ライフサイエンスコーパス: cocaine addiction

1 produce substantial adverse consequences for cocaine addiction.

2 e their potential pathophysiological role in cocaine addiction.

3 es to diverse types of plasticity, including cocaine addiction.

4 ern of maladaptive behaviors associated with cocaine addiction.

5 receptors that are involved in the action of cocaine addiction.

6 stitute a risk factor for the development of cocaine addiction.

7 cluding heroin and prescription opioids, and cocaine addiction.

8 promoting long-term resistance to relapse to cocaine addiction.

9 er impair executive function and learning in cocaine addiction.

10 th cue exposure therapy for the treatment of cocaine addiction.

11 for the development of relapse treatment of cocaine addiction.

12 gene silencing, is involved in regulation of cocaine addiction.

13 tial treatment for both cocaine overdose and cocaine addiction.

14 tion-related behaviors in an animal model of cocaine addiction.

15 al morphology and behavior that may underlie cocaine addiction.

16 provide evidence for a key role of miRNAs in cocaine addiction.

17 be important in regulating vulnerability to cocaine addiction.

18 ls, MPH did not improve treatment outcome in cocaine addiction.

19 of miRNAs that are likely to play a role in cocaine addiction.

20 ich may provide a new rationale for treating cocaine addiction.

21 t individuals with combined heroin and crack cocaine addiction.

22 lasticity associated with the development of cocaine addiction.

23 tment of disrupting mitochondrial fission in cocaine addiction.

24 g GLT1 as a potential therapeutic target for cocaine addiction.

25 long-term behavioral changes associated with cocaine addiction.

26 herapeutic option in the treatment of severe cocaine addiction.

27 et for drug development for the treatment of cocaine addiction.

28 eceptors, within brain regions implicated in cocaine addiction.

29 e likely to be therapeutically beneficial in cocaine addiction.

30 s potential medications for the treatment of cocaine addiction.

31 ting changes in neuronal function underlying cocaine addiction.

32 ontal cortex (mPFC) plays a critical role in cocaine addiction.

33 target for the development of treatments for cocaine addiction.

34 g-term depression, associative learning, and cocaine addiction.

35 dentify clusters of genes that contribute to cocaine addiction.

36 havioral and molecular mechanisms underlying cocaine addiction.

37 vide tools for the study of the mechanism of cocaine addiction.

38 sses for regulating at least some aspects of cocaine addiction.

39 ral associations, including vulnerability to cocaine addiction.

40 and has been hypothesized to play a role in cocaine addiction.

41 target for prospective pharmacotherapies for cocaine addiction.

42 a range of neurological disorders including cocaine addiction.

43 to adaptive changes in the brain related to cocaine addiction.

44 in long-lasting relapse risk associated with cocaine addiction.

45 ons in patients with Parkinson's disease and cocaine addiction.

46 f early childhood stress in vulnerability to cocaine addiction.

47 sporter plays a key role in the mechanism of cocaine addiction.

48 ity to cocaine and may thereby contribute to cocaine addiction.

49 e social-emotional functional alterations in cocaine addiction.

50 complexes may be efficacious treatments for cocaine addiction.

51 paper describes an immunological approach to cocaine addiction.

52 apeutic cocaine vaccine for the treatment of cocaine addiction.

53 r agonists as a possible pharmacotherapy for cocaine addiction.

54 may be useful pharmacotherapeutic agents for cocaine addiction.

55 ntial as an agonist therapy for treatment of cocaine addiction.

56 ovel therapeutic target for the treatment of cocaine addiction.

57 a promising drug target for the treatment of cocaine addiction.

58 , may render individuals more susceptible to cocaine addiction.

59 norectic and a candidate pharmacotherapy for cocaine addiction.

60 ay have translational potential for treating cocaine addiction.

61 icant barrier to the successful treatment of cocaine addiction.

62 n may be valuable tools for the treatment of cocaine addiction.

63 tagonizing 5-HT1A autoreceptors for treating cocaine addiction.

64 harmacological strategy for the treatment of cocaine addiction.

65 of addiction endophenotypes, especially for cocaine addiction.

66 tify and develop novel pharmacotherapies for cocaine addiction.

67 ers including depression, visceral pain, and cocaine addiction.

68 f opiate and nicotine addiction, but not for cocaine addiction.

69 mphetamine addictions, but not for heroin or cocaine addiction.

70 be a therapeutic target for the treatment of cocaine addiction.

71 idates for the development of treatments for cocaine addiction.

72 zheimer's disease, Huntington's disease, and cocaine addiction.

73 tionale supporting sleep-based therapies for cocaine addiction.

74 have therapeutic utility in the treatment of cocaine addiction.

75 te sleep-based therapeutic opportunities for cocaine addiction.

76 including stroke, motor neuron disease, and cocaine addiction.

77 support a personalized treatment approach to cocaine addiction.

78 ription of specific genes that contribute to cocaine addiction.

79 ent a novel drug target for the treatment of cocaine addiction.

80 mor growth and invasion, viral infection and cocaine addiction.

