ライフサイエンスコーパス: coagulation factor IX

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1 an adenoviral vector expressing human blood coagulation factor IX.

2 xicity and promote the delivery of the human coagulation factor IX and alpha-galactosidase genes into

3 We demonstrated that coagulation factor IX and complement component C4-bindin

4 in patients with haemophilia B (defective in coagulation factor IX) and the Marfan syndrome (defectiv

5 is caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for

6 gene on the X chromosome that encodes blood coagulation factor IX, and is predicted to alter RNA spl

7 o demonstrate a polymorphism of human plasma coagulation factor IX antigen in double antibody solid-p

8 g-term expression (>5 months) of human blood coagulation factor IX at levels that were therapeutic in

9 Coagulation factor IX deficiency causes hemophilia B in

10 We have used gene targeting to develop a coagulation factor IX-deficient (factor IX-knockout) mou

11 lia B is caused by the absence of functional coagulation factor IX (F.IX) and represents an important

12 sociated viral (AAV) vector expressing blood coagulation factor IX (F.IX) can result in long-term exp

13 While substantial levels of coagulation factor IX (F.IX) have been achieved using AA

14 coagulopathy caused by absence of functional coagulation factor IX (F.IX).

15 g disorder hemophilia B [deficiency in blood coagulation factor IX (F.IX)] by gene replacement therap

16 In hemophilia B (coagulation factor IX [F.IX] deficiency), lack of endoge

17 at antigenic epitopes derived from an ARF in coagulation factor IX (F9) cDNA can induce CTL reactivit

18 n particular, we target a promoterless human coagulation factor IX (F9) gene to the liver-expressed m

19 d efficient induction of immune tolerance to coagulation factor IX (FIX) by direct intramuscular inje

20 emonstrated induction of immune tolerance to coagulation factor IX (FIX) by hepatic adeno-associated

21 Long-term expression of coagulation factor IX (FIX) has been observed in murine

22 associated viral (AAV) vector encoding blood coagulation factor IX (FIX) into skeletal muscle results

23 d mice with combined deficiencies of Plg and coagulation factor IX (fIX) or XI (fXI) to determine the

24 safety of recombinant fusion protein linking coagulation factor IX (FIX) with albumin (rIX-FP) which,

25 A recombinant fusion protein linking coagulation factor IX (FIX) with human albumin (rIX-FP)

26 coagulopathy caused by absence of functional coagulation factor IX (FIX).

27 calin from Rhodnius prolixus that binds with coagulation factors IX (fIX) and IXa (fIXa).

28 haemophilia B (</=2 IU/dL [</=2%] endogenous coagulation factor IX [FIX] activity).

29 onsidering the enzymatic domain of activated coagulation factor IX (FIXa) is homologous to those of t

30 ient to maintain therapeutic levels of human coagulation Factor IX for more than six months in mice u

31 Oral delivery of coagulation factor IX fused with cholera toxin beta-subu

32 are the result of missense mutations in the coagulation factor IX gene and defective circulating fac

33 cin resistance marker gene (neo) and a human coagulation factor IX genomic construct designed for exp

34 ngle Ca2+ binding EGF-like domain from human coagulation factor IX has recently been solved.

35 tion of immune tolerance to a secreted human coagulation factor IX (hF.IX) antigen by adeno-associate

36 Plasma human coagulation factor IX (hF.IX) levels in mice originating

37 arried out a systematic study on human blood coagulation factor IX (hFIX) and anti-coagulant protein

38 To determine the most robust human coagulation factor IX (hFIX) expression cassette in an a

39 the liver-specific expression of human blood coagulation factor IX (hFIX).

40 d expressing a model therapeutic gene, human coagulation Factor IX, in HEK293T cells.

41 oxylase, it is not stimulated by human blood coagulation factor IX propeptides.

42 closely related fragment, the Gla domain of coagulation factor IX, the structure of which had previo

43 We studied associations of coagulation factors IX through XIII with risk of future

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