ライフサイエンスコーパス: coding region

1 Positive selection is detected in the bindin coding region.

2 in solution and binds to DNA within the sbnC coding region.

3 le small open reading frames upstream of the coding region.

4 anslation control and expression of the EPRS coding region.

5 lowing for increased translation of the EPRS coding region.

6 tide divergence in the viral protein 1 (VP1) coding region.

7 levels of translation initiation at the EPRS coding region.

8 ically G-quadruplex-like DNA, within the CTD coding region.

9 recombination sites inside the viral protein-coding region.

10 and LGP2 specifically bound MV nucleoprotein-coding region.

11 sence of the essential MYB activation domain coding region.

12 and a shorter construct containing only the coding region.

13 (pA)d, and another, (pA)p, within the capsid-coding region.

14 ier that prevents reinitiation at the GADD34 coding region.

15 other complex site, (pA)p, within the capsid-coding region.

16 ader region or continues into the downstream coding region.

17 depends on the nucleotide composition of the coding region.

18 elements (PPREs) upstream of the pre-miR-223 coding region.

19 equires sequences in both the 5' UTR and the coding region.

20 d thereby prevents transcription of the corA coding region.

21 and nucleotide sequence analysis of the VP1 coding region.

22 s rise to viable chimeras in the polyprotein coding region.

23 number of ribosomes on the principal protein-coding region.

24 et elements located at the beginning of thiM coding region.

25 mutations occur at similar frequencies as in coding regions.

26 ed because most GWAS SNPs are located in non-coding regions.

27 yses to variants that are in or proximate to coding regions.

28 persed throughout approximately 40 kb of non-coding regions.

29 d powerful linkage analyses, particularly in coding regions.

30 able genome, and that fusion predominates in coding regions.

31 WSA overall but 97% more information for the coding regions.

32 zation of genomic variants in coding and non-coding regions.

33 VP22), US3, US4 (gG), US6 (gD), and US7 (gI) coding regions.

34 ed with the attention focused on the protein coding regions.

35 introduced premature termination codons into coding regions.

36 es across the GAL cluster gene promoters and coding regions.

37 ll splicing events, and 43% of the events in coding regions.

38 llenging due to a lack of annotations in non-coding regions.

39 H3 levels remain relatively constant within coding regions.

40 (gL), UL2, UL4, UL49 (VP22), UL50, and ICP4 coding regions.

41 nections between stimulus-coding and outcome-coding regions.

42 st, generally in the second half of the gene coding regions.

43 ore difficult to study compared with protein-coding regions.

44 not included in the published annotation of coding regions.

45 tral drift or positive selection, similar to coding regions.

46 selection on regulatory elements as well as coding regions.

47 py of the stem-loop between the NS7- and VP1-coding regions.

48 bition of spurious transcription from within coding regions.

49 erns established by SAGA at promoters versus coding regions.

50 unknown function and located outside protein-coding regions.

51 CEs) that predominantly (>99%) reside in non-coding regions.

52 in coding regions and approaching 90% in non-coding regions.

53 asis of the presence of mutations in protein-coding regions.

54 g indicating disease-causing variants in non-coding regions.

55 outside of functionally well-defined protein coding regions.

56 tely predict all or even most of the protein-coding regions.

57 ilized target sites lie predominantly within coding regions.

58 known about cancer-causing mutations in non-coding regions.

59 (s) for reducing misincorporation in protein-coding regions.

60 nslated regions (UTRs), introns, and protein-coding regions.

61 tations and genomic polymorphisms in protein-coding regions.

62 ntified ORFs and pre-existing annotations of coding-regions.

63 ng patient sequence data from within protein coding-regions.

64 ther hand, exon skipping events were rare in coding regions (1%) but enriched in UTRs where they acco

65 of peripheral-blood gene expression included coding regions (11.41x), conserved regions (4.67x), and

66 cDNAs of the entire capsid coding region (3.9 kb) were obtained from as few as 50 c

67 ulation of peripheral-blood gene expression: coding regions (4.47x), conserved regions (4.51x), and t

68 an especially proficient 'extended FMDV 2A' coding region allows production of two independent prote

69 Variation in GAL coding regions also contributed to the delay when tested

70 e expression analysis revealed that this non-coding region alteration is associated with the signific

71 ional single-nucleotide polymorphism loci in coding regions analyzed.

72 o efficiently capture and amplify the entire coding region and flanking intronic and regulatory seque

73 developed based on the two mutations in the coding region and one in the promoter region and validat

74 This deletion removes about 90 % of the coding region and results in the loss of the SKT/ETL4 pr

75 carries both causal mutations in the TaPHS1 coding region and shows PHS susceptibility.

