ライフサイエンスコーパス: cognitive deficit

1 frontal symptoms), or non-specific (diffuse cognitive deficits).

2 vels are strongly correlated with chorea and cognitive deficit.

3 rimotor axonal neuropathy, optic atrophy and cognitive deficit.

4 on tau phosphorylation and accumulation, and cognitive deficit.

5 rse serum lipids, and smoking associate with cognitive deficits.

6 roduction, in turn leading to depression and cognitive deficits.

7 5q13.3 manifest neuropsychiatric disease and cognitive deficits.

8 ecreased hippocampal neuron loss and rescued cognitive deficits.

9 l-documented evidence that obesity can cause cognitive deficits.

10 es in the medial frontal cortex that lead to cognitive deficits.

11 nnovative strategy to improve age-associated cognitive deficits.

12 be a promising new drug target for different cognitive deficits.

13 rse agonists also may be useful for treating cognitive deficits.

14 the comorbid presentation of depression and cognitive deficits.

15 ermined by fast-scan cyclic voltammetry, and cognitive deficits.

16 ficantly improved lipopolysaccharide-induced cognitive deficits.

17 ut hence inhibit pain behaviors and mitigate cognitive deficits.

18 f p110delta reversed sensorimotor gating and cognitive deficits.

19 s: positive symptoms, negative symptoms, and cognitive deficits.

20 tation of hNSC ameliorated radiation-induced cognitive deficits.

21 necessary to characterize the predictors of cognitive deficits.

22 ant morbidity and long-term neurological and cognitive deficits.

23 is critical for Abeta-mediated synaptic and cognitive deficits.

24 lead to impaired hippocampal plasticity and cognitive deficits.

25 hat is, sleepiness, depression, anxiety, and cognitive deficits.

26 s, Adk(Deltabrain) mice develop seizures and cognitive deficits.

27 y, reducing amyloid pathology, and improving cognitive deficits.

28 Accordingly, these mice displayed cognitive deficits.

29 bit pain behaviors and mitigate pain-related cognitive deficits.

30 therapeutic effects on negative symptoms and cognitive deficits.

31 osomes exacerbate AD-related pathologies and cognitive deficits.

32 than impaired neurogenesis in stress-induced cognitive deficits.

33 urvivors with IVH develop cerebral palsy and cognitive deficits.

34 as a promising therapeutic approach to treat cognitive deficits.

35 urvivors with IVH develop cerebral palsy and cognitive deficits.

36 avenue to combat head trauma-induced chronic cognitive deficits.

37 S) neurodegeneration manifested as motor and cognitive deficits.

38 nign and malignant nervous system tumors and cognitive deficits.

39 urofibrillary tangles, neurodegeneration and cognitive deficits.

40 the pathophysiology of schizophrenia and its cognitive deficits.

41 idate of Down syndrome brain alterations and cognitive deficits.

42 succumb to severe malaria present long-term cognitive deficits.

43 somal disorder associated with developmental cognitive deficits.

44 plasticity and cognitive reserve in limiting cognitive deficits.

45 role of aging microglia in neurodegenerative cognitive deficits.

46 y mediators in the brain in association with cognitive deficits.

47 psy was induced, depression-like profile and cognitive deficits.

48 from the general population have significant cognitive deficits.

49 rdiovascular and mental disorders, including cognitive deficits.

50 lts have significance for the improvement of cognitive deficits.

51 they are likely to develop subsequent subtle cognitive deficits.

52 1(ko) mice in regards to amyloid plaques and cognitive deficits.

53 tom severity (r = .16, P = .01) but not with cognitive deficits.

54 including psychosis, depression, mania, and cognitive deficits.

55 n AD pathology and resultant amelioration of cognitive deficits.

56 ion between neonatal complications and adult cognitive deficits.

57 if such losses are apparently independent of cognitive deficits.

58 r developing optimal strategies for treating cognitive deficits.

59 f CBD on THC-induced anxiety, psychosis, and cognitive deficits.

60 n the absence of depressive-like behavior or cognitive deficits.

