ライフサイエンスコーパス: cocrystallize

1 ation of functionalities that do not readily cocrystallize.

2 een synthesized, biologically evaluated, and cocrystallized.

3 We have cocrystallized a stable complex of recombinant N- and C-

4 The cocrystallized actin-CD structure also revealed changes

5 en the corresponding homologous residues and cocrystallized ADP or nucleotide analogs.

6 ematic changes are made to the participating cocrystallizing agents.

7 Heterocyclic adenine nitrogens of cocrystallized agonist overlaid corresponding positions

8 Uncomplexed guest molecules cocrystallize alongside the threaded complexes in the so

9 trans-3(.+) ) is observed in solution, which cocrystallize and exist in the crystal phase.

10 l membrane environment have been obtained by cocrystallizing antiamoebin with n-octanol.

11 Pyruvate kinase from rabbit muscle has been cocrystallized as a complex with MgIIATP, oxalate, Mg2+,

12 We show here that human insulin can be cocrystallized at preselected ratios with the fully acti

13 Cocrystallized complexes of the macrocyclic PIs and the

14 ccommodate a series of fatty acid analogs by cocrystallizing CYP2E1 with omega-imidazolyl-octanoic fa

15 e-uridine product complex prepared either by cocrystallizing enzyme with uridine or by diffusing cyti

16 ELISA, carbohydrate microarray analysis, and cocrystallized Fab 2G12 with four different oligomannose

17 wild-type transporter, with and without the cocrystallized Fab antibody fragment, to investigate the

18 omputational studies have used the closed or cocrystallized Hsp90 structures in an attempt to explore

19 lecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affin

20 e structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di-GMP and its protein

21 this study, the crystal structure of R-HPCDH cocrystallized in the presence of (S)-hydroxypropyl-coen

22 kynureninase inhibitor, 3-hydroxyhippurate, cocrystallized it with human kynureninase, and solved th

23 ding site at the very C terminus of KAT1 and cocrystallized it with tobacco (Nicotiana tabacum) 14-3-

24 rmed and the lock broken, whether or not the cocrystallized ligand is present.

25 none exchange cavities, allowing exchange of cocrystallized lipids with the bulk membrane and suggest

26 sthydrolysis state is presented, obtained by cocrystallizing MalK with ATP-Mg(2+).

27 The molecules of cocrystallized octanol are found in two different areas

28 pied by small molecule LFA-1 inhibitors when cocrystallized or analyzed by (15)N-(1)H HSQC (heteronuc

29 cy is assessed by redocking ligands from 282 cocrystallized PDB complexes starting from conformationa

30 A substructure analysis of the cocrystallized PDE ligands in combination with those in

31 ng enzyme inhibitor complexes is to start by cocrystallizing PI-PLC with the head group analogs.

32 rs (MMPs) to the atom environment within the cocrystallized protein-ligand complex.

33 A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to stu

34 We cocrystallized selected inhibitors with BACE1 to reveal

35 analysis of dihydrofolate reductase (DHFR) (cocrystallized separately with NADPH, dihydrofolate and

36 hered phases (e.g., substrates, sorbates, or cocrystallized species), suggesting a methodology of eli

37 rotein conformation, complicating the use of cocrystallized structures for ligand screening.

38 binding sites, including those that did not cocrystallize, suggest a framework for explaining the di

39 into the structure-activity relationship, we cocrystallized SylA-GlbA in complex with the proteasome

40 and clotrimazole, and in the present work we cocrystallized the P450 with posaconazole at 2.5 A resol

41 bacterial pyruvate decarboxylase prepared by cocrystallizing the enzyme with pyruvate and a stable an

42 By cocrystallizing the enzyme with various combinations of

43 Hence, cocrystallizing the wild-type enzyme with phosphate resu

44 ible hydrophobic moieties to the analogs and cocrystallize these with the enzyme.

45 at TnsA and a slightly longer version of the cocrystallized TnsC fragment (residues 495-555) might co

46 C, in a crystal lattice isomorphous with the cocrystallized undecamer 5'-AAAGATATCTT previously deter

47 ges in the intensity and the location of the cocrystallized water hydroxyl peaks (3200-3600 cm(-1)).

