ライフサイエンスコーパス: coiled-coil

1 ies of VP35 twist about each other to form a coiled coil.

2 10 coiled-coil fused to the parallel GCN4-p1 coiled coil.

3 al domain; the latter is predicted to form a coiled coil.

4 rlying heptad repeat of a parallel, trimeric coiled coil.

5 ydrogen bond per repeat unit from the parent coiled coil.

6 mic region of the MotB dimer into a parallel coiled coil.

7 main, revealing a 15-nm parallel homodimeric coiled coil.

8 nd the alpha2 helices form a tight two-helix coiled-coil.

9 gma(F) by competing for binding to the beta' coiled-coil.

10 es its tandem BRCT repeats to bind the XRCC4 coiled-coil.

11 he oligomeric structures are predicted to be coiled coils.

12 t have in common a strong propensity to form coiled coils.

13 utcome of adjacent parallel and antiparallel coiled coils.

14 p a region of NEMO (residues 112-150) in its coiled-coil 1 domain that impedes the binding of linear

15 ng of linear (M1-linked) di-ubiquitin to its coiled-coil 2-leucine zipper ubiquitin binding domain.

16 o-forms, one can use designed three-stranded coiled coils (3SCCs) containing tris-thiolate sites to e

17 hobic pocket of the catalytic core, with the coiled-coil aligned near the entrance of the substrate U

18 In this configuration, the P-CR coiled-coil alone is unlikely to regulate substrate acce

19 forms dimers and trimers, potentially via a coiled-coil alpha-helix.

20 companion helices in helical hairpins of the coiled coil and between receptor conformational states g

21 , information on the subunit register in the coiled coil and cross-links to downstream domains provid

22 ck domain between the catalytic core and the coiled coil and thereby reconfigures the two motor domai

23 Both contain coiled coils and a family-48 carbohydrate binding module

24 an unusual structure with an amino-terminal coiled-coil and a carboxy-terminal zinc binuclear cluste

25 The coiled-coil and C-terminal deletion viruses increased BV

26 face-exposed residues of the K10 alpha helix coiled-coil and caused localized disorganization of the

27 The mutant NEMO lacked part of the CC1 coiled-coil and HLX2 helical domain.

28 FHA and catalytic domains contact the XRCC4 coiled-coil and LigIV BRCT repeats.

29 C-terminal domains (CTDs) associate with the coiled-coil and marked-box domains (CMs) of E2Fs.

30 nant protein corresponding to the N-terminal coiled-coil and nucleotide-binding domain regions of the

31 idue," which is likely to locally unwind the coiled-coil and perhaps contributes to the binding speci

32 Deletion of the Rad50 coiled-coil and zinc-hook eliminates Mre11 binding and A

33 ation experiments identified the ArfGAP with coiled-coil, Ank repeat, and pleckstrin homology domain-

34 Coiled coils are the best-understood protein fold, as th

35 rmation and then collapses into a register 2-coiled coil as a result of stabilization provided by bin

36 n amino acids 324-348, between its first two coiled coils, as essential for the formation of TRIOBP-1

37 eatures are revealed, including an extensive coiled-coil assembly domain stabilized by polyphosphate

38 ur findings enable tuning the stabilities of coiled-coil-based building modules match a diverse range

39 peptide that self-assembles into a hexameric coiled-coil bundle and an Fc-binding Protein A fragment,

40 on (213 residues) of chicken INCENP is not a coiled coil but a approximately 32-nm-long single alpha-

41 in the caspase recruitment domain, LATCH, or coiled coil can perturb intramolecular interactions medi

42 designed DNA nanostructures in which protein coiled-coil (CC) dimers serve as building blocks for mod

43 -terminal Toll-interleukin receptor (TIR) or coiled-coil (CC) domain, a central nucleotide-binding (N

44 In a recent model, extended coiled-coil (CC) domains in the integrase subunits are p

45 itici We present the solution structure of a coiled-coil (CC) fragment from Sr33, which adopts a four

46 ceptors Sr33 and Sr50 belong to the class of coiled-coil (CC) NLRs.

47 R429 is located in the third coiled-coil (CC3) domain of the cytoplasmic C terminus o

48 pulations via the formation of a dimeric E/K coiled-coil complex can be rationalized, the reasons for

49 when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogeno

50 dered, dissociated, as well as two alternate coiled-coil conformations: a Fg-nonbinding register 1 an

51 e stemming from GSK180736A, a Rho-associated coiled-coil containing kinase 1 (ROCK1) inhibitor, the o

52 tomyosin cytoskeleton and the Rho-associated coiled-coil containing kinases.

