ライフサイエンスコーパス: cochlear hair cell

1 on of release-ready synaptic vesicles in the cochlear hair cell.

2 lfactory receptor neurons and vestibular and cochlear hair cells.

3 myosin XVa mRNA and protein are expressed in cochlear hair cells.

4 rters and may explain observed properties of cochlear hair cells.

5 wth of stereocilia bundles in vestibular and cochlear hair cells.

6 constant-frequency neurons and contralateral cochlear hair cells.

7 rgans and is required for normal function of cochlear hair cells.

8 26SB), on mechano-electrical transduction in cochlear hair cells.

9 nsors, or pumps to control calcium levels in cochlear hair cells.

10 inetic range needed for electrical tuning of cochlear hair cells.

11 ganisation and has a role in the function of cochlear hair cells.

12 described the loss of afferent contacts from cochlear hair cells.

13 rophages following the selective ablation of cochlear hair cells.

14 synergistically in USH2 complex assembly in cochlear hair cells.

15 he USH2 complex at ankle links in developing cochlear hair cells.

16 oration to express cDNAs and shRNAs in mouse cochlear hair cells.

17 s, resulting in a toxic microenvironment for cochlear hair cells.

18 reocilia of teleost vestibular and mammalian cochlear hair cells.

19 the improper development or degeneration of cochlear hair cells.

20 ngth of the cochlear duct, and the number of cochlear hair cells.

21 oustic signal acquisition and propagation in cochlear hair cells.

22 erlie the late acquisition of BK currents in cochlear hair cells.

23 hat regulates synaptic vesicle exocytosis in cochlear hair cells.

24 and temporally precise neurotransmission by cochlear hair cells.

25 two shorter rows of stereocilia in mammalian cochlear hair cells.

26 tion of the hair bundle is lost in mammalian cochlear hair cells.

27 rons and mechanosensory stereocilia of mouse cochlear hair cells.

28 lly in retinal photoreceptors and developing cochlear hair cells.

29 al photoreceptors and for the development of cochlear hair cells.

30 lification of the mechanical stimulus by the cochlear hair cells.

31 In cochlear hair cells, ACF7 localization is graded, with t

32 everse-polarity" current was investigated in cochlear hair cells after tip-link destruction with BAPT

33 pment, but little is known about its role in cochlear hair cell and Deiter's support cell development

34 Cochlear hair cell and neuronal function was assessed vi

35 specific protease domain and is expressed in cochlear hair cells and a subset of supporting cells.

36 posure destroys synaptic connections between cochlear hair cells and auditory nerve fibers; however,

37 For survival of cochlear hair cells and preservation of hearing, NO-medi

38 l ganglion neurons (SGNs) receive input from cochlear hair cells and project from the cochlea to the

39 sts of spontaneous activity are generated in cochlear hair cells and propagated along central auditor

40 efferent system, which provides feedback to cochlear hair cells and sensory neurons.

41 We report that cochlear hair cells and supporting cells in transcriptio

42 Tmc2 were expressed in mouse vestibular and cochlear hair cells and that GFP-tagged TMC proteins loc

43 GATA2 regulates the development of cochlear hair cells and the inferior colliculus (IC), wh

44 diversity of splice variants exist in rodent cochlear hair cells and this diversity is similar to tha

45 ring loss associated with mild damage to the cochlear hair cells and, strikingly, significant degener

46 lear duct, a decrease in the total number of cochlear hair cells, and defects in the formation of the

47 sion has been reported in photoreceptors and cochlear hair cells, and mutations in whirlin cause Ushe

48 ecific for vestibular hair cells, others for cochlear hair cells, and some are expressed just before

49 ner ear phenotype in that the vestibular and cochlear hair cells are differentially affected.

50 The stereocilia of cochlear hair cells are disorganized and splayed in muta

51 Turtle cochlear hair cells are electrically tuned by a voltage-

52 Cochlear hair cells are inhibited by cholinergic efferen

53 Cochlear hair cells are vulnerable to a variety of insul

54 ssion was transient in early postnatal mouse cochlear hair cells but persisted in vestibular hair cel

55 e for Barhl1 in the long-term maintenance of cochlear hair cells, but not in the determination or dif

56 ediate the intrinsic frequency tuning of the cochlear hair cell by an electrical resonance mechanism.

57 assium currents were characterized in turtle cochlear hair cells by whole-cell voltage clamp during s

58 inoglycoside antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss.

59 The sensory bundle of vertebrate cochlear hair cells consists of actin-containing stereoc

60 Cochlear hair cells convert sound stimuli into electrica

61 Cochlear hair cells convert sound-induced vibration into

62 Our goals were to determine whether cochlear hair cells could survive the trauma and whether

63 s Cx26 and Cx30 gene knockout mice show that cochlear hair cells degenerate after the onset of hearin

64 , partial pontine nucleus migration defects, cochlear hair cell degeneration, and profound hearing lo

65 mouse model that allows temporal control of cochlear hair cell deletion.

66 Recordings from rat cochlear hair cells demonstrate that altering Ca(2+) ent

67 e describe the effects of three mutations on cochlear hair cell development and function.

