ライフサイエンスコーパス: cofactor

1 ding site is stably formed in the absence of cofactor.

2 e hydride transfer from the substrate to the cofactor.

3 concluding with covalent labeling of the PLP cofactor.

4 ansfers electrons to coenzyme Q via a flavin cofactor.

5 -binding site and the requirement for FAD as cofactor.

6 n into the active site to coordinate a metal cofactor.

7 g the GTP-binding energy to offload inactive cofactor.

8 ctivity on an otherwise unreactive iron-haem cofactor.

9 ondria, possesses a covalently attached heme cofactor.

10 DnrF detects NO via its bound heme cofactor.

11 PLP, influencing the electrophilicity of the cofactor.

12 JA2 requires that Tat first binds its P-TEFb cofactor.

13 on site to produce the active Mn(IV)/Fe(III) cofactor.

14 renylated FMN (prFMN), a recently discovered cofactor.

15 ures to securely bind the photoactive flavin cofactor.

16 ransient cycloaddition between substrate and cofactor.

17 oxygenases, for which Fe(II) is an essential cofactor.

18 ide metal ions to protein targets for use as cofactors.

19 duces TGM2 and regulates TGM2 binding to its cofactors.

20 inating the uptake and distribution of metal cofactors.

21 ry and were similarly analyzed for energetic cofactors.

22 depend on Mss116 interplay with its protein cofactors.

23 by using O2, electrons, and metals or other cofactors.

24 N-terminal domain responsible for recruiting cofactors.

25 One reason is the prerequisite of expensive cofactors.

26 tant PBX1 proteins and wild-type TALE or HOX cofactors.

27 hways, via a novel combination of epigenetic cofactors.

28 four steroid receptors and a number of known cofactors.

29 determine CSF levels of monoamines and their cofactors.

30 ction rates comparable to that of the native cofactors.

31 imal Mtr4-dependent decay observed with both cofactors.

32 rrying NCAM fragment is mediated by positive cofactor 4 and cofilin, which we identified as novel PSA

33 ex, five tubulin-specific chaperones, termed cofactors A-E (TBCA-E), and GTP are required for the fol

34 tein termed VP35, which acts as a polymerase cofactor, a viral protein chaperone, and an antagonist o

35 motion of complex formation with Cobl-like's cofactor Abp1.

36 ining how the exosome, along with associated cofactors, achieves the demanding task of targeting part

37 uctases, in a second shell away from the FAD cofactor acting to polarize the peptide bond through int

38 tigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety o

39 pendent thrombin generation independently of cofactor activation by thrombin.

40 cay-accelerating activity (DAA) and factor I cofactor activity (CA).

41 e of carboxylic acids to aldehydes using the cofactors adenosine triphosphate and nicotinamide adenin

42 Heme proteins utilize the heme cofactor, an iron porphyrin, to perform a diverse range

43 DRs appear to contain a non-exchangeable NAD cofactor and may rely on an external redox partner, rath

44 s the ejection of the inactive cob(II)alamin cofactor and requires the presence of an acceptor protei

45 volve a 12-A translocation of the carotenoid cofactor and separation of the N- and C-terminal protein

46 ned at 1.9 A resolution provide insight into cofactor and substrate recognition.

47 ised model for the function of three tubulin cofactors and Arl2 as a multisubunit GTP-hydrolyzing cat

48 y and interactions with DNA, transcriptional cofactors and chromatin.

49 ads to a depletion of essential vitamins and cofactors and decreased de novo synthesis of pyrimidines

50 or the metabolic regulation of electrophilic cofactors and discover novel types of electrophilic modi

51 nderstanding the interplay of AdoMet and Cbl cofactors and expands the catalytic repertoire of Cbl-de

52 the oxidant, coproheme III as substrate and cofactor, and heme b as the product.

