ライフサイエンスコーパス: co-transporter

1 bumetanide, an inhibitor of the Na+-K+-2Cl- co-transporter.

2 ng II) was shown to regulate the MD Na:2Cl:K co-transporter.

3 at least in part, through an apical Na:2Cl:K co-transporter.

4 in C. elegans and the recently cloned human co-transporter.

5 secondary to restoration of affinity of the co-transporter.

6 predominantly through the NaPi-2b (SLC34a2) co-transporter.

7 otif result in defects in the ER exit of the co-transporter.

8 ed for ER exit and surface expression of the co-transporter.

9 and NKCC2, and also affect other related ion co-transporters.

10 rbonic anhydrase 4 (CA4) and Na+/bicarbonate co-transporter 1 (NBC1) is specifically expressed in the

11 ones, alpha-defensin, mucin 2, Na(+)/glucose co-transporter 1 (SGLT1) and transcription factors, Hes1

12 of Cl(-) loaders such as the Na(+)K(+)2Cl(-) co-transporter 1 (Slc12a2) over Cl(-)extruders of uniden

13 tablish that the "neuron-specific" K(+)Cl(-) co-transporter 2 (KCC2, Slc12a5) is expressed in several

14 nnel (gammaENaC), sodium-potassium -chloride co-transporter 2 (NKCC2), sodium chloride co-transporter

15 cial cardiovascular effect of sodium glucose co-transporter 2 inhibitors in T2DM.

16 Sodium glucose co-transporter 2 inhibitors may reduce cardiovascular an

17 an absence of the sodium-potassium-chloride co-transporter 2, NKCC2.

18 imal tubule Na(+)/H(+) exchanger 3, Na(+)/Pi co-transporter 2, phosphorylated Na(+)/K(+)/Cl(-) cotran

19 at present, metformin and the sodium-glucose-co-transporter 2-inhibitor empagliflozin seem to be espe

20 Sodium-glucose co-transporters 2 (SGLT-2) inhibitors have emerged as a

21 short-term treatment with the sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin reduced

22 diovascular risk profile, the sodium-glucose co-transporter-2 (SGLT2) inhibitors empagliflozin and ca

23 (GLP-1) receptor agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce glycaemia and

24 lateral membranes and prolonged the cycle of co-transporter activation, internalization and re-expres

25 ependent MD-NO production, the regulation of co-transporter activity by NO, and the possible interact

26 prevent the OSR1-induced enhancement of ion co-transporter activity in cells, further supporting the

27 utative SPAK2 form), which modestly inhibits co-transporter activity in vitro, is more abundant in th

28 Whilst much is known about the co-transporter activity of NKCC1 and its regulation by p

29 t and that NO and Ang II independently alter co-transporter activity.

30 induces secondary axes, independently of its co-transporter activity.

31 sting that Na(+)/K(+)/2Cl(-) (NKCC1/SLC12A2) co-transporter and ENaC are targets of Nedd4L in the col

32 Bumetanide, an inhibitor of the Na+-K+-2Cl- co-transporter and one of the mechanisms of regulatory v

33 n exporters, particularly sodium bicarbonate co-transporters and carbonic anhydrases, which were also

34 the wild type AtAMT1;2 functions as H(+)/NH3 co-transporter, as well as how the strict substrate coup

35 ds, phosphorylates, and stimulates the NKCC1 co-transporter at the CPE apical membrane.

36 ctivity and phosphorylation of NCC and NKCC2 co-transporters at the residues phosphorylated by SPAK.

37 hway regulator of the Na-dependent glutamine co-transporters, B0AT1 in villus cells and SN2 in crypts

38 or increased rates of degradation of mutant co-transporters, but was instead caused by defects in ma

39 The cation-chloride co-transporters (CCCs) have been identified as important

40 e TLR4-NF-kappaB signaling or the SPAK-NKCC1 co-transporter complex.

41 to form rapidly CFTR- and Na(+),K(+),2Cl(-) co-transporter-dependent cysts that were three- to six-f

42 We propose that SLC4A11 is an NH3/2H(+) co-transporter exhibiting unique characteristics.

43 pite an increase in AQP1, AQP3, and Na-K-2Cl co-transporter expression.

44 ter is distinct from the sodium-myo-inositol co-transporter found in many tissues and accounts for al

45 ported the successful cloning of the choline co-transporter in Caenorhabditis elegans (CHO-1) and rat

46 nce of the secretory isoform of the Na-K-2Cl co-transporter in gerbil, rat and rabbit inner ear.

47 s in the spinal cord and the level of an ion co-transporter in motor neuron membranes required for no

48 We report herein the cloning of the choline co-transporter in the horseshoe crab, Limulus polyphemus

49 known about the activities of NKCC1 that are co-transporter independent.

50 Additional sodium-glucose co-transporter inhibitors are progressing in development

51 We conclude that several cation chloride co-transporters interact with SPAK and/or OSR1, and we h

52 s constrained by a Ca(2+)-dependent cycle of co-transporter internalization, degradation and re-expre

53 KCC1 is a broadly expressed Na(+)-K(+)-Cl(-) co-transporter involved in regulation of ion flux across

54 long-time considered "neuron-specific" KCC2 co-transporter is expressed in pancreatic islet beta-cel

55 cholinium-3 sensitive, high affinity choline co-transporter is rate limiting in the biosynthesis of a

56 The K(+)-Cl(-) co-transporter KCC2 (SLC12A5) tunes the efficacy of GABA

57 cellular potassium accumulation via the K/Cl co-transporter KCC2 in promoting GABA(A)-mediated excita

58 the expression and function of the K(+)Cl(-) co-transporter KCC2 within VTA GABAergic neurons.

59 The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundame

60 ich is set by the neuron-specific K(+)-Cl(-) co-transporter KCC2.

61 y plot analysis predicts the Limulus choline co-transporter (LChCoT) to have thirteen transmembrane d

62 ulate the activity of the sodium-bicarbonate co-transporter, leading to a hyperpolarization of the ne

63 nner ear and show that absence of functional co-transporter leads to structural damages in the inner

64 The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupc

65 previously described SLC5A11-a sodium/solute co-transporter-like-(or cupcake) in Drosophila melanogas

66 This co-transporter may be a site for regulation of tubuloglo

67 y inhibition of monocarboxylate lactate-H(+) co-transporters (MCTs) with AR-C155858.

68 NK4 in inhibition of both thiazide-sensitive co-transporter-mediated Na+ reabsorption and K+ secretio

69 ls and some exchangers (i.e. Na(+)/H(+)) and co-transporters (Na(+)-HCO(3)(minus sign), Na(+)-K(+)-2C

70 The Na(+)/dicarboxylate co-transporter, NaDC-1, couples the transport of sodium

71 The Na+/dicarboxylate co-transporter, NaDC-1, from the kidney and small intest

72 protein levels of the renal sodium-phosphate co-transporter NaPi-IIa in the proximal convoluted tubul

73 l protein expression of the sodium-phosphate co-transporter NaPi-IIa, lower renal Klotho protein expr

74 ntified and characterized the sodium/sulfate co-transporter (NaS-1; Slc13a1) as an Fxralpha target ge

75 ion of the renal basolateral Na(+)-HCO(3)(-) co-transporter (NBC).

76 tions in the electrogenic sodium bicarbonate co-transporter NBCe1 and mice lacking NBCe1 have enamel

77 The electrogenic sodium bicarbonate co-transporter NBCe1 has been localized in mouse amelobl

78 s CA IX co-localizes with sodium bicarbonate co-transporter (NBCe1) and anion exchanger 2 (AE2) that

79 SLC4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regulates intracellular pH (p

80 loride/bicarbonate AEs and Na(+)-bicarbonate co-transporters (NBCs).

81 mice, leading to up-regulation of the Na-Cl co-transporter NCC, p-NCC and the development of salt-se

82 ith elevated activity of the sodium chloride co-transporter (NCC) and, accordingly, NCC abundance is

83 de co-transporter 2 (NKCC2), sodium chloride co-transporter (NCC), aquaporin 2 (AQP2), and EGFR abund

84 the related kinase WNK4 regulates the Na-Cl co-transporter (NCC), paracellular Cl- flux, and the K+

85 this segment through the actions of the NaCl co-transporter (NCC), which is regulated by the with-no-

86 we found that IL18 interacts with the Na-Cl co-transporter (NCC; also known as SLC12A3), a 12-transm

87 g serine-811 in the thiazide-sensitive Na-Cl co-transporter, NCC.

88 ation in the membrane expression of the NaCl co-transporter (NCCT) and the renal outer-medullary K ch

89 se (ERK)1 and -2-dependent Na(+)-K(+)-2Cl(-) co-transporter (NKCC) activity may contribute to total p

90 cellular proliferation, loss of the Na-K-Cl co-transporter NKCC1, and expression of androgen recepto

91 pendent on the basolateral Na(+)-K(+)-2Cl(-) co-transporter (NKCC1).

92 cretion by blockade of the Na(+)/K(+)/2Cl(-) co-transporter, NKCC1, of stimulated CFTR(+) jejunum pre

93 timulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other

94 absorb NaCl via the apical Na(+)/K(+)/2Cl(-) co-transporter NKCC2.