81 te alterations in the glutamate signaling in cocaine addiction.

82 havior and may be useful in the treatment of cocaine addiction.

83 provide novel therapeutic opportunities for cocaine addiction.

84 d inform the development of therapeutics for cocaine addiction.

85 t to the pathophysiologic characteristics of cocaine addiction.

86 e tendencies and relationships may pre-exist cocaine addiction.

87 a period of heightened propensity to develop cocaine addiction.

88 date could facilitate control of behavior in cocaine addiction.

89 ere are no FDA-approved medications to treat cocaine addiction.

90 ovel therapeutic target for the treatment of cocaine addiction.

91 g, making it a promising pharmacotherapy for cocaine addiction.

92 agonism as a viable therapeutic strategy for cocaine addiction.

93 Administration-approved pharmacotherapy for cocaine addiction.

94 ortant target for cue-exposure therapies for cocaine addiction.

95 against cocaine be a viable prophylaxis for cocaine addiction?

96 These findings suggest that in cocaine addiction 1) activation of the corticolimbic rew

97 rticipation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further inv

98 Although tolerance is a hallmark of cocaine addiction and a DSM-V criterion for substance ab

99 subjective effects is a cardinal symptom of cocaine addiction and a DSM-V criterion for substance ab

100 e a novel role for G9a in promoting comorbid cocaine addiction and anxiety and suggest that increased

101 Cocaine addiction and depression are comorbid disorders.

102 ld be considered for their potential role in cocaine addiction and hippocampal-mediated relapse after

103 icroRNA let-7d, which has been implicated in cocaine addiction and other neurological disorders, targ

104 Cocaine addiction and overdose have long defied specific

105 Successful immunotherapy of cocaine addiction and overdoses requires cocaine-binding

106 a critical step in developing treatment for cocaine addiction and preventing cardiac complications.

107 ave therapeutic potential for treating human cocaine addiction and preventing relapse.

108 is thought to be critical for expression of cocaine addiction and relapse.

109 play an important role in sex differences in cocaine addiction and relapse.

110 ing efforts to find effective treatments for cocaine addiction and suggest the application of this pr

111 on resting-state functional connectivity in cocaine addiction and tested whether resting-state funct

112 s in the neuroadaptive cascade that leads to cocaine addiction and withdrawal.

113 be advantageous in immunopharmacotherapy for cocaine addiction, and for emergency cases of drug overd

114 in synaptic plasticity, dopamine signaling, cocaine addiction, and neurodegenerative disorders.

115 al, predict choice to view cocaine images in cocaine addiction; and (ii) whether such behaviour predi

116 Cocaine addiction appears to be associated with a drug-i

117 Treatment efforts for cocaine addiction are hampered by high relapse rates.

118 Whether these two prominent features of cocaine addiction are related to each other and are medi

119 ussed with respect to the role of the BLA in cocaine addiction as well as previous studies characteri

120 cleus accumbens (NAc) has been implicated in cocaine addiction because (1) cocaine reinforcement is m

121 ent a novel pharmacotherapeutic approach for cocaine addiction because it may simultaneously function

122 ical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy.

123 l-molecule therapeutic is available to treat cocaine addiction, but enzyme-based therapy to accelerat

124 g cocaine self-administration contributes to cocaine addiction by acting to facilitate subsequent coc

125 eking behavior, a defining characteristic of cocaine addiction, can be precipitated by contextual cue

126 Cocaine addiction continues to be a major health and soc

127 Cocaine addiction continues to be a significant public h

128 Abnormal function in reward circuitry in cocaine addiction could predate drug use as a risk facto

129 There is no effective treatment for cocaine addiction despite extensive knowledge of the neu

130 Methylphenidate has been used to mediate cocaine addiction due to its lower pharmacokinetics, whi

131 There is evidence for sex differences in cocaine addiction from both clinical and preclinical stu

132 armacotherapeutic actions of amphetamine for cocaine addiction go beyond that of replacement therapy.

133 zes GluA2 AMPARs at synapses but its role in cocaine addiction has not been examined.

134 Investigation of the role of stress in cocaine addiction has yielded an efficacious combination

135 isastrous medical and social consequences of cocaine addiction have made the development of an antico

136 armacological approaches to the treatment of cocaine addiction have thus far been disappointing, and

137 Cocaine addiction in humans is associated with long-term

138 ce every 2-4 wk, or longer, for treatment of cocaine addiction in humans.

139 uricular acupuncture is widely used to treat cocaine addiction in the United States and Europe.