76 m neutrality has been detected in the bindin coding region and suggested in the intron, indicating th

77 iable rhinovirus chimeras in the polyprotein coding region and that recombination hotspots map to non

78 , RTC4 transcription begins near the protein-coding region and the resulting short transcript leader

79 t extends 13 nucleotides into the N-terminal coding region and, when a mRNA structure overlaps or par

80 e methods, reaching 91% balanced accuracy in coding regions and 70% in non-coding regions, while even

81 es and eukaryotes in general - nearly 80% in coding regions and approaching 90% in non-coding regions

82 A majority of these variants reside in non-coding regions and are co-inherited with hundreds of can

83 y-based method, AlignFS, to identify protein-coding regions and correct erroneous frame-shifts, suita

84 tive nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate sites.

85 LA3 variants were not detected by sequencing coding regions and intron-exon boundaries either in 142

86 RNAs with 3' ends within protein-coding regions and introns were less stable than mRNAs t

87 5' positioning of the ER-targeting sequence coding regions and is facilitated by the RNA-binding dom

88 Most RA GWAS loci reside outside of protein-coding regions and likely affect distal transcriptional

89 und evidence that this mechanism of using 5' coding regions and particular RBPs to achieve gene-speci

90 association study (GWAS) signals map to non-coding regions and potentially point to non-coding varia

91 T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous mutation

92 ed a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions of genes.

93 curacy of GeneMarkS-T in identifying protein-coding regions and, particularly, in predicting translat

94 s sequences covered 99.3% to 100% of the HCV coding region, and the average coverage was 6,070 reads/

95 graminearum occur in coding regions, and more than two-thirds of them result

96 codon preference index (CPI) to overlapping coding regions, and use RNAsampleCDS to generate control

97 al gene enhancers, promoters and transcribed coding regions, and was required for transcription initi

98 h regulation of CTD phosphorylation controls coding region APA in the nervous system.

99 the UTR sequences while the sequences of the coding regions are irrelevant.

100 Similar to coding region transcription, non-coding regions are split at transcriptional sites.

101 However, because protein-coding regions are under high selective constraints, the

102 because indels caused by a single cut in non-coding regions are unlikely to produce a functional knoc

103 ught to identify genetic variants in protein-coding regions associated with subclinical atheroscleros

104 ize the need to interrogate the mutations in coding regions beyond their obvious effects on protein s

105 sible for its recruitment to the promoter or coding regions but, rather, are required to orient its a

106 ic traits or disease do not fall within gene coding regions, but in regulatory regions, rendering the

107 ally enables transcription of its associated coding region by favoring an RNA conformation that seque

108 ination may facilitate regulation of a given coding region by multiple cytoplasmic signals.

109 ns (ars1 and ars2) that are similar in their coding region content.

110 s and genomic distance, co-localization with coding regions, CpG islands (CGIs), and regulatory eleme

111 ing the 3' untranslated region (UTR) and the coding region (CR) of Ccnd1 mRNA.

112 replication element (CRE) in the 2C protein-coding region [CRE(2C)] templates the addition of two ur

113 occurs, but RNAP II is absent from the gene-coding region, demonstrating Sas3 and Ada2-dependent his

114 LARP4 mRNA contains a translation-dependent, coding region determinant (CRD) of instability that limi

115 glioma-associated oncogene 1 (GLI1) mRNA by coding region determinant binding protein (CRD-BP) throu

116 is a major criterion for the function of the coding region determinant-binding protein (CRD-BP).

117 Conversely, the RNA-binding protein, coding region determinant-binding protein, was shown to

118 tory apparatuses, and the composition of the coding region determines the abundance of mRNAs near the

119 We show that SCA23 mutations in the Dyn A-coding region disrupted peptide secondary structure lead

120 and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals

121 ntroduced a frameshift mutation in the early coding region, ensuring faithful gene knockout.

122 Some non-coding regions exhibited high mutation frequencies, but

123 Entire coding region, exon-intron junctions of four genes were

124 ion conditions confirmed that coding and non-coding regions explained aspartic and glutamic acid cons

125 lternative splicing tends to remove parts of coding regions from a longer, major isoform, providing e

126 When combined, S. cerevisiae GAL coding regions gave rise to profound growth defects in t

127 r and terminator regions, and regulatory and coding regions (gene "crumpling").