95 absorb NaCl via the apical Na(+)/K(+)/2Cl(-) co-transporter NKCC2.

96 sin level, aquaporin 2, or Na(+)-K(+)-2Cl(-) co-transporter NKCC2/BSC1 protein abundances or UT-A1 mR

97 Mutations in the renal specific Na-K-2Cl co-transporter (NKCC2) lead to type I Bartter syndrome,

98 to modulate aquaporin 2 (AQP2) and Na-K-2Cl co-transporter (NKCC2), pivotal factors in urinary conce

99 Na,K,2Cl co-transporter (NKCC2), the primary NaCl uptake pathway

100 full-length splice isoforms of the Na-K-2Cl co-transporter (NKCC2/BSC1) are expressed along the thic

101 vate the potassium-dependent sodium-chloride co-transporter, NKCC2, and thiazide-sensitive sodium-chl

102 Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome, a

103 MK, and earlier to mutations in the Na-K-2Cl co-transporter, NKCC2.

104 in TgHMW mice, whereas the renal Na(+)/P(i) co-transporter Npt2a mRNA was decreased.

105 The sodium phosphate co-transporters Npt2a and Npt2c play important roles in

106 rane expression of the sodium-dependent P(i) co-transporters, NPT2a and NPT2c, and thus suppresses th

107 bition of B0AT1 in villus cells by restoring co-transporter numbers in the BBM, whereas the stimulati

108 rane solute transfer in the sodium-dependent co-transporter OCTN2.

109 :2Cl-, Na+:K+:2HCO3-, K+:HCO3-, or Na+:HCO3- co-transporters, or any combination of these.

110 ing), cell-specific expression of Na+/2HCO3- co-transporters, or voltage-dependent Na+ channels.

111 and both were reduced by sodium bicarbonate co-transporter (P </= 0.0001) and carbonic anhydrase inh

112 be mediated by a sodium-dependent phosphate co-transporter, Pit-1 (Glvr-1).

113 s the recently described sodium-taurocholate co-transporter polypeptide (NTCP), encoded by the SLC10A

114 emonstrated that the marked reduction in the co-transporter protein levels was essentially due to inc

115 , the basolateral membrane Na(+)/K(+)/2Cl(-) co-transporter protein NKCC1(+), and NKCC1(-) mice were

116 iting glucose reabsorption by sodium glucose co-transporter proteins (SGLTs) in the kidneys is a rela

117 ce of aquaporin 1 (AQP1), AQP3, and Na-K-2Cl co-transporter proteins and a marked reduction of the ur

118 e high affinity and low affinity Na+/lactate co-transporters, respectively, in the kidney.

119 vestigate the dynamics of the sodium glucose co-transporter (SGLT1) upon substrate and inhibitor bind

120 s in the gene encoding for the Na(+)-glucose co-transporter SGLT2 (SLC5A2) associate with familial re

121 These co-transporters share 57% homology at the amino acid lev

122 in the gene encoding the basolateral Na-K-Cl co-transporter Slc12a2 (Nkcc1, mBSC2) cause the deafness

123 via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2.

124 he kidney-specific type IIa sodium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (

125 increased NKCC2 expression by increasing the co-transporter stability.

126 was increased from 25 to 150 mM, indicating co-transporter stimulation.

127 KCC2 is a neuron specific K(+)-Cl(-) co-transporter that controls neuronal chloride homeostas

128 KCC2 is a neuron-specific K(+)-Cl(-) co-transporter that maintains a low intracellular Cl(-)

129 he SLC12A family, a group of cation-chloride co-transporters that are targets of therapeutic drugs an

130 cturally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestin

131 y abundances of the thiazide-sensitive Na-Cl co-transporter, the alpha-subunit of the epithelial sodi

132 is mediated by two isoforms of the Na-K-2Cl co-transporter: the absorptive isoform BSC1 (also called

133 We localized the co-transporter to key secreting epithelia of the mouse i

134 The Na(+)-K(+)-2Cl(-) co-transporter type 1 (NKCC1) is localized primarily thr

135 g mechanism, the sodium-potassium-2 chloride co-transporter, was significantly decreased, as was the

136 l exit of HCO3- via the electrogenic Na/HCO3 co-transporter, which is the subject of at least 10 muta

137 ulating the Na-Cl (NCC) and Na-K-2Cl (NKCC2) co-transporters, which regulate salt reabsorption in the

138 inhibiting the basolateral Na(+),K(+),2Cl(-) co-transporter with bumetanide, which effectively blocke

139 situations where P(Cl)/P(K) is low, the same co-transporters would instead permit RVIs but at the exp