53 e recently discovered prenylated FMN (prFMN) cofactor, and requires oxidative maturation to form the

54 ACs contain metal ions but not organic cofactors, and use ATP to activate substrates through ph

55 orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecul

56 ale benchmark tests show that the new hybrid COFACTOR approach significantly improves the function an

57 Proteins carrying an iron-porphyrin (heme) cofactor are essential for biological O2 management.

58 trapping of the electrons at the iron-sulfur cofactors are prevented by the combination of intense el

59 h encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that fu

60 We found that both iron loading and cofactor assembly in RNR are dependent on the ISC machin

61 otein synthesis to cytoskeletal dynamics and cofactor assimilation and serve as models for uncovering

62 passing electrons to a tightly bound quinone cofactor at a high affinity site (QH site) that stabiliz

63 hich generate visibly emissive isofunctional cofactors based on an isothiazolo[4,3-d]pyrimidine analo

64 of primary metabolites, macromolecules, and cofactors bearing this element.

65 The structural changes suggest that FeMo-cofactor belt sulfurs S3A or S5A are potential protonati

66 nzyme architecture, its active site, and the cofactor binding mode.

67 ries of hydrophobic residues surrounding the cofactor binding site and mutation of both residues nega

68 ergoes conformational changes near the metal cofactor binding site that are not observed when the enz

69 Typically, dehydrogenase cofactor binding sites are open to solvent, which allows

70 h the notion that the S-loop is critical for cofactor binding, allosteric activation and oligomerizat

71 tively demonstrates that TbPRMT1(ENZ) is the cofactor-binding subunit and carries all catalytic activ

72 adical SAM enzymes, including the molybdenum cofactor biosynthetic enzyme MoaA and the RNA methyltran

73 prenylated flavin mononucleotide (prFMN) as cofactor, bound adjacent to a conserved Glu-Arg-Glu/Asp

74 The recruitment of transcriptional cofactors by sequence-specific transcription factors cha

75 ligand-independent activation of the ERalpha-cofactor CARM1.

76 r penetration and the hydration level of the cofactors changes when the electron is transferred along

77 ata indicate transient rather than stable TF-cofactors chromatin interactions at response elements at

78 nisms within all domains of life require the cofactor cobalamin (vitamin B12), which is produced only

79 Firstly, we provided putative cofactors/collaborators analysis (for Drosophila melanog

80 TF responsive enhancers, revealing potential cofactors/collaborators and discovering enriched TF moti

81 ments of high local transcription factor and cofactor concentrations could help low-affinity sites ov

82 Their active site is a complex cofactor consisting of a unique [2Fe] subcluster ([2Fe]H

83 t subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains requiring t

84 n and protein assembly and ensures that only cofactor-containing protein can continue along the assem

85 e establish that a predicted heme-molybdenum cofactor-containing protein, and a complex polyferredoxi

86 ite their similarity in primary sequence and cofactor content, crystallographic, kinetic, and mass sp

87 Molybdenum cofactor deficiency (MoCD) is an autosomal recessive inb

88 GM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme.

89 the metal being coordinated by five protein/cofactor-derived sulfur atoms and a sixth, so far unknow

90 Thus, ZNF764 is a cofactor directing GR transcriptional activity toward sp

91 Thr-238 and the substrate as well as limited cofactor discrimination.

92 arious biological problems including protein-cofactor, domain-domain, protein-protein, protein-DNA an

93 nd loss-of functional evidence in vivo for a cofactor, Dot1L, in gene activation by TR during vertebr

94 NA ligase, to use Fe2+ in place of Mg2+ as a cofactor during catalysis.

95 multiple MeaB chaperone functions, including cofactor editing, loading, and offloading.

96 ared to horseradish peroxidase, the ten heme cofactors enable excellent electronic communication and

97 Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition.

98 Iron-sulfur (Fe-S) clusters are ubiquitous cofactors essential to various cellular processes, inclu

99 s may have cancer-related functions and some cofactors even have prognostic functions.

100 l SDRs in which the insertion buries the NAD cofactor except for a small portion of the nicotinamide

101 ly on an external redox partner, rather than cofactor exchange, for multiple turnover.

102 ched in nuclei, accounting for 35% of folate cofactors, explaining previous observations that nuclear

103 ts into the molecular recognition of the two cofactors, F420 and NAD(P)H by FNO.

104 part from NAD+, another adenosine-containing cofactor FAD and highly abundant uridine-containing cell

105 is formed between VVD residue Cys108 and its cofactor flavin adenine dinucleotide(FAD), and prompts V

106 The riboflavin (RF) cofactors, flavin adenine dinucleotide (FAD) and flavin

107 ,8-Tetrahydrobiopterin (BH4) is an essential cofactor for all nitric oxide synthases.