48 prior work, we have shown that both isoforms cocrystallize with d-glutamate as dimers, and the enzyme

49 ile succinic acid and fumaric acid were each cocrystallized with 1 to provide 2:1 cocrystals of fluox

50 -ray crystallography data obtained for MMP-3 cocrystallized with 20 gave detailed information on key

51 A structure of wild-type PurE cocrystallized with 4-nitroaminoimidazole ribonucleotide

52 determined crystal structures of the enzyme cocrystallized with 5'-deoxy-5'-dimethylthioadenosine an

53 CobT was cocrystallized with 5,6-dimethylbenzimidazole (DMB) in t

54 The PARP domain of TNKS2 was cocrystallized with 66, and the X-ray structure was dete

55 f excess nickel for both NikR alone and NikR cocrystallized with a 30-nucleotide piece of double-stra

56 of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex.

57 andida albicans RNA guanylyltransferase Cgt1 cocrystallized with a carboxy-terminal domain (CTD) pept

58 1 with high catalytic efficiency toward HNE, cocrystallized with a GSH-HNE conjugate analogue, demons

59 glycine and the oxamide of glycine were each cocrystallized with a series of four bipyridines, includ

60 Structure analysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide a

61 Unfortunately only a few compounds have been cocrystallized with AcrB, and thus computational approac

62 Duplex DNA containing 2'-fluoro-m7dG (Fm7dG) cocrystallized with AlkA as a host-guest complex in whic

63 tion of intact BG cells (approximately 5 mg) cocrystallized with alpha-cyano-4-hydroxycinnamic acid.

64 published high-resolution structure of A(2A) cocrystallized with an antagonist.

65 s not require analytes to be incorporated or cocrystallized with an initiator.

66 selectivity toward the plant enzyme and was cocrystallized with Arabidopsis HPPD.

67 tallography data for selected lead compounds cocrystallized with arginases I and II.

68 the same DNA sequence (TATGGATCCATA) as that cocrystallized with BamHI.

69 Here we report the structure of human RFK cocrystallized with both MgADP and FMN.

70 ver, recent studies, including several GPCRs cocrystallized with bound ligands, suggest that the extr

71 Compound 3 was also cocrystallized with Brd4 for determining the ligand bind

72 Compound 32 was cocrystallized with BRD4, yielding a 1.56 A resolution c

73 We show that, in LeuT-E290S cocrystallized with bromide or chloride, the anion is co

74 crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is also reported.

75 ucible and endothelial NOS oxygenase domains cocrystallized with chlorzoxazone and four nitroindazole

76 widely used antidepressant fluvoxamine, was cocrystallized with CYP46A1.

77 S. stercoralis DAF-12 ligand-binding domain cocrystallized with dafachronic acids.

78 of MMOH from Methylococcus capsulatus (Bath) cocrystallized with dibromomethane or iodoethane, or by

79 We compare structures of capsids cocrystallized with different CpAMs and find that they a

80 se structures, a new structure of the enzyme cocrystallized with DNA and calcium ions, and previously

81 By contrast, two structures of K38A cocrystallized with DNA and Mn(2+) ions in different lat

82 mpared to the performance on holo-structures cocrystallized with DNA.

83 1H-indolo[3,2-c]quinoline-6-carboxylic acids cocrystallized with DYRK1A confirmed the predicted bindi

84 Leucettines were cocrystallized with DYRK1A, DYRK2, CLK3, PIM1, and GSK-3

85 nd 1.95 A resolution in the unbound form and cocrystallized with either SO(4)(2)(-) or HCO(3)(-).

86 hydro-2-thiophenecarboxylic acid (SADTA) was cocrystallized with Escherichia coli aspartate aminotran

87 A simple heparin hexasaccharide that cocrystallized with FGF-1 and FGF-2 and protected both a

88 type-II ribosome-inactivating protein (RIP), cocrystallized with galactose is described.

89 ructure of the D-dimer from human fibrinogen cocrystallized with GHRPYam, the packing of which showed

90 lationship of the two active sites, CobU was cocrystallized with GTP and pyrophosphate.

91 y potent potentiator 32 (AM-3607), which was cocrystallized with human GlyRalpha3cryst to afford the

92 t publication of structures of several GPCRs cocrystallized with ligands of differing activity offers

93 s with the recent structure of CCR5 receptor cocrystallized with Maraviroc.

94 The structure of MIF cocrystallized with NAPQI reveals that the NAPQI has und

95 gh-performance liquid chromatography (HPLC), cocrystallized with Ni-(octaethylporphyrin), and charact

96 l structure of retinal dehydrogenase type II cocrystallized with nicotinamide adenine dinucleotide (N

97 single-crystal X-ray diffraction on samples cocrystallized with NiII(octaethylporphyrin).

