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1 s primarily or exclusively in a newly formed coated pit.
2 cond, with fission of the membrane neck of a coated pit.
3 of bulky extracellular domains from clathrin-coated pits.
4 ons reduce recruitment efficiency of OCRL to coated pits.
5 ent redistribution of arrestin2L to clathrin-coated pits.
6 n upon Wnt-induced recruitment into clathrin-coated pits.
7 imilar to how clathrin attracts molecules to coated pits.
8 cles/tubules and exocytosis through clathrin-coated pits.
9 he proteins for internalization via clathrin-coated pits.
10 n, which binds to the endocytic machinery of coated pits.
11 helial cells but is internalized in clathrin-coated pits.
12 ecessary for its internalization by clathrin-coated pits.
13 in, the major structural protein of clathrin-coated pits.
14 been viewed as being initiated via clathrin-coated pits.
15 er with transferrin receptor and to clathrin-coated pits.
16 ling molecules, and the presence of clathrin-coated pits.
17 nternalized rapidly, likely through clathrin-coated pits.
18 and are distinct from caveolae and clathrin-coated pits.
19 ARH-associated LDLR clustering into clathrin-coated pits.
20 sociation of adaptor protein-2 with clathrin-coated pits.
21 alian cells, they are excluded from clathrin-coated pits.
22 own-regulates CD4 by linking CD4 to clathrin-coated pits.
23 ve that SNX9 partially localizes to clathrin-coated pits.
24 ht guide or insert the complex into clathrin-coated pits.
25 roximately 27-fold excess of LDLR outside of coated pits.
26 ins, including beta-arrestin-2 with clathrin-coated pits.
27 esses promote endocytosis of Smo in clathrin-coated pits.
28 in assembly of functionally active clathrin-coated pits.
29 PSMA undergoes internalization via clathrin-coated pits.
30 been implicated in the formation of clathrin-coated pits.
31 ugh spatial segregation of a GAP in clathrin-coated pits.
32 a clathrin/dephosphin-mediated retrieval via coated pits.
33 lls but are prevented from entering clathrin-coated pits.
34 Grb2 binding sites do not efficiently enter coated pits.
35 eps of EGFR internalization through clathrin-coated pits.
36 phosphorylation directs it through clathrin-coated pits.
37 nter non-raft membrane, from which it enters coated pits.
38 sting that endocytosis occurred via clathrin-coated pits.
39 desensitization and endocytosis via clathrin-coated pits.
40 mediating arrestin interaction with clathrin-coated pits.
41 ecruitment of the receptor/cargo to clathrin-coated pits.
42 s, like microvilli, cell-cell junctions, and coated pits.
43 table endocytic vesicles arise from clathrin-coated pits.
44 that undergoes endocytosis through clathrin-coated pits.
45 mobility is restricted by interactions with coated pits.
46 dium, suggesting the involvement of clathrin-coated pits.
47 so found to enter the cell predominantly via coated pits.
48 mine the number of dynamins recruited to the coated pits.
49 VECs), increasing NP uptake through clathrin-coated pits.
50 to invagination and then fission of clathrin-coated pits.
51 e protein (WASP) assembles actin at clathrin-coated pits.
52 llularly into EEA-1+ endosomes from clathrin-coated pits.
53 T-1-HA-GFP internalization requires clathrin-coated pits.
54 mechanism for endocytosis involves clathrin-coated pits [1], but evidence has accumulated for additi
55 investigate the massive increase in clathrin-coated pit abundance that is selectively observed at a s
56 d to contribute to the formation of clathrin-coated pits, although the specific components that conne
57 d at the constricting neck of a fully formed coated pit and immediately after vesicle budding, accumu
58 GAK was disrupted showed a lack of clathrin-coated pits and a complete block in clathrin-mediated en
59 ults in an accumulation of arrested clathrin-coated pits and a greatly reduced synaptic vesicle numbe
60 n-mediated endocytosis with shallow clathrin-coated pits and a strong reduction in the internalizatio
63 olocalizes with clathrin and AP2 in clathrin-coated pits and at the leading edge of migrating cells.
