ライフサイエンスコーパス: cognitive impairment

1 unction and 5,453 voxels in patients without cognitive impairment).

2 core of SOFA (severity of illness) and MMSE (cognitive impairment).

3 s potential use in the treatment of vascular cognitive impairment.

4 hether treatment of SDB might reduce risk of cognitive impairment.

5 All had some degree of cognitive impairment.

6 s underlying pathologic processes leading to cognitive impairment.

7 on the relationship between SDB and risk of cognitive impairment.

8 vation is instrumental in the development of cognitive impairment.

9 othesis that cortical tau is associated with cognitive impairment.

10 causes of clinical stroke can cause vascular cognitive impairment.

11 1.3 L, and 59% had evidence of mild/moderate cognitive impairment.

12 ould be associated with subcortical vascular cognitive impairment.

13 both aging-related Ca(2+) dysregulation and cognitive impairment.

14 ippocampal neurons associated to hippocampal cognitive impairment.

15 were based on standard tests or diagnosis of cognitive impairment.

16 se including developmental delay and AD-like cognitive impairment.

17 psychosocial functioning in people with mild cognitive impairment.

18 st important in conferring late-life risk of cognitive impairment.

19 p between beta-amyloid burden and AD-related cognitive impairment.

20 y obvious developmental defects nor signs of cognitive impairment.

21 at unlike other LGMD types, all patients had cognitive impairment.

22 cluded, and a score less than 82 represented cognitive impairment.

23 ian if the screen results indicated possible cognitive impairment.

24 adation JZL184 did not produce any effect in cognitive impairment.

25 y disease were independently associated with cognitive impairment.

26 ave several concurrent medical disorders and cognitive impairment.

27 ion is a major cause of age-related vascular cognitive impairment.

28 icient to protect these mice from developing cognitive impairment.

29 cytosis by macrophages of patients with mild cognitive impairment.

30 ccidents, psychotic symptoms, and short-term cognitive impairment.

31 nitive reserve were associated with post-HCT cognitive impairment.

32 hysiology of schizophrenia and mechanisms of cognitive impairment.

33 ionship in the association between Abeta and cognitive impairment.

34 V) who have previously had syphilis may have cognitive impairment.

35 served in schizophrenia, and correlates with cognitive impairment.

36 associated variables and post-HCT trends of cognitive impairment.

37 nity for the present reappraisal of vascular cognitive impairment.

38 ataxia, abnormal eye movements, and variable cognitive impairment.

39 rillary tangle (NFT) formation, resulting in cognitive impairment.

40 agnosed Alzheimer's and subcortical vascular cognitive impairment.

41 ons is believed to contribute to age-related cognitive impairments.

42 enal responsivity and reduced stress-induced cognitive impairments.

43 ent and dementia in adults without diagnosed cognitive impairments.

44 wide range of AD-like pathophysiological and cognitive impairments.

45 between oxidative stress and behavioral and cognitive impairments.

46 and believed to be associated with transient cognitive impairments.

47 rdiovascular disorders, and neurological and cognitive impairments.

48 populations with limited health literacy and cognitive impairments.

49 neural damage, often resulting in long-term cognitive impairments.

50 s pathology (including amyloid-positive mild cognitive impairment), 19 patients with progressive supr

51 ally linked to major mental illnesses(2) and cognitive impairment(3).

52 ded 35 patients with type 2 diabetes without cognitive impairment, 35 with MCI, and 35 with AD.

53 The overall effect on cognition in mild cognitive impairment across 17 trials was moderate (Hedg

54 tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spec

55 le sex was associated with increased risk of cognitive impairment after hospital discharge.

