ライフサイエンスコーパス: coenzyme A

1 ut the acyl transfer onto Rv0100 rather than coenzyme A.

2 es its activity by disrupting the binding of coenzyme A.

3 structure of PBCV-1 A654L in a complex with coenzyme A.

4 substituted amino acid aldehydes and malonyl-coenzyme A.

5 he peptide N-myristoylated-GCG and palmitoyl-coenzyme A.

6 sm of living organisms and forms the core of coenzyme A.

7 Caffeoyl-coenzyme A 3-O-methyltransferase (CCoAOMT) is an S-adeno

8 The hotdog-fold enzyme 4-hydroxybenzoyl-coenzyme A (4-HB-CoA) thioesterase from Arthrobacter sp.

9 s conversion of acetyl coenzyme A to malonyl coenzyme A, a carbon donor for long-chain FA synthesis,

10 human Naa60 (hNaa60) in complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA).

11 the transfer of an acetyl group from acetyl-coenzyme A (Ac-CoA) to the amine of a wide range of subs

12 with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralsto

13 Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritio

14 at catalyzes pyruvate's conversion to acetyl coenzyme A (AcCoA), thereby connecting these two pathway

15 ased levels of acetyl phosphate, acetoacetyl coenzyme A (acetoacetyl-CoA), butyryl CoA, acetoacetate,

16 d ferredoxin for glucose oxidation to acetyl coenzyme A (acetyl-CoA) and CO2, NADH for the reduction

17 in conversion of acetyl phosphate to acetyl-coenzyme A (acetyl-CoA) and posttranscriptionally regula

18 oumarate to p-hydroxybenzaldehyde and acetyl coenzyme A (acetyl-CoA) encoded by the couAB operon.

19 Acetyl coenzyme A (acetyl-CoA) generated from glucose and aceta

20 Acetyl coenzyme A (acetyl-CoA) is a key metabolite at the cross

21 Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation

22 riglycerides, suggesting an increased acetyl coenzyme A (acetyl-CoA) load.

23 rnative carbon source utilization for acetyl coenzyme A (acetyl-CoA) production and gluconeogenesis.

24 ferentiation in a manner dependent on acetyl coenzyme A (acetyl-CoA) production by the enzyme ATP-cit

25 esis by suppressing the expression of acetyl coenzyme A (acetyl-CoA) synthetase (Acss), leading to de

26 main-containing enzyme that condenses acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protei

27 d is sensitive to the availability of acetyl coenzyme A (acetyl-CoA), we investigated a role for meta

28 demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA).

29 e, enabling biosynthesis of cytosolic acetyl coenzyme A (acetyl-CoA, the two-carbon isoprenoid precur

30 The results suggest that acetyl coenzyme A acts as a mixed V and K type activator and pr

31 to a promoter region shared with the acetyl coenzyme-A acyl-transferase-1 (ACAA1), was associated wi

32 copurify with the Golgi adaptor protein acyl coenzyme A (acyl-CoA) binding domain protein 3 (ACBD3/GP

33 n architecturally distinct subfamily of acyl coenzyme A (acyl-CoA) dehydrogenase (ACAD) enzymes that

34 ed by a single system intermediate, the acyl-coenzyme A (acyl-CoA) pool.

35 confirmed a preference for short-chain acyl coenzyme A (acyl-CoA) substrates, supporting the identif

36 The AMP-forming acyl coenzyme A (acyl-CoA) synthetases are a large class of e

37 s or longer rescue growth by generating acyl coenzyme A (acyl-CoA) thioester beta-oxidation degradati

38 activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate

39 nd di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficien

40 PqsBC catalyzes the condensation of octanoyl-coenzyme A and 2-aminobenzoylacetate (2-ABA) to form the

41 best inhibitors are competitive with acetyl coenzyme A and an X-ray cocrystal structure reveals that

42 amide synthase that uses C16 fatty acid acyl-coenzyme A and dihydroxy LCB substrates but increased ac

43 e enzyme phosphotransacylase (PTAC) recycles Coenzyme A and generates an acyl phosphate that can serv

44 ation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate.

