ライフサイエンスコーパス: coactivator protein

1 sion occurs through competition for a single coactivator protein.

2 occurs through increased binding to the p300 coactivator protein.

3 factor docking switches on the activity of a coactivator protein.

4 inding to and sequestering the p300 cellular coactivator protein.

5 ing protein (CBP), a transcriptional adaptor/coactivator protein.

6 and inhibited FoxM1B recruitment of the CBP coactivator protein.

7 n of necessary but different transcriptional coactivator proteins.

8 ociation of the GR with either remodeling or coactivator proteins.

9 in structure and the recruitment of receptor coactivator proteins.

10 stent with its inability to recruit receptor coactivator proteins.

11 ) that mediates hormone-dependent binding of coactivator proteins.

12 diated by distinct interactions with related coactivator proteins.

13 y conserved throughout the 300 or so natural coactivator proteins.

14 ve state conformation for optimal binding to coactivator proteins.

15 ors (RARs) competing for limiting amounts of coactivator proteins.

16 ich is essential for recruitment of p300/CBP coactivator proteins.

17 ssociates with transcriptional activator and coactivator proteins.

18 oncerted action of transcription factors and coactivator proteins.

19 th p300-CREB-binding protein transcriptional coactivator proteins.

20 tional activation by recruiting the p300/CBP coactivator proteins.

21 orepressors and promoting the association of coactivator proteins.

22 ther CARM1 can cooperate with other types of coactivator proteins.

23 s accomplished with the help of a variety of coactivator proteins.

24 several levels, including interactions with coactivator proteins.

25 xisome proliferator-activated receptor gamma coactivator protein 1alpha and stimulates hepatic glucon

26 xisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha), a key transcrip

27 antagonist due to ineffective recruitment of coactivator proteins and that enhanced coactivator recru

28 n regarding interactions between the LBD and coactivator proteins and the potential role of these int

29 of helix 12 and, thus, influence binding of coactivator proteins and their regulatory effect on tran

30 well as other biological processes, but both coactivator proteins are expressed in many other tissues

31 Steroid receptors and coactivator proteins are thought to stimulate gene expre

32 protein kinases, which associate with "Mob" coactivator proteins, are central but incompletely under

33 se during HF pathogenesis and identifies BET coactivator proteins as therapeutic targets in the heart

34 show that the C-terminal domain of the human coactivator protein ASC-1 defines a novel superfamily, t

35 The transcriptional coactivator protein CBP and its paralog p300 each contai

36 cription through recruitment of the cellular coactivator protein CBP to the HTLV-I promoter, promotin

37 luding ATF-2, c-jun, Ets, Sp1, Egr-1 and the coactivator proteins CBP/p300 are recruited to the TNF-a

38 While ATF-2, c-Jun, and the coactivator proteins CBP/p300 play a central role in TNF

39 igations, we determine that recruitment of a coactivator protein, CBP (the CREBbinding protein), to t

40 uitment by nuclear receptors (NR) requires a coactivator protein, CCAR1 (cell-cycle and apoptosis reg

41 The APC is regulated by binding of the coactivator proteins Cdc20p and Cdh1p, and by phosphoryl

42 ligands activate transcription by recruiting coactivator protein complexes.

43 to NRs induces a conformation that attracts coactivator proteins containing an Leu-x-x-Leu-Leu motif

44 ive effects of these mutations on binding of coactivator proteins correlated with their cumulative ef

45 gulated by interactions with corepressor and coactivator proteins (CoRs and CoAs, respectively).

46 alpha enhancer complex is dependent upon the coactivator proteins CREB binding protein and p300.

47 teraction with its IFN-beta promoter and its coactivator protein (CREB-binding protein).

48 Here, we show that loss of Sp1-coactivator protein DRIP-130, which is encoded by human

49 Overexpression of coactivator protein DRIP205 resulted in enhanced differe

50 s and the binding of the enhancer-associated coactivator protein Ep300 (also known as p300).

