ライフサイエンスコーパス: cochaperone

1 TTI2 (Tel2-interacting protein 2) molecular cochaperone.

2 more gp93 biology by identifying CNPYb as a cochaperone.

3 mplex is rescued by Sec17, a universal SNARE cochaperone.

4 A is a DnaJ homolog that functions as a DnaK cochaperone.

5 model that trehalose functions as a chemical cochaperone.

6 r J-domain protein, Hdj-2, a recognized CFTR cochaperone.

7 ment, thus revealing novel functions of this cochaperone.

8 requires CHIP, a U box containing cytosolic cochaperone.

9 fer process requires Jac1, a J-protein Hsp70 cochaperone.

10 ces dissociation of the client and remaining cochaperones.

11 ds of client proteins with the assistance of cochaperones.

12 expansive network that includes a variety of cochaperones.

13 d by the integrated expression of regulatory cochaperones.

14 ed proteins, including Hsp90 and most of its cochaperones.

15 culum (ER), is believed to be independent of cochaperones.

16 Ec but retained the ability to act with DnaK cochaperones.

17 dified the association of hsp90 with several cochaperones.

18 ewly identified member of the DnaJ family of cochaperones.

19 nst Hsp90 may be enhanced in the presence of cochaperones.

20 mainly in complex interactions of Hsp70 with cochaperones.

21 ide exchange, which in turn are regulated by cochaperones.

22 on was unaffected in yeast mutated for Hsp90 cochaperones.

23 ractions with tetratricopeptide repeat (TPR) cochaperones.

24 ctions with the Hsp70 chaperone and numerous cochaperones.

25 chaperone, DnaK, but is independent of Hsp90 cochaperones.

26 strategies targeting multiple chaperones and cochaperones.

27 ATP hydrolysis on Hsp90 and the Hop and p23 cochaperones.

28 network of protein-protein interactions for cochaperones.

29 l for their interactions with substrates and cochaperones.

30 ochondrial Hsp70 (mtHsp70) and its J protein cochaperone [2].

31 metazoan protein BCL2-associated athanogene cochaperone 6 (Bag6) forms a hetero-trimeric complex wit

32 BCL2-associated athanogene cochaperone 6 (Bag6) plays a central role in cellular ho

33 haperone functions and interactions with the cochaperone 78-kDa glucose-regulated protein (binding im

34 ble to bind to this site, and that these two cochaperones act competitively, through Hsp90, to modula

35 Here, we find that the cochaperone, activator of Hsp90 ATPase homolog 1 (Aha1),

36 Furthermore, we show that the cochaperone activity of auxilin is required for constric

37 omodimers, a characteristic required for the cochaperone activity of HSP40.

38 h expression level, isoform specificity, and cochaperone activity.

39 he Hsp90 chaperone system is mediated by the cochaperone adaptor protein Cdc37, which acts as a scaff

40 onship between Hsp90 oligomers and the Hsp90 cochaperone Aha1 (activator of Hsp90 ATPase).

41 adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90

42 37) and recruitment of the ATPase activating cochaperone AHA1, but the molecular regulation of this c

43 the activation of its ATPase activity by the cochaperone Aha1.

44 yeast cytosolic Hsp90 can be relieved by the cochaperone aha1.

45 ne function and impacts interaction with the cochaperones Aha1 and Cdc37.

46 R, whereas nearly twice as much of the Hsp90 cochaperone, Aha1, associated with DeltaF508 CFTR.

47 sruption of the excessive association of the cochaperone, Aha1, with DeltaF508 CFTR is associated wit

48 ions in conjunction with Hsp70 and the Hsp70 cochaperones, an Hsp40 (J-protein) and a nucleotide exch

49 s site conserved among Hsp70 proteins alters cochaperone and client interactions.

50 ) is an immunoglobulin-binding protein (BiP) cochaperone and component of the endoplasmic reticulum-a

51 ther find that depleting Cpr7p, an Hsp90 TPR cochaperone and CyP-40 cyclophilin homolog, improved [PS

52 n that they can bypass the requirement for a cochaperone and result in the recovery of client protein

53 a protein family including a tubulin folding cochaperone and the retinitis pigmentosa protein RP2, in

54 As both a cochaperone and ubiquitin ligase, the C-terminal Hsp70 (

55 enables them to be modulated by ligands and cochaperones and "tuned" through evolution.

56 In concert with cochaperones and accessory proteins, heat shock proteins

57 conformational changes that are regulated by cochaperones and numerous posttranslational modification

58 association between HSP70 and several of its cochaperones and substrate proteins.

