ライフサイエンスコーパス: cognitively

1 sh-speaking patients who were physically and cognitively able to fill out the survey without assistan

2 cific imaging in the medial temporal lobe of cognitively assessed, aged rhesus macaques.

3 entia (AD) (n = 24), a disease that has been cognitively associated with CTE.

4 search neuroimaging center on a cohort of 71 cognitively asymptomatic adults enriched for AD risk.

5 Inventory-Questionnaire were less common in cognitively asymptomatic mutation carriers than in non-c

6 xperiencing at least one behavioural sign in cognitively asymptomatic mutation carriers was lower tha

7 found lower rates of depressive symptoms in cognitively asymptomatic mutation carriers.

8 ysis found cingulate cortex to be thinner in cognitively average 80+ year olds (n = 21) than in the h

9 ickness in SuperAgers (n = 31) compared with cognitively average 80+ year olds and also to the much y

10 he cingulate cortex in five SuperAgers, five cognitively average elderly individuals, and five indivi

11 lan to investigate the ItchyQuant further in cognitively challenged populations.

12 found impact on achievement in school and in cognitively challenging careers.

13 ce, the ability to perform a wide variety of cognitively challenging tasks well.

14 Patients were cognitively classified as having ALS with normal cogniti

15 thically justified to accept an offer from a cognitively competent patient with a life-threatening di

16 er, whether such a strategy is efficient for cognitively complex agents, from wild animals to humans.

17 nderstanding spatial exploration patterns of cognitively complex foragers.

18 iation helping in a relatively narrow set of cognitively complex tasks that require creativity and de

19 early automatic attentional (EPN) and later cognitively controlled (N2, LPP) patterns of neural resp

20 I criteria, 70% were cognitively stable, 19% cognitively declined and 11% improved over 36 months.

21 5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improved and 19% fluctuated ov

22 ential process and one might expect it to be cognitively demanding and serial rather than fast and au

23 ng and suggest a critical role for SC in the cognitively demanding Anti task.

24 core component of auditory scene analysis, a cognitively demanding function that is vulnerable in Alz

25 gated how stress shifts processes underlying cognitively demanding learning versus less demanding fea

26 Prolonged continuous performance of a cognitively demanding task induces cognitive fatigue and

27 In humans, cognitively demanding tasks of many types recruit common

28 network is recruited during a wide range of cognitively demanding tasks.

29 ity to task-positive network activity during cognitively demanding tasks; and anhedonia from hypoacti

30 asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and p

31 onment, which is more accurate but also more cognitively demanding.

32 Hypercholesterolemia is associated with cognitively deteriorated states.

33 Importance: Cognitively distinct subgroups of schizophrenia have bee

34 Evolutionary reasoning shows how we can have cognitively driven behavioral universals and yet extreme

35 ely penetrated mainly through the effects of cognitively driven spatial and object-centered attention

36 tinction confirms the existence of multiple, cognitively driven, supraspinal mechanisms for pain modu

37 ated ICU filled with patients who are awake, cognitively engaged, and mobile with family members enga

38 Results Noncontrast MR imaging followed by cognitively guided MR biopsy (no standard biopsy if MR i

39 was analyzed in postmortem frontal cortex of cognitively healthy and histopathologically confirmed in

40 We compared coding region variants of 53 cognitively healthy centenarians and 45 patients with Al

41 au-specific PET radioligand (18)F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (

42 whom had MCI and a history of concussion, 21 cognitively healthy control participants, and 6 control

43 tic mild cognitive impairment (aMCI), and 10 cognitively healthy controls (HCs).

44 Among 193 cognitively healthy controls, 197 patients with mild cog

45 d to measure plasma NFL concentration in 193 cognitively healthy controls, 197 patients with mild cog

46 imer's disease factors in a cohort including cognitively healthy elderly individuals and individuals

47 t with or without dementia (cases group) and cognitively healthy elderly people (control group); data

48 (MCI), Alzheimer's disease (AD) dementia and cognitively healthy elderly, using a ultrasensitive immu

49 itudinal biomarker cohort study involving 35 cognitively healthy individuals who underwent cerebrospi

50 dence of Alzheimer's pathological changes in cognitively healthy individuals.