140 1.6 million people who meet the criteria for cocaine addiction in the United States, and there are cu

141 A new pharmacokinetic approach treating cocaine addiction involves rapidly metabolizing cocaine

142 Cocaine addiction is a chronically relapsing brain disea

143 Cocaine addiction is a debilitating neuropsychiatric dis

144 Cocaine addiction is a disease characterized by chronic

145 Cocaine addiction is a long-lasting relapsing illness ch

146 Cocaine addiction is a major problem for which there is

147 Cocaine addiction is a major public health problem that

148 sequences on behavior.SIGNIFICANCE STATEMENT Cocaine addiction is a neuropsychiatric disorder that is

149 etically tractable model system for studying cocaine addiction is already providing new clues that ma

150 Cocaine addiction is associated with altered resting-sta

151 Cocaine addiction is associated with disturbed rsFC in s

152 Cocaine addiction is characterized by a gradual loss of

153 Cocaine addiction is characterized by a progressive incr

154 Cocaine addiction is characterized by an impaired abilit

155 Cocaine addiction is characterized by long-lasting vulne

156 Cocaine addiction is characterized by patterns of compul

157 Cocaine addiction is characterized by poor judgment and

158 Cocaine addiction is commonly viewed as a disorder of ne

159 One of the core symptoms of cocaine addiction is compulsive drug-seeking behavior.

160 One of the major challenges of cocaine addiction is the high rate of relapse to drug us

161 Cocaine addiction is thought to involve persistent neuro

162 Cocaine addiction is thought to stem, in part, from neur

163 A major goal of treatments for cocaine addiction is to reduce relapse-associated cravin

164 Relapse, a major problem in the treatment of cocaine addiction, is proposed to result in part from ne

165 ral and electrophysiological determinants of cocaine addiction liability.

166 bits is not necessary for the development of cocaine addiction-like behavior in rats.SIGNIFICANCE STA

167 s been identified as a predictive factor for cocaine addiction-like behavior.

168 In a model of cocaine addiction, mAb 15A10 blocked completely the rein

169 Recent evidence suggests that cocaine addiction may involve progressive drug-induced n

170 ining CM with bupropion for the treatment of cocaine addiction may significantly improve outcomes rel

171 peractivity disorder, binge eating disorder, cocaine addiction, obesity, and type 2 diabetes.

172 The impact of cocaine addiction on GMV, tested by (1) comparing the CU

173 f acupuncture as a stand-alone treatment for cocaine addiction or in contexts in which patients recei

174 nsisted of all adults with a heroin or crack cocaine addiction, or both, who started pharmacological

175 D3/D4 receptors as potential treatments for cocaine addiction, particularly in combination with enri

176 1 receptors may represent a novel target for cocaine addiction pharmacotherapies.

177 edited GluA2(Q) represent a novel target for cocaine addiction pharmacotherapies.

178 Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possib

179 her consideration of PDM as a candidate anti-cocaine addiction pharmacotherapy.

180 dol has been explored as a possible agent in cocaine addiction pharmacotherapy.

181 al responses to cocaine in all phases of the cocaine addiction process (induction, maintenance, and r

182 ew cocaine vaccine (dAd5GNE) in antagonizing cocaine addiction-related behaviors in rats.

183 In addition to serving as a therapy for cocaine addiction-related diseases, enhanced bioscavengi

184 rability of impulsive individuals to develop cocaine addiction remain unknown.

185 ate how the mPFC is functionally involved in cocaine addiction remains incomplete.

186 ion, a role of the endocannabinoid system in cocaine addiction remains widely inconclusive.

187 Cocaine addiction remains without an effective pharmacot

188 logical basis of sex-specific differences in cocaine addiction resides in the disparate regulation of

189 oimaging studies have shown that people with cocaine addiction retain some degree of control over dru

190 s a key role in determining vulnerability to cocaine addiction, reveal new molecular regulators that

191 sing therapeutic target for the treatment of cocaine addiction, schizophrenia, Parkinson's disease, a

192 ossibility that the behaviors characterizing cocaine addiction, such as craving-induced relapse, may

193 gene and protein expression associated with cocaine addiction suggest the existence of a mechanism t

194 h rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms a

195 g why women display a more severe profile of cocaine addiction than men.

196 women experiencing a more severe profile of cocaine addiction than men.

197 lying the vulnerability of impulsive rats to cocaine addiction that localize to the OFC, infralimbic

198 network interactions have been identified in cocaine addiction, the association between these brain n

199 asingly more at risk for the consequences of cocaine addiction, the need to establish better-tailored

200 RIP as a novel target for the development of cocaine addiction therapeutics.

201 ver, the actual therapeutic use of a CocH in cocaine addiction treatment is limited by its short biol

202 ed at these complexes may have potential for cocaine addiction treatment.SIGNIFICANCE STATEMENT Toler

203 There is a large unmet medical need for cocaine addiction treatments.

204 Treating cocaine addiction using dopamine replacement strategies,

205 patients with schizophrenia, depression, or cocaine addiction, using functional magnetic resonance i

206 evel effects of methylphenidate; severity of cocaine addiction was assessed by interview and question

207 The results of the study showed that cocaine addiction was associated with a 20% to 22% reduc

208 ocaine-induced increases in actin cycling in cocaine addiction was examined using the reinstatement o

209 velop a pharmacotherapy for the treatment of cocaine addiction, we embarked on synthesizing novel mol

210 ne oxidase inhibitor selegiline for treating cocaine addiction, we required a method for measuring ur