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1 n interaction effect between theobromine and cocoa.
2 key contributors to the astringent taste of cocoa.
3 dio-protective agent found in wine, tea, and cocoa.
4 a lack of information about Ni speciation in cocoa.
5 were significantly repressed in response to cocoa.
6 th two coiled coil coactivators, TRIP230 and CoCoA.
7 ective benefits of dark chocolate containing cocoa.
8 t- and phytochemical-rich dark chocolate and cocoa.
9 and/or overall aroma formation potential of cocoa.
10 either dark chocolate (active treatment; 85% cocoa, 0.55 g/kg body wt; n = 11) or isocaloric amounts
11 antly more with sugar-free than with regular cocoa (5.7 +/- 2.6% compared with 2.0 +/- 1.8%; P < 0.00
14 obromine [theobromine intervention (TB)], 3) cocoa and added theobromine, which provided 1000 mg theo
18 fatty acids (FA) profile were determined in cocoa and chocolates of different geographical origin an
19 ntervention studies have been carried out on cocoa and cocoa-containing products over the past 12 yea
24 ro and in vivo approaches, on the effects of cocoa and its constituent flavonoids have been conducted
25 he commercialization of Mexican genotypes of cocoa and reports the possibility of upcycling fermented
28 risk of cardiovascular diseases (CVDs), and cocoa and tea have been shown to improve CVD risk factor
29 t studies have shown that the consumption of cocoa and tea is associated with lower risk of cardiovas
35 showed similar formation trends of important cocoa aroma markers as a function of fermentation qualit
36 important precursors for the development of cocoa aroma, however cocoa oligopeptide fraction is unde
38 intervention studies have been performed on cocoa as an ingredient, whereas many in vitro studies ha
39 n the particular cleavage specificity of the cocoa aspartic protease, which cannot be substituted by
40 he assays were not due to the polyphenols of cocoa autolysates qualitative and quantitative tests wer
42 ysis of amino acid composition revealed that cocoa autolysates were abundant in hydrophobic amino aci
45 Peptides and amino acids generated during cocoa bean fermentation are the most important precursor
46 showed that the main factor influencing the cocoa bean metabolic profile is the fermentation level.
47 beans, were obtained after semisynthesis of cocoa bean polymers with (+)-catechin as nucleophile and
49 unosensor was used to quantify OTA in spiked cocoa bean samples and the results were compared with th
51 c procyanidins, were isolated from unroasted cocoa beans (Theobroma cacao L.) using various technique
52 s obtained are useful for quality control of cocoa beans allowing their differentiation according to
54 coa butter is the pure butter extracted from cocoa beans and is a major ingredient in the chocolate i
58 onal variety is the most demanded, since its cocoa beans are used to produce the finest chocolates.
59 s therefore useful to characterise fermented cocoa beans as a function of their origin and fermentati
60 d from the vicilin-class(7S) globulin of the cocoa beans by acid-induced proteolysis during cocoa fer
62 aroma precursor extract from well-fermented cocoa beans by ligand-exchange and subsequent Sephadex-L
66 ion of bioactive amines and their changes in cocoa beans during seven days of traditional fermentatio
67 buted to environmental factors affecting the cocoa beans during the fermentation and drying processes
68 rmented, under fermented, and well-fermented cocoa beans from all of the main producing countries, wi
69 as a means to distinguish between fermented cocoa beans from different geographical and varietal ori
70 tiparametric statistical methods allowed the cocoa beans from different origins to be distinguished.
71 Differences in the average Raman spectra of cocoa beans from different sites but within the same var
73 lidated and applied to imported and domestic cocoa beans samples collected over 2 years from smallhol
75 cocoa beans, ILR-CIS-GC-MS data on unroasted cocoa beans showed similar formation trends of important
76 nts per gram non-fat dry matter in raw fresh cocoa beans to 4mg/g in the final chocolate product.
