ライフサイエンスコーパス: co-transcriptional

1 R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids, form natur

2 Here we show that, in yeast, co-transcriptional acetylation is achieved in part by hi

3 l component of E-cadherin junctions and as a co-transcriptional activator of the Wnt/beta-catenin sig

4 Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups o

5 Saccharomyces cerevisiae, we tested whether co-transcriptional activator Sub1, recently identified a

6 The WW domain-containing co-transcriptional activator Yes-associated protein (YAP

7 Here we report the identification of four CO transcriptional activators, named FLOWERING BHLH 1 (F

8 opose that pairing requires Ctcf binding and co-transcriptional activity of Tsix and Xite.

9 teasome resistance and increased protein and co-transcriptional activity.

10 ssed antisense transcripts (SRATs) since the co-transcriptional addition of the H3K36 methyl mark by

11 nt ligand-dependent regulatory activity in a co-transcriptional and cellular context.

12 portant insights into the relative amount of co-transcriptional and post-transcriptional processing,

13 on determined by native gel-shift assays and co-transcriptional assembly is correlated to the G/C con

14 The structure supports the hypothesis of co-transcriptional assembly, centered around L24 in doma

15 r, causes defects in Pol II phosphorylation, co-transcriptional capping, promoter proximal pausing, a

16 polymerase II transcription by coordinating co-transcriptional chromatin modifications and helping r

17 vement of RNAPII through the nucleosome with co-transcriptional chromatin modifications during transc

18 in gene poly(A) signal are associated with a co-transcriptional cleavage (CoTC) activity that acts wi

19 r terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element.

20 beta-globin gene revealed a new phenomenon--co-transcriptional cleavage (CoTC).

21 Co-transcriptional cleavage data were simulated successf

22 the absence of additional factors, efficient co-transcriptional cleavage of the full-length genomic H

23 PR RNA (crRNA)-guided nucleases that perform co-transcriptional cleavage of the viral target DNA and

24 , cleaves pre-rRNA at so-called site A(2), a co-transcriptional cleavage step that separates rRNAs de

25 ian development, and interacts with the PAF1 co-transcriptional complex and other proteins.

26 ulatory processes in the transcriptional and co-transcriptional control of immune-responsive genes an

27 Although the co-transcriptional deacetylation pathway is well charact

28 wtooth-like binding pattern, consistent with co-transcriptional deposition of FUS/TLS.

29 arum: editing is distinct from that of other co-transcriptional editing systems.

30 witches; our analysis of RS3 suggests strong co-transcriptional effects for this riboswitch.

31 ation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activ

32 Pre-mRNA splicing is a predominantly co-transcriptional event which involves a large number o

33 RNA polymerase II coordinates co-transcriptional events by recruiting distinct sets of

34 ing platform for factors involved in various co-transcriptional events.

35 HAT)-mediated chromatin remodeling function, co-transcriptional factor, p300, is also known to play a

36 nes on the template DNA strand, suggesting a co-transcriptional feedback to siRNA biogenesis by DNA m

37 ggest the possibility of co-replicational or co-transcriptional folding of G-quadruplex inside the po

38 In these studies, co-transcriptional folding of the genomic ribozyme was a

39 iary interactions that promote high-fidelity co-transcriptional folding of the riboswitch but are onl

40 A transcripts provided justification for the co-transcriptional folding of these species.

41 This mechanism requires YAP co-transcriptional function and involves the activation

42 l that IQGAP1 binds to YAP and modulates its co-transcriptional function, suggesting that IQGAP1 part

43 state that is sufficient for RNAi-dependent co-transcriptional gene silencing at pericentromeric DNA

44 roteins to nascent RNA transcripts to induce co-transcriptional gene silencing.

45 nt or function, although significant loss of co-transcriptional H3K36 trimethylation is observed.

46 Rpb1 and Spt5 CTD phospho-sites in directing co-transcriptional histone modifications in the fission

47 Our results elaborate the CTD 'code' for co-transcriptional histone modifications.

48 ly equilibrating RNA structures, but rather, co-transcriptional ligand binding kinetically traps the

49 ed by the LARP7-free MePCE and in probably a co-transcriptional manner prior to its sequestration int

50 These data strongly support a co-transcriptional mechanism of Physarum: RNA editing in

51 ich silences transcription, can proceed by a co-transcriptional mechanism that also promotes sRNA gen

52 However, the molecular mechanism of co-transcriptional miRNA processing is poorly understood

53 , these studies suggest that HP1BP3 promotes co-transcriptional miRNA processing via chromatin retent

54 f chromatin retention factors for widespread co-transcriptional miRNA processing.

55 potential of RNA and broadens the exclusive co-transcriptional models that pervade the field.

56 hed light on the order of events for Dbp2 in co-transcriptional mRNP assembly.

