatory molecules.

131 le vaccines together with antibodies against co-stimulatory molecules.

132 ajor histocompatibility complex antigens and co-stimulatory molecules.

133 ivation and immune function are regulated by co-stimulatory molecules.

134 istocompatibility complex (MHC) class II and co-stimulatory molecules.

135 mune responses by differential expression of co-stimulatory molecules.

136 vels of major histocompatibility complex and co-stimulatory molecules.

137 s is associated with increased expression of co-stimulatory molecules.

138 igh expression of PD-L1 and PD-L2 as well as co-stimulatory molecules.

139 sion of major histocompatibility complex and co-stimulatory molecules.

140 wn to engage intraepithelial T cells through co-stimulatory molecules.

141 Activated DCs expressed high levels of co-stimulatory molecules; released inflammatory cytokine

142 the MHC; they are structurally related to B7-co-stimulatory molecules; they are functionally implicat

143 of B lymphocytes, dysregulated cytokine and co-stimulatory networks, infection with potentially onco

144 studies identify a previously unknown T-cell co-stimulatory pathway as a potential therapeutic target

145 with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-spec

146 CD40-CD154 (CD40 ligand) interaction in the co-stimulatory pathway is involved in many (auto)immune

147 The CD28 co-stimulatory pathway is well established for T cell ac

148 Here, we demonstrate that the CD28 co-stimulatory pathway regulates the trafficking of self

149 LS mouse model, we identified a role for the co-stimulatory pathway, a key regulator of immune respon

150 ce to study the impact of targeting a T cell-co-stimulatory pathway, and demonstrate that targeting T

151 approaches for targeting B-cell subsets and co-stimulatory pathways are described here in detail.

152 cal CD28 and the non-canonical SLAMF3/SLAMF6 co-stimulatory pathways cooperate in the recruitment of

153 and that crosstalk between co-inhibitory and co-stimulatory pathways in pathogen-specific CD4 T cells

154 ocyte activation can be targeted by blocking co-stimulatory pathways or inhibiting major histocompati

155 Using either agents that block co-stimulatory pathways or the immunosuppressive drug ra

156 e decreasing FVIII uptake by APCs, modifying co-stimulatory pathways, inducing regulatory T-cell prod

157 -/- mice suggest the existence of additional co-stimulatory pathways.

158 ), in the presence of B7- and CD40-dependent co-stimulatory pathways.

159 ith the desensitization of the TRAF1-binding co-stimulatory receptor 4-1BB, 4-1BBL-deficient mice hav

160 ning, we identified an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a co-receptor of

161 Interestingly, targeting the co-stimulatory receptor CD137 with an agonistic antibody

162 immunoglobulin and ITIM domain (TIGIT), the co-stimulatory receptor CD226 and their ligand PVR are a

163 TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is ana

164 l factors such as CD80 and CD86, ligands for co-stimulatory receptor CD28, and interleukin 2 are requ

165 n species (ROS), in a manner mediated by the co-stimulatory receptor CD40.

166 OX40 is a co-stimulatory receptor expressed on activated T cells.

167 ) iDCs have lower basal GSH levels, enhanced co-stimulatory receptor expression, impaired phagocytic

168 ies and to regulate pathways that control DC co-stimulatory receptor expression.

169 sis and has been implicated in modulating DC co-stimulatory receptor expression.

170 Co-stimulatory receptor gene expression is regulated by

171 e depends on continued signaling through the co-stimulatory receptor ICOS (inducible co-stimulator).

172 lymphocyte activation molecule (Slamf)1 is a co-stimulatory receptor on T cells and regulates cytokin

173 (CTX) and an agonist antibody targeting the co-stimulatory receptor OX40 (OX86) provides potent anti

174 d rodents exhibit atypical expression of the co-stimulatory receptor OX40 on CD4 T cells and that the

175 cal inhibitors, we demonstrate that enhanced co-stimulatory receptor phenotype of Nrf2(-/-) iDC does

176 V and HIV-1 Nefs down-modulate CD28, a major co-stimulatory receptor that mediates effective T-cell a

177 CD28, a major co-stimulatory receptor, is responsible for the optimal

178 ytokine production suggests NTB-A is a novel co-stimulatory receptor.