108 Lipoate is an essential cofactor for enzymes that are important for central meta

109 Results support the role of the PHD3 as a cofactor for HIF-1, independent of PKM2-JMJD5.-Schoepfli

110 However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), l

111 Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized

112 iency of CSF tetrahydrobiopterin, a critical cofactor for monoamine neurotransmitter synthesis.

113 Biotin is an essential cofactor for multiple metabolic reactions catalyzed by c

114 te promotes 5 hmC generation by serving as a cofactor for TET methylcytosine dioxygenases.

115 Copper (Cu) is an essential cofactor for various enzymatic activities including mito

116 d glucose breakdown module and utilizes both cofactors for building terpenes.

117 We conclude that p300 and CBP are limiting cofactors for islet development, and hence for postnatal

118 ivation requires oxidative maturation of the cofactor, for which two distinct isomers, prFMN(ketimine

119 ents downstream of Dre2 was required for RNR cofactor formation.

120 Cbl cofactor forms are decreased in fibroblasts from this pa

121 tase (MCM) and precludes loading of inactive cofactor forms.

122 the cytosol and further processing to these cofactor forms.

123 t the design and application of single-chain cofactor-free kinases with photoswitchable activity.

124 Here, using purified, cofactor-free preparations of recombinant human Hsp70 an

125 ese results demonstrate a new anticoagulant (cofactor) function of FV that targets the early phase of

126 part of the function exerted by the original cofactor, FVIII, in that it promotes colocalization of t

127 can selectively activate the antihemophilic cofactor, FVIII, triggering the hemostatic intrinsic coa

128 on protein (PrP(C)) in lipid rafts and lipid cofactors generating infectious prions in in vitro model

129 ncing energy metabolism (CO/H2 oxidation for cofactor generations) more prominently than carbon fixat

130 [FeFe]-Hydrogenases contain a H2-converting cofactor (H-cluster) in which a canonical [4Fe-4S] clust

131 vitamin B12 that is best known as an enzyme cofactor, has expanded the number of known photoreceptor

132 t interactions to incorporate the biological cofactor heme-B for catalysis.

133 ygen reductase activity, indicating that the cofactors (hemes b and copper for CcoN and cytochromes c

134 llikrein (pKal) and factor XII (FXII), and a cofactor, high-MW kininogen (HK).

135 impact of recruiting or releasing the Mg(2+) cofactor highlights two loop regions for which fragmenta

136 G) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma

137 ent manganese (Mn) functions as redox-active cofactor in active sites of enzymes and, thus, is involv

138 tein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and di

139 e, an essential micronutrient, is a critical cofactor in one-carbon metabolism for many cellular path

140 Vitamin B12 is an important cofactor in one-carbon metabolism whose dysregulation is

141 ese (Mn) for survival, as it is an essential cofactor in oxygen metabolism, especially O2 production

142 y between the formation of the Fe(III)2-Y(*) cofactor in RNR and the cellular iron-sulfur (Fe-S) prot

143 unidentified role of the eukaryote-specific cofactor in substrate interaction.

144 hosphatidylethanolamine, which is a critical cofactor in the formation of synthetic infectious prions

145 ical environment around the active site FeMo-cofactor in the MoFe protein, either by substituting nea

146 cofactor, the recent discovery of iron as a cofactor in the more widespread PhoX and PhoD implies th

147 produce pseudocobalamin, which is used as a cofactor in their specialized methionine synthase (MetH)

148 ur proteins and chaperones that deliver iron cofactors in cells.

149 nd instead support their role as bound redox cofactors in electron transport from nanowires to metal

150 o the potentials of the most oxidizing redox cofactors in nature.