51 suggesting that a subset of T cell-specific coactivator proteins exist to selectively potentiate AP-

52 here that PPARgamma interacts with Hic-5, a coactivator protein expressed in gut epithelial cells.

53 es the previously described nuclear receptor coactivator protein Flightless-I (Fli-I).

54 genomic region of Cited1, a transcriptional coactivator protein for CBP/p300.

55 in complex stimulates recruitment of the CBP coactivator protein for expression of Foxa2, a transcrip

56 Coactivator proteins function prominently in these pathw

57 ts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor an

58 cetyltransferase (SAGA) complex requires the coactivator protein Gcn5 for HAT activity.

59 studies have shown that the transcriptional coactivator protein Gcn5 functions as a catalytic histon

60 The yeast transcriptional coactivator protein GCN5 was recently shown to be a nucl

61 ity blocks the association of MEF2C with the coactivator protein GRIP-1 and thereby inhibits the acti

62 A number of transcriptional coactivator proteins have been identified as histone ace

63 cognition domains (bromodomains) of putative coactivator proteins implicated in transcriptional initi

64 C/EBPalpha transcription factors and the CBP coactivator protein in vivo.

65 iption factors and p300/CREB-binding protein coactivator proteins in cytokine gene induction during T

66 TET2 bound the androgen receptor (AR) and AR-coactivator proteins in LNCaP cell extracts, and TET2 KD

67 ntral regulator of adipogenesis and recruits coactivator proteins in response to ligand.

68 The significance of androgen receptor (AR) coactivator proteins in this androgen-dependent malignan

69 in the ability of ERalpha and ERbeta to bind coactivator proteins in vitro, despite the similarity in

70 ing of the nucleocytoplasmic distribution of coactivator proteins involved in transcription is an act

71 Nuclear receptor binding to coactivator proteins is an obligate first step in the re

72 Consistent with the observed increase in coactivator protein levels, we were also able to observe

73 a loss in interaction between Vps4 with its coactivator protein LIP5 needed to promote the formation

74 r Notch (NotchIC) and the recruitment of the coactivator protein Mastermind to the complex.

75 l activation complex by interacting with the coactivator protein Mastermind-like 1 and the DNA bindin

76 in is required for activity of Notch and its coactivator protein, mastermind, during wing development

77 the ability of ERalpha and ERbeta to recruit coactivator proteins may contribute to the complex tissu

78 or (AR) transcriptional activity mediated by coactivator proteins may drive castration-resistant pros

79 Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revea

80 Coactivator proteins, namely, p300 and AIB1, are found a

81 ticular, Pkc1p causes phosphorylation of the coactivator protein Ndd1p.

82 mplex, through direct phosphorylation of the coactivator protein Ndd1p.

83 e of corepressor proteins and the binding of coactivator proteins necessary for gene transcription.

84 enhanced p53 stability, implying that these coactivator proteins normally operate in p53 turnover co

85 he cyclin E/CDK2-dependent activation of the coactivator protein nuclear protein, ataxia-telangiectas

86 ription factors and with chromatin-modifying coactivator proteins of several types.

87 profiling of a retinoic acid receptor alpha coactivator protein, P/CAF, demonstrated elevated expres

88 drogen receptor (AR) and the upregulation of coactivator protein p300 and pioneer factors (e.g., GATA

89 Interestingly, the coactivator protein p300 can eliminate this BSAP-mediate

90 -subunit (HIF-1alpha) to the transcriptional coactivator protein p300.

91 iption, we examined its interaction with the coactivator protein p300/CBP.

92 3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP.

93 inoblastoma tumor suppressor protein and the coactivator proteins p300/CBP (where CBP is the CREB-bin

94 Since the coactivator proteins p300/CBP, SRC-1A, and RAC3 had prev

95 ast to the interaction of PPARalpha with the coactivator protein, p300, association of the receptor w

96 dk5 was supported by adaptive changes in the coactivator protein p35 and by elevated glycogen synthes

97 cid sequence is similar to that of mammalian coactivator protein PC4.