53 like protein) and TACC1 (transforming acidic coiled-coil containing protein 1)-two genes that we impl

54 contractility via a Shroom3/Rho-associated, coiled-coil containing protein kinase (ROCK) pathway.

55 and subsequent activation of Rho-associated, coiled-coil containing protein kinase (ROCK).

56 n of ERK1/2 and expression of Rho-associated coiled-coil containing protein kinase 1 (ROCK1).

57 TG-specific downstream target Rho-associated coiled-coil containing protein kinase 2, induced K19 exp

58 ith or without inhibitors of Rho-associated, coiled-coil-containing protein kinase (ROCK), ERK, or PI

59 the DR5 signaling pathway or rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) inhibiti

60 cally, these sequences are also replete with coiled-coil destabilizing residues.

61 The probability of coiled coil dimer formation computed for RetGC1/NPRA chi

62 tact TRAP1 revealing a previously unobserved coiled-coil dimer conformation that may precede dimer cl

63 The coiled-coil dimer is a widespread protein structural mot

64 The specificity of coiled-coil dimer pairing is mainly based on hydrophobic

65 Paramyosin is an invertebrate-specific coiled-coil dimer protein that is homologous to the rod

66 ds likely alters interactions that stabilize coiled-coil dimers and thick filaments, causing disrupti

67 tides can be used to tune the stabilities of coiled-coil dimers over a wide range.

68 Tpm forms coiled-coil dimers, which assemble into a helical strand

69 We also show that the RacA C-domain coiled coil directly contacts the coiled coil region of

70 The coiled coil domain probably terminates near the critical

71 Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 t

72 This effect requires the N-terminus and coiled-coil domain (C-C) as mutations within the ORF1p C

73 modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) d

74 ity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site,

75 Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibri

76 ECN1 forms an antiparallel homodimer via its coiled-coil domain (CCD).

77 Its N-terminal coiled-coil domain (Num1CC) is proximal to mitochondria,

78 However, when the coiled-coil domain (the AChR-binding domain of rapsyn) i

79 d by mechanistic studies that determined the coiled-coil domain 1 of EspD as a key compound-binding s

80 Rtt103 forms homodimers via its long coiled-coil domain and associates densely on the repetit

81 11 inhibitory domain and involves the CARD11 coiled-coil domain and two independent regions of HOIP.

82 10 forms oligomers in vitro, mediated by the coiled-coil domain at the N-terminal region of the prote

83 missense mutation, c.92T>C (p.Leu31Ser), in coiled-coil domain containing 115 (CCDC115), the functio

84 es coupling between binding sites, while the coiled-coil domain does not directly participate in the

85 mains form an umbrella-like structure with a coiled-coil domain for the 'pole' and four helical 'ribs

86 d to the gain of function of this N-terminal coiled-coil domain in alphabaculovirus FP25K to aid in n

87 Mutation of the coiled-coil domain in COP1, which prevents dimer formati

88 gest that the acquisition of this N-terminal coiled-coil domain in FP25K is important for the evoluti

89 elopment and highlight the importance of the coiled-coil domain in this process.

90 An N-terminal pentameric coiled-coil domain is linked to a C-terminal coiled-coil

91 uences revealed that the N-terminal putative coiled-coil domain is present in all alphabaculoviruses

92 Two antiparallel alpha-helices form a coiled-coil domain linked by a large extended connector

93 ovirus FP25K protein lacking this N-terminal coiled-coil domain localized predominantly to the nucleu

94 We observed that although the N-terminal coiled-coil domain of ANGPTL4 by itself and full-length

95 We show that the coiled-coil domain of AtZAR1 oligomerizes, and this doma

96 using truncation mutations, we show that the coiled-coil domain of drTRPM7 is involved in the channel

97 re, we describe tsf mutations that alter the coiled-coil domain of elongation factor Ts (EF-Ts) and c

98 during cytokinesis depends on the N-terminal coiled-coil domain of p120 isoform 1A.

