ライフサイエンスコーパス: codeine

1 ted following human metabolism of heroin and codeine.

2 clude remifentanil, methadone, tramadol, and codeine.

3 , oxycodone, hydromorphone, oxymorphone, and codeine.

4 altered by the administration of naloxone or codeine.

5 orphine from tyramine, norlaudanosoline, and codeine.

6 This is the shortest synthesis of codeine (13 steps, 20% overall yield) and, for the first

7 0-mg codeine equivalents per day (30 mg oral codeine = 5 mg oral morphine) to the mean peak dosage of

8 nalogues of morphine-6-glucuronide (M6G) and codeine-6-glucuronide (C6G) were synthesized and evaluat

9 Morphine-6-sulfate (M6S) and codeine-6-sulfate (C6S) are mu-selective opiates which h

10 n of naloxone (16 mg intravenous; n = 9) and codeine (60 mg oral; n = 7).

11 antinociceptive profile of i.p.-administered codeine (7 mg/kg) at 3 and 48 h (144+/-11% and 155+/-9%

12 ted for xenobiotics such as methamphetamine, codeine, alprazolam, and morphine, revealing that NIMS c

13 Acetaminophen, diclofenac, codeine, ampicillin, tetracycline, erythromycin-H2O, and

14 observed between 0.05 and 40 mug mL(-1) for codeine and 0.05 and 42 mug mL(-1) for morphine.

15 one and 300 mg of acetaminophen; or 30 mg of codeine and 300 mg of acetaminophen.

16 -CD(3)]-morphine and the congeners [N-CD(3)]-codeine and [N-CD(3)]-oripavine in urine.

17 DNA concentrations, a sharp anodic wave for codeine and a clear discrimination of codeine and morphi

18 roup; and by 3.9 (95% CI, 3.2 to 4.5) in the codeine and acetaminophen group (P = .053).

19 ere induced by intradermal injection of PAF, codeine and histamine in 14 healthy volunteers.

20 on modes were respectively electrostatic for codeine and intercalation for morphine with two anodic p

21 involve CYP 2D6, which acts on drugs such as codeine and is responsible for its conversion to morphin

22 Electrochemical oxidation of codeine and morphine bonded on dsDNA/MWCNTs-PDDA/PGE was

23 validate its capability for the analysis of codeine and morphine in blood serum, urine samples and p

24 bes and DNA was tested in order to determine codeine and morphine in solution.

25 ve for codeine and a clear discrimination of codeine and morphine oxidation peaks were observed.

26 the solution, the electrochemical signal of codeine and morphine was decreased and shifted to more n

27 In this study, the interaction between codeine and morphine with dsDNA was assessed at pH 7.0.

28 0.041 and 0.043 mug mL(-1) were obtained for codeine and morphine, respectively.

29 , including most notably the opiates such as codeine and morphine.

30 The most commonly prescribed opioids were codeine and oxycodone.

31 al transit (tramadol HCl, acetaminophen with codeine and placebo) in a randomized, double-blind, cros

32 The levels of codeine and thebaine ranged from below LOQ to 348mg/kg a

33 Although codeine and tramadol are frequently used in the postoper

34 All opioid-treated patients received codeine and/or oxycodone.

35 searches with terms such as "no prescription codeine" and "Vicodin," over 50% of the links obtained w

36 anitidine), analgesic (paracetamol), opiate (codeine), and aromatase inhibitor anticancer (anastrozol

37 ll be discussed using tamoxifen, paclitaxel, codeine, and fluorouracil as starting points.

38 caine, benzoylecgonine (cocaine metabolite), codeine, and morphine in a hair standard reference mater

39 ource of pharmaceuticals including thebaine, codeine, and morphine, but is also harvested for heroin

40 ding mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC) and their major

41 s of mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC).

42 dest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to reliev

43 ted that brain uptake and antinociception of codeine are increased during lambda-carrageenan-induced

44 t that the endogenous alkaloids morphine and codeine are involved in the modulation of convulsions an

45 compared with control, respectively) and [3H]codeine at 3 and 48 h (179+/-6% and 179+/-12% compared w

46 lation for morphine with two anodic peaks of codeine being merged into them when DNA concentration wa

47 Codeine, but not PAF or histamine, caused a small but st

48 to codeine over morphine, which differs from codeine by a methyl group.