45 e acetyltransferase 1 in complex with acetyl coenzyme A and histone H4 peptide.

46 irement for growth and specifically inhibits coenzyme A and isoleucine biosynthesis.

47 Concentrations of acetyl-coenzyme A and nicotinamide adenine dinucleotide (NAD(+)

48 biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A

49 ze the hydrolysis of thioester bonds between coenzyme A and phenylacetyl-CoA.

50 Upon incubation of the enzyme with acyl-coenzyme A and reduced nicotinamide adenine dinucleotide

51 Benzoyl-coenzyme A and salicoyl-coenzyme A were the preferred st

52 to depletion of the energy substrate acetyl coenzyme A and the antioxidant glutathione.

53 ynthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB substrates.

54 in vitro assay requiring only isolated LDs, Coenzyme A, and ATP to drive lipid synthesis.

55 imidine, isoprenoid, methionine, riboflavin, coenzyme A, and folate, as well as other biosynthetic pa

56 anine and pantoic acid moieties required for coenzyme A are annotated.

57 s the polymerization of 3-(R)-hydroxybutyryl-coenzyme A as a means of carbon storage in many bacteria

58 cyltransferase that uses preferentially 16:0-coenzyme A as an acyl donor.

59 ounds known to be metabolized by the benzoyl coenzyme A (benzoyl-CoA) pathway.

60 eracting partner, Golgi adaptor protein acyl-coenzyme A binding domain containing protein 3 (ACBD3).

61 uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serves as

62 ed experimental and simulation study of acyl-coenzyme A binding protein (ACBP), a two-state folder (f

63 emperature as the different variants of acyl-coenzyme A binding protein have similar m-values when th

64 re, we identify the PO membrane protein acyl-coenzyme A-binding domain protein 5 (ACBD5) as a binding

65 Low-molecular mass (10 kD) cytosolic acyl-coenzyme A-binding protein (ACBP) has a substantial infl

66 Here we show that acyl-coenzyme A-binding protein (ACBP) potently facilitates v

67 SAR-related proteins THIOREDOXIN h3, ACYL-COENZYME A-BINDING PROTEIN6, and PATHOGENESIS-RELATED1 w

68 This is the second inborn error of coenzyme A biosynthesis to be implicated in NBIA.

69 mulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

70 cellulo and could be used to identify acetyl coenzyme A carboxylase (ACC) in Pseudomonas aeruginosa a

71 s phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC).

72 MPK and its downstream target phospho-acetyl-coenzyme A carboxylase (ACC).

73 ar gene (ACC2) that targets homomeric acetyl-coenzyme A carboxylase (ACCase) to plastids.

74 T cell-specific deletion of acetyl coenzyme A carboxylase 1 (ACC1), an enzyme that catalyze

75 ption factor 1c, fatty acid synthase, acetyl coenzyme A carboxylase 2, and carnitine palmitoyltransfe

76 r with the biotin acceptor protein of acetyl-coenzyme A carboxylase and catalyzes posttranslational b

77 204-5p which was predicted to inhibit acetyl coenzyme A carboxylase beta, a key fatty acid oxidation

78 y the accumulation of plastid-encoded acetyl Coenzyme A carboxylase D proteins accounting for the gen

79 tural environments, where heteromeric acetyl-coenzyme A carboxylase encoded in part by the chloroplas

80 ctrophoretic (CE) assay for measuring acetyl coenzyme A carboxylase holoenzyme (holo-ACC) activity an

81 d nuclear gene that targets homomeric acetyl-coenzyme A carboxylase to plastids, where the multidomai

82 in ACC2, encoding a plastid-targeted acetyl-coenzyme A carboxylase, cause hypersensitivity to specti

83 ation of the AMPK substrates, p53 and acetyl-coenzyme A carboxylase, changes that correlated with inc

84 DI-010976, an allosteric inhibitor of acetyl-coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hep

85 the post-translational biotinylation of acyl coenzyme A carboxylases.