99 In this study, we showed that the coiled-coil domain of rapsyn is required for its targeti

100 t second-site suppressors clustered within a coiled-coil domain of Rz near the outer leaflet of the c

101 A conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in pr

102 with a heterozygous missense mutation in the coiled-coil domain of STAT5B that presented with autoimm

103 Finally, the coiled-coil domain of Steppke was required for Sstn bind

104 n (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations

105 in-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal t

106 We found that an N-terminal coiled-coil domain present in all alphabaculovirus FP25K

107 The coiled-coil domain present on only some orthologues rend

108 with and without a C-terminal, alpha-helical coiled-coil domain respond similarly to the osmolality.

109 rotein (ORF1p), which contains an N-terminal coiled-coil domain responsible for cytoplasmic retention

110 in growth cones, mediated by binding of the coiled-coil domain to myosin-VI.

111 ral protein cage by appending a C4-symmetric coiled-coil domain to the protein through a short, flexi

112 Positive residues around the C-terminal coiled-coil domain were required for membrane binding.

113 ized middle domain that is predicted to be a coiled-coil domain with multiple helices.

114 Novel variants affecting the conserved coiled-coil domain, so far exclusively found in fALS exo

115 mical shift perturbation in SH2, DBD and the coiled-coil domain, suggesting conformational changes in

116 rovide evidence that EURL interacts with the coiled-coil domain-containing protein CCDC85B so as to m

117 pendent of the E3 ligase activity, B-box, or coiled-coil domain.

118 omain (LD), DNA-binding domain (DBD) and the coiled-coil domain.

119 turation upon phosphorylation of S471 in its coiled-coil domain.

120 nected by a disordered region to a predicted coiled-coil domain.

121 contain intrinsically disordered regions and coiled coil domains.

122 articipants stratified for transmembrane and coiled-coil domains 1 (TMCO1) risk alleles using Kaplan-

123 that block spanin function are found within coiled-coil domains and the proline-rich region, motifs

124 be related to the underlying dynamics of the coiled-coil domains by application of a three-state "hop

125 Destabilization of the coiled-coil domains by site-directed mutagenesis increas

126 Coiled-coil domains can direct the assembly of protein b

127 ly, we find that the C-terminal EF-hands and coiled-coil domains do not contribute to PKD2-L1 Ca(2+)-

128 We show that the coiled-coil domains encircling the disaggregase constitu

129 Mutating the two coiled-coil domains in Cavin1 revealed that they mediate

130 Instead, the N-terminal ELKS coiled-coil domains that bind to Liprin-alpha and Bassoo

131 Cp110 in ciliation are generated in part by coiled-coil domains that mediate preferential binding to

132 xpanding the hydrophobic surface area of the coiled-coil domains through introduction of the bulky le

133 structures that uses short de novo designed coiled-coil domains to mediate assembly.

134 ract directly through central and C-terminal coiled-coil domains, and recently it was shown that the

135 coating as well as early infection contained coiled-coil domains, and that these activities were gene

136 ng domain and the Mis18alpha-beta C-terminal coiled-coil domains.

137 rm a heterotetramer through their C-terminal coiled-coil domains.

138 ed from engineered proteins bearing terminal coiled-coil domains.

139 TRIOBP-1, finding it to possess two distinct coiled-coil domains: the central and C-terminal domains.

140 se binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane appos

141 including an N-terminal pleckstrin homology coiled-coiled extension (PHn-CC-Ex) and catalytic Dbl ho

142 the interface between the stalk and buttress coiled-coil extensions of the motor domain.

143 opposing membranes into close proximity via coiled-coil formation and 2) to destabilize both membran

144 ncludes the native helix alpha7 sequence for coiled-coil formation is highly processive with run leng

145 In the absence of coiled-coil formation, the C-terminal domain bound lipos

146 upstream regulators, LET-502 (Rho-associated coiled-coil forming kinase) and MEL-11 (a myosin-binding

147 Deletion of the anti-parallel coiled-coil forming region, but not the EKR-rich region

148 f the single alpha-helical and anti-parallel coiled-coil forming regions, which lie between the motor

149 The building blocks of IFs are extended coiled-coil-forming proteins exhibiting a characteristic

150 four-helix bundle and an extended four-helix coiled coil, functionally important structural dynamics

151 tructure of a short, antiparallel, myosin-10 coiled-coil fused to the parallel GCN4-p1 coiled coil.

152 However, the final structures of coiled-coil fusion proteins have received relatively lit

153 Coiled-coil fusions are a useful approach to enforce dim

154 asymmetry of torsional elastic energy of the coiled-coil gamma -shaft.