56 Cognitive impairment after major noncardiac surgery and

57 a exposure is an independent risk factor for cognitive impairment after major noncardiac surgery asso

58 physiology of neurodegenerative diseases and cognitive impairment after traumatic brain injury, all h

59 The risks and implications of cognitive impairment after WBRT should be considered at

60 owing the most significant associations with cognitive impairment (age, UPSIT, RBDSQ, CSF Abeta42, an

61 In 38 older human adults with amnestic mild cognitive impairment (aMCI) or normative cognition, we m

62 , including 10 probable AD, 15 amnestic mild cognitive impairment (aMCI), and 10 cognitively healthy

63 cific parameters of brain imaging related to cognitive impairment and 2) discriminates patients with

64 imer's disease (AD), non-AD dementia or mild cognitive impairment and 20 age-matched and sex-matched

65 hing is associated with an increased risk of cognitive impairment and a small worsening in executive

66 F-actin levels in postmortem brain from mild cognitive impairment and AD patients compared with subje

67 our findings propose a new way to fight mild cognitive impairment and aging-related cognitive deterio

68 entary on this article.Individuals with mild cognitive impairment and Alzheimer's disease clinical di

69 d was significantly elevated for Abeta+ mild cognitive impairment and Alzheimer's disease subjects re

70 nal changes in microglial activation in mild cognitive impairment and Alzheimer's disease subjects.

71 ation of neuroanatomical alterations in mild cognitive impairment and Alzheimer's disease that can co

72 opathy (EIEE) experience severe seizures and cognitive impairment and are at increased risk for sudde

73 l vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in

74 cognitive decline and delaying the onset of cognitive impairment and dementia in adults without diag

75 ion has previously been associated with mild cognitive impairment and dementia in various cross-secti

76 The prevalence of cognitive impairment and dementia is expected to increas

77 daily living were pooled separately for mild cognitive impairment and dementia trials.

78 Cognitive impairment and dementia, including Alzheimer d

79 is associated with an increased incidence of cognitive impairment and dementia.

80 2 diabetes is associated with a high risk of cognitive impairment and dementia.

81 ciation of playing high school football with cognitive impairment and depression at 65 years of age.

82 eclinical stage of AD who may be at risk for cognitive impairment and eligible for inclusion in AD pr

83 th clinically diagnosed subcortical vascular cognitive impairment and negatively predicted Alzheimer'

84 gic data supporting previous studies on mild cognitive impairment and progression to AD are reviewed,

85 gomers in human brain tissue correlated with cognitive impairment and reductions in synapsin expressi

86 in intervention strategy to prevent or delay cognitive impairment and the target population remain to

87 ants who were judged clinically as having no cognitive impairment and underwent multimodality imaging

88 CL volume was higher in patients with cognitive impairment and was correlated with functional

89 Sleep loss causes profound cognitive impairments and increases the concentrations o

90 ncreased risk of age-associated physical and cognitive impairments and ultimately, death.

91 pleted the study (5 healthy controls, 6 mild cognitive impairment, and 10 AD) received 370 MBq of flo

92 ely healthy controls, 197 patients with mild cognitive impairment, and 180 patients with AD with deme

93 disease (AD) patients, 40 subjects with mild cognitive impairment, and 40 controls with subjective co

94 Clinical symptoms of gait ataxia, diplopia, cognitive impairment, and facial paraesthesia did not di

95 ively normal controls, individuals with mild cognitive impairment, and individuals with AD to assess

96 roinfarcts are independently associated with cognitive impairment, and that these lesions are likely

97 baseline and follow-up in subjects with mild cognitive impairment, and this was compared with subject

98 enrolled adults without clinically diagnosed cognitive impairments, and compared cognitive and dement

99 erectile dysfunction, sleep disturbance, and cognitive impairment-and analysed all remaining AEs grou

100 These radiation-induced cognitive impairments are accompanied by functional and

101 fail to develop or break down, symptoms and cognitive impairments arise.

102 sults showed that BAY reversed Abeta-induced cognitive impairment as shown in the water maze test and

103 r tau binding were associated with increased cognitive impairment, as assessed by Mini-Mental State E

104 Chronic BBB leakiness was associated with cognitive impairment, as assessed by the novel object re

105 lationships between MD-PFC abnormalities and cognitive impairment, as well as the neuronal mechanisms

106 ommentary on this article.Subjects with mild cognitive impairment associated with cortical amyloid-be

107 gnitive dysfunction (POCD), a more prolonged cognitive impairment associated with longer length of ho

108 There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS

109 hrenia Consensus Cognitive Battery (MCCB) in cognitive impairment associated with schizophrenia and t

110 Placebo-controlled trials for cognitive impairment associated with schizophrenia are a

111 based cognitive tests in clinical trials for cognitive impairment associated with schizophrenia can c

112 and ameliorates synapse loss, thus rescuing cognitive impairments associated with hAPP mice.

