ライフサイエンスコーパス: coiled-coil domain

1 ization and increased binding to the Bcr-Abl coiled coil domain.

2 s (alpha1 and alpha2) that intertwine into a coiled coil domain.

3 an A20-like zinc finger (ZnF) domain, and a coiled coil domain.

4 ot expressed, suggesting interference by the coiled-coil domain.

5 n LeEix2, an effect that requires and intact coiled-coil domain.

6 phosphorylation of serine 142 located in the coiled-coil domain.

7 es both in vitro and in living cells via the coiled-coil domain.

8 de insertion within the uncharacterized Gle1 coiled-coil domain.

9 thylated but not methylated DNAs through its coiled-coil domain.

10 C-terminus of the protein near the predicted coiled-coil domain.

11 inc Finger Ubiquitin Binding protein), and a coiled-coil domain.

12 two LRR domains and an extensive C-terminal coiled-coil domain.

13 n in tobacco leaves, which also requires the coiled-coil domain.

14 ce activity and that are mostly found in the coiled-coil domain.

15 n the Talpid3 protein, including a predicted coiled-coil domain.

16 H1/H5-like domain and a C-terminally located coiled-coil domain.

17 s with another Augmin subunit, Dgt2, via its coiled-coil domain.

18 the long C-terminal region downstream of the coiled-coil domain.

19 OX protein BREVIPEDICELLUS through an acidic coiled-coil domain.

20 opsies (9.6%), all within exons encoding the coiled-coil domain.

21 he caspase recruitment domain (CARD) and the coiled-coil domain.

22 e other mediated by a putative intracellular coiled-coil domain.

23 is localized to the plasma membrane via its coiled-coil domain.

24 side of the Golgi and has a large C-terminal coiled-coil domain.

25 his oligomerization of CARMA1 is through its Coiled-coil domain.

26 ins a RING domain, one or two B boxes, and a coiled-coil domain.

27 rectly to the Nup62 C-terminal alpha-helical coiled-coil domain.

28 pendent of the E3 ligase activity, B-box, or coiled-coil domain.

29 omain (LD), DNA-binding domain (DBD) and the coiled-coil domain.

30 turation upon phosphorylation of S471 in its coiled-coil domain.

31 nected by a disordered region to a predicted coiled-coil domain.

32 Dimerization is controlled by a cytoplasmic coiled-coil domain.

33 horylates Mud in vitro within its C-terminal coiled-coil domain.

34 contain intrinsically disordered regions and coiled coil domains.

35 roteins associate with the PKD2 proteins via coiled-coil domains.

36 e interactions and helical propensity of the coiled-coil domains.

37 via apolar bonding between their respective coiled-coil domains.

38 protein H contains four predicted C-terminal coiled-coil domains.

39 -handed models with staggered packing in the coiled-coil domains.

40 ing actin and PP1 binding motifs and PDZ and coiled-coil domains.

41 ng domain and the Mis18alpha-beta C-terminal coiled-coil domains.

42 rm a heterotetramer through their C-terminal coiled-coil domains.

43 ed from engineered proteins bearing terminal coiled-coil domains.

44 eria, such as the presence of eukaryote-like coiled-coil domains.

45 d by mechanistic studies that determined the coiled-coil domain 1 of EspD as a key compound-binding s

46 erminal region of Hec1 directly binds to the coiled-coil domain 1 of Hice1.

47 on, c.139_140delAG, in the transmembrane and coiled-coil domains 1 (TMCO1) gene, as the pathogenic ch

48 articipants stratified for transmembrane and coiled-coil domains 1 (TMCO1) risk alleles using Kaplan-

49 flexible linker (798-827), and an oligomeric coiled coil domain (828-895).

50 ORF1p contains three structured regions, a coiled-coil domain, a middle domain of unknown function,

51 Deletion of its coiled-coil domain abrogates oligomerization but does no

52 The coiled-coil domain, absent from the smaller variants, is

53 on of INCENP has been proposed to comprise a coiled coil domain acting as a spacer between the N- and

54 These results suggest that the coiled-coiled domain adopts at least two conformations t

55 ctional domains including the N terminus and coiled-coil domain affect the localization and increase

56 protein characterized by a highly conserved coiled-coil domain also found in the human orthologue, K

57 d the C-terminal half of OSBP, HePTP binds a coiled-coil domain (amino acids 732-761), and PP2A binds

58 More specifically, a coiled coil domain and a C-terminal helix within CagF co

59 of Srv2 depends on its N-terminal predicted coiled coil domain and that oligomerization optimizes Sr

