ライフサイエンスコーパス: coco

1 n approach termed Codon Consequence Scanner (COCOS).

2 A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces

3 re, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFbeta signalling, in th

4 We find that Coco, a Xenopus DAN family member, and two TGF-beta liga

5 al changes were observed for PTU binding to [CoCo(AAP)] and [CoZn(AAP)] but not for [ZnCo(AAP)], whil

6 c absorption spectra, recorded at pH 7.5 of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] upon addition o

7 he electronic absorption and EPR spectra of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] were recorded i

8 of the catalytically competent [Co_(AAP)], [CoCo(AAP)], and [ZnCo(AAP)] enzymes recorded in the pres

9 EPR spectra of [CoCo(AAP)]-1c, [ZnCo(AAP)]-1c, and [CoZn(AAP)]-1c were a

10 aramagnetic resonance (EPR) spectrum of the [CoCo(AAP)]-bestatin complex exhibited no observable perp

11 Thus, Coco acts as both an inhibitor and an enhancer of signal

12 logical activity, we have renamed this clone Coco, after the Spanish word meaning head.

13 plate (GRP), and aberrant expression of both Coco and Pitx2c were associated with abnormal LR symmetr

14 holds true for all the beak shapes of Tree, Cocos, and Warbler Finches (three distinct genera).

15 y identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFbeta1 signaling.

16 Molecularly, Coco binds to TGFbeta1 and enhances TGFbeta1 binding to

17 In contrast, di-Co(II) Bla2 (CoCo-Bla2) is substantially more active than the mono-Co

18 sembl variant effect predictor (VEP) plugin, COCOS captures amino acid sequence alterations stemming

19 , together with inhibitors such as Lefty and Coco/Cerl2, have been shown to provide the signals that

20 COCO-CL can be used as a semi-independent method to deli

21 We propose a new method, COCO-CL, for hierarchical clustering of homology relatio

22 sorption and EPR spectra of [Co_(DapE)] and [CoCo(DapE)] indicate that the first Co(II) binding site

23 interaction between the two Co(II) ions in [CoCo(DapE)] is very weak.

24 We conclude that derriere, Xnr1, and Coco define a posttranscriptionally regulated signaling

25 for normal levels of Xnr1 expression, while Coco directly inhibits both ligands.

26 ferent from that observed for L-Met binding [CoCo(EcMetAP-I)].

27 Whereas Coco enhances the manifestation of traits associated wit

28 et, the latest clinical trial reported by Lo-Coco et al in the New England Journal of Medicine is a p

29 nstrated that left-right patterning requires Coco exclusively on the right side, and Xnr1 and derrier

30 Mechanistic studies indicate that Coco exerts this effect by blocking lung-derived BMP lig

31 by DFT computation was CO2 -->*COOH-->*CO-->*COCO-->*COCH2 OH-->*CH2 OCH2 OH-->CH3 CH2 OH.

32 ctionalized macrocyclic oligo(cyclooctene)s (cOCOEs) in high purity and high yield by exploiting the

33 Coco induces a discrete gene expression signature, which

34 We show that Coco is required to prevent Activin and Nodal signals in

35 es, inhabiting the Galapagos archipelago and Cocos Island, constitute an iconic model for studies of

36 ron paramagnetic resonance (EPR) spectra of [CoCo(MetAP)] also indicated that the Co(II) geometries a

37 EPR studies on [CoCo(MetAP)] also revealed that at pH 7.5 there is no si

38 the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1).

39 ine the biochemical constituents in coconut (Cocos nucifera L.) haustorium, a spongy tissue formed du

40 Coexpression of a coconut (Cocos nucifera) 12:0-coenzyme A-preferring lysophosphati

41 ocarpus heterophyllus), and mature coconuts (Cocos nucifera) from different Brazilian regions (3 lots

42 ste stream from food crops, such as coconut (Cocos nucifera) shell, which is nonedible, not of use fo

43 m size) within a minute from tender coconut (Cocos nucifera) water.

44 ion of the commonly introduced coconut palm, Cocos nucifera, interrupts the flow of allochthonous mar

45 arnauba [Copernicia prunifera], and coconut [Cocos nucifera]) endocarps contain lignin polymers deriv

46 natae, Tuber curcumae and Scletrotium poriae cocos) on the cytotoxic action of Abeta(1-40) were teste

47 lina hepatica, Serpula lacrymans, Wolfiporia cocos or Dacryopinax sp.

48 he bridging water molecule, observed in the [CoCo(PfMetAP-II)] structure, is absent.

49 est anomaly next to the boundary beneath the Cocos Plate and the Caribbean Plate.

50 ductivity of the LAB beneath the edge of the Cocos plate at the Middle America trench offshore of Nic

51 aves that traverse the deep mantle under the Cocos plate resolve structures above the core-mantle bou

52 present images of the D'' region beneath the Cocos plate using Kirchhoff migration of horizontally po

53 Coco synergizes with TGFbeta1 in both cell culture and X

54 In the absence of Coco, the TGF-beta signal is bilateral.

55 To highlight its significance, COCOS was applied to data from the 1000 Genomes Project.

56 lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated an