ライフサイエンスコーパス: coding sequence

1 gth of the gene body and its surrounding non-coding sequence).

2 amoxifen-inducible Cre recombinase (CreERT2)-coding sequence.

3 utations in the Gag or reverse transcriptase coding sequence.

4 e transcription from the 3' end of the GAL10 coding sequence.

5 ribosome reinitiation at the downstream CHOP coding sequence.

6 ription initiation site at the 3' end of the coding sequence.

7 , the most important being located 3' of the coding sequence.

8 f but instead a V27I mutation in the RNase H coding sequence.

9 sociated with somatic mutations in the ZFP57 coding sequence.

10 on or 3'UTR mRNA binding to ribosomes on the coding sequence.

11 there are only nine SNPs in 25 kb of protein-coding sequence.

12 d the number of alanine repeat codons in the coding sequence.

13 onneutralizing type A-like Hc binding domain coding sequence.

14 ridine additions both reconstituting crucial coding sequence.

15 determine the impact of the mutation on the coding sequence.

16 s are corrected by reintroduction of a TgDCX coding sequence.

17 te translational derepression of the var2csa coding sequence.

18 allele causes a frame-shifted and truncated coding sequence.

19 tream from the start codon, or 1 kb into the coding sequence.

20 ed by the lack of recognizable mitochondrial coding sequences.

21 adds hundreds of uridines to create protein-coding sequences.

22 ead heterozygous structural variation within coding sequences.

23 in humans are scarce and limited to protein-coding sequences.

24 ion initiation, validating many of the novel coding sequences.

25 xpression when added to an intron located in coding sequences.

26 r to that affected by recurrent mutations to coding sequences.

27 bp away and how coregulation coevolved with coding sequences.

28 l tool for the genome-wide detection of AARS coding sequences.

29 ive AAA codons are under-represented in gene-coding sequences.

30 create in-frame and frameshift insertions in coding sequences.

31 be encoded by many different synonymous mRNA coding sequences.

32 understanding of the functional role of non-coding sequences.

33 at were mostly associated with short protein coding sequences.

34 , while minimizing changes to the underlying coding sequences.

35 bout G4 motifs in mRNAs, especially in their coding sequences.

36 assemble exon-based mRNA containing protein-coding sequences.

37 tural proteins or at the 3' end of the viral coding sequences.

38 on phylogenetic analysis of partial VP4/VP2 coding sequences.

39 level of histone acetylation in transcribed coding sequences.

40 rent 3' untranslated regions (3'UTRs) and/or coding sequences.

41 presentation for complex genomic regions and coding sequences.

42 ons and have the potential to change protein coding sequences.

43 uctures within the N-terminal regions of its coding sequences.

44 The transcription of arabinofuranosidase coding sequences 1 and 3 was investigated in plant organ

45 generated because of the overlap of the UL51 coding sequence 5' end with the UL52 promoter sequences,

46 including density of ribosomal footprints on coding sequences, 5' leader ribosomal densities, distrib

47 Variable coding sequence a1 (Vcsa1; the rat opiorphin homologue,

48 t adeno-associated virus containing the CRRY coding sequence (AAV-CRRY) into the subretinal space of

49 tions are indeed conserved within homologous coding sequences across diverse eukaryotic, bacterial, a

50 fferent codon positions along a transcript's coding sequence affects this self-assembly process.

51 More than 60% of the coding sequence alleles analyzed were previously unchara

52 which encodes a lung mucin and exhibits more coding sequence alleles than any HLA class I or II gene

53 Thus, by fusion oncogene coding sequence alone, SS18-SSX1 and SS18-SSX2 can each

54 late IRES activity, independently of protein-coding sequence alterations.