113 +/-) mice that may contribute to epilepsy or cognitive impairments associated with lissencephaly.

114 maturely born individuals and mediates adult cognitive impairments associated with prematurity.

115 nosed Parkinson's disease, the occurrence of cognitive impairment at 2 year follow-up can be predicte

116 uptake on DAT imaging) allowed prediction of cognitive impairment at 2 years (0.80, 0.74-0.87; p=0.00

117 and July 13, 2016, from participants with no cognitive impairment at first assessment who were follow

118 henotypic features that define a syndrome of cognitive impairment, behavioral alterations, intrauteri

119 upportive sign, not only for the presence of cognitive impairment, but also for cerebral small vessel

120 rs have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and ps

121 ted in pathways that generate sleepiness and cognitive impairments, but existing mathematical models

122 In the CNS, mild cognitive impairment can be attributed to obesity-induce

123 Twenty-six (62%) of 42 mild cognitive impairment cases showed a raised cortical amyl

124 ty-two (85%) of the 26 amyloid-positive mild cognitive impairment cases showed clusters of increased

125 ation in a majority of amyloid positive mild cognitive impairment cases, its cortical distribution ov

126 uld be present in most amyloid-positive mild cognitive impairment cases.

127 lammation (microglial activation) in 42 mild cognitive impairment cases.

128 s CA1 and these increases correlate with the cognitive impairment caused by systemic PCP administrati

129 These findings point to the cognitive impairments caused by PCP arising from neural

130 tential target for therapeutics to limit the cognitive impairment characteristic of neuroAIDS.

131 hn1 deficiency in the mouse generated severe cognitive impairments, characterized by both a high occu

132 l dysfunction underlies chemotherapy-induced cognitive impairment (CICI), we explored the efficacy of

133 f housing damage was associated with risk of cognitive impairment (coefficient = 0.04, 95% confidence

134 follow-up microglial activation in the mild cognitive impairment cohort compared to controls were in

135 tion of 18% in microglial activation in mild cognitive impairment cohort over 14 months, which was as

136 es at 2 years' follow-up, and a diagnosis of cognitive impairment (combined mild cognitive impairment

137 s down-regulated in persons with AD and mild cognitive impairment compared with controls.

138 isk score had an increased hazard for global cognitive impairment compared with those in the lowest q

139 s with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional

140 isease and cerebrovascular events, diabetes, cognitive impairment, decreased quality of life, and mot

141 , we built a prediction algorithm for global cognitive impairment (defined as Mini Mental State Exami

142 dysfunction, upper motor neuron dysfunction, cognitive impairment, depression and lower quality of li

143 lationship to age, and to the development of cognitive impairment due to Alzheimer's disease.

144 ntrols, 3 with a history of TBI, 2 with mild cognitive impairment due to suspected Alzheimer disease)

145 Our results are consistent with the idea of cognitive impairments due to distraction by both parties

146 f disease were independently associated with cognitive impairment during and after hospitalization.

147 opathology at death but without evidence for cognitive impairment during life (N = 15) from the autop

148 us coeruleus dysfunction reminiscent of mild cognitive impairment/early Alzheimer's disease.

149 Slopes for individuals who developed mild cognitive impairment (eg, neuroticism: beta = 0.00; 95%

150 Thirty subjects (eight mild cognitive impairment, eight Alzheimer's disease and 14 c

151 teraction among brain regions for early mild cognitive impairment (eMCI) diagnosis.

152 by some adoptees and the adult remission of cognitive impairment, extended early deprivation was ass

153 alizing and social participation may prevent cognitive impairment following natural disaster.

