ライフサイエンスコーパス: coactivator function

1 ediated transcriptional activation through a coactivator function.

2 tion, but it is defective in transcriptional coactivator function.

3 insight into the molecular mechanisms of G9a coactivator function.

4 enhances PKM2 binding to HIF-1alpha and PKM2 coactivator function.

5 the importance of APE1's acetylation in its coactivator function.

6 perties of the TAF4 subunit that lead to the coactivator function.

7 nd has been shown to possess transcriptional coactivator function.

8 y, only a selected subset required BAF57 for coactivator function.

9 sed in terms of our present understanding of coactivator function.

10 nfirmed a critical role for them in in vitro coactivator function.

11 (PPAR)-interacting protein) and enhance its coactivator function.

12 e activity of PRMT2 appeared pivotal for its coactivator function.

13 th other proteins that help to mediate CARM1 coactivator function.

14 significant additive inductive effect on PBP coactivator function.

15 MAPK cascade exerts a positive effect on PBP coactivator function.

16 tion of GRIP1 transcriptional activation and coactivator function.

17 tor HNF4) and thus recapitulates partial USA coactivator function.

18 de a more physiologically relevant assay for coactivator function.

19 DR heterodimers bound to DNA and for TRAP220 coactivator function.

20 with octamer-bound Oct-1 and for subsequent coactivator function.

21 new tool for investigating the mechanism of coactivator function and demonstrates the importance of

22 However, the mechanism of beta-catenin-GRIP1 coactivator function and synergy is different with AR an

23 To correlate the E6-AP coactivator function and ubiquitin-protein ligase functi

24 RM1 to AD2 are required for their respective coactivator functions and for their synergy.

25 The coactivator functions and physical interactions of Smad4

26 AR that is capable of altering AR activity, coactivator function, and AR-dependent proliferation.

27 eviously been implicated in nuclear receptor coactivator function, and we show that, although BAF57 f

28 th respect to specific polypeptide subunits, coactivator functions, and mechanisms of action (activat

29 2 nuclear protein kinase and transcriptional coactivator functions are abolished.

30 The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HA

31 c evidence that this generic transcriptional coactivator functions as a positive modifier of prostate

32 sion by NFI-C may occur by interference with coactivator function at the MMTV promoter.

33 er, our findings suggest that the human CRSP coactivator functions, at least in part, by mediating ac

34 sferase inhibitor UNC0646 did not affect G9a coactivator function but selectively decreased G9a corep

35 icate that phosphorylation coordinates SRC-3 coactivator function by linking the probabilistic format

36 ional activation domain which contributes to coactivator function by recruitment of CoCoA.

37 and it has been recently proposed that these coactivators function by modulating chromatin structure

38 Coactivator functions can be broadly divide into two cla

39 Deletion of AD1 only partially reduced p160 coactivator function, due to signaling through AD2, anot

40 tivator binding sites and that dependence on coactivator function for a given activator can vary acco

41 Our findings reveal a novel coactivator function for Cyc8p/Tup1p at the level of act

42 Our data therefore reveal a novel coactivator function for PIASx(alpha) through reversing

43 ork identified a stimulatory transcriptional coactivator function for the BRCA1 protein, and more rec

44 m changes in TIP60 complex assembly or TIP60 coactivator functions for p53, since a TIP60 complex con

45 acetyl coenzyme A-dependent transcriptional coactivator functions from a chromatin-assembled templat

46 tional activator and suggest that control of coactivator function (i.e. recruitment of CBP and stimul

47 lized TRbeta LBD depleted the extract of the coactivator function in a triiodothyronine-dependent man

48 To better understand PGC-1 coactivator function in brown fat development, we explor

49 plays a role in breast cancer because of its coactivator function in ER signaling, we determined the

50 steine-rich domain) were unnecessary for G9a coactivator function in ERalpha-mediated transcription.