55 ker than the selection on the same codons in coding sequences, although the switches between the codo

56 Thus, the Xist gene carries within its coding sequence an antisense RNA that drives Xist expres

57 for animal evolution, our recent large-scale coding-sequence analyses from vertebrates and invertebra

58 in contained a novel Hn translocation domain coding sequence and a nonneutralizing type A-like Hc bin

59 pt's 3' UTR is to fuse the UTR to a reporter coding sequence and assess the relative expression of th

60 rying mouse and human full-length RPGR-ORF15-coding sequence and conducted a comprehensive long-term

61 ciated viral (AAV) vector carrying human RP2-coding sequence and demonstrated its ability to mediate

62 evolutionarily plastic both at the level of coding sequence and expression across A. thaliana access

63 for miR-200c seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by

64 ive exon 23a falls within the Nf1 GAP domain coding sequence and is tightly regulated in favor of ski

65 The coding sequence and splice site boundaries of the three

66 ation, genes can exhibit divergence in their coding sequence and their expression patterns.

67 ase deletions is preferentially increased in coding sequences and in short rather than long mononucle

68 wn role in ribosomal (rRNA) processing, many coding sequences and intergenic regions appeared to be d

69 c-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and c

70 rrelated with increases in mutation rates in coding sequences and regulatory regions.

71 om 3 to 16 kb and are intermingled with gene-coding sequences and transposable elements.

72 376 other individuals, we identified 244,246 coding-sequence and splice-site ultra-rare variants (URV

73 in the transcripts of many genes, notably in coding sequences, and identify consensus sites for hydro

74 the translational start codon, depletion in coding sequences, and mixed patterns of enrichment in th

75 l densities, distribution of ribosomes along coding sequences, and ribosome codon occupancies.

76 ty patterns and coverage similarities across coding sequences, and showed that they yield comparable

77 These include mature transcripts containing coding sequences, and their processing precursors, as we

78 vast majority of these novel contigs possess coding sequences, and we have validated their existence

79 ximately 6%), and a high fraction of protein-coding sequence ( approximately 39%) with relatively lon

80 The BDNF gene organization and coding sequence are conserved in all vertebrates.

81 ome footprinting suggests that these protein-coding sequences are likely to be mis-annotated.

82 (regions spanning gene models), and protein-coding sequences are more conserved than untranslated ge

83 ve in current studies, genes whose wild-type coding sequences are needed for tumor growth are also of

84 create random nucleotide sequences, protein coding sequences are subject to a unique set of constrai

85 MNase HS regions are therefore on par with coding sequences as annotations that demarcate the funct

86 daptation could involve evolution of protein-coding sequences as well as transcriptome-level regulato

87 o, and reduces NuA4 occupancy of transcribed coding sequences at particular genes.

88 This frequently relies on automated, coding sequence-based approaches such as OrthoMCL, Inpar

89 ae and I. pulchra genomes have many long non-coding sequences between genes, likely driving genome si

90 st known of which are disruptions in protein coding sequences (BRCA1 and 2).

91 ough diverse targeting mechanisms that avoid coding sequences, but conserved principles guiding their

92 ally, Rho promotes termination at the end of coding sequences, but it can also terminate transcriptio

93 ion of an mRNA, despite carrying a canonical coding sequence, can directly cause gene repression.

94 Mature messenger RNAs (mRNAs) consist of coding sequence (CDS) and 5' and 3' UTRs, typically expe

95 (ORF) of the target gene which truncates the coding sequence (CDS) and targets the corresponding tran

96 assessed 24 SNPs located in the 3'UTR or the coding sequence (CDS) of targets.

97 comprising a collection of 82,356 annotated coding sequences (CDS) to identify 2,325 patterns of pre

98 Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated qual

99 We find that uORFs are depleted near coding sequences (CDSes) and have initiation contexts th

100 It has been used to identify new protein-coding sequences (CDSs) and clarify the boundaries of pr

101 sis of 5'-truncated mRNA ends that mapped to coding sequences (CDSs) of Arabidopsis thaliana, rice (O

102 latory sequences and using native microalgal coding sequences (CDSs) with higher GC content improved

103 strategies rely on assumptions about protein-coding sequences (CDSs), e.g., they are conserved, do no

104 s (altORFs) in addition to annotated protein coding sequences (CDSs).

105 synonymous coding and 2 were non-synonymous coding sequence changes.

106 o cause phylogenetic incongruence in protein-coding sequence comparisons between vertebrate taxa.