59 n is modulated through its interactions with cochaperones and the binding and hydrolysis of ATP.

60 involved, although acetylation affects ATP, cochaperone, and client protein binding to hsp90alpha, a

61 Among these were Bag1, encoding a Hsp70 cochaperone, and Csde1, encoding an RNA-binding protein,

62 shown conclusively to hydrolyze ATP or bind cochaperones, and both activities, by contrast, result i

63 ting a functional interplay among DnaK, DnaK cochaperones, and Hsp90Ec.

64 uteri of Fkbp52(-/-) mice, establishes this cochaperone as a critical regulator of uterine P(4) func

65 DNAJC14, a heat shock protein 40 (Hsp40) cochaperone, assists with Hsp70-mediated protein folding

66 rocess, multiple Hsp70- and Hsp90-associated cochaperones associate with receptor-chaperone complexes

67 as a "flag" for Hsp90 dependence and stable cochaperone association.

68 ated by partial siRNA silencing of the Hsp90 cochaperone ATPase regulator Aha1.

69 te that BNRF1 substitutes for the repressive cochaperone ATRX to form a ternary complex of BNRF1-Daxx

70 icated GARRPR motif at the N terminus of the cochaperone Bag-1L functions through the BF-3 pocket.

71 ere we show that the AR AF-1 is bound by the cochaperone Bag-1L.

72 We further provide evidence that the cochaperone BAG2 contributes to HSP70 stabilization in t

73 t mechanism of Tau degradation involving the cochaperone BAG2.

74 ncompassing exon 4 of the heat shock protein cochaperone BCL2-associated athanogene 3 (BAG3), was fou

75 formation also relies on the stress-induced cochaperone Bcl2-associated athanogene 3.

76 Many important cochaperones bind Hsp90 through their tetratricopeptide

77 and FKBP4 for efficient RNAi and that these cochaperones bind to hAgo2, we predict that loading of h

78 These findings reveal a new cochaperone binding site near the N terminus of hsp90, a

79 s a strong determinant of client protein and cochaperone binding.

80 rone whose activity is regulated not only by cochaperones but also by distinct posttranslational modi

81 malian gp96 was further found to require the cochaperone canopy 3 (CNPY3) for proper folding and expr

82 Hsp90 and its cochaperone Cdc37 cooperate to provide requisite support

83 Here, we report that the Hsp90 cochaperone Cdc37 directly interacts with IRE1alpha thro

84 at its activation is ATP-dependent, with the cochaperone Cdc37 increasing the efficiency.

85 PP5-mediated dephosphorylation of the cochaperone Cdc37 is essential for activation of Hsp90-d

86 The cochaperone CDC37 promotes the association of HSP90 with

87 Hsp90 requires cochaperone Cdc37 to load its clients to the Hsp90 super

88 ar factor kappa-B kinase (IKK) together with cochaperone Cdc37, which is critical for the activity of

89 3 ligases for interaction with HSP90 and its cochaperone CDC37.

90 kinases to Hsp90 is actively mediated by the cochaperone Cdc37.

91 mportant subset of clients requiring the key cochaperone CDC37.

92 blishment of the heat-shock protein 90/Hsp90 cochaperone Cdc37/Hsp90-Hsp70-organizing protein chapero

93 Here we show that the Hsp90 cochaperones Cdc37, Aha1, FKBP4, and p23 are required fo

94 e molecular chaperone by the kinase-specific cochaperone cell division cycle 37 (Cdc37).

95 MHC I was also inhibited by knockdown of the cochaperone CHIP that interacts with heat shock proteins

96 gnition of the altered nNOS by Hsp70 and its cochaperone CHIP, an E3-ubiquitin ligase, has been propo

97 -translational degradation in the ER through cochaperone CHIP, Hsp105 has a primary role promoting CF

98 binding EEVD domain and association with the cochaperone CHIP, resulting in ubiquitination and protea

99 to systematically characterize the chaperone-cochaperone-client interaction network in human cells.

100 ith the PIH1D1 adaptor component of the R2TP cochaperone complex, we examined the requirement of ECD

101 osis and also to be part of a prefoldin-like cochaperone complex.

102 s, delineate their participation in specific cochaperone complexes, and establish a surprisingly dist

103 which come from crystal structures of Hsp90 cochaperone complexes.