60 T2 are two Arabidopsis proteins containing a coiled-coil domain and a C-terminal predicted transmembr

61 domains in the N-terminal half of drebrin-a coiled-coil domain and a helical domain-that independent

62 bind to HP1alpha, and two domains of Orc3, a coiled-coil domain and a mod-interacting region domain,

63 n a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPRY domain, are involved in va

64 ocalization of the kinase via the C-terminal coiled-coil domain and activation via activation segment

65 These effects require PACSIN2 coiled-coil domain and are not due to a reduction of FN

66 Rtt103 forms homodimers via its long coiled-coil domain and associates densely on the repetit

67 of the C-terminal region with the N-terminal coiled-coil domain and is in agreement with previous res

68 the linker region connecting the N-terminal coiled-coil domain and NPcore are essential for hantavir

69 l SUN-domain proteins including a functional coiled-coil domain and nuclear localization signal.

70 CKT2 is a 30.2 kDa protein with one coiled-coil domain and six putative phosphorylation site

71 C-3 self-association through the cytoplasmic coiled-coil domain and suggest a model by which this may

72 ation of TRIM5alpharh, which depended on the coiled-coil domain and the ensuing linker 2 region, was

73 the C terminus of RFWD3, which encompass the coiled-coil domain and the WD40 domain, is necessary for

74 11 inhibitory domain and involves the CARD11 coiled-coil domain and two independent regions of HOIP.

75 was dependent on the presence of the distal coiled-coil domain and was disrupted by pathogenic misse

76 minal microtubule-binding domain followed by coiled-coil domains and a C-terminal cargo-binding domai

77 A is predicted to be a membrane protein with coiled-coil domains and a peptidoglycan-binding SPOR dom

78 t Protein1 (NMCP1), which contains extensive coiled-coil domains and localizes to the nuclear periphe

79 that block spanin function are found within coiled-coil domains and the proline-rich region, motifs

80 overs the Diaphanous inhibitory-dimerization-coiled coil domains, and the third is the Spa2p-binding

81 o the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 bina

82 with heme, one without), two PAS domains, a coiled-coil domain, and two cyclase domains.

83 RDM12 encodes a protein with XS and coiled-coil domains, and is similar to SGS3, which is a

84 ract directly through central and C-terminal coiled-coil domains, and recently it was shown that the

85 coating as well as early infection contained coiled-coil domains, and that these activities were gene

86 omomers and heteromers in vivo, and that the coiled-coil domains are required for this.

87 The conserved XS and coiled-coil domains are responsible for RNA-binding acti

88 Using putative sulfonylurea receptor (SUR) coiled-coil domains as baits in a 2-hybrid screen agains

89 -rich repeat region at residues 16-164 and a coiled-coil domain at residues 171-191.

90 10 forms oligomers in vitro, mediated by the coiled-coil domain at the N-terminal region of the prote

91 for NBS-LRR disease resistance proteins with coiled-coil domains at their N terminus.

92 d to encode a protein of 488 residues with a coiled-coil domain between residues 345 and 382.

93 The N-terminal coiled coil domain binds three antiparallel C-heptad rep

94 teins, we discovered a recurrent presence of coiled-coil domains both in the partners and in segments

95 Deletion of the first coiled-coil domain (BRMS1(DeltaCC1)) did not disrupt dir

96 ubunit oligomerization through the conserved coiled-coil domain, but can be partially replaced by fus

97 e signal peptide, the lumenal segment or the coiled-coil domain, but not in mutants lacking the long

98 cytoplasmic proteins; MldB has two predicted coiled-coil domains, but MldC lacks obvious conserved do

99 We have modeled approximately 85% of the coiled-coil domain by joining our new HIP1 371-481 struc

100 be related to the underlying dynamics of the coiled-coil domains by application of a three-state "hop

101 Destabilization of the coiled-coil domains by site-directed mutagenesis increas

102 This effect requires the N-terminus and coiled-coil domain (C-C) as mutations within the ORF1p C

103 Here we demonstrate that the GCN4 coiled-coil domain can populate either a dimer or trimer

104 Coiled-coil domains can direct the assembly of protein b

105 modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) d

106 The second coiled-coil domain (CC2; aa 424-474) of GIT1 mediates bi

107 ed, but they all contain a predicted Central Coiled-Coil Domain (CCCD).