107 Here we present a protocol for generating coding-sequence-complete genomes, comprising an online p

108 nts that mapped near the 5' or 3' end of the coding sequence, consistent with initiation of decay fro

109 s, comparative and functional studies of non-coding sequences, contamination detection, etc.

110 pinpointing risk factors of disease from non-coding sequence data.

111 in the gland rather than gene death through coding sequence degradation.

112 ted with p16 silencing in the absence of p16 coding sequence deletion and MAX induction restores p16

113 septaurelia, mating type O is determined by coding-sequence deletions in a different gene, mtB, whic

114 f PRPS2 but not PRPS1 is regulated through a coding sequence-dependent mechanism that combines elemen

115 d nonsense (NS) variants disrupt the protein-coding sequence downstream of the mutation site by chang

116 identify the disruption of exon-proximal non-coding sequences (e.g., the promoter) as functionally co

117 ts value in predicting and analyzing protein coding sequences, established and emerging work has also

118 nsus primers capable of detecting homologous coding sequences even when low-to-moderate sequence info

119 ient function for ATHs and demonstrates that coding sequence evolution can underlie quantitative vari

120 Therefore, interplay between enhancer and coding sequence evolution created a potentially adaptive

121 However, the role of coding sequence evolution remains unresolved.

122 ugh male-biased genes show elevated rates of coding sequence evolution, consistent with previous repo

123 iation between sexual selection and rates of coding sequence evolution, suggesting that expression ch

124 al start codon while the bulk of the protein-coding sequence evolved through a CAG repeat expansion.

125 The fused coding sequence for ECSTEC94C_1402 from E. coli strain S

126 tified an unusual gene in Apicomplexa with a coding sequence for membrane-docking and structure-speci

127 portion of RNA1 5' UTR but extends into the coding sequence for nine nucleotides, thus was missed in

128 n, and the distal part of ALK, including the coding sequence for the entire kinase domain.

129 its entire stem-loop precursor overlaps the coding sequence for the Kaposin (Kap) A/C proteins.

130 Because of negative selection, the coding sequence for the prothrombin-binding D1-D2 domain

131 A coding sequence for the proximal Runx3 mRNA is preceded

132 have leveraged this technology to delete the coding sequences for a known type III effector.

133 e transgenesis, we screened 15 conserved non-coding sequences for enhancer activity, identifying thre

134 or 99% of IMD isolates, including those with coding sequences for MnB, MnC, MnW, and MnY, and the phe

135 -associated virus serotype 10 expressing the coding sequences for the CLN2 gene implicated in late in

136 at specific positions in a set of homologous coding sequences, for example to tune translation rate w

137 yoglobin were deduced by cDNA cloning of the coding sequence from mRNA.

138 o GPA was overcome by expression of the ADF3 coding sequence from the phloem-specific SUC2 promoter,

139 manized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replace

140 We cloned a full-size Tg coding sequence from western clawed frog (Xenopus tropic

141 ble and can be warmed-up (gene promoters and coding sequences), from those that remain refractory (ge

142 al cancer-associated, functional non-protein-coding sequence germline variants associated with ovaria

143 HDR-mediated insertion of a coding sequence (green fluorescent protein or CD40L) ups

144 arasite lines, where the P. berghei csp gene coding sequence has been replaced with either full-lengt

145 le for synonymous rare codons farther within coding sequences has not yet been established, several r

146 Rare codons at the 5' terminus of coding sequences have been shown to increase translation

147 Translated regions distinct from annotated coding sequences have emerged as essential elements of t

148 Here, whole genome alignment of coding sequences identified widespread parallel amino ac

149 ing enhancers (ESEs) overlap with amino acid coding sequences implying a dual evolutionary selective

150 analyzed the genetic variation in the FOXP2 coding sequence in 63 chimpanzees, 11 bonobos, 48 gorill

151 ollowing the UGA codon and forms part of the coding sequence in bacterial selenoproteins.

152 e of a 6-nucleotide insertion in the protein-coding sequence in C57BL/6J and because of robust and se

153 through binding at the N-terminal amino acid coding sequence in EXT2 mRNA.

154 xpression changes may be more important than coding sequence in sexual selection.

155 coding gene and tRNA overlap with little non-coding sequence in the compact P. rubra genome.