61 d alpha-synuclein in the CNS and ameliorated cognitive deficits.

62 can be precisely mapped onto behavioral and cognitive deficits.

63 ment poverty and slowness, tremor and subtle cognitive deficits.

64 at result from their use are associated with cognitive deficits.

65 titive behavior, and is also associated with cognitive deficits.

66 for other neurodevelopmental disorders with cognitive deficits.

67 ment is an important factor underlying these cognitive deficits.

68 nd impaired cBF integrity results in lasting cognitive deficits.

69 s, attenuates synapse loss, and thus rescues cognitive deficits.

70 acology prevents the pHFD-induced prefrontal cognitive deficits.

71 n vehicle emissions result in behavioral and cognitive deficits.

72 may be a misnomer because BECTS is linked to cognitive deficits, a more severe phenotype with intract

73 sterase 4B (PDE4B) inhibitor reduces chronic cognitive deficits after TBI and rescues deficits in hip

74 Sleep loss produces well-characterized cognitive deficits, although there are large individual

75 In addition to cognitive deficits, Alzheimer's disease (AD) is associat

76 disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality.

77 nic mice displayed exacerbated Abeta-induced cognitive deficits and a selective decrease in synapsins

78 Cognitive deficits and alimentation had the greatest imp

79 ith type 1 diabetes (T1D) has been linked to cognitive deficits and altered brain anatomy and connect

80 nist for Retinoid X receptors (RXR) improves cognitive deficits and amyloid-beta (Abeta) clearance in

81 after B-TBI prevented the induction of both cognitive deficits and B-TBI induced changes in SYP stai

82 f molecular and cellular events that produce cognitive deficits and can culminate in the development

83 in Alzheimer's Disease (AD), driving initial cognitive deficits and clinical manifestation.

84 romes and accumulate over time, resulting in cognitive deficits and dementia.

85 athology, peripheral lipoprotein metabolism, cognitive deficits and dendritic morphology of Apoe/Apoa

86 for patients experiencing the combination of cognitive deficits and depression associated with AD.

87 ific pathology, resulting in protection from cognitive deficits and depressive-like behavior.

88 and female wild-type and TgF344-AD rats from cognitive deficits and depressive-like behavior.

89 Anti-LGI1 encephalitis is associated with cognitive deficits and disability as a result of structu

90 nia remain a key puzzle in understanding the cognitive deficits and dysfunction of dorsolateral prefr

91 n-robot interaction, partly accounted for by cognitive deficits and medication.

92 ntagonizing D2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questi

93 ys underlying tau pathology-induced synaptic/cognitive deficits and neurodegeneration are poorly unde

94 ising surrogate imaging markers for modeling cognitive deficits and perhaps, guiding treatment develo

95 Subthreshold behavioral symptoms (e.g., cognitive deficits and substance abuse) often precede th

96 terations in intrinsic LFOs that covary with cognitive deficits and symptoms.

97 PLX5622 diet exhibited no radiation-induced cognitive deficits, and exhibited near complete loss of

98 at lead to dysregulated synaptic plasticity, cognitive deficits, and increased seizure risk.

99 hippocampus and thalamus, reduced long-term cognitive deficits, and reduced the occurrence of post-t

100 nsight into how the microdeletion results in cognitive deficits, and they suggest possible targets fo

101 redictive coding contributes to symptoms and cognitive deficits, and this dysfunction is further posi

102 Cognitive deficits are a common feature of psychiatric d

103 Cognitive deficits are a core clinical feature of schizo

104 Cognitive deficits are among the most severe and pervasi

105 for a scientific commentary on this article.Cognitive deficits are common among epilepsy patients.

106 Progressive cognitive deficits are common in patients with fragile X

107 the exact mechanistic underpinnings of these cognitive deficits are largely unknown, deficits in cort

108 Cognitive deficits are not observed in males of either g

109 molecular mechanisms underlying age-related cognitive deficits are not yet fully elucidated.

