ライフサイエンスコーパス: cobblestone

1 Superficial hemangiomas with a cobblestone appearance or rough surface left more severe

2 proliferate on the SF and denuded AM with a cobblestone appearance, abundant microvilli on the surfa

3 Amot was sufficient to restore an epithelial cobblestone appearance, Yap1 localization, and growth co

4 Epithelial sheets often present a "cobblestone" appearance, but the mechanisms underlying t

5 w stromal cell lines: HS-27a, which supports cobblestone area formation by early hematopoietic progen

6 of primitive hematopoietic cells, using the cobblestone area forming cell (CAFC) assay, in marrow of

7 The frequency of cobblestone area forming cells (CAFC) was used as a mean

8 tion of 45% of primary CFU-Cs, 33% of week-5 cobblestone area forming cells (CAFCs), and 18% of week-

9 ic progenitor cells (PHP), as defined by the cobblestone area-forming cell (CAFC) assay, and for bone

10 ed in eight strains of inbred mice using the cobblestone area-forming cell (CAFC) assay.

11 tive transplantation and quantitative week-5 cobblestone area-forming cell (CAFC) assays.

12 sigma-deficient BM cells displayed increased cobblestone area-forming cell (CAFC) capacity and augmen

13 -forming units (CFUs) in methylcellulose and cobblestone area-forming cell (CAFC) subsets in stromal-

14 tion between colony-forming cell (n = 10) or cobblestone area-forming cell (n = 9) numbers and clinic

15 m repopulating ability and day 28 and day 35 cobblestone area-forming cell [CAFC] frequencies).

16 topoietic stem cells as measured in vitro by cobblestone area-forming cell assays and in vivo by comp

17 (BU; 30 micro M) for 6 h also inhibited the cobblestone area-forming cell frequency but failed to ca

18 on were assessed for colony-forming cell and cobblestone area-forming cell potential, and multilineag

19 itro hematopoiesis as evidenced by continued cobblestone area-forming cells (CAFC) activity for at le

20 The frequency of cobblestone area-forming cells (CAFC) day-35 in DBA feta

21 FU-GM), and a 12-fold to 17-fold increase of cobblestone area-forming cells (CAFC) over input.

22 Sorted cells were highly enriched in cobblestone area-forming cells (CAFC), but their frequen

23 weeks and examined the migratory activity of cobblestone area-forming cells (CAFCs) and long-term cul

24 ion of the frequency of various day types of cobblestone area-forming cells in association with the i

25 tors, but enhanced the growth of stem cells (cobblestone area-forming cells), resulting in a profound

26 These surviving cells (1) are enriched for cobblestone area-forming cells, (2) repopulate fragments

27 LEC-1 and 5-FUBMC cocultures showed cobblestone-area formation and the presence of hematopoi

28 In MS-5 stromal cocultures, numerous early cobblestone areas (CAs) were generated within 10 to 14 d

29 ivity in vitro, but lost the ability to form cobblestone areas after 5 to 6 weeks in culture.

30 found to increase the size and frequency of cobblestone areas at 4 weeks in stromal cultures in the

31 cloning efficiency and a lower frequency of cobblestone areas compared with normal granulocyte colon

32 These cobblestone areas contain both primitive high-proliferat

33 ed stem cells by promoting the formation of "cobblestone areas" of proliferation.

34 Cobblestone brain malformation (COB) is a neuronal migra

35 to endothelial-like cells characterized by a cobblestone cell morphology, expression of endothelial m

36 , elongated morphology to an epithelium-like cobblestone clustering.

37 omal-dependent, cytokine-driven formation of cobblestone colonies on secondary plating.

38 oncentrations of colony-forming unit spleen, cobblestone colonies, and long-term colony-initiating ce

39 ic electrodiagnostic changes, brain MRI with cobblestone complex, and mutation in the fukutin gene.

40 g finding typically seen in combination with cobblestone cortex and congenital muscular dystrophy in

41 re four crucial events in the development of cobblestone cortex, namely defective pial basement membr

42 Cortical dysplasia resembling cobblestone cortex, with basement membrane breakdown and

43 drusen, senile reticular pigmentary changes, cobblestone degeneration, and FAF abnormalities.