64 t OCRL visits late-stage, endocytic clathrin-coated pits and binds the Rab5 effector APPL1 on periphe
65 h receptor-mediated endocytosis via clathrin-coated pits and caveolae, that actin filaments and micro
67 e peptides inhibit the formation of clathrin-coated pits and coated vesicles during synaptic vesicle
68 or, which is highly concentrated at clathrin-coated pits and coordinates acquisition of bilayer curva
69 ution, we detected the arrival of dynamin at coated pits and defined dynamin dimers as the preferred
70 oblasts, these two receptors co-localized in coated pits and endosomal compartments following PDGF st
72 ich were concentrated at late-stage clathrin-coated pits and in lamellipodia, also dissociated from t
73 ARH colocalizes with megalin in clathrin coated pits and in recycling endosomes in the Golgi regi
75 te that E-selectin clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is
77 t whether cortactin associates with clathrin-coated pits and participates in receptor-mediated endocy
78 distinct endocytic pathways (i.e., clathrin-coated pits and plasma membrane lipid rafts) that delive
79 7 is constitutively internalised by clathrin-coated pits and that physiological stimulators such as G
80 ution images of living cells, using clathrin-coated pits and the transferrin cargo as model systems.
81 rafficking; it is recruited to both clathrin-coated pits and to ensuing uncoated endocytic vesicles (
82 ane protein that is endocytosed via clathrin-coated pits and traffics through the acidic endosomes, t
83 d FcRY-mediated internalization via clathrin-coated pits and transport involving early and recycling
85 in, and F-actin and increased the amounts of coated pits and vesicles at the apical plasma membrane.
88 in heavy chain (Chc), a major constituent of coated pits and vesicles, is the most abundant protein c
92 selective increase in unconstricted clathrin-coated pits and, in the case of swinholide, an additiona
95 rotein required for the assembly of clathrin-coated pits, and DN PAK-1, an obligate mediator of macro
96 s from the plasma membrane, through clathrin-coated pits, and into the cell for lysosomal degradation
97 A associates with Arc, localizes to clathrin-coated pits, and is associated with endocytic sites in d
98 ents, three-dimensional tracking of clathrin-coated pits, and long-term imaging spanning >10 h and en
99 ternalization was also dependent on clathrin-coated pits, and Lp(a) was targeted for lysosomal and no
100 interacts with AP-2, is enriched on clathrin-coated pits, and requires clathrin but not RAB-5 for cor
101 to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of "scaffo
102 tered into HRPTEC via caveolae, not clathrin-coated pits, and that BKV is maximally associated with c
103 re most likely internalized through clathrin-coated pits, and then returned to the plasma membrane vi
104 to be internalized independently of clathrin-coated pits, and there is evidence to suggest that lipid
105 reveal distinct mechanisms for sorting into coated pits, and thereby explain differential effects on
106 th clathrin and other components of clathrin-coated pits, AP-2 did not seem to be present in clathrin
110 naling, in cells in which endocytic clathrin-coated pits are frozen at a deeply invaginated state, th
113 in multimolecular clusters unassociated with coated pits, as assessed by immuno-electron microscopy.
114 ucing GLUT1 internalization through clathrin-coated pits, as well as indirectly, by reducing the leve
117 ro cells is slow, is independent of clathrin-coated-pit assembly, is dependent on an intact caveolin-
120 ved during recruitment of EGF receptors into coated pits at 4 degrees C and reached maximum at 37 deg
126 mbles around the necks of deeply invaginated coated pits at the plasma membrane and catalyzes vesicle
127 he clathrin adaptors AP2 and AP1 in clathrin-coated pits at the plasma membrane and trans-Golgi netwo
128 etramers stimulates formation of constricted coated pits at the plasma membrane by regulating the cha
129 er photobleaching, that clathrin in clathrin-coated pits at the plasma membrane exchanges with free c
130 s with membranes, and the number of clathrin-coated pits at the plasma membrane increased when PIP2 i
131 the scission of deeply invaginated clathrin-coated pits at the plasma membrane, but the mechanisms g
136 ficantly affecting the structure of clathrin-coated pits, both clathrin and AP2 at the plasma membran
139 e HCl, which blocks endocytosis via clathrin-coated pits, but not by nystatin and cholera toxin B, wh
140 orming a collar around the necks of clathrin-coated pits, but the specific structural interactions an
141 errin receptor is incorporated into clathrin-coated pits by associating, via tyrosine-based motifs, w
142 ctivated receptors are recruited to clathrin-coated pits by beta-arrestins, scaffolding proteins that
143 marked as cargo for inclusion into clathrin-coated pits by common internalization signals (e.g. YXXP
145 n 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by conformation
146 Live-cell imaging of individual clathrin-coated pit (CCP) dynamics has revealed a broad variation
150 corresponded to a decreased rate of clathrin-coated pit (CCP) initiation and increased lifetimes of p
151 ACT: Some endocytic cargoes control clathrin-coated pit (CCP) maturation, but it is not known how suc
153 (PTE), where it is concentrated in clathrin-coated pits (CCPs) and vesicles in the brush border regi
155 l CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma membrane, which invagin
158 Consistently, Lpd localizes to clathrin-coated pits (CCPs) just before vesicle scission and regu
159 observed heterogeneous dynamics of clathrin-coated pits (CCPs) might be the different cargo content.
