ライフサイエンスコーパス: coat color

1 ult in obesity, hyperinsulinemia, and yellow coat color.

2 aganglionic megacolon associated with white coat color.

3 tes and partially restores the normal agouti coat color.

4 >9 widely distributed mammals with seasonal coat color.

5 icient melanosome transfer and a dilution of coat color.

6 ehavior, body composition, reproduction, and coat color.

7 t produce visually striking changes in mouse coat color.

8 these molecules giving rise to lighter skin/coat color.

9 he developing hair, leading to a dilution of coat color.

10 seen in yellow mice, including the change in coat color.

11 describe a bright coat color mutant, Bright coat color 1 (Bcc1), which develops light-colored hair a

12 ve numbers of brown, yellow, or intermediate coat color A(vy)/a offspring.

13 Cdk5 knockdown in mice causes a lightened coat color, a polarized distribution of melanin and hype

14 the hSCF220 transgene display a more severe coat color abnormality.

15 o Collins paw preference in interaction with coat-color among females of a genetically heterogeneous

16 and F3 A(vy)/a offspring were classified for coat color, an indicator of A(vy) methylation.

17 by Corin plays a critical role in specifying coat color and acts downstream of agouti gene expression

18 able to reduce mismatch between the seasonal coat color and an increasingly snow-free background.

19 se coat color mutant mahoganoid (md) darkens coat color and decreases the obesity of A(y) mice that e

20 ying null alleles of dilute have a lightened coat color and die from a neurological disorder resembli

21 ding behavior in the trypanotolerant N'Dama, coat color and horn development in Ankole, and heat tole

22 in mast cells in vivo, and partially rescues coat color and mast cell defects in W(41) mice.

23 ions in transgenic mice for their effects on coat color and obesity.

24 and mg suppressed the effects of Ay on both coat color and obesity.

25 conspicuously among breeds, including size, coat color and texture, behavior, skeletal morphology, a

26 dilute alleles that vary in their effects on coat color and the nervous system.

27 Coat color and type are essential characteristics of dom

28 d beyond brief descriptions of a dilution of coat color and white spotting of the belly and extremiti

29 ic nervous system and does not affect renal, coat color, and retinal choroid development.

30 se, have been identified in mice by abnormal coat color, anemia, and germ cell defects.

31 stibular defects, and have variegated/dilute coat color as a result of pigmentation defects.

32 poson-mediated mutagenesis, which allows for coat color-based genotyping, we created mice in which th

33 All three mutations produce a lightened coat color because of defects in pigment granule transpo

34 us, exhibit a nearly complete restoration of coat color, but, surprisingly, melanosomes remain concen

35 us studies suggest that agouti causes yellow coat color by antagonizing the binding of alpha-melanocy

36 locus encoding a skin peptide that modifies coat color by antagonizing the melanocyte-stimulating ho

37 he 6- to 10-cM region surrounding the albino coat color (c = tyrosinase) locus on mouse chromosome 7.

38 the Prader-Willi/Angelman domain, an agouti coat color cassette was inserted into the downstream ope

39 ther plasticity in the initiation or rate of coat color change will be able to reduce mismatch betwee

40 Furthermore, coat color changed from normal brown to silver.

41 the melanocytes, and MC1R mutations causing coat color changes are known in many mammals.

42 Whereas coat color changes in the mouse mutants W (c-kit defect)

43 y discovered by genetic studies on the mouse coat color changes, and its deletion results in an itchy

44 us mutant ES cells were able to generate low coat color chimeric mice, only the wild-type allele was

45 -of-function Kit phenotypes, including white coat color, decreased numbers of dermal mast cells, and

46 d Bace2(-/-) but not Bace1(-/-) mice display coat color defects, implying a specific role for BACE2 d

47 ozygous for the hSCF transgene demonstrate a coat color deficiency seen in some mice homozygous for m

48 me functional domains of agouti important to coat color determination are important for inducing obes

49 Chm(Flox), Tyr-Cre+ mice exhibited coat color dilution and pigment abnormalities of the RPE

50 by hearing loss, vestibular dysfunction, and coat color dilution.

51 F1 mice exhibit microphthalmia with complete coat color dilution.

52 eration of melanogenesis to result in marked coat color dilution.

53 ne, dilute suppressor (dsu), suppresses this coat color dilution.

54 o this endocrine-active compound shifted the coat color distribution of viable yellow agouti (Avy) mo

55 ed in genes regulating blood group antigens, coat color, fecundity, lactation, keratin formation, neu

56 mplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted re

57 id (md) are negative modifiers of the Agouti coat color gene, which encodes a paracrine signaling mol

58 Although the genetic basis of coat color has been well characterized, relatively littl

59 s exhibit variable microphthalmia and patchy coat color hypopigmentation.