44 c retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rh

45 retinal tuft, meridional fold, lattice, and cobblestone degenerations.

46 n of EGCG and U0216 resulted in cells with a cobblestone epithelial phenotype.

47 mammalian target of rapamycin (mTOR) rescues cobblestone formation in myr-AKT-expressing bone marrow

48 ongly impaired primary AML cell survival and cobblestone formation in stromal cocultures.

49 row was obtained for determination of early (cobblestone forming cells) and late (granulocyte-macroph

50 Bone marrow cellularity, cobblestone forming cells, granulocyte-macrophage colony

51 ressing bone marrow cells are unable to form cobblestones in long-term cocultures.

52 ure undergo a commitment stage, during which cobblestone-like cells grow to high density past conflue

53 rons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the ph

54 o neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation.

55 king reversion from poorly differentiated to cobblestone-like epithelial morphology, indicating a cru

56 al cells (DMVEC) transforms the cells from a cobblestone-like monolayer to foci-forming spindle cells

57 Stem-cell-derived RPE cells exhibit cobblestone-like morphology, transcripts, proteins and p

58 ques without affecting the contact-inhibited cobblestone-like phenotype of adjacent uninfected DMVEC.

59 Heterotopias resembling those found in cobblestone lissencephalies in which neuroepithelial cel

60 pathways are involved in the pathogenesis of cobblestone lissencephalies.

61 Cobblestone lissencephaly (COB) is a severe brain malfor

62 matrix (ECM) are frequently associated with cobblestone lissencephaly and mental retardation.

63 l form of congenital muscular dystrophy with cobblestone lissencephaly and structural eye defects to

64 nd gliosis also occurred, similar to type II cobblestone lissencephaly as seen in congenital muscular

65 the functions of TMTCs provide insight into cobblestone lissencephaly caused by deficiency in TMTC3.

66 ortex in both humans and mice that resembles cobblestone lissencephaly, which is characterized by ove

67 nized laminin in meningeal fibroblasts and a cobblestone lissencephaly-like phenotype in the developi

68 cits, 2 phenotypes that frequently accompany cobblestone lissencephaly.

69 sembling the cerebral cortex malformation in cobblestone lissencephaly.

70 some features resembling defects in type 2 (cobblestone) lissencephaly or congenital muscular dystro

71 om neighboring cells and lost their original cobblestone monolayer pattern when CsA was added.

72 bsence of any effect on cells present in the cobblestone monolayer.

73 othelial cells retained their characteristic cobblestone morphology and expression of tight junction

74 cells assume the characteristic endothelial cobblestone morphology and form tubes.

75 WNT5A expressing cells demonstrated cobblestone morphology and reduced in vitro migration re

76 Cell monolayers exhibited cobblestone morphology and were immunopositive for corne

77 he cortex, and cell shapes were altered from cobblestone morphology to irregular shape.

78 he epithelial cells stayed in their original cobblestone morphology with treatment of TGF-beta1 inhib

79 ells, immature cells differentiated, assumed cobblestone morphology, and labeled with the epithelial

80 ial cells, as indicated by the appearance of cobblestone morphology, induction of E-cadherin expressi

81 ike shape replaced characteristic epithelial cobblestone morphology.

82 fining characteristics of ECFCs such as (i) 'cobblestone' morphology of cultured cell monolayers; (ii

83 ithelial morphology with a less well-defined cobblestone pattern than the parental line.

84 ndrome presented with skin-colored to yellow cobblestoned plaques to the neck and bilateral antecubit

85 nsively, and can redifferentiate into stable cobblestone RPE monolayers.

86 VEC) in culture results in the conversion of cobblestone-shaped cells to spindle-shaped cells, a char

87 in vivo, including phenotypic maturation of cobblestone-shaped osteoblasts into stellate-shaped oste

88 uggest that tonal GSK3beta repression at the cobblestone stage of osteoblast differentiation permits

89 n DMVECs was associated with a change from a cobblestone to a spindle shape, LANA expression, and an

90 Cobblestone (type II) lissencephaly and mental retardati

91 evere cortical lamination defects resembling cobblestone (type II) lissencephaly.

92 show that two ileal IBD-stereoenterotypes ('cobblestones' versus 'villous mini-aggregation') cluster