104 shock proteins (HSPs), molecular chaperones/cochaperones constituting a major component of the cell

105 e authors' findings reveal that the Hop/Sti1 cochaperone could act as a cell-intrinsic restriction fa

106 gs indicate that the TPR-containing Hop/Sti1 cochaperone could act as a cell-intrinsic virus restrict

107 The cochaperone cysteine-string protein (Csp) is located on

108 f translocating proteins delayed at Sec61 is cochaperone dependent.

109 The association of BAG2 with CHIP provides a cochaperone-dependent regulatory mechanism for preventin

110 rotein activity at the same time as delaying cochaperone dissociation from inhibited HSP90-client com

111 In accord with prior observations the cochaperone DnaJ stimulates the ATPase activity of DnaK,

112 show that overexpression of the ER-resident cochaperone DNAJC14 affects YFV polyprotein processing a

113 by down-regulation of the antagonistic Hsc70 cochaperone DNJ-13, implying that the severe phenotype i

114 Hsc70 with its cochaperone, either auxilin or GAK, not only uncoats cla

115 led degradation, with degradation-inhibiting cochaperones exerting essential prosurvival functions.

116 he ER lumen where its putative function as a cochaperone explains the stress-sensitivity phenotype of

117 ombination of pharmacological inhibition and cochaperone expression reveals that, in vivo, cytosolic

118 are stabilized by the TTT (Tel2, Tti1, Tti2) cochaperone family, whose actions are mediated by CK2 ph

119 Here, we show that the Hsp90 cochaperone, FK506-binding protein 51 (FKBP51), which po

120 The steroid-induced immunophilin cochaperone FKBP51 inhibits PR- and GR-mediated transcri

121 Here, we report that the Hsp90 cochaperone FKBP51 is upregulated in LAPC-4 AI tumors gr

122 ptors is potentiated by the Hsp90-associated cochaperone FKBP52, although not by the closely related

123 has thus established CNPY3 as a TLR-specific cochaperone for gp96.

124 V replication assay and identified the Cns1p cochaperone for heat shock protein 70 (Hsp70) and Hsp90

125 ring protein alpha (CSPalpha), a presynaptic cochaperone for Hsc70, is required for synapse maintenan

126 Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during

127 he Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

128 Deletion of Fkbp52, an immunophilin cochaperone for PR, results in uterine-specific P(4) res

129 dc37) is a key heat shock protein 90 (Hsp90) cochaperone for protein kinase clients, and Akt/Hsp90 in

130 The immunophilin FKBP52 serves as a cochaperone for steroid hormone nuclear receptors to gov

131 erichia coli DnaJ homolog, can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its

132 The essential Hsp40, Sis1, is a J-protein cochaperone for the Ssa class of Hsp70's of Saccharomyce

133 Hsp90 functions in association with several cochaperones for folding of protein kinases and transcri

134 degeneration in mice, presumably because the cochaperone function of CSPalpha is essential for neuron

135 ion and that YFV probably utilizes DNAJC14's cochaperone function to modulate processing at the NS3/4

136 Suppression by CHIP requires its cochaperone function, suggesting that CHIP acts to facil

137 t shock protein 90 (Hsp90) and its accessory cochaperones function by facilitating the structural mat

138 , heat shock protein 70 (Hsp70), and several cochaperones functionally colocalize with this protein c

139 es, which encode the GroEL chaperone and its cochaperone GroES, responded to heat shock.

140 enes that encode the chaperone GroEL and its cochaperone, GroES, including all of the fully sequenced

141 The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate more than half o

142 manner to peptides derived from the histone cochaperones HirA and CAF-I.

143 Thus Rad53 competes with histones H3-H4 and cochaperones HirA/CAF-I for binding to Asf1.

144 on substrate, histone H3, in addition to its cochaperone, HIRA.

145 We identified four Hsp70 genes and two GrpE cochaperone homolog genes (CGE) in moss that encode chlo

146 Sti1p, a TPR cochaperone homolog of mammalian Hop1 (Hsp70/90 organizi

147 he molecular chaperones Hsp70 and Hsp90, the cochaperone HOP, and ubiquitin ligase, CHIP.

148 ultaneously, which is also a property of the cochaperone Hop.

149 The cochaperone HOP/Sti1p also participates in VHL quality c

150 endoplasmic reticulum to the nucleus via the cochaperone Hsp40 pathway.