51 I when occurring alone or in combination and cognitively healthy non-depressed controls.

52 nt presence of amyloid-beta in the brains of cognitively healthy older people has been interpreted as

53 METHODS AND We analysed data from 2,315 cognitively healthy participants aged 65 y and over in t

54 tic group (P < 0.001) and was seen in 21% of cognitively healthy people but only 6% in dementia patie

55 graphy amyloid-beta, is relatively common in cognitively healthy people may be considered when using

56 iple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large

57 ted with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathol

58 erred in beta-amyloid-positive (Abeta+) mild cognitively impaired (MCI) and cognitively normal (CN) p

59 orth American populations of converting mild cognitively impaired (MCI) subjects (Alzheimer's disease

60 2 subjects with a premortem diagnosis of non-cognitively impaired (NCI; n = 23), mild cognitive impai

61 ed testing, fighters were separated into the cognitively impaired and nonimpaired groups on the basis

62 gh Compound B (PiB) PET at baseline were not cognitively impaired at baseline and had at least 1 clin

63 of donepezil greater for those who were more cognitively impaired before study treatment.

64 ean age+/-SD 62+/-11 years; 16% (n=237) were cognitively impaired during hospitalization, and 11% (n=

65 ts by CR tended to be more pronounced in the cognitively impaired group compared with the cognitively

66 11 in a cognitively normal group and 57 in a cognitively impaired group) from the Wisconsin Registry

67 composed of a cognitively normal group and a cognitively impaired group, higher CR was associated wit

68 rse on all motor and sensory tests, and were cognitively impaired in processing speed and verbal memo

69 In cognitively impaired irradiated mice we observed increas

70 d is present at higher levels in brains from cognitively impaired mice and humans with AD.

71 u deposition in 41 cognitively normal and 11 cognitively impaired older adults using the radioactive

72 ide relief to a large group of depressed and cognitively impaired older adults who have few treatment

73 Results Cognitively impaired patients (n = 53 [49.1%], classifie

74 A total of 471 cognitively impaired patients and 243 cognitively normal

75 Supportive therapy for cognitively impaired patients focuses on expression of a

76 Compared with CN individuals, cognitively impaired patients had a greater frequency of

77 Cognitively impaired patients showed increased variabili

78 ficance of diagonal earlobe crease (DELC) in cognitively impaired patients using imaging biomarkers,

79 Compared with Abeta-negative cognitively impaired patients with minimal WMH, Abeta-po

80 density may increase diagnostic accuracy in cognitively impaired patients.

81 jective: To contrast tau aggregation in DLB, cognitively impaired persons with PD (PD-impaired), cogn

82 f amyloid imaging results is desired by many cognitively impaired subjects and seems to be safe once

83 d detection will translate into a benefit to cognitively impaired subjects.

84 Twenty patients (39.2%) were considered cognitively impaired using a cutoff of <23 of 30 points.

85 4] vs 1.50 x 10-4 [0 to 1.01 x 10-3]) and in cognitively impaired vs unimpaired individuals (count: 2

86 ed suicide in the previous 2 months, or were cognitively impaired, or who had bipolar disorder or psy

87 s, they overreach by claiming that vision is cognitively impenetrable.

88 aortic valve area was lower in patients who cognitively improved (median aortic valve area 0.60 cm(2

89 ation score <26 points), 18 patients (37.5%) cognitively improved.

90 younger than 60 years (range, 33-57 years), cognitively intact "aged" individuals aged older than 60

91 from 79 individuals was evaluated, including cognitively intact "young" individuals aged younger than

92 patients with late-onset AD (LOAD), and 7001 cognitively intact controls (age at examination, >65 yea

93 (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with A

94 ogy (p < 0.001) were more severe in MCI than cognitively intact controls.

95 Rare individuals remain cognitively intact despite the presence of neuropatholog

96 sh white individuals comparing AD cases with cognitively intact elderly controls.

97 s analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD an

98 anol consumption on cognitive performance in cognitively intact elderly subjects.

99 nd only approximately 20% of patients remain cognitively intact in the long term.

100 Fifteen cognitively intact nursing home residents from two facil

101 A total of 1657 cognitively intact older adults receiving treatment for

102 t a compromised mesocorticolimbic pathway in cognitively intact PD patients with apathy.

103 A community-based sample of 181 cognitively intact, healthy adults were recruited from t

104 uals older than 85 years of age who remained cognitively intact.