51 d blocks both its enzymatic activity and its coactivator function in regulating basal p21 gene expres

52 re the requirement of ubiquitylation for the coactivator function in regulating HIV-1 transcriptional

53 potent, activator-dependent transcriptional coactivator function in response to VP16, Sp1, and Sp1/S

54 In this study, we investigated PC4 coactivator function in the control of LHR transcription

55 tigate the requirement of lipin-1 PAP versus coactivator function in the establishment of Pparg expre

56 These results strongly suggest that a p160 coactivator functions in CAR-mediated transactivation in

57 insic acetyltransferase activity whose exact coactivator functions in the acetylation of nucleosomal

58 Here we show that PC4 coactivator function, in contrast to basal (activator-in

59 roles in vivo and suggest a new mechanism of coactivator function, in which a single adaptor protein

60 nts, suggesting that the complex possesses a coactivator function independent from remodeling.

61 Thus, SAF6 is essential for SAGA coactivator function independent of the enzymatic activi

62 Thus, whereas GRIP1 coactivator function involves direct binding to nuclear

63 eginning E(2) treatment, suggesting that G9a coactivator function is by direct interaction with ERalp

64 scriptional regulation, suggest that SRCAP's coactivator function may depend on its ability to promot

65 the N-terminal domain and that the increased coactivator function of AIB1-Delta4 is due to the loss o

66 This coactivator function of atrogin-1 was dependent on its u

67 The synergistic coactivator function of beta-catenin and CARM1 is not re

68 ption activator target that is essential for coactivator function of both the SAGA and NuA4 histone a

69 The coactivator function of cAMP-responsive element-binding

70 We previously demonstrated that the coactivator function of CARM1 depends both on the methyl

71 other domains of CARM1 are required for the coactivator function of CARM1 in addition to the methylt

72 AD, the interaction of CoCoA with p300, the coactivator function of CoCoA for estrogen receptor alph

73 sactivation activity and is required for the coactivator function of CoCoA with nuclear receptors.

74 ding transcriptional activator proteins, the coactivator function of GRIP1 with Lef1 follows a novel

75 Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of it

76 The coactivator function of Mediator-P.5 was not impaired wh

77 only a minor contribution to the long-range coactivator function of Mll3/4.

78 g Ag recognition via direct control over the coactivator function of p300/CBP.

79 n was accompanied by inhibition of the basal coactivator function of PELP1 upon estrogen receptor tra

80 gion of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compro

81 cted with SRC1 and p300, suggesting that the coactivator function of RIZ1 may be mediated by its inte

82 These results establish a coactivator function of TAF4 and provide a strategy to d

83 studies have shown that the transcriptional coactivator function of the Mediator involves direct lig

84 that reduced actin binding also reduced the coactivator function of this Fli-I fragment.

85 ely to result in differential effects on the coactivator functions of CBP/p300 for different classes

86 ed with the ability of ORF2 to stimulate the coactivator functions of HMGA1.

87 The coactivator functions of p300 and CARM1 depended on the

88 on in vivo, we have investigated further the coactivator functions of steroid receptor coactivator-1

89 ce of S675 phosphorylation and transcription coactivator function on BIG2 AKAP-C sequence.

90 TR as well as progesterone receptor-mediated coactivator function on reporter gene expression.

91 e previously shown that yeast TFIID provides coactivator function on the promoters of ribosomal prote

92 Dual DNA-binding and coactivator functions provide an additional level of com

93 PHD3 knockdown inhibits PKM2 coactivator function, reduces glucose uptake and lactate

94 mechanisms by which phosphorylation affects coactivator function remains largely undefined.

95 Finally, we show that mPus1p-coactivator function required SRA, mPus1p-associated mRA

96 mmary tumor virus (MMTV) promoters, and this coactivator function required the methyltransferase acti

97 rmone responses in vivo and that loss of its coactivator function results in partial resistance to ho

98 tivator complex but differentially modulates coactivator function such that inhibition of the CBP/p30

99 This coactivator function, surprisingly, is independent of it

100 says identify a domain of TAF3 that mediates coactivator functions targeted by MyoD.

101 owever, the molecular basis underlying MAML1 coactivator function that contributes to Notch signaling

102 role for G9a as a molecular scaffold for its coactivator function, the G9a-specific methyltransferase

103 results are in contrast to the classic ARA55 coactivator function to enhance AR transactivation parti

104 function of E6-AP was defective whereas the coactivator function was intact.

105 GRIP1 mutants deficient in GR binding and coactivator functions were also defective for corepressi

106 ty of CARM1 is important for its synergistic coactivator function with beta-catenin.