156 ations have been identified in the rhodanese coding sequence in the French Caucasian population.

157 y polynucleotide and were located within the coding sequences in both wild type and degradosome mutan

158 supports the role of common variants in non-coding sequences in influencing complex phenotypes throu

159 arge number of GGDEF proteins, nearing 1% of coding sequences in some cases, raises the question of w

160 leotide tails were mostly located within the coding sequences in the degradosome mutants compared to

161 an 200 rice lincRNA genes had homologous non-coding sequences in the maize genome.

162 Yet surprisingly, many protein coding sequences include large clusters of synonymous ra

163 We detected 227 nonsilent variants in the coding sequence, including 24 samples with nonoverlappin

164 lastoid cell lines, we identified 7273 novel coding sequences, including 2442 translated upstream ope

165 Each gene has a coding sequence insertion/deletion mutation within the S

166 rom translation of mRNA molecules beyond the coding sequence into the 3'-untranslated region.

167 election, followed by integration of the tag-coding sequence into the endogenous locus in zebrafish.

168 f ALAS2 expression, indicating that this non-coding sequence is indispensable for ALAS2 expression in

169 ity and/or translation, while changes in the coding sequences lead to mRNAs encoding distinct protein

170 e evolutionary pressure, protein complexity, coding sequence length, and the number of paralogs.

171 e novo sequence variants are biased in their coding-sequence length and longer genes tend to cluster

172 es upstream of the green fluorescent protein-coding sequence markedly reduces the levels of gfp mRNA

173 changes in RNA polymerase fidelity, and that coding sequences may have evolved to minimize the effect

174 ggest that multiple hemerythrin-like protein coding sequences might have been acquired by lateral gen

175 ull-length genome (DBN3a), with a strain-DBN coding sequence, modified NS5B consensus sequence, pS52

176 in different reading frames from overlapping coding sequences; moreover, structure compatibility/inco

177 ntly in cis with the WT allele than the TERT coding sequence mutation.

178 ong controls, about 1 in 217 carried an LDLR coding-sequence mutation and had plasma LDL cholesterol

179 The prevalence of BCL2 coding sequence mutations was 12% in FL at diagnosis and

180 Recent evidence has connected MI risk with coding-sequence mutations at two genes functionally rela

181 e-transcriptome sequencing recurrent somatic coding-sequence mutations in the PTPN1 gene.

182 We identified two genes in which rare coding-sequence mutations were more frequent in MI cases

183 5 tag single-nucleotide polymorphisms in the coding sequence of ADAMTS1 among 230 unrelated cases and

184 l II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently o

185 vigilin binds to CU-rich regions in the mRNA coding sequence of Apob and other proatherogenic secrete

186 shown that mutations that modify the protein-coding sequence of ATP1A3, the gene encoding the alpha3

187 and transcriptional evidence of decay in the coding sequence of both Mx1 and Mx2 in four species of O

188 showed that miR-K6-5p directly targeted the coding sequence of CD82 molecule (CD82), a metastasis su

189 The coding sequence of CDH3 fits within the packaging limit

190 ucing an in-frame nonsense mutation into the coding sequence of Cre recombinase (nsCre).

191 ort the notion that SNPs in the 3'UTR or the coding sequence of disease-relevant genes may be importa

192 The coding sequence of each human pre-mRNA is interrupted, o

193 nabled over 1000 modifications affecting the coding sequence of genes in each target genome.

194 nce to missense variation within the protein-coding sequence of genes.

195 of ribosomes with both the uORF and the main coding sequence of GGP.

196 H3K9ac is added at promoter close to ATG and coding sequence of HvS40 after onset of senescence.

197 single or double mutations within the 3CLpro coding sequence of inhibitor-resistant virus.

198 eotides, so-called polyA tracks, to the gene coding sequence of interest will decrease translation el

199 ion because overexpression of a noncleavable coding sequence of MYB83 significantly increased plant s

200 The biphenyl 4-hydroxylase (B4H) coding sequence of rowan (Sorbus aucuparia) was isolated

201 the contribution of genetic variants in the coding sequence of the ABCA4 gene.