86 3) Direct acetyl transfer between LD and coenzyme A catalyzed by E2pCD was observed with a rate c

87 We have found previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition

88 physical interaction of the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related en

89 ress the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not

90 ched-chain amino acid metabolism, isovaleryl-Coenzyme A (CoA) and isobutyryl-CoA, with three molecule

91 N-acyltransferase reaction using fatty acyl-coenzyme A (CoA) and long-chain base (LCB) substrates to

92 Cofactors such as NAD, AMP, and Coenzyme A (CoA) are essential for a diverse set of reac

93 Here we identify coenzyme A (CoA) as the key metabolic signal that inhibi

94 Currently, little is known about coenzyme A (CoA) biodegradation and even less is known a

95 (PanK) is a regulatory enzyme that controls coenzyme A (CoA) biosynthesis.

96 olution crystal structure of AF-Est2 reveals Coenzyme A (CoA) bound in the vicinity of the active sit

97 discussed in the context of the peroxisomal coenzyme A (CoA) budget.

98 roduce mm flux through the key fluoromalonyl coenzyme A (CoA) building block, thereby offering the po

99 Pharmaceutical inhibition of acetyl-coenzyme A (CoA) carboxylase (ACC), a key fatty acid bio

100 (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that cont

101 kinase (AMPK) levels, and diminished acetyl coenzyme A (CoA) carboxylase phosphorylation than in the

102 Two genes, Psyr_2474, encoding an acyl-coenzyme A (CoA) dehydrogenase, and Psyr_4843, encoding

103 brid pathway used to assimilate benzoate via coenzyme A (CoA) derivatives in bacteria.

104 Here, we show that several coenzyme A (CoA) derivatives, such as acetyl-CoA, butyry

105 The Arabidopsis (Arabidopsis thaliana) acyl-coenzyme A (CoA) desaturase-like (ADS) gene family conta

106 p of the phenylpropanoid pathway, exchanging coenzyme A (CoA) esterified to p-coumaric acid with shik

107 catalyzes the reduction of hydroxycinnamoyl-coenzyme A (CoA) esters using NADPH to produce hydroxyci

108 in turn is decarboxylated to produce acetyl-coenzyme A (CoA) for various biosynthetic purposes.

109 metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitami

110 eport the identification of a putative enoyl-coenzyme A (CoA) hydratase/isomerase that is required fo

111 While homologous to mammalian enoyl-coenzyme A (CoA) hydratases, EchA6 is non-catalytic yet

112 ty of SPT, allowing utilization of myristoyl-coenzyme A (CoA) in addition to its canonical substrate

113 brida) flowers have the precursor 4-coumaryl coenzyme A (CoA) in common.

114 Plants make coenzyme A (CoA) in the cytoplasm but use it for reactio

115 -HB-CoA to form 4-hydroxybenzoate (4-HB) and coenzyme A (CoA) in the final step of the 4-chlorobenzoa

116 atalyzes the reversible conversion of acetyl-coenzyme A (CoA) into acetylcarnitine.

117 Coenzyme A (CoA) is an essential cofactor for all forms

118 tion of HMP is also compromised in vivo when coenzyme A (CoA) levels are reduced.

119 ary and sequence information about conserved coenzyme A (CoA) ligase motifs, a cDNA encoding cinnamat

120 zyme DmdB, a methylmercaptopropionate (MMPA)-coenzyme A (CoA) ligase, catalyzes the second step in th

121 a BL-04 gene encoding long-chain fatty acid coenzyme A (CoA) ligase.