110 Although cognitive deficits are one of the factors most strongly

111 ebrospinal fluid of HIV-infected people with cognitive deficits as compared with infected people with

112 r) and appeared to be associated with future cognitive deficits as determined by CDR.

113 s of AD by inducing synaptic dysfunction and cognitive deficits associated with Abeta-mediated pathop

114 ill unknown whether Nrf2 plays a role in the cognitive deficits associated with AD.

115 and/or cGMP activities, which may ameliorate cognitive deficits associated with AD.

116 a decrease in DBN levels is correlated with cognitive deficits associated with ageing and dementia,

117 N-predominant disease and those with ALS and cognitive deficits associated with alterations in diffus

118 hronically activated microglia contribute to cognitive deficits associated with brain insults.

119 promising strategy for the treatment of the cognitive deficits associated with diseases including Al

120 These changes may form the basis for the cognitive deficits associated with mutations in DISC1 an

121 europlasticity and can alleviate hippocampal cognitive deficits associated with neurodegenerative dis

122 heir development and thus contributes to the cognitive deficits associated with neurological diseases

123 Network and cognitive deficits associated with neurological disorder

124 Cognitive deficits associated with neurotoxicity can be

125 anges in cAMP-PKA-LIMK-cofilin signaling and cognitive deficits associated with sleep deprivation.

126 for hippocampal dysfunction that may explain cognitive deficits associated with some forms of PD.

127 tem are thought to contribute to the core of cognitive deficits associated with such disorders.

128 y, yet the mechanisms underlying the chronic cognitive deficits associated with TBI remain unknown.

129 therapeutic targets to mitigate or delay the cognitive deficits associated with this devastating dise

130 These animals demonstrate cognitive deficits, autistic-like social behavior, aberr

131 Cognitive deficits belong to the most prevalent chronic

132 etiologic syndrome characterized by multiple cognitive deficits but not always by the presence of cog

133 bate Abeta pathology, neuroinflammation, and cognitive deficits, but it is unknown how the loss of LC

134 Cerebral microbleeds are associated with cognitive deficits, but the mechanism is unclear.

135 fore and during behavioral tests rescued the cognitive deficits; but withdrawal of PB treatment for 2

136 hagy contributes to synaptic dysfunction and cognitive deficits by triggering Abeta and Tau accumulat

137 hinal input on hippocampal hyperactivity and cognitive deficits characterizing early stages of AD, es

138 In patients with LMN-predominant disease, cognitive deficits correlated with alterations in diffus

139 pectedly, low PH-Tau resulted in significant cognitive deficits, decrease in the number of synapses (

140 involved in these effects is crucial because cognitive deficits during nicotine withdrawal may predic

141 -beta (Abeta) is a prime suspect for causing cognitive deficits during the early phases of Alzheimer'

142 Thus, sublethal cognitive deficits elicited by neonicotinoids on a broad

143 Studies of patients with acquired cognitive deficits following brain damage and studies us

144 It encompasses the full range of cognitive deficits from mild cognitive impairment to dem

145 available, current treatments for AD-related cognitive deficits have quite limited efficacy.

146 on/dysfunction, thought to comprise the core cognitive deficit in FXTAS.

147 the lack of BACE1 S-palmitoylation mitigates cognitive deficits in 5XFAD mice.

148 ted the effects of EC-DBS on the progressive cognitive deficits in a genetically-based mouse model of

149 3 overexpression prevented synaptic loss and cognitive deficits in a mouse model of neurodegeneration

150 ific cardiovascular disease risk factors and cognitive deficits in a predominantly midlife multiethni

151 estation produce communication, learning and cognitive deficits in a rat model that can be prevented

152 a potential network correlate for persistent cognitive deficits in absence epilepsy despite effective

153 a potential network correlate for persistent cognitive deficits in absence epilepsy despite effective

154 such as losartan restore cerebrovascular and cognitive deficits in AD is unknown.

155 reviously to reduce Abeta levels and improve cognitive deficits in AD mouse models by inducing the tr

156 ns to counteract oAbeta-induced synaptic and cognitive deficits in AD.