60 e relation between variants of this gene and coat color in animals, suggests that the MC1R is an inte

61 modify this interaction to obtain different coat color in distinct environments are poorly understoo

62 Skin pigmentation in humans and coat color in fleece-producing animals are regulated by

63 lecular cause of recessively inherited black coat color in hamsters (historically referred to as nona

64 Dun is a wild-type coat color in horses characterized by pigment dilution w

65 that acts in a paracrine manner to regulate coat color in mammals.

66 Reports that maternal diet influences coat color in mouse offspring carrying the agouti A(vy)

67 r, we show that a gene responsible for black coat color in the Large Munsterlander has a 40-Mb region

68 c interactions between two mice of different coat colors in their home cage.

69 mosaics-either visible (manifesting mottled coat color) in the scored generation (G2) or masked, amo

70 In Soay sheep, dark coat color is associated with large size, which is herit

71 nsible for 17 viable dilute alleles, a mouse-coat-color locus encoding unconventional myosin-VA.

72 Coat color maps to chromosome 2 where a strong candidate

73 ermline transmission can be scored through a coat color marker.

74 By incorporating mouse coat color markers into the vectors, we illustrate a wid

75 were administered CTx followed by BMT using coat color-mismatched female donors.

76 wn loci and transposase transgenes exhibited coat color mosaicism, indicating somatic transposition.

77 )) at the mouse albino locus that results in coat-color mottling has been characterized at the molecu

78 The mouse coat color mutant mahoganoid (md) darkens coat color and

79 similar to those of the recently identified coat color mutant mahogany (Atrn(mg)).

80 Here, we describe a bright coat color mutant, Bright coat color 1 (Bcc1), which dev

81 The classical recessive coat color mutation misty (m) arose spontaneously on the

82 mahoganoid is a mouse coat-color mutation whose pigmentary phenotype and genet

83 sulted in over 100 years of intense study of coat color mutations in laboratory mice, thereby creatin

84 The d, ash, and ln coat color mutations provide a unique model system for t

85 at have been studied for decades using mouse coat color mutations.

86 Despite a large number of murine coat-color mutations, only one gene in humans, the melan

87 mutation at this locus, Ay, develop a yellow coat color, obesity, and diabetes, as the result of a de

88 phenotype characterized by a uniform yellow coat color, obesity, overgrowth, and metabolic derangeme

89 models in the field, we show that the light coat color of deer mice that recently colonized the ligh

90 , these results explain how dsu restores the coat color of dilute mice without restoring intracellula

91 me 15 and, at the same time, exhibit lighter coat color on their ears and tails, making this modified

92 ional myosin heavy chain locus cause diluted coat color, opisthotonic seizures, and death.

93 nd choline produced offspring with different coat colors or with kinked tails.

94 at may have contributed to the phenotypes in coat color patterns, body size, cashmere traits, as well

95 elanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been s

96 Without evolution in coat color phenology, the reduced snow duration will inc

97 e small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab3

98 The dilute coat color phenotype is caused by irregular clumping of

99 The coat-color phenotype of young homozygous double-mutant m

100 ab38 and Tyrp1 produced mice with ocular and coat color pigment dilution greater than that seen with

101 he other that suggests a genetic basis for a coat color polymorphism in bears.

102 In contrast, seasonal coat color polyphenism creating camouflage against snow

103 an agouti allele (A(iapy)), which provided a coat color readout for the methylation status of the IAP

104 d several lines of transgenic mice exhibited coat colors resembling dominant Agouti allele phenotypes

105 anosomal forms, leading to the hypopigmented coat colors seen in these strains.

106 tigated both the DNA methylation changes and coat color shift in the irradiated offspring.

107 ts homozygous for this mutation (sl) exhibit coat color spotting and congenital intestinal agangliono

108 The transgene has no effect on coat color spotting, indicating the critical time for ED

109 tant mice considerably darkened their yellow coat color suggesting a previously unreported role for e

110 mutants of M. truncatula exhibit darker seed coat color than wild-type plants, with myb5 also showing

111 d congenic mice of black, yellow, and albino coat colors to investigate the induction of DNA lesions

112 round, which yields a phenotypic copy of m/m coat color traits.

113 be the molecular changes underlying adaptive coat color variation in a natural population of rock poc

114 The ep mice have a coat color very similar to the black-colored parental st

115 Offspring coat color was concomitantly shifted toward pseudoagouti

116 As expected, average A(vy)/a coat color was darker in the supplemented group (P<0.01)

117 s segregating for black, yellow, and brindle coat colors, we demonstrate that pigment type switching

118 nly the ability of agouti to induce a yellow coat color when expressed in the skin of the lethal yell

119 Agouti gene is responsible for the wild-type coat color where hairs are banded black and yellow.