ライフサイエンスコーパス: cocaethylene

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1 y of cocaine in brain and plasma relative to cocaethylene.

2 Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the

3 Cocaethylene, a metabolite of cocaine and alcohol, is a

4 A similar rate is observed for hydrolysis of cocaethylene, a more potent cocaine metabolite that has

5 e-dependent decrements in CAP amplitude, but cocaethylene and isopropylcocaine at medium to high conc

6 erve impulse blockade by lidocaine, cocaine, cocaethylene and isopropylcocaine using rat sciatic nerv

7 he active cocaine metabolites norcocaine and cocaethylene and its inability to hydrolyze benzoylecgon

8 activating mutant channel to close, trapping cocaethylene and slowing the recovery.

9 aine and potent cocaine derivatives, such as cocaethylene, and for additional humanization of the ant

10 Cocaine, ecgonine methyl ester, norcocaine, cocaethylene, and mephedrone were mainly transformed by

11 estigated the local anesthetic properties of cocaethylene as well as isopropylcocaine, another potent

12 t additional mechanisms, such as more stable cocaethylene binding, may be a more important determinan

13 h an important role for fast inactivation in cocaethylene binding.

14 Cocaethylene caused an inhibition of dopamine synthesis

15 Cocaethylene-induced behaviors were significantly less i

16 ivation slow the recovery and potentiate the cocaethylene inhibition of the Nav1.5 channel by distinc

17 A rapid component of cocaethylene inhibition was observed in a noninactivatin

18 iminated rapid inactivation and weakened the cocaethylene inhibition, consistent with an important ro

19 56C mutation did not alter the recovery from cocaethylene inhibition.

20 Cocaethylene is a naturally occurring cocaine derivative

21 n, and ability to hydrolyze both cocaine and cocaethylene make cocE an attractive candidate for rapid

22 ocomotor activity was not observed following cocaethylene preexposure.

23 candidates, and suggest a mechanism whereby cocaethylene produces a decreased euphoria in humans com

24 Cocaethylene produces minimal tonic block under resting

25 The present study assessed the ability of cocaethylene to induce sensitization to the behavioral a

26 the behavioral and neurochemical effects of cocaethylene treatment in Long-Evans (LE) and Sprague-Da

27 Serotonin synthesis was also suppressed by cocaethylene treatment, however this phenomenon was less

28 l, suggesting that this mutation facilitates cocaethylene untrapping, which seems to be the rate-limi

29 DM-CocE hydrolyzes norcocaine and cocaethylene with 58 and 45% of its catalytic efficiency

30 t the aptamer binds cocaine, norcocaine, and cocaethylene with similar affinities and aminoglycosides

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