157 s the most important pathologic correlate of cognitive deficits in AD.

158 etes neuronal BRCA1, which may contribute to cognitive deficits in AD.

159 or the cortical spine loss and PFC-dependent cognitive deficits in adulthood.

160 erneurons that correlated with the extent of cognitive deficits in aged mice.

161 CANCE STATEMENT Clinical research identified cognitive deficits in alcoholic individuals as a risk fa

162 Social cognitive deficits in ALS have been recently described a

163 NCE STATEMENT Synaptic dysfunction underlies cognitive deficits in Alzheimer's disease (AD).

164 plored as promising targets for ameliorating cognitive deficits in Alzheimer's disease.

165 s measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease.

166 ted that LC lesions exacerbate pathology and cognitive deficits in amyloid-based mouse models.

167 fied Abeta oligomers during the evolution of cognitive deficits in an aggressive model of Abeta amylo

168 induce schizophrenia-like symptoms including cognitive deficits in animals and humans.

169 that increasing brain p62 expression rescues cognitive deficits in APP/PS1 mice, a widely used animal

170 t the lack of Nrf2 significantly exacerbates cognitive deficits in APP/PS1, without altering gross mo

171 posure to antipsychotic medications leads to cognitive deficits in both schizophrenia patients and an

172 which intermittent seizures drive persistent cognitive deficits in conditions accompanied by recurren

173 be reflected in the observed persistence of cognitive deficits in D2R-OE mice.

174 ectly the neural circuitry implicated in the cognitive deficits in depression.

175 esting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP

176 iod appear sufficient to produce significant cognitive deficits in Dp16.

177 ell as their relationship with developmental cognitive deficits in DS.

178 Cognitive deficits in early abstinence are associated wi

179 ges might be involved in the pathogenesis of cognitive deficits in ET.

180 dation protein (FMRP) is thought to underlie cognitive deficits in FXS, but no direct evidence has de

181 rly pregnancy is associated with significant cognitive deficits in humans; however, it is difficult t

182 dy showed significant gender differences for cognitive deficits in immediate and delayed memory in sc

183 d therapeutically to ameliorate synaptic and cognitive deficits in individuals with AS.

184 ions and ERPs may contribute to the observed cognitive deficits in macaques, and enhance our understa

185 inhibition can ameliorate radiation-induced cognitive deficits in mice.

186 ounteracting Abeta oligomer (oAbeta)-induced cognitive deficits in mice.

187 nding, impair aggregate clearance, and cause cognitive deficits in mice.

188 heir independent relationship with motor and cognitive deficits in MS.

189 s may provide a fruitful approach to prevent cognitive deficits in neuropsychiatric and neurocognitiv

190 t of novel therapeutic approaches to prevent cognitive deficits in neuropsychiatric and neurocognitiv

191 ng interference are at the core of disabling cognitive deficits in neuropsychiatric disorders.

192 nonpharmacological interventions to address cognitive deficits in neuropsychiatric disorders.

193 d whether their dysregulation could underlie cognitive deficits in neuropsychiatric illness.

194 Indeed, depression often precedes cognitive deficits in patients with AD.

195 mation integration and organization and thus cognitive deficits in patients with PD.

196 l studies exploring its ability to attenuate cognitive deficits in patients with schizophrenia.

197 frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple scler

198 Cognitive deficits in psychiatric and age-related disord

199 stones of clinical neurology, behavioral and cognitive deficits in psychiatry remain impervious to th

200 itive period for the emergence of prefrontal cognitive deficits in response to HFD.

201 ma-band (30-80 Hz) oscillations may underlie cognitive deficits in schizophrenia (SZ).

202 a potential therapeutic target for improving cognitive deficits in schizophrenia and other disorders.

203 onnectivity is responsible for 2 of the core cognitive deficits in schizophrenia- reduced information

204 to impaired gamma frequency oscillations and cognitive deficits in schizophrenia.

205 gical substrate for cortical dysfunction and cognitive deficits in schizophrenia.