105 Fourteen TD and 12 PIGD cognitively-intact patients and 21 age- and sex-matched

106 e cognitively rich interpretations as far as cognitively lean interpretations are conceivable, and ap

107 iated by the MR, resulting in a dominance of cognitively less demanding amygdala-based learning, whic

108 Comparison between cognitively matched normal adult subgroups, delineated a

109 cross-sectional observational study of 1331 cognitively non-impaired subjects aged 50-89 drawn from

110 neration (N+) changed dramatically by age in cognitively non-impaired subjects.

111 developed incident MCI vs those who remained cognitively normal (-2.0 [5.1] vs -1.2 [4.9] kg; P = .00

112 As part of a cohort study, cognitively normal (Clinical Dementia Rating [CDR] of 0)

113 A total of 59 participants who were cognitively normal (CN) (Clinical Dementia Rating [CDR]

114 of 471 cognitively impaired patients and 243 cognitively normal (CN) individuals were included in thi

115 Cognitively normal (CN) participants had olfactory funct

116 Among cognitively normal (CN) participants oversampled for ele

117 (Abeta+) mild cognitively impaired (MCI) and cognitively normal (CN) participants.

118 ly individuals without dementia, including a cognitively normal (CN) subsample of 144 adults, enrolle

119 We studied 26 cognitively normal (CN), 194 MCI (39 MCI-progressors, 14

120 age 50-95 years) comprising amyloid negative cognitively normal (n = 42), clinically-diagnosed mild c

121 and AD risk in 309 individuals (191 AD, 118 cognitively normal [CN] controls) from the San Francisco

122 Cognitively normal ADRC participants (n = 219) were 60.7

123 pants were a population-based sample of 1519 cognitively normal adults 55 years and older.

124 In cognitively normal adults, CAC was associated with corti

125 isodic-memory performance and MTL atrophy in cognitively normal adults, independent of Abeta.

126 ints, they were obtained from 22 others when cognitively normal and 1 to 10 yr later when diagnosed w

127 Here we examined tau deposition in 41 cognitively normal and 11 cognitively impaired older adu

128 K-6240 in tissue slices and homogenates from cognitively normal and AD human brain donors to evaluate

129 P using postmortem orbitofrontal cortex from cognitively normal and AD human brains.

130 he model's staging system strongly separates cognitively normal and Alzheimer's disease subjects (max

131 hile more variable results were observed for cognitively normal and non-Alzheimer's disease groups.

132 increases in Abeta+ and Abeta- subgroups and cognitively normal APOE4 carriers and noncarriers; the s

133 ects in Abeta+ pAD, MCI, and NC subjects and cognitively normal APOE4 carriers.

134 in cognitively normal controls (NCs), and in cognitively normal apolipoprotein E4 (APOE4) carriers an

135 riant and found a mother-daughter pair, both cognitively normal at ages 72 and 84 years, respectively

136 ears old at the beginning of the study, were cognitively normal at baseline (a Mini-Mental State Exam

137 Participants 70 years or older who were cognitively normal at baseline were followed up to the o

138 Of the 1630 participants who were cognitively normal at the time of the smell test, 33 die

139 Exploratory analyses of a cognitively normal cohort followed up for a median of 3.

140 = 0.492 (P < 0.001) for p-tau181 Within the cognitively normal cohort, levels of amyloid-beta42, but

141 ese estimates with cross-sectional data from cognitively normal control individuals (age 65-89 years)

142 r mild cognitive impairment (n = 13), and 21 cognitively normal control subjects (ages 41-76, nine ma

143 nical diagnosis of very mild AD (n = 23) and cognitively normal controls (n = 64) who were enrolled i

144 nts with mild cognitive impairment (MCI), in cognitively normal controls (NCs), and in cognitively no

145 decline in patients with symptomatic AD and cognitively normal controls over time.

146 he frequency of this variant in AD cases and cognitively normal controls to determine whether this va

147 decline in patients with symptomatic AD and cognitively normal controls was performed.

148 inical diagnosis of early symptomatic AD and cognitively normal controls who were enrolled in longitu

149 Cognitively normal controls whose CSF VILIP-1, tau, or p

150 ere evaluated in 8943 US AD cases, 10 480 US cognitively normal controls, 862 Swedish AD cases, and 7

151 linical dataset representing the spectrum of cognitively normal controls, individuals with mild cogni

152 or frontotemporal dementia (FTD) and matched cognitively normal controls.