49 he new method, cocaine, benzoylecgonine, and codeine can be quantified from four samples in less than

50 Codeine caused a significant but variable histamine rele

51 l other analgesics (co-codamol, paracetamol, codeine, co-dydramol, tramadol, oxycodone, and morphine)

52 BOTTOM LINE Weak opioids (such as codeine, dextropropoxyphene, and tramadol) may be effect

53 PAF, unlike histamine and codeine, did not cause a statistically significant rise

54 Dosage escalations of > 2 30-mg codeine equivalents occurred 19 times in 17 LTO patients

55 initial opioid dosage of 5.0 +/- 12.2 30-mg codeine equivalents per day (30 mg oral codeine = 5 mg o

56 ean +/-SD initial dosage was 2.1+/-1.7 30-mg codeine equivalents/day, the mean peak was 3.4+/-3.3 per

57 11 drugs (amphetamine, cannabidiol, cocaine, codeine, heroine, methamphetamine, morphine, phentermine

58 ve inhibition of morphine glucuronidation by codeine, IC50 (on-line) = 170 vs 580 microM (off-line).

59 nds (morphine and/or its glucuronides and/or codeine) in the adult mouse spinal cord using a well-val

60 n brain uptake of a commonly used analgesic, codeine, in relation to the fundamental properties of th

61 Morphine and codeine levels in peripheral tissues (heart, lung, splee

62 alamus (5-10 fold), In contrast to morphine, codeine levels were also increased in the hippocampus (2

63 Codeine levels were also markedly increased in hypothala

64 tion of convulsions and that morphine and/or codeine may act as an endogenous anticonvulsant.

65 IAs), including the pharmaceutical compounds codeine, morphine, noscapine and papaverine.

66 Morphine, codeine, morphine-6-glucuronide, and morphine-3-glucuron

67 vinylation, we found that the fourth ring of codeine/morphine could be formed.

68 riety of opioid medication terms, including "codeine," "no prescription Vicodin," and "OxyContin." Tw

69 enases, thebaine 6-O-demethylase (T6ODM) and codeine O-demethylase (CODM).

70 ged treatment of rheumatic disease pain with codeine or oxycodone was effective in reducing pain seve

71 proaches, we found the presence of morphine, codeine, or morphine glucuronides in gamma-aminobutyric

72 Both aptamers exhibit high specificity to codeine over morphine, which differs from codeine by a m

73 on of four representative opioids (morphine, codeine, oxycodone, hydrocodone) and five stimulants (am

74 Medications prescribed were codeine, oxycodone, propoxyphene, tramadol, morphine, me

75 n (RSD) using MAI for a mixture of morphine, codeine, oxymorphone, oxycodone, clozapine, and buspiron

76 ode material for the sensitive and selective codeine phosphate (COD) determination in the presence of

77 lyst toward the electroanalytical sensing of codeine phosphate (COD).

78 Elaboration of 15 into (+/-)-codeine proceeds via the previously unknown alpha-epoxid

79 In the biosynthetic pathway for morphine and codeine, salutaridine is reduced to salutaridinol by sal

80 tion under acidic conditions, arrives at the codeine skeleton 15.

81 not comply with the limits set for morphine, codeine, thebaine and noscapine by Hungarian legislation

82 he content of six opium alkaloids (morphine, codeine, thebaine, noscapine, papaverine and narceine) i

83 The conversion of codeine to (8S)-8-bromomorphide, a potentially valuable

84 RNA aptamers that bind the opium alkaloid codeine were generated using an iterative in vitro selec

85 crose (a membrane impermeant marker) and [3H]codeine were investigated using an in situ brain perfusi

86 the endogenous opiate alkaloids morphine and codeine were significantly elevated in specific rat brai

87 vert the pivotal tricyclic intermediate into codeine, which has been demethylated in high yield to mo

88 cases reported using medications containing codeine while pregnant or nursing than did mothers of co

89 d) and, for the first time, allows access to codeine without having to reduce codeinone.