57 system has provided further support for the co-transcriptional nature of editing in Physarum polycep

58 The co-transcriptional nature of mRNA processing has permitt

59 otein interactions and provides insight into co-transcriptional, post-transcriptional and cytoplasmic

60 We propose a model for co-transcriptional pre-mRNA processing that incorporates

61 AP III (POLR3A) is not sufficient to enhance co-transcriptional pre-mRNA splicing or capping in vivo.

62 erasure of the ubiquitin mark from ubH2B and co-transcriptional pre-mRNA splicing.

63 lts can help understand other time sensitive co-transcriptional processes in pro- and eukaryotes.

64 d factor that functions in transcription and co-transcriptional processes.

65 ter understand its role in transcription and co-transcriptional processes.

66 II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transc

67 ical kinase for transcription elongation and co-transcriptional processing of eukaryotic genes.

68 D) is essential for normal transcription and co-transcriptional processing of mRNA precursors.

69 ates the elongation of RNA polymerase II and co-transcriptional processing of nascent transcripts.

70 , and alternative splicing in the context of co-transcriptional processing of pre-mRNA.

71 ex can be recruited to chromatin to catalyze co-transcriptional processing of primary microRNAs (pri-

72 Ribosomal RNA gene transcription, co-transcriptional processing, and ribosome biogenesis a

73 RNAs with 5' caps prior to their removal by co-transcriptional processing.

74 phosphorylated CTD is required for efficient co-transcriptional processing.

75 ligand-dependent termination is obligatorily co-transcriptional, providing a clear readout of the fol

76 with their DNA template via the formation of co-transcriptional R-loop structures.

77 Co-transcriptional R-loops could aggravate such conflict

78 These findings suggest that co-transcriptional recruitment of the RNA processing mac

79 Together with CO transcriptional regulation, FKF1 protein controls rob

80 Post-transcriptional and co-transcriptional regulation is a crucial link between

81 We report herein that an additional layer of co-transcriptional regulation is required for exopolysac

82 d a novel functional approach to demonstrate co-transcriptional regulation of alternative splicing.

83 hancer factor 2C), functioning as its potent co-transcriptional regulator.

84 eling and deacetylation (NuRD) complexes are co-transcriptional regulators implicated in differentiat

85 termind-like) proteins are a family of three co-transcriptional regulators that are essential for Not

86 To relate these findings to co-transcriptional regulatory activity, we have investig

87 36me) is thought to participate in a host of co-transcriptional regulatory events.

88 Co-transcriptional RNA binding by Trf4 may link RNA and

89 a 'torpedo' mechanism for Pol I termination: co-transcriptional RNA cleavage by Rnt1 provides an entr

90 y Rnt1 inactivation in vivo reveals a second co-transcriptional RNA cleavage event at T1 which provid

91 We also show that a lincRNA-specific co-transcriptional RNA cleavage mechanism acts to induce

92 We simulated co-transcriptional RNA folding dynamics to identify comp

93 Numerous links exist between co-transcriptional RNA processing and the transcribing R

94 tion genome-wide profiles of nascent RNA and co-transcriptional RNA processing that are associated wi

95 RNA polymerase (RNAP) is the central step in co-transcriptional RNA proofreading.

96 global increase in the formation of R-loops, co-transcriptional RNA-DNA products, which in some insta

97 Co-transcriptional RNAi releases RNA polymerase II (Pol

98 Surprisingly, co-transcriptional self-cleavage occurs when the number

99 ribozyme was assayed in vitro by monitoring co-transcriptional self-cleavage of transcripts having v

100 therefore likely to affect the efficiency of co-transcriptional self-cleavage.

101 These co-transcriptional silencing mechanisms form powerful RN

102 We examined if the kinetic determinants for co-transcriptional splicing (CTS) might be reflected in

103 ole in splicing is dependent on the cellular co-transcriptional splicing activators Tat-SF1 and CA150

104 ol II CTD phosphorylation states reveal weak co-transcriptional splicing and poly(A) signal-independe

105 nscribing RNA polymerase II over introns and co-transcriptional splicing events.

106 for access to nascent transcripts undergoing co-transcriptional splicing in order to detect and silen

107 ng, but this mutation could be suppressed by co-transcriptional splicing in the presence of Cbp2.

108 Together, our work establishes a system for co-transcriptional splicing in vitro, in which the splic

109 we established an efficient model system for co-transcriptional splicing in vitro.

110 elongation through a chromatin template and co-transcriptional splicing including alternative splici

111 RNAPII with a K1246R mutation showed reduced co-transcriptional splicing.

112 reports, we show that HSV-1 does not inhibit co-transcriptional splicing.

113 icity of FGFR2 alternative splicing requires co-transcriptional splicing.

114 strong promoters; however, it might require co-transcriptional synthesis of a polypeptide.

115 mosomal expansion due to transertion enables co-transcriptional translation throughout the nucleoids.