153 no history of seizures, and 19 age-matched, cognitively normal controls.

154 in atrophy in participants with early AD and cognitively normal controls.

155 trols, 862 Swedish AD cases, and 707 Swedish cognitively normal controls.

156 tal of 17,008 individuals with AD and 37,154 cognitively normal elderly controls.

157 al lobe, together with Abeta PET imaging, in cognitively normal elderly human participants.

158 xtend investigations on fcMRI in a sample of cognitively normal elderly humans to regional measures o

159 Cognitively normal elderly individuals who engage in spe

160 In cognitively normal elderly individuals, incidental CMBs

161 We studied 393 cognitively normal elderly participants in the populatio

162 ology, and longitudinal cognitive decline in cognitively normal elderly subjects between 70 and 90 ye

163 dundant information and (2) relatively young cognitively normal elders tend to have either neurodegen

164 ectional cohort of 268 individuals (211 in a cognitively normal group and 57 in a cognitively impaire

165 In a sample composed of a cognitively normal group and a cognitively impaired grou

166 cognitively impaired group compared with the cognitively normal group.

167 pared with the mild cognitive impairment and cognitively normal groups (16.2 [9.4] vs 20.0 [10.3] and

168 The study comprised 265 cognitively normal individuals (135 women and 130 men; m

169 Fifty-four cognitively normal individuals (age = 65.8 +/- 8.3 years

170 A total of 564 cognitively normal individuals (median age, 78 years) fr

171 cognitive impairment (MCI) (n = 192) and in cognitively normal individuals (n = 110) from the Alzhei

172 Cognitively normal individuals (n = 164) who had undergo

173 = 530) and Alzheimer's disease (n = 314) and cognitively normal individuals (n = 399), thereby adding

174 We included 1425 cognitively normal individuals aged 70 to 89 years who w

175 rkers to predict future cognitive decline in cognitively normal individuals and, therefore, will be a

176 We analyzed data on 1394 cognitively normal individuals at baseline (8643 visits;

177 ges, we investigated baseline CSF markers in cognitively normal individuals at different stages of am

178 , we reprogramed human skin fibroblasts from cognitively normal individuals carrying APOE epsilon3/ep

179 mer disease (AD) are increasingly focused on cognitively normal individuals in the preclinical phase

180 udinal cognitive and biomarker data from 445 cognitively normal individuals in the United States and

181 treatment effect, such trials need to enroll cognitively normal individuals likely to show cognitive

182 als with mild cognitive impairment (MCI) and cognitively normal individuals receiving care at Alzheim

183 treatment effect, clinical trials enrolling cognitively normal individuals should selectively recrui

184 A cross-sectional study of 55 cognitively normal individuals with a mean (SD) age of 8

185 or Alzheimer-related cognitive decline among cognitively normal individuals with elevated brain amylo

186 vely impaired persons with PD (PD-impaired), cognitively normal individuals with PD (PD-normal), and

187 We enrolled 1,215 cognitively normal individuals, all of whom underwent hi

188 Among cognitively normal individuals, elevated brain amyloid (

189 We studied 1246 cognitively normal individuals, including 1209 participa

190 In cognitively normal individuals, neurodegeneration biomar

191 s associated with worse memory and HVa among cognitively normal individuals, while APOE epsilon4 is n

192 cal phenotypes, and 15 amyloid-beta-negative cognitively normal individuals, who underwent (18)F-AV14

193 and cortical thickness in a large sample of cognitively normal individuals, with special emphasis in

194 tissues with Abeta plaques from both AD and cognitively normal individuals.

195 and cortical thickness in a large sample of cognitively normal individuals.

196 rks of Alzheimer's disease (AD) pathology in cognitively normal individuals: (1) Tau, detected with a

197 healthy young adults (age range: 20-30), 96 cognitively normal older adults (age range: 61-96), and

198 Cognitively normal older adults (n = 174) were recruited

199 MTL atrophy contribute to episodic memory in cognitively normal older adults (n = 83; age, 77 +/- 6 y

200 Although some cognitively normal older adults also have Abeta plaques

201 very 18 months after the baseline visit (402 cognitively normal older adults in the ADNI and 49 cogni

202 ively normal older adults in the ADNI and 49 cognitively normal older adults in the IMAS were include

203 Forty-three young and 62 cognitively normal older adults underwent an fMRI sessio

204 tomography) and cognitive performance in 128 cognitively normal older adults who provided eligibility

205 n distinguish AD brain tissues from those of cognitively normal older adults with Abeta plaques.