77 nts per gram non-fat dry matter in raw fresh cocoa beans to 6mg epicatechin equivalents per gram in t
78 a sensitive Ochratoxin A (OTA) detection in cocoa beans using competitive aptasensor by differential
79 od for the analysis of pesticide residues in cocoa beans using gas and liquid chromatography-tandem m
80 he routine analysis of pesticide residues in cocoa beans via a monitoring study where 10% of them was
82 al conditions for fermentation and drying of cocoa beans were 6days of fermentation, followed by dryi
84 easurements of fermented, dried and unpeeled cocoa beans were performed using a handheld spectrometer
86 le compounds with flavour notes desirable in cocoa beans, as well as to avoid the production of compo
87 ch only requires small aliquots of unroasted cocoa beans, can be automatated, requires no sample prep
88 tion (HS-SPME-GC-MS) on conventional roasted cocoa beans, ILR-CIS-GC-MS data on unroasted cocoa beans
89 nd the level of contamination present in the cocoa beans, this experiment demonstrated that 93.6% of
90 ch are not present naturally in the analysed cocoa beans, were obtained after semisynthesis of cocoa
92 ounces (237 mL) of an artificially sweetened cocoa beverage or similar placebo products each day for
93 We attempt to explain the contribution of cocoa bioactive compounds to cardiovascular effects obse
95 F) were studied and compared with those from cocoa butter (CB), to explore their possibilities as con
99 nd stearic-based surfactants greatly reduced cocoa butter crystal size whereas the oleic acid-based s
104 of three sunflower hard stearins (SHSs) and cocoa butter equivalents (CBEs) formulated by blending S
109 te surfactant esters accelerated early-stage cocoa butter solidification while suppressing later grow
112 earic-based surfactants only associated with cocoa butter's high-melting fraction, with the oleic aci
113 diet supplemented with milk fat, instead of cocoa butter, both increased the severity of and shorten
118 ng the natural ochratoxin A contamination in cocoa by-products, the highest levels of ochratoxin A we
119 ocoas can be differentiated from unfermented cocoas by their possession of a higher total amount of o
121 obtained from broccoli, potatoes, salmon and cocoa cakes cooked using an innovative RF oven were repo
122 ment can cause upregulation of MKP, and that cocoa can prevent inflammatory responses in trigeminal g
124 f Swiss consumption impacts rest abroad with cocoa, coffee and palm oil imports being responsible for
127 e ingestion of dark chocolate and sugar-free cocoa compared with placebo (dark chocolate: systolic, -
133 one or in concert with appropriate catalytic cocoa compounds, may be useful for helping people contro
134 e classical random-effects model showed that cocoa consumption can reduce systolic blood pressure (SB
136 ial effects of short-term dark chocolate and cocoa consumption on any of the neuropsychological or ca
137 ocoa (containing 22 g cocoa powder), sugared cocoa (containing 22 g cocoa powder), or a placebo (cont
138 were randomly assigned to consume sugar-free cocoa (containing 22 g cocoa powder), sugared cocoa (con
139 n studies have been carried out on cocoa and cocoa-containing products over the past 12 years, with a
140 Furthermore, our data provide evidence that cocoa contains biologically active compounds that would
144 These treatments were compared with dry cocoa controls produced in a Samoa drier and by a sun-dr
145 ine whether (-)-epicatechin (mainly found in cocoa) could attenuate detraining effects in the hindlim
147 and proanthocyanidin-rich foods (apples and cocoa drinks; P = 0.04) and, in younger participants (ag
148 : -0.98, -0.36) was improved by chocolate or cocoa due to significant reductions in serum insulin.
149 fat, probiotics, fermentation, coffee, tea, cocoa, eggs, specific vegetable and tropical oils, vitam
150 this study was to determine the effects of a cocoa-enriched diet on the expression of key inflammator
152 ed: (I) sequences exclusively cleaved by the cocoa enzyme, (II) sequences cleaved by both pepsin and
153 II) sequences cleaved by both pepsin and the cocoa enzyme, and (III) those cleaved exclusively by pep
156 tential antioxidant activity of cinnamon and cocoa extract and the interaction of their mixtures by v
159 modify Keap1, sulforaphane was spiked into a cocoa extract, and LC-MS/MS using high resolution mass s
161 coa beans by acid-induced proteolysis during cocoa fermentation are essential precursors of the cocoa
165 investigate in healthy adults the effects of cocoa flavanol (CF) intake amount and intake duration on
166 eers were randomly assigned to either a high-cocoa flavanol (HCF) group (494 mg cocoa flavanols/d) or
167 F) group (494 mg cocoa flavanols/d) or a low-cocoa flavanol (LCF) group (23 mg cocoa flavanols/d) for
174 e in vivo changes were closely paralleled by cocoa flavanol-induced bacterial changes in mixed-batch
175 est drinks that contained various amounts of cocoa flavanols (0-820 mg) and methylxanthines (0-220 mg
179 to determine whether an interaction between cocoa flavanols and methylxanthines exists that influenc
180 er time was higher after the co-ingestion of cocoa flavanols and methylxanthines than after the intak
181 ch of these changes was more pronounced when cocoa flavanols and methylxanthines were ingested togeth
182 t time to our knowledge, that consumption of cocoa flavanols can significantly affect the growth of s
186 sed FMD 2 h after intake, the consumption of cocoa flavanols with methylxanthines resulted in a great
187 l analysis, the naturally occurring forms of cocoa flavanols, (-)-epicatechin and (+)-catechin, was d
189 er a high-cocoa flavanol (HCF) group (494 mg cocoa flavanols/d) or a low-cocoa flavanol (LCF) group (
191 ntrol diet or an isocaloric diet enriched in cocoa for 14days prior to an injection of noxious stimul
193 late bar (containing 22 g cocoa powder) or a cocoa-free placebo bar (containing 0 g cocoa powder).