151 reaction and the use of iron-sulfur cluster cofactors in reductive ring opening and hydroxy-group el

152 hibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-met

153 ionally restricted, requires region-specific cofactors in the form of Hox proteins to co-activate sub

154 ids, reaching the level of specialized redox cofactors in the late amino acids tryptophan and selenoc

155 to interrogate the transcription factors and cofactors in thermogenic gene activation and identified

156 elative orientation of the two molybdopterin cofactors, in a variant of the Ray-Dutt twist of classic

157 al B12 metabolism and that itaconyl-CoA is a cofactor-inactivating, substrate-analog inhibitor of the

158 ade up of one catalytic RNA and five protein cofactors including L7Ae, which is known to bind the kin

159 y activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helic

160 d in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct

161 Here, cleavage temporally orchestrates cofactor insertion and protein assembly and ensures that

162 mino acids or transferring the isolated FeMo-cofactor into a different peptide matrix, changes the ne

163 a new paradigm for the insertion of the Fe/S cofactor into a radical SAM protein.

164 d incorporate a niacin-derived Ni-containing cofactor into LarA, an Ni-dependent lactate racemase.

165 Cobalamins are important biological cofactors involved in methyl transfer, radical rearrange

166 and flavin mononucleotide (FMN), are two key cofactors involved in oxidative metabolism.

167 Cofactors involved in prolyl hydroxylase domain activity

168 organism and containing an iridium porphyrin cofactor (Ir(Me)-PIX) in place of the heme catalyze enan

169 NAzyme adopts a V-shape fold, and the Pb(2+) cofactor is bound at the pre-organized pocket.

170 3 as a hypoxia inducible factor (HIF)-1alpha cofactor is controversial and remains unknown in skeleta

171 ons where an additional disease-predisposing cofactor is present during LIP.

172 This cofactor is required for catalysis by multiple mitochond

173 Evaluation of comorbidities and cofactors is important.

174 of iron-sulfur clusters as electron-transfer cofactors is in merging protein-water fluctuations with

175 While positioning of chlorophyll cofactors is well understood and rationalized by the pri

176 (RT) from a stable diferric-tyrosyl radical cofactor located >35 A away across the alpha2:beta2 subu

177 synthesis to coordinate the expression, Fe-S cofactor maturation, and activity of the respiratory com

178 s also found to bind FAD, hinting that these cofactors may be involved in sensing the cellular redox

179 HDH complex with His and NAD(+) displays the cofactor molecule situated in a way that would allow for

180 sites for RNA polymerase II and the exosome cofactors Mtr4 (TRAMP complex) and Nab3 (NNS complex) by

181 iate transcription with adenosine-containing cofactor NAD+, which was proposed to result in a portion

182 h a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.

183 as invalidated by honey oxidising the enzyme cofactor NADH.

184 A linear arrangement of cofactors (NADPH, FAD, and two membrane-embedded heme mo

185 Histone deacetylase 3 and its cofactor NCOR1 regulate hepcidin; histone deacetylase 3

186 We propose that the reduced cofactor nicotinamide adenine dinucleotide (NADH) is a p

187 lution of SARS-CoV nsp14 in complex with its cofactor nsp10 adds to the uniqueness of CoVs among RNA

188 The catalytic cofactor of [FeFe]-hydrogenses (H-cluster) is composed o

189 med by interaction of a radical with a metal cofactor of a catalytic site.

190 Initially recognized as an enzyme cofactor of a few enzymes, recent studies have revealed

191 Tetrahydrobiopterin (BH4) is a cofactor of a number of regulatory enzymes.

192 We have previously shown that BCA2, a cofactor of BST2 in the restriction of HIV-1, also preve

193 III latency genes and that TET2 protein is a cofactor of EBNA2 and coregulator of the EBV type III la

194 of all organisms owing to its function as a cofactor of enzymes collectively known as biotin-depende

195 ty that chelates with zinc ion to become the cofactor of HDAC enzymes.

196 denum, as a component of the iron-molybdenum cofactor of nitrogenase, is essential for symbiotic nitr

197 ndings demonstrate that Gdf3 is an essential cofactor of Nodal signaling during establishment of the

198 n in the biosynthesis of phytochromobilin, a cofactor of photoconvertible phytochromes.

199 s approach, we demonstrate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1)

200 , we show that postnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (AP

201 The FAD cofactor of the enzyme is buried within the proteinaceou

202 Heme a is an essential metalloporphyrin cofactor of the mitochondrial respiratory enzyme cytochr

203 In this study, we show that p37/UBXN2B, a cofactor of the p97 AAA ATPase, regulates spindle orient

204 phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, neg

205 d through its ability to methylate RUVBL1, a cofactor of the TIP60 complex.

