ライフサイエンスコーパス: coagulase

1 .9%; Staphyloslide, 99.1 and 98.9%; and tube coagulase, 99.3 and 100%.

2 ere ectopically expressed, the expression of coagulase, a sae target with low affinity for phosphoryl

3 pigmentation, and decreased hemolysis and/or coagulase activity are periodically isolated by the clin

4 trate phenotypic growth patterns and lack of coagulase activity consistent with SCVs.

5 ency of vWbp or VWF as well as inhibition of coagulase activity reduced S aureus adhesion.

6 gnificantly alter the expression patterns of coagulase and alpha-hemolysin, two well-known sae target

7 pression of major virulence factors, such as coagulase and alpha-hemolysin.

8 P1 did not affect the expression pattern of coagulase and alpha-hemolysin.

9 ting with 125I-fibrinogen, we could identify coagulase and an additional unidentified 52-kDa protein

10 hibitory clindamycin stimulates synthesis of coagulase and fibronectin binding protein B, also at the

11 genes encoding alkaline shock protein 23 and coagulase and have demonstrated SigB and RsbW dependence

12 gy, tests for clumping factor, and tests for coagulase and urease activities and were also tested wit

13 s, assembly of protective fibrin shields via coagulases and protein A-mediated B cell superantigen ac

14 lthough it was deficient in clumping factor, coagulase, and pigment.

15 Protein A and coagulases are distinctive virulence attributes for S. a

16 he increased expression and transcription of coagulase as shown by Western (immunoblot) and Northern

17 ons were regulated by SaeRS and dependent on coagulase-catalyzed conversion of fibrinogen into fibrin

18 Staphylococcus aureus secretes coagulase (Coa) and von Willebrand factor-binding protei

19 protein A (spa), gamma hemolysin (hlg), and coagulase (coa) were also located on the map by PFGE and

20 ulated surface determinants (IsdA and IsdB), coagulase (Coa), and von Willebrand factor binding prote

21 S. aureus secretes coagulase (Coa), which activates host prothrombin and ge

22 nfection, Staphylococcus aureus secretes two coagulases (Coa and von Willebrand factor binding protei

23 the variable prothrombin binding portion of coagulases confer type-specific immunity through the neu

24 tudy, we use a S. aureus mutant lacking both coagulases (Deltacoa/vwb) and dabigatran, a pharmacologi

25 ty and its relationship to the expression of coagulase (encoded by coa) and clumping factor (encoded

26 ureus was identified from all media by slide coagulase, exogenous DNase, and mannitol fermentation as

27 By combining variable portions of coagulases from North American isolates into hybrid Coa

28 Coagulase gene (coa) short sequence repeat region sequen

29 agment length polymorphism (PCR-RFLP) of the coagulase gene and pulsed-field gel electrophoresis (PFG

30 d based on improved PCR amplification of the coagulase gene and restriction fragment length polymorph

31 ally, strains were subtyped according to the coagulase gene in order to strengthen discriminatory pow

32 The coagulase gene PCR products for 24 isolates of MRSA and

33 Further coagulase gene sequence analysis subtyped those 20 strai

34 the genomes of different S. aureus isolates, coagulase gene sequences are variable, and this has been

35 irulence factors such as alpha-hemolysin and coagulase; however, the molecular mechanism of this sign

36 hese findings emphasize the critical role of coagulase in staphylococcal escape from opsonophagocytic

37 Thus, coagulase is a major binding protein for soluble fibrino

38 Coagulase-mediated biofilms exhibited increased antimicr

39 Adhesion was further enhanced by coagulase-mediated fibrin formation that clustered bacte

40 Nine mauve colonies were slide coagulase negative and were subsequently identified as S

41 ased risk of nosocomial bacterial sepsis and coagulase negative staphylococcal infections, and thus s

42 The dominant isolates were Coagulase negative Staphylococci (CNS) 9(29.0%), Staphyl

43 predominantly isolated pathogen, followed by Coagulase negative staphylococci (CoNS) (33.5%) and Kleb

44 ith another enteric bacteria (n=23), or with coagulase negative staphylococci (CONS) (n=24).

45 Coagulase negative Staphylococci (CoNS) were the most co

46 The proportion of coagulase negative Staphylococci among the Gram positive

47 ssociated with Klebsiella pneumoniae whereas Coagulase negative Staphylococci and Bacillus spp. are c

48 The resistance of S. aureus and coagulase negative staphylococci clinical isolates to te

49 the most frequently isolated species of the coagulase negative staphylococci from human stool.

50 ccus viridians, Streptococcus pneumoniae and Coagulase negative Staphylococci in endophthalmitis diag

51 P. aeruginosa and E. coli in dacryocystitis; Coagulase negative Staphylococci, Pseudomonas aeruginosa

52 s far as this review, Staphylococcus aureus, Coagulase negative Staphylococci, Streptococcus pneumoni

53 ial infection is common, particularly due to coagulase negative staphylococci.

54 les was high and the predominant isolate was coagulase negative Staphylococci.

55 ed among the S. aureus isolates; however, 10 coagulase-negative isolates were MecA+ but oxacillin sen

56 Fewer coagulase-negative staphylococcal (CoNS) contaminants gr

57 validated by correctly identifying 36 of 37 coagulase-negative staphylococcal (CoNS) isolates identi

58 caprae was the cause of 6 of 18 episodes of coagulase-negative staphylococcal bacteremia, was the mo

59 ive quantitative blood cultures and definite coagulase-negative staphylococcal bloodstream infection.

60 occus aureus rather than those caused by its coagulase-negative staphylococcal counterparts.

61 Differentiating true coagulase-negative staphylococcal infection from contami

62 ntries showed a trend of increasing risk for coagulase-negative staphylococcal infection.

63 has been implicated in a large proportion of coagulase-negative staphylococcal infections in very-low

64 re comorbidity and a rise in enterococci and coagulase-negative staphylococcal infections.

65 The presence of icaA in a coagulase-negative staphylococcal isolate associated wit

66 ed non-prosthetic joint infection-associated coagulase-negative staphylococcal isolates were icaA pos

67 A total of 46% (20 out of 44) of coagulase-negative staphylococcal prosthetic joint infec

68 mong which filamentous fungi (25, 39.1%) and coagulase-negative staphylococci (14, 21.9%) comprised a

69 56%), Staphylococcus aureus (28%), and other coagulase-negative staphylococci (16%).

70 ms causing CLABSI in oncology locations were coagulase-negative staphylococci (16.9%), Escherichia co

71 Staphylococcus epidermidis (MSSE) (9), other coagulase-negative staphylococci (19), Streptococcus sal

72 Common pathogens were coagulase-negative staphylococci (21%, 10/48) and methic

73 The most frequent causal microorganisms were coagulase-negative staphylococci (24%), followed by Stap

74 Coagulase-negative staphylococci (36%) were the most com

75 The most common pathogens were coagulase-negative staphylococci (68%) and Staphylococcu

76 organism (128 patients [23.0%]), followed by coagulase-negative staphylococci (94 patients [16.9%]).

77 , (ii) distinguish between S. aureus and the coagulase-negative staphylococci (CNS) (based on amplifi

78 ut not for Streptococcus spp. (P = 0.85) and coagulase-negative staphylococci (CNS) (P = 0.88).

79 Coagulase-negative staphylococci (CNS) are important cau

80 Coagulase-negative staphylococci (CNS) are the most comm

81 s and 100 isolates of erythromycin-resistant coagulase-negative staphylococci (CNS) were examined by

82 Coagulase-negative staphylococci (CNS) were the most com

83 lococcus epidermidis, Staphylococcus aureus, coagulase-negative staphylococci (CNS), Peptostreptococc

84 as among mecA(+) strains of other species of coagulase-negative staphylococci (CNS).