151 sence of excess Cur1 are counteracted by the cochaperone Hsp40-Sis1 in a dosage-dependent manner, and

152 otein-specific kinase, directly binds to the cochaperones Hsp40/DNAjc8 and Aha1, which mediate dynami

153 iated with cellular chaperones (HSP70) and a cochaperone (Hsp40) which can be coimmunoprecipitated wi

154 nits Rpb1 and Rpb8 associated with the HSP90 cochaperone hSpagh (RPAP3) and the R2TP/Prefoldin-like c

155 te and analyze transgenic mice that lack the cochaperone HSPBP1, a nucleotide-exchange factor of HSP7

156 in yeast or knockdown of the orthologous Hop cochaperone in plants leads to increased CIRV replicatio

157 cation, and knockdown of the orthologous Hop cochaperone in plants results in a 3-fold increase in CI

158 ovides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action

159 mice for a potential role of an immunophilin cochaperone in the etiology of human endometriosis.

160 Cytosolic HSP90 requires multiple cochaperones in folding client proteins.

161 nases after screening several chaperones and cochaperones in gene deletion mutant strains.

162 Given the number and diversity of cochaperones in mammals, it is likely that combinatorial

163 We assayed the role of nine different cochaperones in the activation of Ste11, a Saccharomyces

164 multiprotein complex enriched in chaperones/cochaperones including Hsc70.

165 The ATPase cycle is regulated by cochaperones, including DnaJ proteins that accelerate AT

166 Hsp90 functions in concert with a number of cochaperones, including the Hsp110 homolog Sse1.

167 Our results indicate that a hierarchy of cochaperone interaction controls different aspects of th

168 that linker sequence affects Hsp90 function, cochaperone interaction, and conformation.

169 e mechanism of client protein binding or how cochaperone interactions modulate Hsp90 conformational s

170 obiocin, indicating that alteration of Hsp90/cochaperone interactions was not the cause of the novobi

171 ha1 stimulates the ATPase activity, restores cochaperone interactions, and compensates for the functi

172 forms stable complexes through a multidomain cochaperone interface.

173 rexpressing AtHSCB, encoding a mitochondrial cochaperone involved in [Fe-S] cluster biosynthesis, and

174 mammals, we first sought ER-associated Hsp40 cochaperones involved in CFTR maturation.

175 , binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

176 tive regulation of the MAL activator by Aha1 cochaperone is proposed.

177 cyclophilin and the Ttc4 oncogene-like Cns1 cochaperone, is a strong inhibitor of CIRV replication.

178 he BAG family of heat shock protein (HSP) 70 cochaperones, is expressed in response to stressful stim

179 Hsp70s work together with their cochaperones, J domain proteins and nucleotide exchange

180 kdown of expression levels of the identified cochaperones leads to disruption of purinosomes.

181 we show that MCJ is a type II transmembrane cochaperone localized in the Golgi network and present o

182 p23 is a heat shock protein 90 (Hsp90) cochaperone located in both the cytoplasm and nucleus th

183 Interestingly, viral cochaperones LT and ST were essential for stable interac

184 Tid1 (DNAJA3), a DnaJ cochaperone, may promote degradation of oncogenic kinase

185 Thus, although both nucleotides and J cochaperones modulate Hsp70 NBD:linker and NBD:SBD inter

186 s (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR

187 ctivity revealed a pattern of defects in the cochaperone mutant strains that were similar to the gene

188 Several cochaperone mutants tested had reduced FIG1 induction or

189 ostulated that CNPYb would be a TLR-specific cochaperone of gp93.

190 Tid1 also is known as a cochaperone of heat shock protein 70 (HSP70) and binds t

191 Dimeric yeast Mge1, the cochaperone of heat shock protein 70 (Hsp70), is essenti

192 e in [RNQ(+)] propagation, Sis1, a J-protein cochaperone of Hsp70 Ssa, is also specifically required

193 Zuo1 functions as a J-protein cochaperone of its partner Hsp70.

194 AHA1 (activator of HSP90 ATPase) is a cochaperone of the ATP-dependent molecular chaperone, HS

195 ovel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associate

196 Aha1 is a ubiquitous cochaperone of the Hsp90/Hsp70 chaperone machine.

197 ir composition by inducing the attachment of cochaperones of HSP70, such as the mitotic-phase phospho

198 J-proteins are obligate cochaperones of Hsp70s and stimulate their ATPase activi

199 roteins are structurally diverse, obligatory cochaperones of Hsp70s, each with a highly conserved J d

200 J proteins are obligate cochaperones of Hsp70s, stimulating their ATPase activit

201 characteristic of proteins acting either as cochaperones of Hsp90 or as independent small heat shock

202 inally, we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, Dn

203 s various HSPs, chaperones, and at least one cochaperone on their cell surfaces; and that HSPs may be

204 Our data suggest a hypothesis that cochaperone or substrate domain binding perturbs the rel

205 s coding sequences of a homolog of the HSP90 cochaperone p23 (p23(H)) to those of AlaXp, to create p2

206 Overexpression of the hsp90 cochaperone p23 also promotes AR112Q degradation, and in

207 d 17-AAG-mediated attenuation of ATP and the cochaperone p23 binding to hsp90.