122 o enzymes, Ptr4CL3 and Ptr4CL5, catalyze the coenzyme A (CoA) ligation of 4-coumaric acid to 4-coumar

123 Coenzyme A (CoA) mediates thiol-based acyl-group transfe

124 of both the cellular glycine and the acetyl-coenzyme A (CoA) needed for SAM synthesis.

125 ation of the meta-hydroxyl group of caffeoyl-coenzyme A (CoA) on the pathway to monolignols, with the

126 ps linked through a thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP).

127 enzymes catalyze the reduction of fatty acyl-coenzyme A (CoA) or fatty acyl-acyl carrier protein subs

128 ity were correlated with changes in the acyl-coenzyme A (CoA) pool in developing seeds of transgenic

129 cate that YacG is frequently associated with coenzyme A (CoA) production enzymes, linking the protein

130 transition pore (PTP) openings, followed by coenzyme A (CoA) release, acyl CoA synthesis, and membra

131 levels of intermediate and anaplerotic acyl-coenzyme A (CoA) species incorporated into the Krebs cyc

132 tauri extraplastidial lipids, while the 16:4-coenzyme A (CoA) species was not detected.

133 ferase activity when presented with caffeoyl-Coenzyme A (CoA) substrate, thus we have named this acyl

134 carbon-carbon bond forming step between acyl coenzyme A (CoA) substrates offer a versatile route for

135 he condensation of two long-chain fatty acyl-coenzyme A (CoA) substrates.

136 aloferax volcanii 3-hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (EC 2.3.310).

137 essive missense mutations in COASY, encoding coenzyme A (CoA) synthase in one NBIA-affected subject.

138 tochondrion-associated long-chain fatty acyl coenzyme A (CoA) thioesterase that is highly expressed i

139 Coenzyme A (CoA) thioesters are ubiquitously present in

140 cept for the one responsible for ligation of coenzyme A (CoA) to 4HB.

141 VimA mediated coenzyme A (CoA) transfer to isoleucine and reduced bran

142 The enzymes YfdW, a formyl coenzyme A (CoA) transferase, and YfdU, an oxalyl-CoA de

143 It ligates coenzyme A (CoA) with hydroxycinnamic acids, such as 4-c

144 key role in metabolism as building blocks of coenzyme A (CoA), an essential cofactor utilized in ~4%

145 lysophosphatidylethanolamine (LPE) with acyl-coenzyme A (CoA), designated LYSOPHOSPHATIDYLETHANOLAMIN

146 Acetyl coenzyme A (CoA), malonyl-CoA, adenosine triphosphate (A

147 ing the final and committed step in the acyl-coenzyme A (CoA)-dependent biosynthesis of triacylglycer

148 metabolites into 4-methyl-pentanol (4MP) via coenzyme A (CoA)-dependent chemistry were taken from nin

149 production of 1-butanol by the fermentative coenzyme A (CoA)-dependent pathway using the reversal of

150 Coenzyme A (CoA)-transferases catalyze transthioesterifi

151 ynthesis of the universal essential cofactor Coenzyme A (CoA).

152 s FALDH) prior to activation via coupling to coenzyme A (CoA).

153 anine, spermine, dihydrouracil, and acryloyl-coenzyme A (CoA).

154 ocess that requires the generation of acetyl-coenzyme A (CoA).

155 on via the reductive conversion to propionyl-coenzyme A (CoA).

156 ffusion of the much larger cofactors NAD and coenzyme A (CoA).

157 coenzyme A and oxaloacetate from citrate and coenzyme A (CoA).

158 n complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA).

159 gluconeogenesis due to sequestration of free coenzyme A (CoASH).