202 hile the first one corresponds to the entire coding sequence of the Bo17 gene, the second results fro

203 The relevance of changes to the coding sequence of the c-MYC oncogene to malignancy is c

204 anscribed from a promoter located within the coding sequence of the cutC gene.

205 eted NE isoforms rather than by altering the coding sequence of the full-length protein.

206 genotype-phenotype differences more than the coding sequence of the fusion gene created.

207 ulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream t

208 mozygous nonsynonymous point mutation in the coding sequence of the gene, resulting in an arginine to

209 sing a lentivirus containing the full-length coding sequence of the human NR2B subunit.

210 Based on the coding sequence of the influenza virus A/Shanghai/2/2013

211 In HepG2 cells stably expressing the coding sequence of the MT2 gene, TMPRSS6, incubation wit

212 e largest dataset tested, which included all coding sequences of 100 bacterial species.

213 Consistently, San1 associates with the coding sequences of active genes to regulate Spt16's abu

214 To enable this reconstitution, coding sequences of histidine kinase (HK) and response r

215 led abundant genetic variation affecting the coding sequences of human transcription factors (TFs), b

216 otein (DB fusion) was created by joining the coding sequences of IpaD and IpaB.

217 both in promoter regions and throughout the coding sequences of many genes and is particularly enric

218 egion from within LUR, containing the entire coding sequences of ORF50-encoding reactivation transact

219 ic analysis of somatic complex indels in the coding sequences of samples from over 8,000 cancer cases

220 fy an average of 14+/-5 somatic mutations in coding sequences of sorted monocyte DNA and the signatur

221 ognize new targets that we identified in the coding sequences of the chloroplast atpA and petA genes,

222 describes a new method for interrogating all coding sequences of the human genome at single-cell reso

223 an diseases can be made by exploring the non-coding sequences of the human genome.

224 sh p53 pathway by introducing regulatory and coding sequences of the human tumor suppressor ARF into

225 the potential impact of mutations on the DNA coding sequences of these targets, and compare these res

226 chain differed markedly from the light chain coding sequences of toxin types A-G.

227 raction reporter to intracellularly fuse the coding sequences of two interacting proteins and next-ge

228 grammed ribosomal frameshift (PRF) fuses the coding sequences of two TraR-activated genes, msi172 and

229 We compared protein-coding sequences of vertebrate species that employ prefo

230 ences on the papaya X chromosome and protein-coding sequences on the S. latifolia X chromosome, our m

231 and it likely originated de novo from a non-coding sequence or domain divergence after duplication.

232 Some elements have preferences for non-coding sequence or for the beginning and end of coding r

233 nor the implications of DTU on their protein coding sequences or functions, are currently well unders

234 is linked to type 2 diabetes risk through a coding sequence polymorphism (rs1535500); however, its p

235 encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity o

236 y activating transcription, altering protein-coding sequences, producing noncoding RNAs, and even sup

237 ligands and receptors exhibit similarity of coding sequences, protein structures, and chromosomal po

238 SgrS binding within the purR coding sequence recruits the RNA chaperone Hfq to direct

239 s located adjacent to UGA codons, additional coding sequence regions necessary for efficient producti

240 r have largely focused on genes, whereas non-coding sequences remain relatively unexplored.

241 We hypothesise that these modules in non-coding sequence represent distinct cis-regulatory loci t

242 ATHs and the ancestral-like coding sequences rescued sensory organ fate in atonal mu

243 Few of such variants disrupt coding sequences resulting in gain or loss of function f

244 Phylogenetic analysis of mitochondrial coding sequences revealed accelerated rates of sequence

245 Phylogenetic analysis of the complete coding sequence showed that EPEV represents a distinct c

246 Further analysis of the AraEXLB8 coding sequences showed high conservation across the Ara

247 of San1 impairs chromatin reassembly at the coding sequence, similarly to the results seen following

248 More than 75% of these 104 genes have coding sequences small enough to be packaged efficiently

249 To remove rRNA and enrich coding sequences, subtractive hybridization procedures h

250 NA identified several mutations in the opsin coding sequence, suggesting the loss of cone cell functi

251 ation in the translation levels of their two coding sequences, suggesting a potential regulatory role