128 ophilia B, the large size of the factor VIII coding region has precluded improved outcomes with gene

129 High-throughput sequencing of DNA coding regions has become a common way of assaying genom

130 Although variants in protein-coding regions have received the most attention, numerou

131 GR-ORF15 cDNA that includes a purine-rich 3'-coding region; however, its effectiveness has recently b

132 ocused their efforts in polymorphisms within coding regions, ignoring those within regulatory regions

133 sociated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as f

134 verning translation initiation at N-terminal coding regions, improving the predictive design of post-

135 3 in nonsyndromic clefting, we sequenced its coding region in 576 Europeans with nsCL/P and 96 with n

136 We detected somatic mutations in protein-coding regions in 140 benign tissue samples representing

137 Sequencing of all VWF coding regions in 3 affected individuals did not identif

138 H3K36 methylation ubiquitously functions in coding regions in all eukaryotes.

139 ted here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that exten

140 during sexual reproduction and mainly in the coding regions in filamentous ascomycetes, involving ade

141 , such example adds to the importance of non-coding regions in human pathology.

142 work significantly expands the set of known coding regions in humans.

143 de sequences that target both coding and non-coding regions in spCas9 CRISPR system across human, mou

144 The sizes of non-coding regions in the Longidoridae nematodes were very s

145 nal analysis of CALM1, CALM2, and CALM3 gene-coding regions, in vitro measurement of CaM-Ca(2+) (Ca)-

146 not only from coding exons but also from non-coding region including core promoters generated by rand

147 acting elements within the N-terminal capsid coding region, including the stem-loop structure (5'SL6)

148 led an abundance of miR target sites in gene coding regions, including several sites pointing to new

149 so identify novel recurrent mutations in non-coding regions, including the 3' region of NOTCH1, which

150 ows for translation reinitiation at the CReP coding region independent of stress.

151 ion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory seque

152 ries both the causal mutations in the TaPHS1 coding region, indicating that the mis-splicing (+646) m

153 a gene caused by a small deletion in the non-coding region is a novel mechanism, which to the best of

154 this gene has accumulated mutations, so its coding region is unlikely to produce a functional protei

155 Accurate annotation of protein coding regions is essential for understanding how geneti

156 t fraction of Pol III transcription from non-coding regions is not subjected to Xist-mediated transcr

157 fying these transcriptional regions from non-coding regions is the first step towards lincRNA recogni

158 ing sequence or for the beginning and end of coding regions, largely explained by target site motifs.

159 on rates have been extensively calibrated in coding regions, leading to the identification of many dr

160 rast, the number of coding genes, as well as coding region length, has remained similar.

161 SNPs) (including imputed ones) fall into non-coding regions, making it difficult to associate statist

162 s that functional properties attributed to a coding region may in fact be carried out by an embedded

163 10a miRNA, whose precursor overlaps the KapA-coding region, may account for the oncogenic properties

164 Even in the absence of TET coding region mutations, TET loss-of-function is strongl

165 retinoblastoma uncovered a tumor that had no coding-region mutations or focal chromosomal lesions oth

166 Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4

167 elaborate eccentricities, such as scrambled coding regions, nonstandard genetic codes, and convolute

168 Functional mutations in coding regions not only affect the structure and functio

169 interference (RNAi) using the extracellular coding region of a maize zmbri1 complementary DNA knocke

170 ly designed RNA hairpins into the N-terminal coding region of a reporter protein with steadily increa

171 This variant is located in the coding region of all nine YAP1 spliceforms, and results

172 e caused by a polyglutamine expansion in the coding region of ATXN1.

173 For engineering nuclear male sterility, the coding region of Brassica napus cysteine protease1 (BnCy

174 netic variants, both common and rare, in the coding region of complement factor H (CFH).

175 We performed direct sequencing of the entire coding region of CYP1B1.

176 nymous single nucleotide polymorphism in the coding region of HAB rodents revealed that it caused a h

177 ally conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-re

178 air, 3 base pair indels were observed when a coding region of HIV-1 was targeted.

179 mputation of CPI for the Gag-Pol overlapping coding region of HIV-1.

180 hod to efficiently amplify the entire capsid coding region of human enteroviruses (EVs) including PV.

181 trates that FMRP preferentially binds to the coding region of its targets but also revealed binding a

182 in exon 16, have been identified within the coding region of LPH in a Japanese infant with CLD.