85 The most common organisms identified were Coagulase-negative Staphylococci (CoNS) [65.9% (91/138)]

86 ) to accurately differentiate S. aureus from coagulase-negative staphylococci (CoNS) and other Gram-p

87 investigating issues related to isolation of coagulase-negative staphylococci (CoNS) and other skin m

88 Coagulase-negative staphylococci (CoNS) and Staphylococc

89 gh horizontal gene transfer originating from coagulase-negative staphylococci (CoNS) and through clon

90 Coagulase-negative staphylococci (CoNS) are important pa

91 Coagulase-negative staphylococci (CoNS) are the main cau

92 microdilution and disk diffusion testing of coagulase-negative staphylococci (CoNS) by using a PCR a

93 Coagulase-negative staphylococci (CoNS) form a thick, mu

94 he presence of secreted cytotoxic factors of coagulase-negative staphylococci (CoNS) from bovine clin

95 Differentiating Staphylococcus aureus from coagulase-negative staphylococci (CoNS) is important in

96 used to determine the clinical importance of coagulase-negative staphylococci (CoNS) is isolation of

97 P67 card for detecting methicillin-resistant coagulase-negative staphylococci (CoNS) is not known.

98 sis is an aggressive, virulent member of the coagulase-negative staphylococci (CoNS) that is responsi

99 Unbiased species-level identification of coagulase-negative staphylococci (CoNS) using matrix-ass

100 .01 for detection of oxacillin resistance in coagulase-negative staphylococci (CoNS) was compared to

101 s for detection of Staphylococcus aureus and coagulase-negative staphylococci (CoNS) were 99.5% (217/

102 inical isolates of Staphylococcus aureus and coagulase-negative staphylococci (CoNS) were determined

103 Five hundred isolates of coagulase-negative staphylococci (CoNS) were recovered f

104 spersal of S. aureus, a 1.4-fold increase in coagulase-negative staphylococci (CoNS), and a 3.9-fold

105 methicillin-resistant S. aureus (MRSA), and coagulase-negative staphylococci (CoNS), including methi

106 and 53 strains of Staphylococcus aureus and coagulase-negative staphylococci (CoNS), respectively.

107 it ocular isolates of Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus p

108 dical Center for the rapid identification of coagulase-negative staphylococci (CoNS).

109 abilities to detect oxacillin resistance in coagulase-negative staphylococci (CoNS).

110 lar for infections caused by enterococci and coagulase-negative staphylococci (CoNS; adjusted SHR, 0.

111 BSIs were caused by coagulase-negative staphylococci (n = 27), enterococci (

112 ), followed by Enterobacteriaceae (n=22) and coagulase-negative staphylococci (n=6).

113 ruginosa (2 of 4), streptococci (2 of 5), or coagulase-negative staphylococci (none of 8) (P = 0.02).

114 More staphylococci (P < 0.05), especially coagulase-negative staphylococci (P < 0.05), and yeasts

115 < 0.001), Staphylococcus aureus (P = 0.003), coagulase-negative staphylococci (P = 0.008), gram-negat

116 N anaerobic bottle, while significantly more coagulase-negative staphylococci (P = 0.01), Streptococc

117 and streptococci slightly declined, whereas coagulase-negative staphylococci and enterococci consist

118 enced recurrence in this study (isolation of coagulase-negative staphylococci and inadequate duration

119 Coagulase-negative staphylococci and other gram-positive

120 Coagulase-negative staphylococci and Staphylococcus aure

121 ganisms; the species cultured were typically coagulase-negative staphylococci and were associated wit

122 Coagulase-negative staphylococci are by far the most com

123 Coagulase-negative staphylococci are common nosocomial p

124 Approximately 75% of coagulase-negative staphylococci are resistant to methic

125 Coagulase-negative staphylococci are the most frequently

126 species identification of blood isolates of coagulase-negative staphylococci as a predictor of the c

127 ); (ii) controlled cultural findings showing coagulase-negative staphylococci as the most common isol

128 s more likely to have poor final acuity than coagulase-negative staphylococci cases (adjusted OR, 11.