155 Restraints of the flexibility of the coiled-coil greatly reduce serylation efficiencies.

156 The parallel architecture of the coiled coil has mechanistic implications for the arrange

157 The coiled coil has two spatially distinct conserved regions

158 Self-association via the coiled-coil has been suggested to be crucial for catalyt

159 recruitment domain (CARD), LATCH domain, and coiled coil have been shown to disrupt intramolecular ID

160 Coiled coils have frequently been used to construct nano

161 l globular alpha/beta domain and an extended coiled-coil heliacal domain.

162 by acutely down-regulating coiled-coil-helix-coiled-coil-helix domain 4 (CHCHD4), a carrier protein t

163 d activity of p53 by acutely down-regulating coiled-coil-helix-coiled-coil-helix domain 4 (CHCHD4), a

164 It demonstrates a parallel, coiled-coil heterodimer with a predominantly hydrophobic

165 g its TOG domains, which bind GTP-tubulin, a coiled-coil homodimerization domain, and a domain that i

166 er assembly distinct from classical trimeric coiled-coils in solution.

167 hat EmMBD2/3 and EmGATAD2A/B proteins form a coiled-coil interaction known to be critical for the for

168 We conclude that an intact Mcm10 coiled-coil interaction surface is important for origin

169 Specifically, heterophilic coiled-coil interactions linked Sstn and Steppke in vivo

170 ne microparticles, either through reversible coiled-coil interactions or through intermolecular isope

171 used a large quantitative set of 4,549 bZIP coiled-coil interactions to develop a predictive model t

172 Coiled-coil interactions, between or among alpha-helices

173 nsertions within the hydrophobic core of the coiled-coil interface.

174 ighly cooperative manner compatible with the coiled-coil intermediate state.

175 ate, in which the gp41 heptad repeat 1 (HR1) coiled coil is assembled at the trimer axis.

176 Free energy profiles confirm that the coiled coil is the most stable form for dimers and trime

177 The coiled-coil is a docking site for sigma factors on RNA p

178 hat an accurate prediction of the start of a coiled-coil is currently difficult to achieve.

179 gy Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dish

180 GSK180736A, developed as a Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor, was identified a

181 Double knockdown of Rho-associated coiled-coil kinase 2a (Rock2a) and Rho-associated coiled

182 d-coil kinase 2a (Rock2a) and Rho-associated coiled-coil kinase 2b (Rock2b) similarly disrupted INM a

183 by the actin cytoskeleton and Rho-associated coiled-coil kinases (Rocks).

184 ucidated the head-to-tail arrangement of the coiled-coil linear strands and their hexagonal, antipara

185 We find that the coiled coil linker and the attached histidine kinase dom

186 coli with (GCwCCRho) and without (GCRho) the coiled-coil linker.

187 and Synagis (Syn) using both beta-sheet and coiled-coil linkers.

188 an unexpected regulatory concept executed by coiled-coil MDs to tightly control AAA+ chaperone activi

189 parse, particularly with respect to ORF1p, a coiled coil-mediated homotrimeric nucleic acid chaperone

190 Inhibition of coiled coil-mediated interactions has significant biomed

191 associate via head-to-head contacts between coiled-coil middle domains (MDs).

192 more complex nanostructures using additional coiled-coil modules, other protein parts, or templated s

193 Although the coiled coil motif is highly conserved, it is uniquely su

194 on and molecular sizes of auxiliary trimeric coiled-coil motif and NHR fragments on the antiviral pot

195 tide sequences based on the parallel dimeric coiled-coil motif and varied residues known to be import

196 Correspondingly, we also found that the coiled-coil motif in Mff is not essential for Drp1 inter

197 channel architecture, and is stabilized by a coiled-coil motif protruding into the mitochondrial matr

198 onserved residue-residue interactions in the coiled-coil motif.

199 tral oligomerization domain with a predicted coiled-coil motif.

200 among SS isoforms and contains several long coiled-coil motifs, typically implicated in protein-prot

201 ion) as homologous to barley Mla, encoding a coiled-coil nucleotide-binding leucine-rich repeat (CC-N

202 Mi-1.2 encodes a coiled-coil nucleotide-binding leucine-rich repeat prote

203 e region including two linked genes encoding coiled-coil nucleotide-binding leucine-rich repeat prote

204 The trypanosomatid coiled-coil NUP-1 protein is a lamina component function

205 interface involves interactions between the coiled coil of one WipA molecule and the phosphatase dom

206 r residues 1214-1396, that include the first coiled coil of TANGO1, specifically recruit ERGIC membra

207 ion of the transmembrane region and proximal coiled coil of the complex.