179 ing cascades that integrate information from co-stimulatory receptors and locally available cytokines

180 Immature DCs (iDCs) expressing low levels of co-stimulatory receptors are highly efficient at antigen

181 es of the cytoplasmic tails of integrins and co-stimulatory receptors in complex with intracellular s

182 imulation of the T cell receptor complex and co-stimulatory receptors is associated with acute tyrosi

183 ranscription factor NF-kappaB to antigen and co-stimulatory receptors is required for the temporal co

184 Modulation of co-inhibitory and co-stimulatory receptors of the immune system has become

185 munity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulat

186 zes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing

187 d in the T-cell receptor signal strength and co-stimulatory requirements needed for their generation.

188 cells are cycling but are defective in their co-stimulatory response when stimulated.

189 Given the co-stimulatory role of natural-killer group 2, member D

190 d thus far produce either an activation or a co-stimulatory signal alone, thus limiting the spectrum

191 TNFSF4 produces a potent co-stimulatory signal for activated CD4+ T cells after e

192 sponse to antigenic challenge by providing a co-stimulatory signal for TCR.

193 To be fully active, immune T cells need a co-stimulatory signal in addition to the main antigen-dr

194 lexes (ICs) in human CD4(+) T-cells produced co-stimulatory signal like CD28 that triggered IFN-gamma

195 The co-stimulatory signal promotes T-cell proliferation, lym

196 B7-2 on antigen-presenting cells deliver the co-stimulatory signal through CD28 and CTLA-4 on T cells

197 4(+) T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4(+) T-cells in the absence o

198 cell activation receptor that can provide a co-stimulatory signal to other activation receptors and

199 er338 through PI 3-kinase and Pak provides a co-stimulatory signal which together with Ras leads to s

200 onses require both an antigen-specific and a co-stimulatory signal.

201 ire an antigen-specific signal and a second, co-stimulatory, signal for optimal T-cell activation.

202 hways suggested LGMD2B-specific increases in co-stimulatory signaling between dendritic cells and T c

203 sing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology.

204 ch to this problem is to manipulate specific co-stimulatory signaling pathways to enhance CD8(+) effe

205 in sIBM there is upregulation of ICOS.ICOS-L co-stimulatory signalling in association with enhanced p

206 keletal engagement, which is permissive, and co-stimulatory signals (calcium or protein kinase C) gen

207 et, which are dependent on the antigen dose, co-stimulatory signals and the cytokine environment, cri

208 in human cells, promoting the expression of co-stimulatory signals and the secretion of pro-inflamma

209 Because co-stimulatory signals are critical for regulating T-cel

210 tical framework for clinical trials in which co-stimulatory signals are manipulated in an attempt to

211 cells are dependent on accessory cell-bound co-stimulatory signals for activation.

212 f the TNFR family known to provide essential co-stimulatory signals for T cell growth and B cell Ig s

213 es the pre-TCR, beta-selection also requires co-stimulatory signals from Notch receptors - key cell f

214 ctivation by NFAT without the cooperation of co-stimulatory signals in lymphocytes can also impose a

215 nced network of positive and negative T-cell co-stimulatory signals is important in regulating T-cell

216 TLR-inducible expression of co-stimulatory signals is one of the mechanisms of self/

217 ating T-cell activation, an understanding of co-stimulatory signals may enable the design of rational

218 ar and can present antigen in the context of co-stimulatory signals required for the stimulation of b

219 r whether or how the inducible expression of co-stimulatory signals would distinguish between self an

220 ative signals concurrent with blocking CD154 co-stimulatory signals would facilitate islet allograft

221 was enhanced by concurrent blockade of CD154 co-stimulatory signals, as demonstrated by T-cell prolif

222 Here, we propose that the integration of co-stimulatory signals, which regulate the ability of pr

223 and(s) on T cells, thereby delivering T cell co-stimulatory signals.

224 TNF-alpha and suppressing the expression of co-stimulatory surface markers CD80 and CD86.

225 T-cell receptor (TCR) and the CD28 and 4-1BB co-stimulatory surface molecules.