183 We performed Sanger sequencing of the entire coding region of MPL in 62, and of JAK2 in 49 additional

184 Inserting the ER-targeting sequence coding region of NA into different 5' UTRs confirmed tha

185 d recombinants throughout the non-structural coding region of poliovirus from dually transfected cell

186 approach to effectively delete an important coding region of Sav1, which increased the editing effic

187 ation efficiency at high salinity map to the coding region of sigH and in the regulatory region of ki

188 METTL3 induces m(6)A modification within the coding region of the associated mRNA transcript, and enh

189 on of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type zinc finger nucleic acid-

190 Phylogenetic inference using the non-coding region of the chloroplast psbA gene resolves S. t

191 the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame 72

192 A representative iRAP within the coding region of the essential gene, nadD, greatly reduc

193 ition gene, while the analysis of the entire coding region of the FANCM gene in familial index cases

194 URKC c.744C > G (AURKC p.Y248*) occur in the coding region of the gene and are the focus of this stud

195 tion has been constrained in Melanesians the coding region of the MC1R gene was sequenced in 188 indi

196 f oncogenic H-Ras and K-Ras, we replaced the coding region of the murine K-Ras locus with H-Ras(G12V)

197 showing that the mRNAs terminate within the coding region of the opposite open reading frame.

198 A mutation in the coding region of the phospholamban (PLN) gene (R14del) i

199 Pol I occupancy of the coding region of the rDNA in THO mutants is decreased to

200 Heterozygous mutations in the coding region of the RET gene cause a severe form of Hir

201 identified Hoip-responsive sequences in the coding region of the Tm2 mRNA that are essential for Tm2

202 Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5);

203 iple evolutionary events in the promoter and coding region of VAC-INVcis-QTL were also detected for A

204 The mutations in the coding region of voltage-gated sodium channel alpha 1 su

205 Here we sequence the protein-coding regions of 10,503 adult participants in the Pakis

206 ore than 10 million mutations in the protein-coding regions of 2,735 mutant lines of tetraploid and h

207 The coding regions of 409 cancer-related genes were investig

208 A custom panel was designed to cover the coding regions of 81 NSCLC-related genes and 40 ancestry

209 nd fibers condensed up to 10-fold containing coding regions of active genes, constitute the euchromat

210 g resulted in low nucleosome turnover in the coding regions of active genes, stably expressed at inte

211 In addition, CpG methylation is found in coding regions of active genes.

212 Sequencing of the coding regions of all linked genes failed to identify bi

213 rt through every guide targeting the protein-coding regions of any mouse or human gene.

214 odel specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on mappi

215 ential missense and other alterations in the coding regions of every IGF family gene, but the vast ma

216 relation to genetic variation in the protein-coding regions of five genes thought to be important in

217 evealed that RE are extensively spliced into coding regions of gene transcripts yielding thousands of

218 umber variants or point mutations in protein-coding regions of genes contribute to risk, and some of

219 ce of a regular chromatin structure over the coding regions of genes occurs co-transcriptionally via

220 ied 5hmC induction in putative enhancers and coding regions of genes that have pivotal roles in drug

221 titutive transcription initiation within the coding regions of genes.

222 hairpin RNAs (dual-shRNA) against different coding regions of HBV delivered by a self-complementary

223 r RNA duplexes, a depletion of duplexes from coding regions of highly translated mRNAs, an unexpected

224 ymous single nucleotide variants (nsSNVs) in coding regions of human genes frequently lead to patholo

225 Through targeted sequencing of coding regions of lipid-modifying genes in 328 individua

226 somes in euchromatic regions, notably in the coding regions of long genes that were expressed at low

227 binding to the 5' untranslated and/or early coding regions of mRNA targets, causing changes in trans

228 roline, glutamate, serine, threonine) domain coding regions of NOTCH3 in a panel of cell lines.

229 The significance of editing within non-coding regions of RNA is poorly understood.

230 We analysed all three genes (the whole coding regions of SLC2A1 and PRRT2 and exons one and two

231 exanucleotide expansions, GGGGCC, in the non-coding regions of the C9orf72 gene were found in major f

232 atistical approach to isolate coding and non-coding regions of the cancer genome that appear enriched

233 The leader and trailer non-coding regions of the EBOV genome likely regulate its tr

234 utations in PIGY can occur in coding and non-coding regions of the gene and cause variable phenotypes

235 s, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorige

236 of disease pathogenesis confined to protein-coding regions of the genome may be incomplete because m

237 e contribution of regulatory and non-protein coding regions of the genome, we conducted aggregate tes

238 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an inte

239 ants that are likely to be causal are in non-coding regions of the genome.

240 of rare single-nucleotide variants (SNVs) in coding regions of the genome.

241 sociation study (GWAS) risk loci fall in non-coding regions of the genome.

242 dentified, the vast majority residing in non-coding regions of the genome.