160 we determined the structure for the FAD- and coenzyme A-containing holoenzyme from P. horikoshii to 2

161 ecreased the expression of medium-chain acyl coenzyme A dehydrogenase (MCAD) and short-chain acyl coe

162 A dehydrogenase (MCAD) and short-chain acyl coenzyme A dehydrogenase (SCAD), involved in the regulat

163 The hepatic activities of 3-hydroxyacyl-coenzyme A dehydrogenase short chain and glutamate dehyd

164 3 candidate gene, CTLA-4, NRAMP1, and acetyl-coenzyme A dehydrogenase, long-chain (ACADL) (candidate

165 mical analyses showed lower beta-hydroxyacyl coenzyme-A dehydrogenase activity and higher lactate deh

166 the response regulator CpxR and (ii) acetyl coenzyme A-dependent acetylation of the alpha subunit of

167 methionine, which MddA detoxifies by acetyl coenzyme A-dependent acetylation.

168 rrier protein) synthase (ACPS) catalyzes the coenzyme A-dependent activation of apo-ACPP to generate

169 unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids dur

170 Changes in stearoyl-coenzyme A desaturase (SCD) expression and activity were

171 0 (P = 1.6 x 10(-8)) as a marker of stearoyl coenzyme A desaturase 1 activity, and the ratio of 20:3n

172 This review provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic ta

173 ate (P-HPD, an isomer of AI-2-phosphate) and coenzyme A, determine the crystal structure of an LsrF c

174 ccumulation in sdp1 roots requires both ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) and P

175 of increased or decreased expression of ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) or PH

176 FAD and NAD(P)H-dependent coenzyme A disulfide reductases/polysulfide reductases (

177 ex (PDHc), which converts pyruvate to acetyl coenzyme A, enables E. coli to resist these antimicrobia

178 level on the non-heme diiron enzyme benzoyl coenzyme A epoxidase, BoxB.

179 es high carbon flux through the ethylmalonyl coenzyme A (ethylmalonyl-CoA) pathway (EMC pathway).

180 The ethylmalonyl coenzyme A (ethylmalonyl-CoA) pathway is one of the cent

181 ond within acetyl-CoA, producing acetate and coenzyme A for a range of cellular processes.

182 gen sources for protein synthesis and acetyl-coenzyme A for cytosol-localized fatty acid elongation.

183 e binding sites for both the upstream acetyl coenzyme A formation and fatty acid synthase modules ena

184 cast into three modules: the upstream acetyl coenzyme A formation module; the intermediary acetyl-CoA

185 The biosynthesis of the major acyl carrier Coenzyme A from pantothenic acid (PA) is critical for su

186 psulatum homolog of 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) lyase (HCL1).

187 tein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked t

188 inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and subsequently the isop

189 Until recently, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have

190 blockers (ARBs), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), and

191 e shown that the 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors known as stati

192 Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are

193 Statins, or 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have anti-inf

194 ition particle or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.

195 d by increased (14) C-glucose-derived acetyl-coenzyme A incorporation into sterols for fecal excretio

196 We describe, for example, a putative coenzyme-A-induced-fit substrate binding mechanism media

197 degradation through hydration of the dienoyl-coenzyme A intermediate as observed in Geobacter metalli

198 Acetyl coenzyme A is an activator, and GarA, a forkhead associa

199 Coenzyme A is an essential metabolite known for its cent

200 In cells, Coenzyme A is synthesized de novo in five enzymatic step

201 Downregulation of 4-coumaric acid:coenzyme A ligase (4CL) can reduce lignin content in a n

202 4-Coumaric acid:coenzyme A ligase (4CL) is involved in monolignol biosyn

203 n Escherichia coli, synthesis of the malonyl coenzyme A (malonyl-CoA) required for membrane lipid syn

204 nolignols under the catalysis of p-coumaroyl-coenzyme A monolignol transferase (PMT).