129 All Staphylococcus aureus and coagulase-negative staphylococci clinical isolates cultu

130 Cure proportions were highest for coagulase-negative staphylococci followed by gram-negati

131 temic infections is usually required because coagulase-negative staphylococci have become increasingl

132 Coagulase-negative staphylococci have long been regarded

133 8), Candida albicans in 5.8% (26/443), other coagulase-negative staphylococci in 6.0% (27/448), Propi

134 ferentiate between Staphylococcus aureus and coagulase-negative staphylococci in blood cultures growi

135 or determining beta-lactam susceptibility in coagulase-negative staphylococci in our laboratory.

136 Other important infections due to coagulase-negative staphylococci include central nervous

137 days for S. aureus infection vs. 14 days for coagulase-negative staphylococci infection [p < 0.001]).

138 olonisation of indwelling medical devices by coagulase-negative staphylococci is a prevalent risk in

139 iated with prosthetic joint infection and 23 coagulase-negative staphylococci isolated from noninfect

140 Clinical isolates of coagulase-negative staphylococci often elaborate a biofi

141 eliability of routine sensitivity testing in coagulase-negative staphylococci often lead to the use o

142 Isolation of coagulase-negative staphylococci only in broth, in the a

143 oximately 60% of the samples (730) contained coagulase-negative staphylococci or nonstaphylococci as

144 species of Acinetobacter, Enterobacter, and coagulase-negative staphylococci recovered from the hand

145 monas aeruginosa, Staphylococcus aureus, and coagulase-negative staphylococci strains.

146 Of 118 strains of coagulase-negative staphylococci tested, 81 were oxacill

147 As it has been shown for coagulase-negative staphylococci that some autolysins ar

148 Similar numbers of consecutive patients with coagulase-negative staphylococci were analyzed for compa

149 Coagulase-negative staphylococci were identified in 7 ey

150 nstitutional rates of 73% contamination when coagulase-negative staphylococci were identified, 67.6%

151 Coagulase-negative staphylococci were more frequently as

152 cocci, and 11/42 (26%) methicillin-resistant coagulase-negative staphylococci were mupirocin resistan

153 Strains from 11 species of coagulase-negative staphylococci were selected such that

154 Coagulase-negative staphylococci were the only pathogens

155 n pathogens were associated with device use: coagulase-negative staphylococci with central lines, P.

156 eudomonas with piperacillin (1 of 28, 3.6%), coagulase-negative staphylococci with oxacillin (2 of 74

157 isolate each of Propionibacterium acnes and coagulase-negative staphylococci) in FAN bottles, wherea

158 aureus and 56 [31.6% {95% CI, 24.9%-39.0%}] coagulase-negative staphylococci); and a high prevalence

159 For the coagulase-negative staphylococci, 150 were MecA+ and 111

160 tive bacteria, 40 Staphylococcus aureus, 152 coagulase-negative staphylococci, 28 streptococci, 22 en

161 6.2% of cases (Staphylococcus aureus, 26.6%; coagulase-negative staphylococci, 9.7%).

162 ssociated infections are currently caused by coagulase-negative staphylococci, a pathogen that incite

163 isms that are often considered contaminants (coagulase-negative staphylococci, aerobic and anaerobic

164 isolates, 3/16 (19%) methicillin-susceptible coagulase-negative staphylococci, and 11/42 (26%) methic

165 Propionibacterium species, coagulase-negative staphylococci, and Corynebacterium sp

166 lates were Staphylococcus epidermidis, other coagulase-negative Staphylococci, and Corynebacterium sp

167 d isolates, including Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis,

168 Although coagulase-negative staphylococci, including Staphylococc

169 increased isolation of Enterococcus species, coagulase-negative staphylococci, intrinsically antibiot

170 epidermidis and a series of closely related coagulase-negative staphylococci, most of which are oppo

171 -1), enterotoxin, and other superantigens by coagulase-negative staphylococci, no associated pathogen

172 negative bacterial rods and three species of coagulase-negative staphylococci, recovered from both th

173 in-susceptible S. aureus, and 14 and 35% for coagulase-negative staphylococci, respectively.

174 Contrary to other coagulase-negative staphylococci, S. lugdunensis bound t

175 methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, vancomycin-resistant e

176 Coagulase-negative staphylococci, with the leading speci

177 . aureus and 100% sensitive and specific for coagulase-negative staphylococci.