108 ity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site,

109 Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibri

110 Previous crystallography studies of the coiled-coil domain (CCD) of NSP4 from two different rota

111 is unclear, crystallographic studies of the coiled-coil domain (CCD) of NSP4 from two different stra

112 ECN1 forms an antiparallel homodimer via its coiled-coil domain (CCD).

113 oprotein lipase (LPL) through its N-terminal coiled-coil domain (ccd-Angptl4) inducing dissociation o

114 SK1, SK2, and SK3 subunits contain coiled-coil domains (CCDs) in the C termini.

115 The coiled-coil domains (clathrin light chain-binding) of Hi

116 , where present, there is generally only one coiled-coil domain close to the triple helix, and it is

117 466 in the second short helix of the alpha1 coiled-coil domain closer to the catalytic domain.

118 by one or two B box domains and a C-terminal coiled-coil domain (collectively termed the RBCC domain)

119 Mutations in the gene encoding FYVE and coiled-coil domain containing 1 (FYCO1), a PI(3)P-bindin

120 In this study, we report that FYVE and coiled-coil domain containing 1 (FYCO1), a protein previ

121 s mutant schmalhans (smh(tn222)) encodes the coiled-coil domain containing 103 protein (Ccdc103), a f

122 missense mutation, c.92T>C (p.Leu31Ser), in coiled-coil domain containing 115 (CCDC115), the functio

123 Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator f

124 ing transcriptional profiling, we identified coiled-coil domain containing 80 (Ccdc80; also known as

125 We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a p

126 appeared to be specific, as similar secreted coiled-coiled domain containing proteins from L. pneumop

127 Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 t

128 te that CG42630 encodes a novel protein, the coiled coil domain-containing protein 56 (CCDC56), conse

129 rovide evidence that EURL interacts with the coiled-coil domain-containing protein CCDC85B so as to m

130 e cytokinesis effector kinase Rho-associated coiled-coil domain-containing protein kinase 2 (Rock2),

131 5.3, which spans fatty acid synthase (FASN), coiled-coil-domain-containing 57 (CCDC57), and solute-ca

132 A central coiled-coil domain contains a specific Rab9 binding site

133 inhibition of ligase oligomerization via its coiled-coil domain could be of therapeutic benefit to br

134 Functional analyses demonstrate that the coiled-coil domain couples inactivation with channel ope

135 This Mud coiled-coil domain directly binds the adjacent Pins-bind

136 ly, we find that the C-terminal EF-hands and coiled-coil domains do not contribute to PKD2-L1 Ca(2+)-

137 es coupling between binding sites, while the coiled-coil domain does not directly participate in the

138 ARNO lacking the coiled-coil domain does not promote migration and does n

139 We show that the coiled-coil domains encircling the disaggregase constitu

140 hape appears to reside within the N-terminal coiled-coil domain encoded by exons 1-4.

141 ic mutant R4227X, which lacks the C-terminal coiled-coil domain, failed to down-regulate PC2 expressi

142 and two liprin-betas which all contain long coiled-coil domains followed by three tandem SAM domains

143 in Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity, suggesting t

144 mains form an umbrella-like structure with a coiled-coil domain for the 'pole' and four helical 'ribs

145 This coiled-coil domain forms a homotrimer, in both solution

146 A TRPP3 C-terminal coiled-coil domain forms a trimer in solution and in cry

147 etion analysis indicated that the C-terminal coiled-coil domain (H2) of snapin is required for UT-A1

148 , C-terminal ankyrin-repeat, and intervening coiled-coil domains, has multiple actions in cells and a

149 n which four leucine residues in the central coiled-coil domain have been replaced by alanines.

150 teins act on a region of WIT1 containing the coiled-coil domain, HSC70-1 additionally acts on the C-t

151 and Tyr-398 or a mutant with deletion of the coiled-coil domain impaired the formation of dorsal ruff

152 d to the gain of function of this N-terminal coiled-coil domain in alphabaculovirus FP25K to aid in n

153 reveal a pivotal role of a highly asymmetric coiled-coil domain in coordinating the assembly of cargo

154 Mutation of the coiled-coil domain in COP1, which prevents dimer formati

155 gest that the acquisition of this N-terminal coiled-coil domain in FP25K is important for the evoluti

156 helix of the F-BAR domain of Pacsin 2 via a coiled-coil domain in its C-tail.

157 and crystal structure, and binds to a single coiled-coil domain in the C terminus of PKD1.

158 A newly identified coiled-coil domain in the C terminus of TRPP2 is critica

159 inus resides in the lumen of the ER with the coiled-coil domain in the cytoplasm.

160 elopment and highlight the importance of the coiled-coil domain in this process.

161 Mutating the two coiled-coil domains in Cavin1 revealed that they mediate

162 t correlation between helical content of the coiled-coil domains in isolation and binding affinity fo

163 clarify the roles of both the hinge and the coiled-coil domains in MukB function.