154 d clinical stage (Alzheimer's disease > mild cognitive impairment > older cognitively normal) and was

155 on between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzhei

156 tion of vitamin D with incident dementia and cognitive impairment have been inconsistent.We investiga

157 l syndrome included younger age, preexisting cognitive impairment, higher preweaning mean daily opioi

158 ne: hazard ratio [HR] = 0.57, p < 0.05; mild cognitive impairment: HR = 0.19, p < .01), indicating th

159 l and neuropathological variables related to cognitive impairment in 1,092 participants (mean age = 7

160 flammation and neuronal damage that leads to cognitive impairment in 40-70% of HIV-infected people.

161 ions, and high NPC scorewere associated with cognitive impairment in a unique Brazilian sample with l

162 with Nrxs or NLs mediates synapse damage and cognitive impairment in AD models.

163 We found only subtle objective cognitive impairment in alumni athletes in the context o

164 ) protein may cause synapse degeneration and cognitive impairment in Alzheimer's disease (AD) by reac

165 gy is related in a region-specific manner to cognitive impairment in Alzheimer's disease.

166 ted the hypothesis that neurosyphilis causes cognitive impairment in HIV by amplifying HIV-related ce

167 or prevent neuroinflammation and subsequent cognitive impairment in HIV-positive patients.

168 ing that circulating ovarian hormones induce cognitive impairment in Met carriers.

169 Cognitive impairment in older individuals is a complex t

170 ed with the pathogenesis of vascular-related cognitive impairment in older individuals.

171 p a clinical-genetic score to predict global cognitive impairment in patients with the disease.

172 DISCUSSION: Cognitive impairment in PD is complex, with some individ

173 ET for assessment and risk stratification of cognitive impairment in PD.

174 a shared neurobiological mechanism underlies cognitive impairment in psychotic disorders.

175 f ultrastructural tract damage contribute to cognitive impairment in symptomatic CAD, which suggests

176 ation of seven imaging biomarkers related to cognitive impairment in the cohort of active professiona

177 Cognitive impairment in the group who spent more than 6

178 However, cognitive impairment in the later cohorts increased annu

179 hould be included in assessments of vascular cognitive impairment in the older population and as pote

180 Collectively, our results illustrate that cognitive impairment in zebrafish could be associated wi

181 he Rho-GAP oligophrenin-1 is associated with cognitive impairments in both human and mouse.

182 aumatic brain injury (B-TBI) induced lasting cognitive impairments in novel object recognition and le

183 cell/circuit underpinnings that may underlie cognitive impairments in offspring of mothers that abuse

184 de the mechanism underlying a broad range of cognitive impairments in schizophrenia.

185 the development of interventions that target cognitive impairments in this chronic and debilitating m

186 Alzheimer's disease-related pathological and cognitive impairments in vivo and indicate the potential

187 Importantly, persistent cognitive impairments in working memory, verbal memory,

188 HIV-infected individuals, the likelihood of cognitive impairment increases with age, and duration of

189 uld reflect that activated microglia in mild cognitive impairment initially may adopt a protective ac

190 gagement, conduct or emotional problems, and cognitive impairment (IQ score <80) during childhood (ag

191 SUMMARY OF BACKGROUND DATA: Postoperative cognitive impairment is a prevalent individual and publi

192 Purpose Cancer-related cognitive impairment is an important problem for patient

193 Vascular cognitive impairment is common both after stroke and in

194 Cognitive impairment is one of the most common problem s

195 Purpose Cognitive impairment is reported frequently by cancer su

196 Purpose Cognitive impairment is well-recognized after myeloablat

197 ess, inflammatory arthritis, prosthetic leg, cognitive impairment, lack of a telephone, or contraindi

198 of neurogenetic syndromes in general (e.g., cognitive impairment), limited progress has been made in

199 Cognitive impairment, lower gray matter volume, and whit

200 g provision included: caring for people with cognitive impairment; managing the emotions of patients,

201 Monocyte/macrophages of patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) ar

202 cally classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants

203 n, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been establi

204 dy was conducted among individuals with mild cognitive impairment (MCI) and cognitively normal indivi