68 egulating epithelial polarity, ion channels, cochlear hair cell development, vesicular sorting, and n

69 postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechan

70 However, SGNs degenerate following loss of cochlear hair cells, due at least in part to a reduction

71 associated with these mutations is caused by cochlear hair cell dysfunction, as indicated by conspicu

72 After substantial loss of cochlear hair cells, exogenous neurotrophins prevent deg

73 For mammalian cochlear hair cells, fate determination is normally comp

74 Cochlear hair cells form ribbon synapses with terminals

75 ti-functional small molecule drug, protected cochlear hair cells from gentamicin damage.

76 opment in the 1970s of objective measures of cochlear hair cell function (cochlear microphonics, otoa

77 iary localization of TRPML3 and investigated cochlear hair cell function in varitint-waddler (Va(J))

78 m by which the corticofugal system modulates cochlear hair cells has been unexplored.

79 Cochlear hair cells (HCs) are mechanosensory receptors t

80 Alpha9 AChR mRNA was first observed in cochlear hair cells (HCs) at embryonic day 18 (E18), inc

81 ness associated with a rapid degeneration of cochlear hair cells (HCs) but have a normal endocochlear

82 ns (SGNs) extend their neurites to innervate cochlear hair cells (HCs) with their soma aggregated int

83 eurons via the corticofugal system modulates cochlear hair cells in a highly specific way according t

84 tes both the hearing loss and destruction of cochlear hair cells in guinea pigs treated with aminogly

85 Loss of cochlear hair cells in mammals is currently believed to

86 We recorded from cochlear hair cells in SK2 knockout mice to evaluate fur

87 Cochlear hair cells in the av mutants show abnormal ster

88 genetic strategies to ablate neonatal mouse cochlear hair cells in vivo.

89 quired for the maintenance of vestibular and cochlear hair cells in vivo.

90 (2+)-activated K(+) channel of the chicken's cochlear hair cell interacts with beta-catenin.

91 Efferent inhibition of cochlear hair cells is mediated by 'nicotinic' cholinerg

92 ly believed that mechanical amplification by cochlear hair cells is necessary to enhance the sensitiv

93 Furthermore, Gfi1 mutant mice lose all cochlear hair cells just prior to and soon after birth t

94 GPR98 and WHRN, to ankle links in developing cochlear hair cells, likely through its direct interacti

95 rin-1 protein expressed in transfected mouse cochlear hair cells localized to the bundle; however, th

96 ry brainstem responses (ABRs) and determined cochlear hair cell loss in 13-month-old 129/CD-1 mice wi

97 Cochlear hair cell loss results in secondary regression

98 fe, CBA/J (CBA), with one that suffers early cochlear hair cell loss, C57BL/6 (BL/6).

99 c gradients underlying sound transduction in cochlear hair cells necessary for hearing.

100 Cochlear hair cells normally detect positive deflections

101 lls of the cochlea and vestibule and also to cochlear hair cell nuclei and stereocilia.

102 We identified >600 enriched transcripts in cochlear hair cells, of which 90% have not been previous

103 pendent hearing loss is not due to a loss of cochlear hair cells or spiral ganglion neurons, both of

104 for Notch-mediated lateral inhibition during cochlear hair cell patterning, we also detected abnormal

105 In contrast, cochlear hair cell polarity is disorganized.

106 CaBP2 was expressed by cochlear hair cells, preferentially in inner hair cells

107 Electron microscopy of cochlear hair cells revealed loss of some tall stereocil

108 Using RT-PCR of rat cochlear hair cell-specific cDNA libraries, we detect an

109 lls, and HCN1 protein was immunolocalized to cochlear hair cell stereocilia.

110 ids, open neural tube, and misorientation of cochlear hair cell stereociliary bundles, indicative of

111 ortant in sites such as the gamma-actin-rich cochlear hair cell stereocilium where local mm calcium c

112 -CreER activity was also detected in >50% of cochlear hair cells, suggesting that Sox2-CreER may not

113 fi1, two transcription factors implicated in cochlear hair cell survival, depends upon continued Atoh

114 2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but

115 n neurons communicate sound information from cochlear hair cells to auditory brainstem neurons throug

116 lion neurons (SGNs) relay acoustic code from cochlear hair cells to the brainstem, and their stimulat

117 Cochlear hair cells transduce mechanical stimuli into el

118 ding neuronal firing, synaptic transmission, cochlear hair cell tuning, insulin release, and smooth m

119 lia organization in the cochlea, and rescues cochlear hair cells, vestibular function and low-frequen

120 l synapses mediate cholinergic inhibition of cochlear hair cells via alpha9alpha10-containing ionotro

121 Otoferlin, the proposed Ca(2+) sensor in cochlear hair cells, was similarly distributed in both c

122 We found that when cochlear hair cells were depolarized near the Ca(2+) rev

123 toxicity, changes in lysosomal activities in cochlear hair cells were evaluated during a repeated adm

124 hlear function was rapidly abolished and all cochlear hair cells were missing within 24 h after treat

125 g loss accompanied by loss of mechanosensory cochlear hair cells, while the endocochlear potential an

126 rapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafnes

127 mice resulted in nearly complete ablation of cochlear hair cells, with no evident pathology among sup

128 for specific Usher protein variants in mouse cochlear hair cells, with the apical variants playing a

129 Given that Myo7a is also expressed in cochlear hair cells, Yy1 shows the appropriate localizat