206 reversing cortical-related symptoms, such as cognitive deficits in schizophrenia.

207 residual positive and negative symptoms and cognitive deficits in schizophrenia.

208 approaches in the treatment of WM and other cognitive deficits in ScZ.

209 uld be a factor contributing to WM and other cognitive deficits in ScZ.

210 nd synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including Parkin

211 au) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of wh

212 pressive-like behavior occurred earlier than cognitive deficits in TgF344-AD rats, consistent with AD

213 he aged hippocampus, eventually resulting in cognitive deficits in the aged brain.

214 rodegenerative disorder that leads to severe cognitive deficits in the elderly population.

215 s that failures of neural coordination cause cognitive deficits in the judicious processing and use o

216 vels and, more important, rescues AD-related cognitive deficits in these mice.

217 in Alzheimer's disease, one of the earliest cognitive deficits in this type of dementia.

218 However, the observed cognitive deficits in victimized individuals were largel

219 mutant K174Q slows tau turnover and induces cognitive deficits in vivo.

220 beta1-40 ratio, prevented the development of cognitive deficits in Y-maze test and improved synaptic

221 Patients also display cognitive deficits including impairments in working memo

222 ns of cortical networks may underlie various cognitive deficits, including a substantial reduction in

223 hood maltreatment is associated with various cognitive deficits, including inhibitory deficits and hy

224 th schizophrenia typically suffer a range of cognitive deficits, including prominent deficits in work

225 Age-associated motor and cognitive deficits increase the risk of falls, a major c

226 mpal insulin resistance is a key mediator of cognitive deficits independent of glycemic control.

227 nal network function that possibly underlies cognitive deficits, indicating promise as a clinical tre

228 amyotrophic lateral sclerosis (ALS) exhibit cognitive deficits indicative of frontotemporal dementia

229 modify the locomotor response to Amph or the cognitive deficits induced by PCP, whereas the silencing

230 the ISR, reversed the hippocampal-dependent cognitive deficits induced by TBI in two different injur

231 Many of these cognitive deficits involve dysfunction of the newly evol

232 This cognitive deficit is consecutive to PKA deregulation in

233 Screening for cognitive deficits is essential in neurodegenerative dis

234 Gaining insight into these cognitive deficits is essential, as subtle impairments m

235 r understanding of the pathogenesis of these cognitive deficits is needed.

236 dent hilar GABAergic interneuron decline and cognitive deficits late in life, suggesting early interv

237 stained and the variability of the resulting cognitive deficits makes treating these problems difficu

238 en the complex polypharmacy in HF treatment, cognitive deficits may be important in predicting medica

239 models of HD suggests that some of the early cognitive deficits may have a hippocampal basis.

240 Individuals with DS show a variety of cognitive deficits, most notably in hippocampal learning

241 phamide and natalizumab, did not improve her cognitive deficits, necessitating admission to a nursing

242 gic system to demonstrate an exacerbation of cognitive deficits, neuroinflammation, neurodegeneration

243 To examine whether the general cognitive deficit observed across psychotic disorders is

244 etwork efficiency play a role in the general cognitive deficit observed across the psychosis spectrum

245 ynapse function, which may contribute to the cognitive deficits observed in pathological mitochondria

246 ransmission could contribute to the onset of cognitive deficits observed in schizophrenia because pro

247 thought to contribute to the development of cognitive deficits observed in schizophrenia.

248 ing and treating Alzheimer's disease, before cognitive deficits occur, has become the health challeng

249 e that DISC1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through pr

250 ta40/42, amyloid plaque density, and rescued cognitive deficits of APP/PS1 transgenic mice.

251 re consistently and robustly associated with cognitive deficits of ASD and ID in humans, and overexpr

252 hibitor of 2-AG biosynthesis O7460 abolished cognitive deficits of nicotine abstinence, whereas the i

253 r the treatment of the clinical symptoms and cognitive deficits of schizophrenia is unsatisfactory, w

254 amofrontal connectivity has been involved in cognitive deficits of schizophrenia.