205 The rice (Oryza sativa) p-COUMAROYL-Coenzyme A MONOLIGNOL TRANSFERASE gene was introduced in

206 Plants expressing the p-COUMAROYL-Coenzyme A MONOLIGNOL TRANSFERASE transgene can therefor

207 tion, we cloned and characterized a caffeoyl-coenzyme A O-methyltransferase (PhCCoAOMT1) from the pet

208 a-oxidation double mutant acx1acx2 (for acyl-Coenzyme A oxidase), levels of TAG actually increased in

209 s and in vivo rescue potential of the acetyl-Coenzyme A precursor S-acetyl-4'-phosphopantetheine as a

210 One therapeutic strategy is to generate Coenzyme A precursors downstream of the defective step i

211 Tricarboxylic acid acetyl coenzyme A production and ATP production were reduced in

212 ctivity, contributed significantly to acetyl-coenzyme A production.

213 (AT1) is shown to encode a hydroxycinnamoyl-coenzyme A:putrescine acyltransferase responsible for ca

214 spectrometric sequencing: a hydroxycinnamoyl-Coenzyme A:quinate hydroxycinnamoyl transferase (HQT) wa

215 ne expressing castor FA hydroxylase and acyl-Coenzyme A:RcDGAT2 in its seeds.

216 Cinnamoyl-coenzyme A reductase (CCR) catalyzes the reduction of hy

217 olesterol, in the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) activity, and in the in vit

218 odies recognizing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are found in patients with

219 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting e

220 ombination with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) inhibitor (statin), will re

221 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors, commonly known

222 the formation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), a main regulator of choles

223 ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which catalyzes a rate-lim

224 particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).

225 ncoding PCSK9 and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; the target of statins) as i

226 interfering with 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR) activity, a key player in is

227 tylase (HDAC) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) by having a hydroxamate grou

228 The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) has a key regulatory role in

229 Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory

230 Inhibitors of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase and isoprenylation attenuated, wher

231 ins targeting the 3-hydroxy-3-methylglutaryl coenzyme A reductase but also inhibitors of oxidosqualen

232 Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an

233 fects of statins, 3-hydroxy-3 methylglutaryl coenzyme A reductase inhibitor, have been shown to modif

234 The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors ("statins") have anti-in

235 es of the influence of hydroxymethylglutaryl-coenzyme A reductase inhibitors (also known as statins)

236 Purpose The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity

237 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been vari

238 The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the develop

239 Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have been shown to impro

240 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are an important group

241 fects of statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) on renal, cardiovascula

242 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), commonly prescribed in

243 er statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are safe to use has bee

244 ted with elevated 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels and anti-Src-Tyr416 imm

245 osynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase results from its sterol-induced bin

246 roxylase) and ccr1g (deficient for cinnamoyl-coenzyme A reductase) lines, albeit to a lower extent.

247 protein 2, human 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and human low-density lipoprotein

248 e-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and increased plasma membrane chol

249 rved lower activity of hydroxymethylglutaryl-coenzyme A reductase, the key enzyme in the mevalonate p

250 ically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is a rate-limiting enzyme fo

251 d proteolysis of 3-hydroxyl-3-methylglutaryl coenzyme A reductase, which may undermine other host res

252 e development of anti-hydroxymethyl glutaryl-coenzyme A reductase-positive statin-induced myopathy.

253 ive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase.

254 ive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase.

255 rget of pitavastatin, hydroxymethylglutarate coenzyme-A reductase (HMGCR), was found to be over-expre

256 tins, or HMG CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, are drugs with multipl

257 ECR encoding the mitochondrial trans-2-enoyl-coenzyme A-reductase involved in human mtFAS.

258 Here, we reintroduced CINNAMOYL-COENZYME A REDUCTASE1 (CCR1) expression specifically in

259 he genes encoding 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE1 (HMGR1) and MAKIBISHI1, the rate-l

260 ctly dependent on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others

261 Here, two hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyl transferas

262 olignol biosynthetic enzyme hydroxycinnamoyl coenzyme A:shikimate hydroxycinnamoyl transferase (HCT)

263 The acyl-Coenzyme A substrate for this acyltransferase accumulate

264 onversion of alpha-ketoglutarate to succinyl coenzyme A (succinyl-CoA) and CO(2).