208 To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we foc

209 rm-selective inhibitors of Hsp90(alpha/beta)/cochaperone p23 interactions, we developed a dual-lucife

210 The cochaperone p23 plays an important role in estrogen rece

211 ow that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming

212 sp90 and loss of complex formation with AhR, cochaperone p23, and XAP-2.

213 ly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity.

214 a Pro-Xaa-Leu-Glu (PXLE) motif in the HSP90 cochaperone p23, thereby recruiting PHD2 to the HSP90 pa

215 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 rema

216 tylation, its dissociation from an essential cochaperone, p23, and a loss of chaperone activity.

217 a ternary complex with kinase client and the cochaperone p50(Cdc37), Hsp90 proceeds through a cycle o

218 dly enhanced by haploinsufficiency of the ER cochaperone p58(IPK).

219 teracting protein (CHIP), a ubiquitin ligase/cochaperone, participates in protein quality control by

220 aining TCP-1 (CCT; also called TRiC) and its cochaperone phosducin-like protein 1 (PhLP1).

221 stance of the cytosolic chaperonin CCT and a cochaperone, phosducin-like protein 1 (PhLP1) for dimer

222 ients by the Hsp90 system is mediated by the cochaperone protein Cdc37.

223 tetratricopeptide repeat (TPR) domains, the cochaperone protein Hop/Sti1 has been proposed to play a

224 ractions with a chaperone protein HscA and a cochaperone protein HscB.

225 f the JCI, Dickey and colleagues show that a cochaperone protein, carboxyl terminus of Hsp70-interact

226 Tid1, a DnaJ cochaperone protein, is the mammalian homologue of the D

227 endent molecular chaperone Hsp90 and partner cochaperone proteins are required for the folding and ac

228 w nucleotides affect Hsp90 interactions with cochaperone proteins, we monitored assembly of wild-type

229 conformational changes and interactions with cochaperone proteins, which facilitate activation of Hsp

230 sp90 dimer and interaction with a network of cochaperone proteins.

231 es have dramatic effects on interaction with cochaperone proteins.

232 us combinations of purified chaperone and/or cochaperone proteins.

233 h PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the asse

234 cognition is modulated by its ribosome-bound cochaperone, RAC.

235 unity, as well as HSP90 chaperones and their cochaperones RAR1 and SGT1B, are required for the DFPM-i

236 We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein an

237 ET1A, an H3K4 methyltransferase, and BAT3, a cochaperone recruiter, as binding partners for BORIS, an

238 However, how these cochaperones regulate protein folding and whether they h

239 This Hsp70 cochaperone regulates binding between CTA and the ER Hsp

240 recipitated with p97/VCP indicating that the cochaperones remain associated with the misfolded propro

241 ults identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90

242 to better understand the abundant yeast p23 cochaperone Sba1.

243 We have discovered that Hsp90 and the cochaperone Sba1/p23 accumulate in the nucleus of quiesc

244 Hsp70-type chaperone Kar2 and the Hsp40-type cochaperone Scj1 bind to Hrd3KR.

245 The HSP40 cochaperone SEC63 is associated with the SEC61 transloco

246 -inducible phosphoprotein 1 (STI1), an Hsp90 cochaperone secreted by astrocytes, binds to PrP(C) in t

247 Hop-like stress-inducible protein 1 (Sti1p) cochaperone selectively inhibits the mitochondrial membr

248 Hop-like stress-inducible protein 1 (Sti1p) cochaperone selectively inhibits the mitochondrial membr

249 nt and animal innate immunity depends on the cochaperone Sgt1 and, at least in plants, on a cysteine-

250 The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a

251 y the small glutamine-rich tetratricopeptide cochaperone Sgt2.

252 sp70) chaperone pair Ssa1/Ssa2 and the Hsp40 cochaperone Sis1 are essential for degradation.