178 less accurate for methicillin resistance in coagulase-negative staphylococci.

179 osed in vitro to opsonized S. pneumoniae and coagulase-negative staphylococci.

180 r internalization of either S. pneumoniae or coagulase-negative staphylococci.

181 er contained biofilms comprised primarily of coagulase-negative staphylococci.

182 Standards breakpoint of 4 micrograms/ml for coagulase-negative staphylococci.

183 including endocarditis, compared with other coagulase-negative staphylococci.

184 ugh cloth and paper gowns was performed with coagulase-negative staphylococci.

185 The most prevalent pathogens were coagulase-negative staphylococcus (39.4%), followed by S

186 The prevalence of coagulase-negative Staphylococcus (40.9% in group A and

187 ost frequent germs found in the samples were coagulase-negative Staphylococcus (48.6%).

188 olate was Propionibacterium acnes (11/26) vs coagulase-negative Staphylococcus (57/92); and 4) patien

189 The most common isolate overall was coagulase-negative Staphylococcus (CNS) and the most com

190 ely 30 Staphylococcus aureus isolates and 20 coagulase-negative staphylococcus (CoNS) isolates in a p

191 disk and MIC breakpoints, the CLSI M100-S25 coagulase-negative Staphylococcus (CoNS) oxacillin MIC b

192 and 9 (2.5%) were identified by StaphPlex as coagulase-negative Staphylococcus (CoNS), methicillin-re

193 teremia and blood cultures contaminated with coagulase-negative Staphylococcus (CoNS).

194 thicillin-sensitive S. aureus (n = 134), and coagulase-negative Staphylococcus (n = 176).

195 Coagulase-negative staphylococcus accounted for 41 of th

196 on at both DEI (70%) and LAC+USC (68%), with coagulase-negative Staphylococcus being the most common

197 tes, the most commonly isolated organism was coagulase-negative Staphylococcus both at baseline (73%)

198 organism (30.6%), but the number of isolated coagulase-negative Staphylococcus cases increased signif

199 significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline c

200 re gram-positive bacteria (91.3%), including coagulase-negative Staphylococcus in 78.3%.

201 Coagulase-negative Staphylococcus isolates were not cons

202 For 155 Staphylococcus aureus and 261 coagulase-negative Staphylococcus isolates, the bDNA ass

203 aphylococcal bacteremia, was the most common coagulase-negative staphylococcus recovered from the nar

204 Coagulase-negative staphylococcus remains the most frequ

205 llin-resistant Staphylococcus aureus (4.4%), coagulase-negative Staphylococcus species (15.3%), Strep

206 vestigations revealing no microorganism or a coagulase-negative Staphylococcus species (CNSP), and fu

207 Certain coagulase-negative Staphylococcus species appeared more

208 Propionibacterium acnes and coagulase-negative Staphylococcus species were the most

209 d methicillin-susceptible S. aureus species, coagulase-negative Staphylococcus species, and other cli

210 Gram-positive bacteria, particularly coagulase-negative Staphylococcus spp, remain the leadin

211 gnificantly more Bacillus spp. (P < 0.0001), coagulase-negative Staphylococcus spp. (P < 0.0001), and

212 es of Staphylococcus aureus (P = 0.0113) and coagulase-negative Staphylococcus spp. (P = 0.0029) than

213 tream infections (septic episodes) caused by coagulase-negative Staphylococcus spp. (P = 0.0146).