206 hogenesis, because it serves as an essential cofactor of the viral polymerase as well as a potent ant

207 ntation with tetrahydrofolate, the essential cofactor of this cycle, and other oxidation-prone folate

208 Here, we identified novel cofactors of Arabidopsis AGOs, named RICE1 and RICE2.

209 SPA proteins are essential cofactors of COP1, but their exact role in the COP1/SPA

210 stinct mechanisms and that protein and metal cofactors of the spliceosome alter how snRNAs respond to

211 Moreover, 75% of the predicted cofactors of these transcription factors may have cancer

212 ding of the active 5'-deoxyadenosylcobalamin cofactor onto methylmalonyl-CoA mutase (MCM) and preclud

213 nt baculovirus vector and the phosphoprotein cofactor (P) in Escherichia coli and purified the result

214 recruitment of its associated transcription cofactors p300/HDAC1 to these co-regulated genes, thereb

215 Loss of Cdk5, or its required cofactor p35, reduces S437-Acn phosphorylation, whereas

216 rganelles are thought to sequester a private cofactor pool, minimize the effects of toxic intermediat

217 phenylacrylic acid using a newly identified cofactor, prenylated flavin mononucleotide (prFMN).

218 traint setting an upper limit on the rate of cofactor production possible.

219 ferent metallocofactor anchoring strategies, cofactors, protein scaffolds, and mutagenesis strategies

220 The vitamin B6 cofactor pyridoxal was conjugated with the luminescent B

221 he same methionine-tyrosine-tryptophan (MYW) cofactor radical intermediate at the earliest reaction t

222 The latter also identified the RNMT cofactor RAM, whose presence is required for cytoplasmic

223 eduction step is taken from the pyranopterin cofactors rather than from the tungsten ion.

224 c polypeptide-1 (APOBEC1), together with its cofactor RBM47, mediates robust editing in different tis

225 u(Hw) code, wherein DNA binding dictates its cofactor recruitment and regulatory output.

226 ades are defined here as cascades relying on cofactor recycling by the metabolism or on a metabolite

227 validated the intrinsic disorderness of NS2B cofactor region of NS2B-NS3 protease.

228 ifications without a thorough examination of cofactor relationships.

229 urnover, thus setting up its dependence on a cofactor repair system.

230 data demonstrate that SAGA acts as a general cofactor required for essentially all RNA polymerase II

231 ing those that synthesize the substrates and cofactors required for lignin biosynthesis.

232 Assembly of this cofactor requires O2, Fe(II), and a reducing equivalent.

233 te, the product dioxygen is released and the cofactor returns to its lowest oxidation state, S0.

234 Correlation with peritransplant cofactors revealed a significant difference in EC betwee

235 Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl so

236 We found that binding by the cofactor S-adenosylmethionine mitigates this autoinhibit

237 The new role of the versatile cofactor SAM is likely to be found in other examples of

238 tural models through the BioLiP library, the COFACTOR server infers three categories of protein funct

239 300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1

240 for broad application to studies of protein cofactor-small molecule interactions.

241 ated, in vitro oxidation to the mature prFMN cofactor stalls at formation of a radical prFMN species

242 city is related to the availability of Hsp70 cofactors, such as Hsp40 J-proteins and nucleotide excha

243 tracellular targeting of ABCD4 and cobalamin cofactor synthesis.

244 Here, we report that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase

245 ation explains why Fe2+ can be a more potent cofactor than Mg2+ in a variety of folding and catalytic

246 1 encodes a nuclear receptor transcriptional cofactor that directly interacts with the retinoic acid

247 these data indicate that Atro is a major Trl cofactor that functions to moderate developmental gene t

248 NA-binding domain, FHL2 is a transcriptional cofactor that plays the role of coactivator or corepress

249 st that cell-surface PS acts as an important cofactor that promotes the fusogenic restructuring of pr

250 BCA2/Rabring7 is a BST2 cofactor that promotes the lysosomal degradation of trap

251 [4Fe-4S] cluster, TsrM contains a cobalamin cofactor that serves as an intermediate methyl carrier i

252 modifying enzymes make use of substrates and cofactors that are intermediates of metabolic pathways,

253 es and therefore, bypass the need of soluble cofactors that had to be continuously exchanged or regen

254 ng well-known roles as second messengers and cofactors that help regulate diverse biochemical process

255 d mechanistic details of enzymes and protein cofactors that participate in Ubl conjugation cascades.