98 FGF21, in turn, induces the transcriptional coactivator protein peroxisome proliferator-activated re

99 increased the mRNA and protein levels of the coactivator protein PGC1alpha, and this effect was depen

100 Here, we investigated whether the CBP coactivator protein played a different role in regulatin

101 tor of nuclear receptors by modulating SRC-3 coactivator protein-protein complex formation and ultima

102 ity together with elevated levels of the CBP coactivator protein provided a 6.2-fold synergistic incr

103 likely the result of the concerted action of coactivator proteins recruited by the activators' short

104 iption, but also suggest that it can augment coactivator protein recruitment to at least some members

105 (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription throug

106 complexed by transcriptional corepressor or coactivator proteins, respectively.

107 on these results, we propose that a limiting coactivator protein(s) interacts with the AF-2 of PR or

108 des containing the LXXLL motifs derived from coactivator protein sequences.

109 The steroid coactivator protein SRC-1, through interactions with dev

110 rotein (TBP), TAF4, and TAF6] as well as the coactivator proteins SRC-1a and TIF2.

111 n receptor alpha (ERalpha), steroid receptor coactivator proteins (SRC), and acetylated histones H3/H

112 C termini or recruitment of steroid receptor coactivator proteins (SRC-1 or -2), although SRC transfe

113 fects that different ERalpha ligands have on coactivator protein steady-state levels and demonstrate

114 mpaired in interaction with AF-2-interacting coactivator proteins such as SRC-1 and GRIP-1.

115 Functional CAR:RXR heterodimers recruit coactivator proteins, such as the steroid receptor coact

116 The coactivator protein TAF(II)31 binds to p53 at the amino-

117 itamin D receptor (VDR) and nuclear receptor coactivator protein that is unrelated to other VDR coact

118 ing to estrogen response elements (EREs) and coactivator proteins that act as bridging proteins betwe

119 k, we examine the roles of the Ada2 and Ada3 coactivator proteins that are functionally linked to Gcn

120 anscription involves chromatin remodeling by coactivator proteins that are recruited by DNA-bound tra

121 sses formation of astrocytes by sequestering coactivator proteins that are required by signal transdu

122 fied into an emerging set of transcriptional coactivator proteins that function to facilitate vitamin

123 studies have identified a universal motif in coactivator proteins that mediates association with rece

124 t at a FoxA-specific site, HNF-6 serves as a coactivator protein to enhance FoxA2 transcription, wher

125 ranscription factor (HNF-6) functioning as a coactivator protein to potentiate the transcriptional ac

126 more clusters reduced binding to all of the coactivator proteins to background levels.

127 LL motifs shown previously in other types of coactivator proteins to be essential for mediating NR bi

128 ranscription factors require transcriptional coactivator proteins to mediate their stimulation of tra

129 DNA-bound transcription factors recruit many coactivator proteins to remodel chromatin and activate t

130 sociated with their target genes and recruit coactivator proteins to remodel chromatin structure, rec

131 ith the C-terminal fragment of a coiled-coil coactivator protein, transforming acidic coiled-coil coa

132 toregulatory transcription factor, acting as coactivator proteins when ComK is present at low concent

133 YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins

134 D response elements in the DNA and specific coactivator proteins which help to initiate transcriptio

135 r molecule for the recruitment of additional coactivator proteins, which can finely regulate HBV tran

136 n of these transcription factors and the CBP coactivator protein with the endogenous mouse Foxa2 prom

137 ad, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together

138 the interaction of transcription factors and coactivator proteins with the promoter of steroidogenic

139 The nature of the interaction of coactivator proteins with transcriptionally active promo

140 g acts via a non-DNA-binding transcriptional coactivator protein, Yorkie.