214 ty-nine clinical staphylococcal isolates (58 coagulase-negative Staphylococcus spp. [CoNS] and 41 Sta

215 ion, using breakpoints for human isolates of coagulase-negative Staphylococcus spp., had low sensitiv

216 fied as 10 MRSA strains, 10 MSSA strains, 12 coagulase-negative Staphylococcus strains, and 8 Microco

217 Staphylococcus lugdunensis is a coagulase-negative staphylococcus that has several simil

218 Staphylococcus caprae, a hemolytic coagulase-negative staphylococcus that is infrequently a

219 Coagulase-negative Staphylococcus was isolated in 39 of

220 For coagulase-negative Staphylococcus, an increased inoculum

221 easts, Actinobacillus actinomycetemcomitans, coagulase-negative Staphylococcus, Campylobacter rectus,

222 nd II, and vitreous cultures for infections (coagulase-negative Staphylococcus, Candida, Fusarium, an

223 ye preparations demonstrated the presence of coagulase-negative Staphylococcus, Streptococcus type al

224 in 4 of 5 cases; all positive cultures grew coagulase-negative Staphylococcus.

225 (P < 0.001), S. aureus isolates (P < 0.001), coagulase-negative staphyococci (P = 0.003), and total o

226 For coagulase-negative strains at 24 h of incubation, breakp

227 h enhanced expression of clumping factor and coagulase on immunoblots.

228 Confirming coagulase on pink isolates, the sensitivity and specific

229 d-phase fibrinogen, clumping factor, but not coagulase, plays a major role in binding to immobilized

230 ositive S. agnetis isolates were found to be coagulase positive at 4 h.

231 Overall, 88% (37/42) of coagulase-positive S. agnetis isolates were found to be

232 The herd-level prevalence of coagulase-positive S. agnetis ranged from 0 to 2.17%.

233 on that had previously been characterized as coagulase-positive S. hyicus based on phenotypic species

234 Although Staphylococcus intermedius and coagulase-positive species of staphylococci are reported

235 Staphylococcus pseudintermedius is a coagulase-positive species that colonizes the nares and

236 ection control decisions requires that these coagulase-positive staphylococci are accurately identifi

237 All coagulase-positive staphylococci produced a single PCR a

238 Coagulase-positive Staphylococcus aureus (S. aureus) is

239 , partially controls exoprotein synthesis in coagulase-positive Staphylococcus aureus by modulating t

240 nrichment method was optimum for recovery of coagulase-positive Staphylococcus spp.

241 phenotypic properties of beta-hemolysis and coagulase positivity allowed the clinical isolates to ma

242 acing between promoter elements in P1 or the coagulase promoter was altered to the optimal spacing of

243 polysaccharide (CP8), nuclease, alpha-toxin, coagulase, protease, and protein A.

244 and nuclease but a repressor of alpha-toxin, coagulase, protease, and protein A.

245 losest match being the Staphylococcus aureus coagulase protein.

246 ified 56/56 S. aureus isolates identified by coagulase/protein A latex agglutination.

247 The secretion of coagulases, proteins that associate with and activate th

248 S. aureus secretes the coagulases staphylocoagulase and von Willebrand factor-b

249 an S. aureus strain with genetic deletion of coagulases, survival of mice improved, highlighting the

250 tested using the BNSA test and a direct tube coagulase test (DTCT).

251 h (API) (bioMerieux, Durham, N.C.), the tube coagulase test (TCT) read at 4 h, and peptide nucleic ac

252 The assays were compared to the tube coagulase test and latex agglutination (LA) (Sanofi Diag

253 Staphaurex Plus, Staphyloslide, and the tube coagulase test for the identification of staphylococcal

254 nd definitive treatment compared to the tube coagulase test interpreted at 24 h (TCT24).

255 Data suggest that the tube coagulase test may be interpreted at 4 h (TCT4) with lit

256 o difference in the performance of the slide coagulase test or in susceptibility testing performed on

257 on TSA II was confirmed by Gram staining, a coagulase test, and a cefoxitin disk test.

258 coccus aureus by Gram stain morphology and a coagulase test.

259 Isolates were coagulase tested and identified to the species level usi

260 Direct tube coagulase testing for identification of Staphylococcus a

261 uding VWF-binding protein (vWbp), a secreted coagulase that activates the host's prothrombin to gener

262 protection against challenge with different coagulase-type S. aureus strains in mice was derived.

263 5 pulsed-field gel electrophoresis types, 4 coagulase types, and 2 ribotypes.

264 us hyicus and Staphylococcus agnetis are two coagulase-variable staphylococcal species that can be is