160 tors, either recruiting cargos into clathrin-coated pits (CCPs) or initiating clathrin-coat assembly
161 fate by regulating the dynamics of clathrin-coated pits (CCPs) that mediate their internalization.
163 ial increase in the ratio of "open" clathrin-coated pits (CCPs) to "necked"/"closed" CCVs and a doubl
164 on of the lifetime distributions of clathrin-coated pits (CCPs) to measure independent aspects of CCP
165 ls and is concentrated at endocytic clathrin-coated pits (CCPs) via interactions with the scaffold pr
166 ME is initiated by the formation of clathrin-coated pits (CCPs), in which adaptors nucleate clathrin
167 e known to accumulate into maturing clathrin-coated pits (CCPs), whether and how cargo recruitment af
171 at markedly affect the structure of clathrin-coated pits, clathrin exchange was blocked but AP2 at th
172 eractor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily
173 akdown on the dynamics of endocytic clathrin-coated pit components and of the actin regulatory comple
175 Interestingly, recruitment of EGFR into coated pits did not require physiological temperature be
177 they are recruited to a diffraction-limited coated pit during its assembly at the plasma membrane.
178 ates initially in the maturation of clathrin-coated pits during early stages of synaptic vesicle recy
179 this paper, we describe a study of clathrin-coated pit dynamics in living cells using ion conductanc
181 ent endocytosis of heptahelical receptors in coated pits employs the clathrin adaptor beta-arrestin p
182 density lipoprotein (LDL) receptor (LDLR) in coated pits employs the clathrin adaptor protein ARH.
183 s and its metabolic processing, the clathrin-coated pit endocytosis pathway, and the ubiquitin/26 S p
184 , ARH and megalin are first seen in clathrin coated pits followed by sequential localization in early
188 uggest a role for synaptojanin 2 in clathrin-coated pit formation and imply that lipid hydrolysis is
189 efore function to initiate calcium-regulated coated pit formation at the cell surface or on intracell
190 nding domain of AP180, which blocks clathrin-coated pit formation but not clathrin-independent endocy
193 clathrin-coated vesicle formation, including coated pit formation, constriction, and internalization.
199 ally believed that the formation of clathrin-coated pits in epithelial cells occurs randomly along th
200 , MORs are rapidly internalized via clathrin-coated pits in heterologous cells and dissociated striat
205 nt internalization, indicating that clathrin-coated pits, in concert with mechanisms dependent on raf
206 nvaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice.
207 lly defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins are confi
208 ccessory proteins typical of plasma membrane-coated pits, including AP2, AP180, and epsin, but not Hi
209 rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and antigen pres
217 on of the SNX9.dynamin-2 complex to clathrin-coated pits is blocked by interactions with the abundant
218 of G protein-coupled receptors via clathrin-coated pits is dependent on the adaptor protein beta-arr
219 mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecular detail
220 hich to engage adaptors to recruit them into coated pits, is problematical; that of prion protein in
222 olocalization of EGF-rhodamine conjugate and coated pits labeled with yellow-fluorescent-protein-tagg
223 15 is found at the growing edges of clathrin-coated pits, leading to the hypothesis that it participa
225 microscopy, which revealed cadherin-enriched coated pit-like structures in close association with adh
226 We conclude that, in contrast to signals for coated pit localization that are in the cytoplasmic tail
227 and TGN46, but not the AP-2 plasma membrane-coated pit marker nor the endosomal markers EEA1, Hrs, a
230 ter that is a critical component of clathrin-coated pit-mediated endocytosis, as well as in stress re
231 h chase and became undetectable if clathrin-coated pit-mediated trafficking was blocked with chlorpr
232 ature and mature DCs are capable of clathrin-coated pit-mediated uptake of SIV, supporting the notion
234 and-bound EGFR is incorporated into clathrin-coated pits--membrane structures containing clathrin and
235 the receptors can exhibit mean lifetimes in coated pits much shorter than the lifetime of the pit at
237 sensors, disappearance of endocytic clathrin-coated pits, nearly complete inhibition of KCNQ2/3 chann
238 vate the concentration of PtdIns(4,5)P(2) at coated pit necks, and effectively cluster (or sequester)
239 t a model in which endophilin recruitment to coated pit necks, because of its curvature-sensing prope
242 microscopy to study the assembly dynamics of coated pits on the dorsal and ventral membranes of migra
243 tors are delivered selectively from clathrin-coated pits on the plasma membrane into a specific subpo
247 desialylated glycoproteins via the clathrin-coated pit pathway and mediates their delivery to lysoso
252 on, up to a final value of 30 nm just before coated-pit pinching and formation of the coated vesicle.
253 clathrin/AP-2 puncta may represent loci for coated pit production and that previous models that assu
254 le TGF-beta receptors to AP2 and to clathrin-coated pits, providing the first in vivo evidence for in
257 ite may represent receptor interactions with coated-pit regions in the cell membrane or with other ce
258 okine receptors internalize through clathrin-coated pits, regulation of the receptor trafficking is n
259 to coordinate cargo selection into clathrin-coated pits, results in a significant impairment in endo
260 ansmembrane receptors requires that clathrin-coated pits retain the receptors long enough to allow ve
261 vity, and axonal boutons containing clathrin-coated pits showed a more pronounced decrease in presyna
262 t due to failure of receptors to localize in coated pits since the number of LDLRs in coated pits was
263 the recruitment of P-selectin into clathrin-coated pits, slowed the internalization of P-selectin, a
264 nd it remains controversial whether clathrin-coated pits specialize to internalize particular recepto
265 e cells (untreated or treated to alter their coated pit structure), we demonstrated that their mobili
266 ment of adaptor proteins present in clathrin-coated pits, such as epsin, Eps15 (epidermal growth fact
267 enrichment of LDLR-Y807C-bound beta-VLDL in coated pits, suggesting that beta-VLDL binding promoted
269 Dab2 colocalizes with integrin beta1 in coated pits that are dispersed over the cell surface, su
270 ted DSL proteins to a particular subclass of coated pits that have special properties essential for N
271 t burst of EGFP-SNX9 recruitment to clathrin-coated pits that occurs during the late stages of vesicl
272 lin is required for constriction of clathrin-coated pits, the same early step in endocytosis known to
273 en as the cargoes being enclosed in clathrin-coated pits, they slow down the active rotation and expe
274 an adaptor that couples late-stage endocytic coated pits to actin polymerization and which we found t
275 eveal a link between progression of clathrin-coated pits to endocytic vesicles and an activation-deac
276 nd hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkles
277 indings indicate that BRAG2 acts at clathrin-coated pits to promote integrin internalization by activ
278 bsence of SCAR, some WASP relocated from the coated pits to the leading edge, where it behaved with s
279 5 that is an essential component of clathrin-coated pits, to investigate the extent and importance of
280 is of ligand-receptor complexes via clathrin-coated pits, trafficking of the internalized ligand to l
282 cells, LKT moves to lipid rafts and clathrin-coated pits via a dynamic process that results in LKT in
285 INPP5B visits late stage endocytic clathrin-coated pits, was earlier shown to contain another bindin
286 ivated PAR1 internalization through clathrin-coated pits we examined the function of a highly conserv
287 s they were swept back toward the cell body; coated pits were absent from the corresponding ventral m
290 e sorting nexin, SNX9, localizes to clathrin-coated pits where it interacts with dynamin and function
291 ism for 7TMR internalization is via clathrin-coated pits, where clathrin and adaptor protein complex
292 omplex with the GTPase dynamin-2 at clathrin-coated pits, where it provokes fission of vesicles to co
293 e at the base of arrested endocytic clathrin-coated pits, where they support the growth of dynamic lo
294 ith PD158780 prevented EGFR recruitment into coated pits, whereas the inhibitor did not block the int
295 nternalized, P-selectin clusters in clathrin-coated pits, which enhances its ability to support leuko
296 esicles and an increase in U-shaped clathrin-coated pits, which may result from sequestration of coat
298 domain of E-selectin or disrupting clathrin-coated pits with hypertonic medium blocked internalizati
299 and is thought to coordinate constriction of coated pits with membrane fission (via dynamin) and subs
300 defect included an accumulation of clathrin-coated pits with wide necks, as previously observed afte
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