ライフサイエンスコーパス: cobamide

1 r ligand prior to its incorporation into the cobamide.

2 ave a requirement or preference for phenolyl cobamides.

3 loop of adenosylcobalamin (AdoCbl) and other cobamides.

4 g rise to a wide variety of lower ligands in cobamides.

5 also been shown to contain histidine-ligated cobamides.

6 in its preferential utilization of phenolyl cobamides.

7 confirm the incorporation of phenol into the cobamide, and mass spectrometry was used to identify SoA

8 nzimidazoles, indicating that benzimidazolyl cobamides are not functionally equivalent to the phenoly

9 Phenolyl cobamides are structurally and chemically distinct from

10 Phenolyl cobamides are unique members of a class of cobalt-contai

11 te the direct involvement of this protein in cobamide biosynthesis in archaea.

12 solely responsible for the observed block in cobamide biosynthesis in this archaeon.

13 ic acid, a known intermediate of the de novo cobamide biosynthesis pathway, but efficiently salvaged

14 P, a known intermediate of the late steps of cobamide biosynthesis.

15 kinase activity is not required for de novo cobamide biosynthesis.

16 identify orthologues of all of the bacterial cobamide biosynthetic enzymes.

17 Cobamides (Cbas) are cobalt (Co) containing tetrapyrrole

18 ch are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not form ax

19 The chemical structures of cobamides [cobalamin (Cbl)-like compounds] are the same,

20 Cobamide cofactors facilitate diverse reactions in proka

21 not functionally equivalent to the phenolyl cobamide cofactors produced by S. ovata.

22 tes is capable of synthesizing B12 and other cobamide cofactors.

23 placement appears to be an emerging theme in cobamide-containing methyltransferases.

24 inoids and that this archaeon can synthesize cobamides de novo under aerobic growth conditions.

25 wn to synthesize phenolyl cobamides, several cobamide-dependent acetogenic metabolisms have a require

26 To our knowledge, S. ovata is unique among cobamide-dependent organisms in its preferential utiliza

27 Cobamides have an upper (Cobeta) ligand (5'-deoxyadenosy

28 romusa ovata synthesizes two unique phenolic cobamides (i.e., Coalpha-(phenolyl/p-cresolyl)cobamide),

29 Given the importance of cobamides in environmental, industrial, and human-associ

30 ligands, despite its preference for phenolyl cobamides in the metabolism of certain energy substrates

31 The biosynthesis of cobamides is complex and is only performed by some bacte

32 erium Rhodobacter sphaeroides to procure the cobamide it needs to grow on acetate as a carbon and ene

33 ot only B12 itself, but also for three other cobamide lower ligands whose biosynthesis was previously

34 can incorporate a wide range of compounds as cobamide lower ligands, despite its preference for pheno

35 to have resulted from an indirect effect on cobamide metabolism.

36 conversion of AdopseudoCbl into AdoCbl, the cobamide needed for the catabolism of acetate.

37 e synthesis and production of benzimidazolyl cobamides occur upon the addition of benzimidazoles, ind

38 imidazole, all of which are lower ligands of cobamides produced by other organisms, are intermediates

39 Implications of these findings for cobamide remodelling in R. sphaeroides and in other CbiZ

40 e only organism known to synthesize phenolyl cobamides, several cobamide-dependent acetogenic metabol

41 microbial metabolism, the ability to predict cobamide structure may lead to an improved ability to un

42 ting that these genes can be used to predict cobamide structure.

43 t from the more commonly used benzimidazolyl cobamides such as cobalamin, as the lower axial ligand i

44 Suppression of native p-cresolyl cobamide synthesis and production of benzimidazolyl coba

45 incorporating other phenolic compounds into cobamides that function in methanol metabolism.

46 e resulting ribotides were incorporated into cobamides that were differentially utilized by methionin

47 Why the lower ligand of cobamides varies and what the mechanism of lower ligand

48 This cobamide was isolated by HPLC, identified by UV-visible

49 obamides (i.e., Coalpha-(phenolyl/p-cresolyl)cobamide), which are used in the catabolism of methanol

50 ity for the rapid synthesis and isolation of cobamides with structurally different lower-ligand bases

51 the commonly observed lower ligands found in cobamides with the exception of the phenolic lower ligan