253 Finally, we show that the HSP-90 cochaperone spaghetti protein (SPAG) antagonizes DBT aut

254 such analysis, we establish that NUDC family cochaperones specifically associate with structurally re

255 f Hsp104 to hexamerize, to interact with the cochaperone Sti1, and to bind protein aggregates.

256 ults demonstrate a role of the ISC HscA/HscB cochaperone system in facilitating efficient [2Fe-2S] cl

257 role of the Azotobacter vinelandii HscA/HscB cochaperone system in ISC-mediated iron-sulfur cluster b

258 Molecular chaperone Hsp90 and its cochaperone Tah1 are required for the stability of Pih1

259 and mammals, TTI2 associates with two other cochaperones, TEL2 (Telomere maintenance 2) and TTI1 (Te

260 BAG1 is a Hsp70/Hsc70-regulating cochaperone that also interacts with glucocorticoid rece

261 n translational control, encodes a cytosolic cochaperone that associates with the ER protein transloc

262 hilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR)

263 FKBP5 is a molecular cochaperone that contributes to the functional status of

264 bly, as well as by Jac1, the J-protein Hsp70 cochaperone that functions in cluster transfer from Isu.

265 turation of the kinase and identify SIP as a cochaperone that is critical to the HSP90-mediated activ

266 hsp90, but this can be reversed by FKBP52, a cochaperone that is thought to act later in the pathway.

267 Here, we identify MCJ/DnaJC15 as a distinct cochaperone that localizes at the mitochondrial inner me

268 suggest that UBQLN is a polyubiquitin-TDP-43 cochaperone that mediates the autophagosomal delivery an

269 nteraction with Hsp40 (Ydj1p), another Hsp70 cochaperone that promotes substrate binding but is dispe

270 Hsp40 is a cochaperone that regulates Hsp70 chaperone activity.

271 Sti1 is an Hsp70 cochaperone that regulates the spatial organization of a

272 aracterized as an Hsp70 and Hsp90-associated cochaperone that specifically regulates androgen recepto

273 The NBD is also a center of interaction with cochaperones that couple into the allostery.

274 mily is an evolutionarily conserved group of cochaperones that modulate numerous cellular processes.

275 FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of st

276 FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of st

277 90 and Hsp70 are highly regulated by various cochaperones that participate in the activation of stero

278 ionarily conserved, multifunctional group of cochaperones that perform diverse cellular functions ran

279 Therefore, alterations of Hsp70 cochaperones that promote or prolong Hsp70 substrate bin

280 s determined by the balance of activities of cochaperones that regulate Hsc70 and Hsp90 functions.

281 hieved through a diverse family of J-protein cochaperones that select substrates for Hsp70.

282 e with a large and diverse set of cofactors (cochaperones) that regulate their specificity and functi

283 In addition, two cochaperones, the C terminus of Hsp70-interacting protei

284 ese processes, the chaperone cooperates with cochaperones, the presequence translocase, and other cha

285 postulate that the spoke HSP40 operates as a cochaperone to assist chaperone machinery at the flagell

286 Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) recepto

287 insight into the interplay between CCT and a cochaperone to orchestrate the folding of a protein subs

288 import by recruiting Ssc1 and its J protein cochaperone to the translocon and coordinating their int

289 ouples an aspartyl protease with a molecular cochaperone to trigger autophagy and plant defense, prov

290 se (GAK) are homologous proteins that act as cochaperones to support the Hsc70-dependent clathrin unc

291 F1- and HSF2-mediated expression patterns of cochaperones, transcriptional regulators, and signaling

292 of Hsp70 relies on the interaction with the cochaperone ubiquitin ligase carboxyl terminal of Hsp70/

293 the presence of tau was able to recruit the cochaperone ubiquitin ligase CHIP, which is known to fac

294 Cochaperones were also involved in Hsp90-mediated remova

295 he ATP-hydrolyzing Hsp70s are regulated by J cochaperones, which contain J domains that stimulate Hsp

296 rs to function as an unexpected but critical cochaperone with Hsc70 in endocytosis.

297 ly, we describe the roles of the plethora of cochaperones with which Hsp90 cooperates and growing ins

298 However, yeast with a deletion of the Hsp70 cochaperone YDJ1 showed a dramatic reduction in FHV RNA

299 ants indicated that SWI/SNF, Gcn5, the Hsp70 cochaperone Ydj1, and chromatin-associated factor Yta7 a

300 o the 'Chord and Sgt1' domain of known Hsp90 cochaperones, yet Shq1p does not interact with the yeast