195 aracterization of the phenolic profile of 25 cocoa genotypes established in a Mexican gene bank was c
196 e rate assessments in the dark chocolate and cocoa group were significantly higher than those at base
198 vanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits
201 ports the possibility of upcycling fermented cocoa husks, which are rich in bioactive compounds and f
204 tion of both solid dark chocolate and liquid cocoa improved endothelial function and lowered blood pr
208 e effects of solid dark chocolate and liquid cocoa intake on endothelial function and blood pressure
209 ed 150 mg theobromine and 325 mg flavonoids [cocoa intervention (CC)], 2) 850 mg pure theobromine [th
210 omine and 325 mg flavonoids [theobromine and cocoa intervention (TB+CC)], or 4) neither cocoa nor the
212 ested to promote many health benefits, since cocoa is a rich source of flavanols; but amounts and pro
216 be suggested that besides other compounds of cocoa, its peptides and amino acids could contribute to
217 ietary intervention with flavanol-containing cocoa leads to an improvement of endothelial dysfunction
219 les of raw and roasted beans from the global cocoa market originated from 12 countries and 4 continen
221 nce from clinical studies has suggested that cocoa may increase high-density lipoprotein (HDL)-choles
222 s to test the hypothesis that consumption of cocoa may simultaneously lower blood pressure, improve e
223 es that, compared with placebo (an alkalized cocoa mixture containing essentially no epicatechin or p
224 Intakes of beverages with the nonalkalized cocoa mixture that contained 0.6 mg epicatechin, 0.2 mg
225 bination of epicatechin and the nonalkalized cocoa mixture that contained 1.6 mg epicatechin/kg body
227 se a decrease in appetite: 1) a nonalkalized cocoa mixture; 2) epicatechin plus placebo; and 3) procy
231 t acute and chronic benefits of chocolate or cocoa on FMD and previously unreported promising effects
234 No significant group (dark chocolate and cocoa or placebo)-by-trial (baseline, midpoint, and end-
235 ield in the flow direction, we aggregate the cocoa particles into prolate spheroids in micrometers.
237 t capacity of dark chocolates with different cocoa percentage and the in vivo response on antioxidant
238 units, respectively, by the sixth day, while cocoa powder added directly did not produce any effect.
239 ead, Selenium and Vanadium were evaluated in cocoa powder and chocolate by the validation of an ICP-M
243 nally, the results suggest that compounds of cocoa powder purified extract are able to affect tight j
245 cocoa (shell, nibs, liquor, butter, cake and cocoa powder) and the reduction of ochratoxin A during c
246 a solid dark chocolate bar (containing 22 g cocoa powder) or a cocoa-free placebo bar (containing 0
247 ocoa powder), sugared cocoa (containing 22 g cocoa powder), or a placebo (containing 0 g cocoa powder
248 to consume sugar-free cocoa (containing 22 g cocoa powder), sugared cocoa (containing 22 g cocoa powd
252 observed in roasted barley, roasted malt and cocoa powders, with the concomitant presence of 2-MEI an
256 of the biodiversity impacts from land use of cocoa production, including a worldwide cocoa products t
257 Blood pressure reduction by consumption of cocoa products depends on the dose of ingested epicatech
260 heterogeneity and increasing consumption of cocoa products require fast and efficient methods for qu
262 ith the aim to obtain a better definition of cocoa quality and a deeper comprehension of biochemical
264 ected and the extent of epimerization during cocoa roasting was shown to be a function of temperature
265 te manufacturers as a routine method to sort cocoa samples according to their level of fermentation.
266 d to analyze NH(3) levels in several hundred cocoa samples at different fermentation levels from six
267 ttern was observed also among well-fermented cocoa samples of different geographical origin, suggesti
270 ained during the technological processing of cocoa (shell, nibs, liquor, butter, cake and cocoa powde
273 eobromine used as a proxy measure for nonfat cocoa solids (NFCS) was not a good predictor of epicatec
274 ls) and extracts (pure theobromine, defatted cocoa solids, protein, lipids) obtained from fermented c
275 ver, no positive correlation was found with% cocoa solids, the most significant quality parameter.
277 ptides responsible for the generation of the cocoa-specific aroma components, we have developed a pro
279 otein are required for the generation of the cocoa-specific aroma notes during the roasting process.
282 ed by in vitro studies, the formation of the cocoa-specific aroma precursors depends on the particula
283 with 2.7 +/- 6.4 mm Hg; P = 0.01; sugar-free cocoa: systolic, -2.1 +/- 7.0 mm Hg compared with 3.2 +/
284 emometrics to study the metabolic profile of cocoa (Theobroma cacao L.) beans of different varieties,
287 Fermentation is a key step in obtaining fine cocoa through the formation of potent aroma precursors.
290 One of the most devastating diseases of cocoa trees is caused by fungal phytopathogen Moniliopht
291 oid and polyphenol contents of two clones of cocoa (UIT1 and PBC 140) were removed and the remaining
294 e of all the classes of soluble compounds of cocoa, was therefore useful to characterise fermented co
297 and polyphenol extracts of teas, coffee and cocoa were studied by fluorescence and CD spectroscopy a
298 as a crucial step in technical treatment of cocoa, which leads to flavanol losses and modifications,
299 ne 200-mL drink/d for 4 wk that contained 1) cocoa, which naturally provided 150 mg theobromine and 3
300 methods for quality assessment of fermented cocoa with regard to fermentation quality and flavor pot
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