208 and the C-terminal domain, that 'clamps' the coiled coil of the plug, thus stabilising the activated

209 ication of a single, essential heptad in the coiled-coil of Spc110 and a minimal PACT domain.

210 c CC MBS in which amino acids 932-967 form a coiled-coil of two monomeric alpha-helices in parallel o

211 structural differences occurring between the coiled-coils of myosin and the stereotypical tropomyosin

212 EB exists in at least a low-molecular weight coiled-coil oligomeric form and an amyloid fiber form in

213 All regions encompass coiled-coil or alpha-helical structures, and three are i

214 emonstrating the importance of understanding coiled-coil orientation and stability.

215 ndependent crystal structures that elucidate coiled-coil packing between l- and d-peptide helices.

216 nucleotide-binding domain and the C-terminal coiled-coil participate in the tetrameric assembly of th

217 ngle beta-barrel domain and an extracellular coiled-coil ("passenger") domain.

218 The design is a trifaceted coiled-coil peptide helix, which self-assembles into ult

219 new class of crystalline materials based on coiled-coil peptides bearing unnatural metal-chelating t

220 l-ion-mediated strategy to assemble trimeric coiled-coil peptides in a head-to-tail fashion into line

221 Centriolar coiled coil protein 110 (CP110) caps the distal end of t

222 Deregulation of the transforming acidic coiled-coil protein 3 (TACC3), an important factor in th

223 nd TACC3, members of the transforming acidic coiled-coil protein family, can act as +TIPs to regulate

224 orce manipulations in silico on a variety of coiled-coil protein fragments from myosin, chemotaxis re

225 hat mud, which encodes a microtubule-binding coiled-coil protein homologous to NuMA and LIN-5, is an

226 ere macromolecular assemblies are defined by coiled-coil protein interactions.

227 re we report the characterization of a novel coiled-coil protein Rng10 and its relationship with the

228 , we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole d

229 rhabditis elegans, PCM assembly requires the coiled-coil protein SPD-5.

230 Chibby1 (Cby1) is a small, conserved coiled-coil protein that localizes to centrioles/basal b

231 at ZapA is encoded in an operon with a small coiled-coil protein we named ZauP.

232 Golgb1 is a ubiquitously expressed large coiled-coil protein, also known as giantin, that is loca

233 The large coiled-coil protein, pericentrin, participates in PCM as

234 the nuclear pore complex (NPC) and a second coiled-coil protein, which we termed NUP-2, were found.

235 One of these, transforming acidic coiled-coil proteins (TACC) 3, stabilizes EGFR on the ce

236 s2 interacts via Bbp1 with Spc29, one of the coiled-coil proteins forming the central plaque of the S

237 elle biogenesis are activated by the related coiled-coil proteins Multicilin and Gemc1.

238 Extended coiled-coil proteins of the Golgin family play prominent

239 ate that aggregates formed by association of coiled-coil proteins, in contrast to those linked by iso

240 We also found that the RING B-box coiled-coil (RBCC) domain in KAP1 and the proximal coupl

241 hed MKS module components and depends on the coiled coil region of MKS-5 (Rpgrip1L/Rpgrip1) for TZ lo

242 A C-domain coiled coil directly contacts the coiled coil region of the polar protein DivIVA, which an

243 pting locus (STIL) protein interacts via its coiled-coil region (STIL-CC) with PLK4 in vivo.

244 hich depends on a region located between the coiled-coil region and the glycosyltransferase domain of

245 th dimerization and the functionality of the coiled-coil region are conserved among SS4 proteins from

246 A and CD93 bind to the same non-glycosylated coiled-coil region of MMRN2, but the binding of CD248 oc

247 ds to RNA polymerase and specifically to the coiled-coil region of the beta' subunit.

248 state to a heterodimeric state in which the coiled-coil region of WipA is engaged in a protein-prote

249 RING domain, one or two B-box domains and a coiled-coil region that mediates ligase dimerization.

250 We identify a coiled-coil region within PxdA that is necessary and suf

251 Here we show that the coiled-coil region within the N-terminal portion of SS4

252 The N-terminal coiled-coil region works like a long-range lever to prec

253 Downstream of the EF-hand domain lies a coiled-coil region, which is involved in the assembly an

254 Cterm can form an oligomer, mediated by the coiled-coil region.

255 ation D453G within a predicted alpha-helical coiled-coil region.

256 ional changes in the cytosolic juxtamembrane coiled-coil region.

257 EH domain, the proline-rich region, and the coiled-coil region.

258 is interrupted between the transmembrane and coiled coil regions by a flexible Gly-rich linker.

259 homology (CH2) domain followed by two large coiled-coil regions.

260 2, located between the kinase domain and the coiled-coil regulation domain.

261 The presence of the coiled-coil replaced those phenomena with CL-dependent b

262 hat destabilization of the membrane-proximal coiled coil restores function for defective spanin allel

263 The Bicaudal-D2 coiled coil runs between dynein and dynactin to stabiliz

264 ed to a polyhedral nano-net held together by coiled-coil segments.

265 mmetric Y; two globular heads project from a coiled-coil shaft.

266 ARE) proteins that zipper together to form a coiled-coil SNARE bundle that brings the two fusing memb

267 ear model, which should help improve current coiled-coil stability prediction algorithms.

268 lix alpha7 that constitutes the start of the coiled-coil stalk.

269 dues, which connects the motor domain to its coiled-coil stalk.

270 ptor agonist antibody by first introducing a coiled-coil "stalk" into CDR3H of the antibody herceptin

271 ns because helix alpha7, which initiates the coiled-coil, started earlier in the sequence than predic

272 ix was engineered to be locked in a parallel coiled coil state, mimicking the open state of the stato

273 tail domain that contains several predicted coiled-coils, structural motifs involved in protein-prot

274 ax=320A) than predicted for a fully extended coiled-coil structure (>500A).

275 These features are evident in the irregular coiled-coil structure and thermal instability of M prote

276 s that reducing the flexibility of native Tm coiled-coil structure decreases the optimum interactions

277 eparated from the GT99 chain terminator by a coiled-coil structure that forms a molecular ruler to de

278 hairpin, the tip of which adopts a canonical coiled-coil structure.

279 have suggested that the LcrG family forms a coiled-coil structure.

280 ic modern protein (151p) wherein 9 of the 30 coiled coil substitutions retain their ancestral state.

281 ps comparable in length to its 50-nanometer coiled-coil subunits, indicative of a translocation mech

282 mino acids within the core of the tetrameric coiled coil suggests that the coil may split into two in

283 globular head of Uso1 binds to Ypt1 and its coiled-coil tail binds to the Golgi-associated SNARE, Se

284 ory vesicles by Ypt1-SW1(Sec4), the extended coiled-coil tail blocks docking to the plasma membrane.

285 larly well suited to the approximately 750-A coiled coil that mediates trimer assembly, and our resul

286 terotrimer from three pairs of heterodimeric coiled coils that mediate specific interactions while av

287 The targets are coiled coils that stabilize myosin-10 in single-molecule

288 ex, revealing the F1 attachment points and a coiled-coil that bifurcates toward the membrane with its

289 s ppGpp, and its N-terminal region, like the coiled-coil tip of DksA, engages the active-site region

290 ransmembrane domain with a soluble hexameric coiled coil to produce active YME1L hexamers that can be

291 s the modularity of orthogonally interacting coiled coils to create a self-assembled protein nanotria

292 coiled-coil domain is linked to a C-terminal coiled-coil trimer by two glycine residues.

293 Recent studies revealed the role of three coiled-coil-type NLRs (CNLs) of the ADR1 family - ADR1,

294 mechanical and kinetic properties of protein coiled-coils under mechanical nonequilibrium conditions

295 Non-associating pairs of coiled-coil units were strategically fused to generate t

296 Spindly's N-terminal coiled-coil uses distinct motifs to bind dynein light in

297 interaction mediated by interactions between coiled-coils, we hypothesize that WipA can thereby trans

298 this structure is a continuous, antiparallel coiled coil where GCN4-p1 pairs with myosin-10 rather th

299 The result is an alpha/beta coiled coil, which retains only one backbone hydrogen bo

300 late the stabilities in an orthogonal set of coiled-coils without affecting their binding preferences