205 u level, cognitive decline, and risk of mild cognitive impairment (MCI) and dementia; (2) whether thi

206 atients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD witho

207 epression is common in individuals with mild cognitive impairment (MCI) and may confer a higher likel

208 f patients with Alzheimer's disease and mild cognitive impairment (MCI) are defective in amyloid-beta

209 brain atrophy and cognitive function in mild cognitive impairment (MCI) due to Alzheimer's disease (A

210 scriminates patients with diabetes with mild cognitive impairment (MCI) from those with normal cognit

211 d biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (AD

212 Mild cognitive impairment (MCI) is common in early Parkinson'

213 f patients with Alzheimer's disease and mild cognitive impairment (MCI) is deregulated with highly in

214 nging from normal aging to AD-including mild cognitive impairment (MCI) not converting or converting

215 iduals with high risk of progression to mild cognitive impairment (MCI) or AD.

216 activities and decreased odds of having mild cognitive impairment (MCI) or Alzheimer disease have bee

217 and AD, as well as in their prodromal, mild cognitive impairment (MCI) phases.

218 s in serum samples from AD patients and Mild cognitive impairment (MCI) subjects relative to healthy

219 on CSF biomarkers and progression from mild cognitive impairment (MCI) to Alzheimer's dementia.

220 a clinical marker for progression from mild cognitive impairment (MCI) to dementia.

221 470 patients (138 with AD, 332 with mild cognitive impairment (MCI)) were selected from the Alzhe

222 on method during sleep in patients with mild cognitive impairment (MCI), a precursor of AD, and advan

223 ely healthy controls, 197 patients with mild cognitive impairment (MCI), and 180 patients with AD dem

224 to prevent or delay cognitive decline, mild cognitive impairment (MCI), or dementia are uncertain.

225 to prevent or delay cognitive decline, mild cognitive impairment (MCI), or dementia is uncertain.

226 spectroscopic imaging in subjects with mild cognitive impairment (MCI), patients with Parkinson dise

227 clinicians, especially in patients with mild cognitive impairment (MCI).

228 hich is already evident at the stage of mild cognitive impairment (MCI).

229 ate the nature of olfactory deficits in mild cognitive impairment (MCI).

230 comes following a clinical diagnosis of mild cognitive impairment (MCI).

231 mes for adults with normal cognition or mild cognitive impairment (MCI).

232 nical BDNF data in patients with AD and mild cognitive impairment (MCI, a prodromal stage of AD) with

233 Forty-five patients with mild cognitive impairment (mean age +/- SD, 72.69 +/- 6.54 y;

234 ning of GLUT1-DS in children and adults with cognitive impairment, movement disorder, or epilepsy.

235 imer's disease n = 110; subcortical vascular cognitive impairment n = 116) with standardized MRI and

236 ed 4 categories of those with no significant cognitive impairment (n = 42), those with frontal subcor

237 mical differences between subjects with mild cognitive impairment (n = 530) and Alzheimer's disease (

238 s (Abeta) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic pr

239 tion of synaptic activity is associated with cognitive impairment observed in a number of psychiatric

240 Cognitive impairment occurs across the psychosis spectru

241 patient despite evidence that postoperative cognitive impairment occurs in up to 65% of older patien

242 ange in personality before the onset of mild cognitive impairment or dementia was identified.

243 nosis of cognitive impairment (combined mild cognitive impairment or dementia) at 2 years as outcome

244 pathology, resulting in mixed forms of mild cognitive impairment or dementia.

245 bout the efficacy of CCT in people with mild cognitive impairment or dementia.

246 lled trials of CCT in older adults with mild cognitive impairment or dementia.

247 nality traits occur before the onset of mild cognitive impairment or dementia.

248 lation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders i

249 the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/A

250 The study included 262 patients with mild cognitive impairment or subjective cognitive decline fro

251 1.2-2.7, P = 0.002) and subcortical vascular cognitive impairment (OR 2.4, 95% CI 1.6-3.6, P < 0.001)

252 lar disease typically manifests with stroke, cognitive impairment, or both.