252 iolate these parametric assumptions for such coding sequences, suggesting that a non-parametric appro

253 er, we show that when placed downstream of a coding sequence, sxRNA can be used to switch "ON" transl

254 other locations include 5' UTRs, introns and coding sequences (termed herein as non-3UTR), as well as

255 richment in operons and more slowly evolving coding sequences than other genes, along with a small gr

256 other bilaterians, and deeply conserved non-coding sequences that are candidates for conserved gene-

257 ously undetected indels and 7.49 Mb of novel coding sequences that could not be aligned to the human

258 est that in addition to allelic variation of coding sequence, the heterogenous nature of the tetraplo

259 In the coding sequence, these mutations are found in multiple l

260 in-frame deletion of 54 bp of triple-helical coding sequences, thus mimicking the most common molecul

261 en the TMPRSS2 promoter sequence and the ERG coding sequence (TMPRSS2:ERG) in urine, noninvasive scre

262 o acid change in the hexose transporter HXT7 coding sequence to be responsible for the evolved phenot

263 h included optimising the codon usage of the coding sequence to better suit sugar cane.

264 he 5p15.33 rearrangements juxtapose the TERT coding sequence to strong enhancer elements, resulting i

265 ession and the contribution of a 3' terminal coding sequence to this process.

266 of Cpf1 by approximately threefold in human coding sequences to one cleavage site per approximately

267 dentified by in silico changing the C57BL/6J coding sequences to the SPRET/Ei sequences, converting t

268 targeted, along with a preceding 2A-peptide coding sequence, to be integrated just upstream to the A

269 A non-synonymous coding sequence variant (c.2 T > C; p.1Met?) found in VD

270 to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 ind

271 ve selection in these evolved regulatory and coding sequence variants and showed that modulating RCO

272 Focusing our analysis on coding sequence variants in 63 genes with preferential k

273 Two coding sequence variants in the APOL1 gene (G1 and G2) e

274 ia luciferase assays, we showed that all six coding sequence variants observed in individuals signifi

275 erized RP were completely screened for TRNT1 coding sequence variants, and a second family was identi

276 Understanding the link between non-coding sequence variants, identified in genome-wide asso

277 view of all transcripts having nonsynonymous coding sequence variants.

278 nctional consequences of both coding and non-coding sequence variants.

279 Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in

280 We show that non-coding sequence variation at the FRO2 locus leads to var

281 To examine the role of recurrent coding sequence variation in CRC aetiology, we genotyped

282 comprehensively explores the contribution of coding sequence variation to CRC risk, identifying assoc

283 ic specificity, and interprets the action of coding sequence variations in proteins, people and popul

284 eiotropic SNPs among regulatory elements and coding sequence variations.

285 Drosophila atonal coding sequence was endogenously replaced with that of a

286 uced ribosome accumulation on the 5' side of coding sequences was cycloheximide-dependent.

287 fected by recurrent mutations disrupting non-coding sequences was similar to that affected by recurre

288 ed on Jug r 1, Jug r 3, and Jug r 4 allergen-coding sequences, was set up and validated.

289 amples of protein evolution via mutations in coding sequences, we have very limited understanding on

290 f novel HA mutations directly altered the HA coding sequence were identified.

291 Functional B4H coding sequences were also isolated from two apple (Malu

292 egulation than cognate recombinants in which coding sequences were introduced into the K3 locus.

293 500 coding exons totaling more than 1 Mbp of coding sequence, were selected from the whole-exome data

294 As validation, virus lineages, and variant coding sequences, were confirmed by next-generation sequ

295 tional ability of a luciferase reporter gene coding sequence when it is preceded by multiple tyrosine

296 ying mechanism is likely programmed into the coding sequence, where Shine-Dalgarno-like elements trig

297 available that allow users to create random coding sequences with specified amino acid composition a

298 8) per base pair per generation in autosomal coding sequence, with a corresponding non-crossover gene

299 th heterogeneity in the common region of dsx coding sequences within and among orders, possibly resul

300 Recombinants harboring coding sequences within the K5 locus showed higher K3 an