243 structural RNA motifs that occur in multiple coding regions of the HCV genome, and we demonstrate tha

244 and copy number variants (CNVs), in the non-coding regions of the human genome can play an important

245 especially chromosomal rearrangements in non-coding regions of the human genome, remains one of the b

246 ect, pathogenic or neutral, of indels in non-coding regions of the human genome.

247 potential pathogenic impact of indels in non-coding regions of the human genome.

248 man structural variants, particularly in non-coding regions of the human genome.

249 RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing the

250 cing, our method successfully identified all coding regions of the mouse picobirnavirus for the first

251 ically relevant sites in both coding and non-coding regions of the transcriptome.

252 The non-coding regions of tumour cell genomes harbour a consider

253 lly, basal histone acetylation levels in the coding regions of WRKY33, ORA59, and PDF1.2 are reduced

254 ene containing transcripts, possess long non-coding regions (often >45 kb) and remain chromatin bound

255 edicting the effects of mutations in protein coding regions on nucleic acid binding affinities.

256 protein-centric standpoint; however, protein-coding regions only make up approximately 1% to 2% of th

257 limited because many associations are in non-coding regions or difficult to target genes.

258 We sequenced the coding regions or hotspot areas of 68 recurrently mutate

259 efficiently link the effects of mutations in coding regions or promoter elements in a highly parallel

260 similar technology to deoptimize the capsid-coding region (P1) of foot-and-mouth disease virus (FMDV

261 tudy, a 606-bp fragment (comprising the pncA coding region plus the promoter) was sequenced using Ion

262 Coding-region polymorphisms may directly impact protein

263 nsisting of an sgRNA adjoining a GFP protein coding region produced indels and viral-based GFP overex

264 We propose histone H3 acetylation in the coding region provides rate-limiting control during the

265 r two protein-coding genes and conserved non-coding regions putatively involved in replication and/or

266 Anchoring the coding region rbcL in multigene tiered approach, the com

267 associated somatic mutations outside protein-coding regions remain largely unexplored.

268 ought to test this assumption by focusing on coding regions required for splicing.

269 in the positions +646 and +666 of the TaPHS1 coding region result in wheat PHS susceptibility.

270 atin domains, whereas H1X is associated with coding regions, RNA polymerase II-enriched regions, and

271 Their impact on retrotransposons in non-coding regions shed light on important aspects of mammal

272 the strongest repression, whereas targeting coding regions showed consistent strand bias.

273 Highly conserved non-coding regions showing rapid sequence changes along the

274 mic regions and also showed that defined non-coding regions, such as first introns of genes and regul

275 ed evidence of rearrangements within the CTD coding region, suggesting that DNA instability may play

276 ssociation studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component

277 ats (Di-SSRs) in the genomes, coding and non-coding regions than non Vampire Pathogens (N_VP).

278 cluding the polyA tail), including 909 bp of coding region that encoded a polypeptide of 302 amino ac

279 invadens We demonstrate that a gene's coding region that has abundant antisense small RNAs (sR

280 ation study to discover germline variants in coding regions that affect risk for pancreatic cancer, c

281 For coding regions, the corresponding percentages were 83.5%

282 s in sequences that are repeated within gene coding regions, thereby leading to the synthesis of neoa

283 Although Apela contains a coding region, this coding ability is dispensable for Ap

284 dramatically increased diversity in the gene coding regions, though obvious blocks were formed on mos

285 plication element (CRE) from the polyprotein coding region to the 3' non-coding region we have furthe

286 ibution of both rare and common variation in coding regions to prostate cancer risk, we sequenced the

287 Similar to coding region transcription, non-coding regions are spli

288 e translated upstream of the primary protein-coding region (uORFs) and 4% are translated downstream (

289 We compared coding region variants of 53 cognitively healthy centena

290 ntified four patients with MBL2 promoter and coding region variations associated with MBL deficiency

291 e show that editing levels in non-repetitive coding regions vary more between tissues than editing le

292 n, Setting, and Participants: The entire GBA coding region was screened for mutations and E326K in 74

293 of S. cerevisiae GAL promoter alleles or GAL coding regions was sufficient for partial reconstruction

294 the polyprotein coding region to the 3' non-coding region we have further developed a cell-based ass

295 in RNA (shRNA) targeted against the reporter coding region, we have characterized the dynamics of the

296 t mutations and a common risk variant in the coding region, we have identified an important contribut

297 h high CpG/UpA sequences inserted into a non-coding region were similarly replication defective.

298 While most indels at non-coding regions were a single base pair, 3 base pair inde

299 ed accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be achiev

300 segment roughly follows that seen within the coding regions, with HLA-B showing the highest ( approxi