255 eep-dependent memory consolidation among the cognitive deficits of SZ and implicates reduced sleep sp

256 e abnormal prediction error signaling in the cognitive deficits of the disorder.

257 efore study enrollment with either objective cognitive deficits or subjective cognitive complaints we

258 ssive syndrome (PCS), neuropsychological and cognitive deficits, or chronic traumatic encephalopathy

259 sociated with abnormal levels of biomarkers, cognitive deficits, or with impaired axonal integrity of

260 However, clinical reports of long-lasting cognitive deficits, particularly in subjects who discont

261 At more advanced ages (16-19 months), cognitive deficits progressed in conjunction with restin

262 onsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-

263 have employed lighting conditions that cause cognitive deficits rather than improvements.

264 anied by recurrent seizures, the severity of cognitive deficits reflects the degree of calbindin redu

265 to anodal tDCS as a promising tool to reduce cognitive deficits related to working memory in stress-r

266 genetic mechanisms underlying developmental cognitive deficits remain poorly understood, and no trea

267 elevant contributing factor for the onset of cognitive deficits resulting from abnormal increases of

268 nally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as repor

269 -linked P497S or P506T UBQLN2 mutations have cognitive deficits, shortened lifespans, and develop mot

270 Clinically, cognitive deficits should be conceptualized as individua

271 identification of treatments for age-related cognitive deficits.SIGNIFICANCE STATEMENT People and mic

272 ormance (r = 0.182; P = .184) and related to cognitive deficits such as attention and perception (rho

273 s that could underlie adaptive behaviors and cognitive deficits, such as those observed in neuropsych

274 yrus, may participate in hippocampal-related cognitive deficits, such as those reported in patients w

275 a) plaques, tau neurofibrillary tangles, and cognitive deficits, suggesting that it contributes to th

276 re more likely to develop mood disorders and cognitive deficits than women in the general population.

277 This dysfunction is manifest as cognitive deficits that appear to arise from disturbance

278 ropathic pain and underlie the mPFC-specific cognitive deficits that are comorbid with neuropathic pa

279 Schizophrenia is characterized by profound cognitive deficits that are not alleviated by currently

280 companying these changes were behavioral and cognitive deficits that could be rescued by either desig

281 d far less than the social-communication and cognitive deficits that define ASD, but a mechanistic un

282 for PS symptoms, with the former relating to cognitive deficits that increase the risk for developing

283 imized individuals were largely explained by cognitive deficits that predated childhood victimization

284 Schizophrenia is associated with cognitive deficits that reflect impaired cortical inform

285 r could also be key to the poorly understood cognitive deficits, that typically accompany sleep depri

286 , the hybrid 10 rescued transgenic mice from cognitive deficits, thereby emerging as an interesting d

287 f nicotine and related agonists for treating cognitive deficits, these data suggest that daily dosing

288 This suggests that tau pathology may lead to cognitive deficits through a variety of mechanisms, incl

289 ullary pinning in male mice, associated with cognitive deficits, we characterized the effects on the

290 ed with prenatal brain insults and premorbid cognitive deficits, we tested the a priori hypothesis th

291 examine possible neuroanatomical sources of cognitive deficits, we used a comprehensive diffusion-we

292 effects of glutamate positive modulators on cognitive deficits were evaluated for overall cognitive

293 s before the study and with varied motor and cognitive deficits were randomly assigned by use of comp

294 ia (ALL) or brain tumor (BT) with identified cognitive deficits were randomly assigned to computerize

295 ecipitation of nicotine withdrawal, when the cognitive deficits were still present.

296 unclear whether these changes are related to cognitive deficits, which have been described in ET pati

297 These effects can result in cognitive deficits with functional effects on work and s

298 terised by a triad of motor, psychiatric and cognitive deficits with the latter classically attribute

299 associated with increased anxiety and robust cognitive deficits without locomotor dysfunction.

300 een associated with psychiatric symptoms and cognitive deficits, yet we have almost no knowledge of t