98 leoside hydrolase from Crithidia fasciculata cocrystallized with p-aminophenyliminoribitol reveals ti

99 This hit (1) was cocrystallized with PaTMK, and several potent PaTMK inhi

100 ross-react with both PFA1 and PFA2 and, when cocrystallized with PFA1, binds in an identical conforma

101 t revealed by the crystal structure of PheRS cocrystallized with Phe.

102 s of phospholipid binding further, GM2AP was cocrystallized with phosphatidylcholine (PC), known to i

103 led to a submicromolar inhibitor, which was cocrystallized with Plm II to produce an X-ray structure

104 X-ray crystal structures of wild-type HpMTAN cocrystallized with S-adenosylhomocysteine (SAH), Formyc

105 ucture of an inactive variant (HpMTAN-D198N) cocrystallized with SAH.

106 X-ray crystal structures of MTAN cocrystallized with several inhibitors show them to bind

107 Representative compounds were cocrystallized with Streptococcus pneumoniae (Spn) ParE;

108 comes accessible only in structures that are cocrystallized with strong agonists.

109 ures of 19 of these enzymes, including seven cocrystallized with substrate analogs or products; and t

110 factor-independent epimerases and racemases, cocrystallized with substrates or substrate analogues, t

111 stal structures of fibrin double-D fragments cocrystallized with synthetic peptides corresponding to

112 o(2+)-substituted Bacillus subtilis LuxS was cocrystallized with the 2-ketone intermediate and the st

113 ate constants in the structure of the mutant cocrystallized with the alternate substrate, 4-nitrobuty

114 Chicken smooth muscle alpha-actinin was cocrystallized with the beta1-integrin cytoplasmic domai

115 ive site of ligand-bound forms that had been cocrystallized with the bicyclic diketone substrate bicy

116 In addition, compound 9a was cocrystallized with the catalytic domain of FGF-R1 provi

117 Selected inhibitors were cocrystallized with the catalytic domain of human HDAC4.

118 midazole group by pyridylimidazole, has been cocrystallized with the dodecanucleotide sequence d(CGCG

119 itors, starting from an inhibitor previously cocrystallized with the enzyme (K(i) = 0.8 muM).

120 into their modes of binding, they were also cocrystallized with the extracellular domain of PSMA.

121 receptor positive allosteric modulators were cocrystallized with the GluA2 ligand binding domain in o

122 Recently, two crystal structures of BACE cocrystallized with the inhibitors OM99-2 and OM00-3 wer

123 uzi, etiologic agent of Chagas' disease, was cocrystallized with the inosine analogue Formycin B (FmB

124 conformation of PPH even when the enzyme was cocrystallized with the oxalate inhibitor.

125 (residues 118-424) of human PheOH (hPheOH), cocrystallized with the oxidized form of the cofactor (7

126 E4 inhibitor resembling the structure of 8a, cocrystallized with the PDE4.

127 The 89 kDa protein was cocrystallized with the peptide Gly-His-Arg-Pro-amide, w

128 The 180 kDa covalent dimer was cocrystallized with the peptide Gly-His-Arg-Pro-amide, w

129 complex was obtained from enzyme aerobically cocrystallized with the substrate stachydrine (N,N-dimet

130 re analysis of the monopyrrolinone compounds cocrystallized with the wild-type HIV-1 protease provide

131 X-ray crystal structures of CYP2A6 cocrystallized with three furan analogues bearing methan

132 stal structure of compound 1m in this class, cocrystallized with unactivated p38 alpha protein, indic

133 crystal structures of bovine Arp2/3 complex cocrystallized with various bound adenine nucleotides an

134 t was supported by X-ray structures of BACE1 cocrystallized with various ligands and molecular modeli

135 was supported by X-ray structures of ERbeta cocrystallized with various ligands as well as molecular

136 ived from tRNATyr (supF) with glutamine were cocrystallized with wild-type tRNAGln and their structur

137 o TM0665 protein, and the mutant protein was cocrystallized with Zn(2+) to determine the structure by

138 tris(iodoethynyl)-2,4,6-trifluorobenzene (1) cocrystallizes with a variety of halide salts, namely, E

139 orless insulator where the dicarboxylic acid cocrystallizes with two of its monoanionic conjugated ba

140 though minocycline and doxorubicin have been cocrystallized within the large binding pocket in the pe

141 We cocrystallized ZnF8-12 of hPRDM9A with an oligonucleotid