164 m that of the individual components, such as coiled-coil domains in proteins and the eukaryotic axone

165 Requirements for the CARD, linker 1, and coiled-coil domains in signaling are consistent with the

166 mains, which place their critical GTPase and coiled-coil domains in the cytosol.

167 model also contains approximately 20% of the coiled-coil domain, including an unusual coiled-coil dev

168 rangement of AAA+ modules with the prominent coiled-coil domain intercalated between the AAA+ domains

169 physiological functions, and deletion of the coiled-coil domains interferes with correct subcellular

170 We found that the novel WRN coiled coil domain is necessary for multimerization of t

171 at flexibility between the transmembrane and coiled coil domains is functionally important.

172 A small region of Arc containing the coiled-coil domain is also restricted to beta-spectrin-p

173 sociated with zippering of the water-soluble coiled-coil domain is expected to lead to tilting of the

174 An N-terminal pentameric coiled-coil domain is linked to a C-terminal coiled-coil

175 ligomers rather than homo-oligomers, and the coiled-coil domain is necessary and sufficient for this

176 On the other hand, the presence of the coiled-coil domain is necessary for efficient Nrdp1 auto

177 uences revealed that the N-terminal putative coiled-coil domain is present in all alphabaculoviruses

178 The PDZD8 coiled-coil domain is sufficient for HIV-1 capsid bindin

179 tional and, in combination with a portion of coiled-coil domain, is sufficient for nuclear envelope l

180 a-sheet-rich region, domain III, and a short coiled coil, domain IV, which, although not required for

181 nteraction with this region located within a coiled-coil domain, juxtaposing the Ca(2+)/calmodulin- a

182 and show that novel variants outside of the coiled-coil domain lead to constitutively activated NF-k

183 Linker2 region dock to alpha-helices of the coiled-coil domain, likely establishing proper orientati

184 Two antiparallel alpha-helices form a coiled-coil domain linked by a large extended connector

185 ovirus FP25K protein lacking this N-terminal coiled-coil domain localized predominantly to the nucleu

186 Fin1 mutants lacking the C-terminal coiled-coil domains localized to spindle pole bodies but

187 Finally, the middle of this coiled-coil domain may be intrinsically flexible and sug

188 ion into plant cells, whereas the C-terminal coiled-coil domain mediates interaction with M.

189 structure-guided mutagenesis, we found that coiled-coil domains modulate in vivo properties of two Q

190 Intriguingly, TRIM5alpharh coiled-coil domain mutants (M133T and/or T146A) showed i

191 Experimental introduction of CARD11 coiled-coil domain mutants into lymphoma cell lines resu

192 ng the head, all 5IQ motifs and the putative coiled coil domain (myosin VIIa-5IQ).

193 m homo- and hetero-oligomers via a conserved coiled-coil domain near their amino termini.

194 Its N-terminal coiled-coil domain (Num1CC) is proximal to mitochondria,

195 Key mutations in the coiled coil domain of Bcr-Abl were identified that reduc

196 The hydrophobic pocket within the coiled coil domain of HIV-1 gp41 is considered to be a h

197 ee detection of inhibitors which bind to the coiled coil domain of human immunodeficiency virus type

198 Moreover, the coiled coil domain of RabGEF1 is required for Rabaptin-5

199 and deletions identifies a region within the coiled coil domain of STAT5a that is critical for nuclea

200 WTX interacted with the coiled coil domain of TRIM28 required for its binding to

201 We observed that although the N-terminal coiled-coil domain of ANGPTL4 by itself and full-length

202 protein-protein interactions mediated by the coiled-coil domain of ARNO are required for ARNO induced

203 We show that the coiled-coil domain of AtZAR1 oligomerizes, and this doma

204 f A33 is sufficient for interaction with the coiled-coil domain of B5 and capable of directing B5-gre

205 t through their lumenal domains and that the coiled-coil domain of B5 is sufficient for an interactio

206 38Ala); these three mutations lie within the coiled-coil domain of CARD14.

207 Disruption of the predicted structure of the Coiled-coil domain of CARMA1 impaired its oligomerizatio

208 The coiled-coil domain of cartilage oligomeric matrix protei

209 tion of Ret51, whereas the carboxyl-terminal coiled-coil domain of CD2AP was dispensable.

210 using truncation mutations, we show that the coiled-coil domain of drTRPM7 is involved in the channel

211 re, we describe tsf mutations that alter the coiled-coil domain of elongation factor Ts (EF-Ts) and c

212 n superficial hydrophobicity patterns of the coiled-coil domain of EVI5, which, in turns, affects the

213 Here, we report the X-ray structure of the coiled-coil domain of HIP1 (residues 482-586) that inclu

214 We show that the coiled-coil domain of mRIC-3 is not required for the int

215 n between the N terminus of BK-beta1 and the coiled-coil domain of MuRF1 was demonstrated by pulldown

216 ed by the addition of recombinant N-terminal coiled-coil domain of Ndel1.