253 linical diagnosis of Alzheimer disease, mild cognitive impairment, or normal cognition underwent T1-w

254 ditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers.

255 polarization and improved cognition in mild cognitive impairment patients on omega-3 supplementation

256 indicated greater tau binding in AD and mild cognitive impairment patients than in controls in a patt

257 rapy Cognitive Function [FACT-COG] perceived cognitive impairment [PCI] subscale): difference between

258 Cognitive impairment persists despite suppression of pla

259 xposure has been associated with age-related cognitive impairment, possibly because of enhanced infla

260 Vascular cognitive impairment refers to all forms of cognitive di

261 d with subsequent mortality, disability, and cognitive impairment, regardless of age.

262 Long-term comorbidities such as cognitive impairment remain prevalent in otherwise effec

263 tially diagnosed as having MCI or subjective cognitive impairment (SCI).

264 n discoordination as the root of PCP-induced cognitive impairment.SIGNIFICANCE STATEMENT Hippocampal

265 ifiable risk factors for delirium, including cognitive impairment, sleep deprivation, immobility and

266 p<0.001), disability (SMD=0.58; p=0.01) and cognitive impairment (SMD=-0.22; p=0.03) were all associ

267 nitiative cohort, including progressive mild cognitive impairment, stable MCI and Normal Control part

268 VT was greater in mild cognitive impairment subjects than controls in the occip

269 ically diagnosed Alzheimer's disease or mild cognitive impairment subjects.

270 Motor dysfunction and cognitive impairment, suggested by corresponding Interna

271 alities in sleep markers are correlated with cognitive impairment, suggesting that not only seizures,

272 Cognitive impairment, termed chemobrain, is a common neu

273 rt that male schizophrenia patients had more cognitive impairment than females on reasoning and probl

274 nabis use, such as addiction, psychosis, and cognitive impairment) than cannabis with lower concentra

275 ting the acute inflammatory response reduces cognitive impairments, the degree of neuropathology, and

276 e full range of cognitive deficits from mild cognitive impairment to dementia.

277 toms that range from anxiety, depression and cognitive impairment to seizures and, in rare cases, psy

278 ognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patie

279 alance, speech, swallowing, eye movement and cognitive impairment, ultimately leading to death.

280 Cognitive impairments, uncontrolled drinking, and neurop

281 Accuracy of prediction of cognitive impairment using age alone (area under the cur

282 structed a prediction model for diagnosis of cognitive impairment using logistic regression analysis.

283 During 24569 person-years, mild cognitive impairment was diagnosed in 104 (5.1%) individ

284 ociation between Abeta1-42 and Abeta1-40 and cognitive impairment was only observed in patients with

285 Dementia or disabling cognitive impairment was predicted with an AUC of 0.88 (

286 At 3 years post-HCT, global cognitive impairment was present in 18.7% of autologous

287 ations between neuropathological lesions and cognitive impairment were investigated using ordinal log

288 lon4 allele; those with subcortical vascular cognitive impairment were more likely to have hypertensi

289 f restricted multiple lobar CMBs or CSS with cognitive impairment were partially mediated by thinning

290 .3%] and 64 men [27.7%]) without significant cognitive impairment were randomly assigned to the TIP i

291 Too few cases of cognitive impairment were reported for a statistically r

292 Those with Alzheimer's disease-related cognitive impairment were younger, more likely to have a

293 Cognitive impairments were also related to greater suppr

294 by peripheral and central symptoms including cognitive impairments which have been associated with re

295 Cognitive impairment, which has been a non-supporting fe

296 microglial activation in subjects with mild cognitive impairment, while subjects with Alzheimer's di

297 s performed in elderly people diagnosed with cognitive impairment with or without dementia (cases gro

298 6; 95% CI, 1.05-1.50) more likely to develop cognitive impairment, with no evidence of publication bi

299 The cognitive risk score predicted cognitive impairment within 10 years of disease onset wi

300 s born prematurely, a leading cause of neuro-cognitive impairment worldwide [7].