206 nectivity in the default mode network in the cognitively normal older adults with amyloid burden, eff

207 mpound-B positron emission tomography in 154 cognitively normal older adults with four complementary

208 f loneliness with cortical amyloid burden in cognitively normal older adults, suggesting that lonelin

209 ues has the potential to distinguish AD from cognitively normal older adults, with or without Abeta a

210 den is associated with greater loneliness in cognitively normal older adults.

211 nal change in Abeta using PIB-PET imaging in cognitively normal older adults.

212 ation of Alzheimer's pathology are common in cognitively normal older adults.

213 ctivity in the MTL during memory encoding in cognitively normal older adults.

214 anges in human sleep quantity and quality in cognitively normal older adults.

215 amyloid burden and cognitive performance in cognitively normal older adults.We performed cross-secti

216 F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young con

217 rtance: Emotional and behavioral symptoms in cognitively normal older people may be direct manifestat

218 ease (AD) but both pathologies also occur in cognitively normal older people.

219 < 0.001) and Pittsburgh compound B-positive cognitively normal older subjects (T = 10.62, P < 0.001)

220 ained both in Pittsburgh compound B-negative cognitively normal older subjects (T = 6.66, P < 0.001)

221 but, only the Pittsburgh compound B-positive cognitively normal older subjects group showed significa

222 Among cognitively normal older subjects, 32 were further class

223 ction of diagnostic group among Abeta- older cognitively normal or clinically diagnosed Alzheimer's d

224 Among the participants who were cognitively normal or had subjective cognitive concerns,

225 Thirty-four healthy, cognitively normal participants (12 men, 22 women) aged

226 We report data from 238 cognitively normal participants (humans), sampled across

227 The study included 163 patients: 37 cognitively normal participants (mean [SE] age, 64 [2] y

228 person levels of NGRN increased over time in cognitively normal participants (mean [SE] level, 90 [45

229 range, 1651-3416 pg/mL]) were higher than in cognitively normal participants (median level, 1712 pg/m

230 e elevated in patients with AD compared with cognitively normal participants and predicted progressio

231 Within-person levels of NGRN increased in cognitively normal participants but not in patients with

232 r a mean follow-up of 4.4 years, 524 of 1895 cognitively normal participants developed incident MCI (

233 A total of 209 cognitively normal participants had data on neurodegener

234 ons of tau and Abeta deposits in a sample of cognitively normal participants in the Harvard Aging Bra

235 Among the 1430 cognitively normal participants included, the mean (SD)

236 In this cohort study, cognitively normal participants were classified into 1 o

237 Two hundred twenty-two cognitively normal participants were included in the ana

238 re were 250 incident cases of MCI among 1430 cognitively normal participants.

239 The final cohort consisted of 1929 cognitively normal persons (median age at baseline, 77 y

240 resultant mcSUVrs were evaluated in 74 young cognitively normal subjects (age < 50 y) with a negligib

241 ognitive impairment (n = 173), as well as in cognitively normal subjects (n = 110).

242 with greater AD signature hypometabolism in cognitively normal subjects (OR, 1.93; 95% CI, 1.03-3.62

243 but no dementia, are indistinguishable from cognitively normal subjects based on the measures report

244 ned by the event-based model to discriminate cognitively normal subjects from those with Alzheimer's

245 In contrast, florbetapir Abeta- older cognitively normal subjects showed an increase in florta

246 hold mcSUVr of less than 1.10, 100% of young cognitively normal subjects were correctly classified as

247 217 subjects including 16 young and 58 older cognitively normal subjects, 95 subjects with mild cogni

248 In a large multicentre sample of cognitively normal subjects, as a function of age, gende

249 exus region of interest) compared to younger cognitively normal subjects, but no increased standard u

250 ns of increased retention appeared in Abeta+ cognitively normal subjects.