265 We show that succinyl-coenzyme A (succinyl-CoA) binds to KAT2A.

266 The acetyl coenzyme A synthase (ACS) enzyme plays a central role in

267 onfirmed the role of a hydroxymethylglutaryl-coenzyme A synthase cassette, three flavin-dependent tai

268 Previously, it was shown that beta-ketoacyl-coenzyme A synthase ECERIFERUM6 (CER6) is necessary for

269 ein-based model for the NiP center of acetyl coenzyme A synthase using a nickel-substituted azurin pr

270 ox (hydrogenases and CO dehydrogenase/acetyl coenzyme A synthase), they have never been associated wi

271 nic genes such as 3-hydroxy-3-methylglutaryl-coenzyme A synthase, fatty acid synthase, and stearoyl-C

272 this study is to explore parasite fatty acyl-coenzyme A synthetase (ACS) as a novel drug target.

273 or the acetylation of the AMP-forming acetyl coenzyme A synthetase (SacAcsA, SACE_2375).

274 Succinyl Coenzyme A synthetase (SCS) is a key mitochondrial enzym

275 Although many Archaea have AMP-Acs (acetyl-coenzyme A synthetase) and ADP-Acs, the extant methanoge

276 ctroscopy, the cutin mutants long-chain acyl-coenzyme A synthetase2 (lacs2), permeable cuticle1 (pec1

277 enin polyketide biosynthetic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PK

278 is activation is mediated by long-chain acyl-coenzyme A synthetases (LACSs), which are encoded by a f

279 knockout plants have a higher level, of acyl-coenzyme A than the wild type.

280 cycle for the generation of cytosolic acetyl-coenzyme A that can be used for fatty acid and cholester

281 need to be converted to their corresponding coenzyme A thioesters to become metabolically available.

282 It catalyzes acyl-coenzyme A thioesters to synthesize naringenin chalcone

283 talyze the sequential esterification of acyl-coenzyme A thioesters to the R4, R3, R3', and R2 positio

284 aine via the activated benzoyl- or cinnamoyl-Coenzyme A thioesters, respectively.

285 Of the two major 3-ketoacyl coenzyme A thiolases, KAT2 plays the primary role in BA

286 LDHA maintains high concentrations of acetyl-coenzyme A to enhance histone acetylation and transcript

287 m the FAR2-catalyzed reduction of fatty acyl-coenzyme A to fatty alcohols, which are possible precurs

288 n enzyme that catalyzes conversion of acetyl coenzyme A to malonyl coenzyme A, a carbon donor for lon

289 the transfer of an acetyl group from acetyl coenzyme A to polyamines such as spermidine and spermine

290 hydrolyzes phosphatidylcholine and also acyl-coenzyme A to release fatty acids.

291 rix where glycine is condensed with succinyl coenzyme A to yield delta-aminolevulinic acid.

292 results suggest that OsAT10 is a p-coumaroyl coenzyme A transferase involved in glucuronoarabinoxylan

293 ss-expanded and -diverged clade of BAHD acyl-coenzyme A-utilizing transferases identified four mutant

294 the synthesis of nicotinate, NAD+, NADP+ and coenzyme A were detected among the essential vitamins an

295 Benzoyl-coenzyme A and salicoyl-coenzyme A were the preferred starter substrates.

296 for their mission: E1 and E2 generate acetyl-coenzyme A, whereas the FAD/NAD(+)-dependent E3 performs

297 onverted to the central intermediate benzoyl-coenzyme A, which is enzymatically reduced to cyclohexa-

298 ich decarboxylates pyruvate and forms acetyl-coenzyme A with concomitant reduction of low-potential f

299 enzyme catalyzing the condensation of acetyl coenzyme A with malonyl-ACP in P. aeruginosa.

300 he transfer of an acetyl group from P-HPD to coenzyme A yielding dihydroxyacetone phosphate and acety