256 Iron-sulfur clusters are ancient cofactors that play a fundamental role in metabolism and

257 Most exoribonucleases function with cofactors that recognize ncRNAs with accessible 5' or 3'

258 To elucidate the cellular cofactors that regulate RIG-I signalling, we performed t

259 p97 interacts with different cofactors that target it to distinct pathways; an import

260 The presence of monoamines and their cofactors (the pterins and vitamin B6 (pyridoxal phospha

261 fidelity structural model for the biological cofactor, the complex is shown to mediate proton coupled

262 PhoA family of APases that utilize zinc as a cofactor, the recent discovery of iron as a cofactor in

263 enes of the MLL chimeras and their oncogenic cofactor, the super elongation complex.

264 hysiologically compatible conditions without cofactors, the P102L mutation in recombinant hamster PrP

265 the role of dengue virus and other possible cofactors, the small number of comparative epidemiologic

266 nt protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C re

267 to two ammonia (NH3) at its active site FeMo-cofactor through a mechanism involving reductive elimina

268 endogenous FVIIa engages its cell-localized cofactor tissue factor (TF), which stimulates activity t

269 nked to an adenosine moiety as in the AdoMet cofactor to generate transition state mimics.

270 s a diferric-tyrosyl radical (Fe(III)2-Y(*)) cofactor to initiate nucleotide reduction.

271 tates the recruitment of HIF-1alpha and p300 cofactor to the target promoters.

272 ghborhood to assist the binding of other TFs/cofactors to the enhancer.

273 involved in an early cytoplasmic step in the cofactor-trafficking pathway.

274 omplex, the reduced nicotinamide ring of the cofactor transiently enters the active site where it dis

275 The silencing cofactor TRIM28 was found to promote the degradation of

276 We show that the established Cdc48 cofactor Ufd1 is required for SREBP cleavage but does no

277 3 complex, with the aid of the heterodimeric cofactor UFD1/NPL4 and the UBA-UBX-containing protein UB

278 The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated prote

279 ation can be controlled by a switch in metal cofactor usage.

280 LP) is a fundamental, multifunctional enzyme cofactor used to catalyze a wide variety of chemical rea

281 Biotin is an essential cofactor utilized by all domains of life, but only synth

282 Capacity for electron transfer among redox cofactors versus charge recombination with nearby donors

283 hways, particularly lipids, amino acids, and cofactors/vitamins.

284 tructure of the active Vps4 hexamer with its cofactor Vta1, ADP.BeFx, and an ESCRT-III substrate pept

285 The COFACTOR web server is a unified platform for structure-

286 last step in the biosynthesis of the lipoyl cofactor, which is the attachment of two sulfhydryl grou

287 bout the maintenance of labile pools of this cofactor, which likely ensures its timely bioavailabilit

288 ioxidant enzymes, reduced thiols and NADP(H) cofactors, which is critical for cancer cells survival a

289 appear to represent a wide repertoire of HOX cofactors, which may coregulate enhancers through distin

290 However, exchange of its flavin cofactor with a 5-deazaflavin analogue dramatically supp

291 adjacent rather than opposite to the Me-Cbl cofactor with respect to the substrate in the enzyme act

292 ors an active site tungsten-bis-pyranopterin cofactor with the metal being coordinated by five protei

293 ) beta subunits, which self-assemble dimetal cofactors with stable one-electron oxidants that serve t

294 eports the interaction of various vitamin B6 cofactors with the red emitting glutathione stabilized c

295 products in the absence of other proteins or cofactors (with catalytically competent kinetics) plus h

296 rate without any buffer system or additional cofactors, with 64.0% conversion in 19 h and a productiv

297 The electron-transfer chain of iron-sulfur cofactors within the water-soluble peripheral part of th

298 recruits Mtr4, but it is less clear if these cofactors work together.

299 e renewal, we found that the transcriptional cofactors YAP and TAZ are required both to maintain TA c

300 onotopic membrane protein with just a flavin cofactor, yet no consensus exists on its mechanism.