251 ort of age-matched older adults ranging from cognitively normal to AD, we demonstrate that basal fore

252 racterized elderly individuals, ranging from cognitively normal to demented.

253 nced accuracy of 77% over 3 years), and from cognitively normal to mild cognitive impairment (maximum

254 e full spectrum of disease progression, from cognitively normal to mild cognitive impairment to Alzhe

255 nitive impairment to Alzheimer's disease and cognitively normal to mild cognitive impairment.

256 functional and WM structural network between cognitively normal varepsilon4 carriers and non-carriers

257 structural and functional network changes in cognitively normal varepsilon4 carriers is essential for

258 assessment, we addressed these questions in cognitively normal young and older adults.

259 disease > mild cognitive impairment > older cognitively normal) and was significantly elevated for A

260 Two hundred and eighty-five subjects (92 cognitively normal, 129 mild cognitive impairment, 64 Al

261 agnosed as 4 young cognitively normal, 5 old cognitively normal, 5 mild cognitive impairment, and 5 A

262 ubjects were clinically diagnosed as 4 young cognitively normal, 5 old cognitively normal, 5 mild cog

263 ata from the Harvard Aging Brain Study of 79 cognitively normal, community-dwelling participants.

264 pants were categorized by consensus as being cognitively normal, having MCI, or having dementia accor

265 on-based, cross-sectional study included 150 cognitively normal, late middle-aged (mean [SD] age, 60.

266 s for AD on brain functional connectivity in cognitively normal, preclinical, prodromal, and AD demen

267 7% with mild cognitive impairment, and 49.5% cognitively normal.

268 to 100 years who were medically healthy and cognitively normal.

269 One hundred eighty-three participants (cognitively normal: n = 70; subjective cognitive concern

270 ipants (median age, 79.0 y; 56.5% men, 81.0% cognitively normal; 20.6% diabetic individuals), (18)F-F

271 at a stage of vision, namely late vision, is cognitively penetrated mainly through the effects of cog

272 me genes in 654 psychiatric patients and 889 cognitively-phenotyped control subjects, on whom we prev

273 sciplinary discussion necessary to produce a cognitively plausible model of linguistic representation

274 from the surgical procedure.Surgeons need to cognitively relate 2-dimensional sectional images to the

275 ency in FC, and prolonged and suppressed the cognitively relevant P300 component of mean ERPs in FC a

276 assified the APOE epsilon4 carriers as being cognitively resilient vs nonresilient by comparing their

277 proach as an overdue encouragement to refuse cognitively rich interpretations as far as cognitively l

278 These results indicate that, even in cognitively simple organisms such as zebrafish, neurogen

279 irment were grouped into those that remained cognitively stable for at least 2 years (stable mild cog

280 silon3/epsilon3 group, all patients remained cognitively stable or improved; in the ApoE epsilon3/eps

281 Applying level I criteria, 70% were cognitively stable, 19% cognitively declined and 11% imp

282 level II criteria (1, 1.5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improv

283 as based on systematic transrectal biopsy or cognitively targeted biopsy results, if available.

284 109 lesions were analyzed, including 39 with cognitively targeted sampling.

285 Here we cognitively tested aged female rhesus macaques on (1) th

286 A seemingly distinct challenge is that, cognitively, theories of RL have largely involved proced

287 Cognitively triggered amnesia constitutes an unrecognize

288 adigm, providing an underlying mechanism for cognitively triggered jerks.

289 tive Generation Study, a prevention trial in cognitively unimpaired APOE-e4/e4 homozygote individuals

290 in mechanisms allow these patients to remain cognitively unimpaired despite substantial dopamine dysr

291 erials and Methods Between 2011 and 2013, 61 cognitively unimpaired former collegiate and professiona

292 istics and prevalence of each ATN profile in cognitively unimpaired individuals aged 50 years and old

293 METHODS AND We included cognitively unimpaired individuals aged 60-75 y, consist

294 cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for t

295 rates for glucose and gray matter volumes in cognitively unimpaired mutation carriers and noncarriers

296 Compared with noncarriers, cognitively unimpaired mutation carriers had significant

297 Thirty-one cognitively unimpaired PD participants off dopaminergic

298 thological profiles can be identified in the cognitively unimpaired population.

299 o cause motor symptoms, many patients remain cognitively unimpaired.

300 abnormalities among individuals who remained cognitively unimpaired.