217 Here, we show that overexpression of the coiled-coil domain of Num1 specifically depletes dynein-

218 long microtubules upon overexpression of the coiled-coil domain of Num1, an event that is not observe

219 during cytokinesis depends on the N-terminal coiled-coil domain of p120 isoform 1A.

220 pathway at two levels: CARM1 methylates the coiled-coil domain of p54(nrb), resulting in reduced bin

221 d mutagenesis of critical amino acids in the coiled-coil domain of PC1 required for coupling to PC2 a

222 lar loop of FtsX(Spn) and the amino terminal coiled-coil domain of PcsB.

223 with the septin complex is dependent on the coiled-coil domain of Pnut.

224 xist between the C terminus of Mre11 and the coiled-coil domain of Rad50.

225 In this study, we showed that the coiled-coil domain of rapsyn is required for its targeti

226 t second-site suppressors clustered within a coiled-coil domain of Rz near the outer leaflet of the c

227 A conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in pr

228 ver, loss of the C-terminus or the predicted coiled-coil domain of Shs1p generates expanded zones of

229 We find that the conserved C-terminal coiled-coil domain of Slik, which is necessary and suffi

230 with a heterozygous missense mutation in the coiled-coil domain of STAT5B that presented with autoimm

231 Finally, the coiled-coil domain of Steppke was required for Sstn bind

232 The second coiled-coil domain of STIM1 is required for coupling to

233 ALK kinase via dimerization mediated by the coiled-coil domain of STRN and to a kinase-dependent, th

234 Specifically, the coiled-coil domain of SYP-1 is required both for its hom

235 n (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations

236 embly is the formation of a parallel 3-helix coiled-coil domain of the carboxy-terminal leucine zippe

237 the high-resolution crystal structure of the coiled-coil domain of the channel enzyme TRPM7.

238 CNK1 that interacts constitutively with the coiled-coil domain of the cytohesins, and found that CNK

239 in the dystonin gene (DST) that encodes the coiled-coil domain of the epithelial isoform of bullous

240 tide inhibitors of the C-terminal metastable coiled-coil domain of the essential yeast septin Cdc12p.

241 we further showed that it only requires the coiled-coil domain of the NF7 tripartite motif/RBCC moti

242 y crystal structures of the parallel 3-helix coiled-coil domains of CNGA1 and CNGA3 subunits were sim

243 t, the N-terminal pleckstrin homology and/or coiled-coil domains of GRF1 are key to the induction of

244 Coiled-coil domains of Hip1 and Hip1R differed in their

245 The coiled-coil domains of Rad50 are important for the DNA b

246 esult in amino acid changes within all three coiled-coil domains of the BICD2 protein, and include a

247 Nop56/58-fibrillarin complexes linked by the coiled-coil domains of the Nop56/68 proteins.

248 Abraxas and Brcc36 associate through coiled-coil domains on each protein.

249 oteins containing point mutations in the HA2 coiled-coil domain or in an HA1 histidine or basic patch

250 in-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal t

251 se observations point to a model whereby the coiled-coil domain plays a key role in regulating Nrdp1

252 erved coiled-coil arginines suggest that the coiled-coil domain plays a major role in the extraction

253 tains two transmembrane helices (TMHs) and a coiled-coil domain predicted to mediate protein-protein

254 We found that an N-terminal coiled-coil domain present in all alphabaculovirus FP25K

255 The coiled-coil domain present on only some orthologues rend

256 The coiled coil domain probably terminates near the critical

257 We find that the coiled-coil domain promotes the assembly of a multiprote

258 Galpha, we found that the transmembrane and coiled-coil domain protein 1 (TCC-1) contributes to prop

259 ding motif (UIM)-containing protein RAP80, a coiled-coil domain protein CCDC98/Abraxas, and a deubiqu

260 CHIBBY (CBY) is a coiled-coil domain protein first described as interactin

261 PC1 that interacts with PC2 via a C-terminal coiled-coil domain regulates PC2 expression in vivo and

262 enforced expression of the isolated p66alpha coiled-coil domain relieves MBD2-mediated globin gene si

263 ain is again fused to an extended C-terminal coiled-coil domain reminiscent of eukaryotic DMPK (Myoto

264 eric disruption resulting from this modified coiled coil domain represents a viable alternative to sm

265 Full rescue by the coiled-coil domain requires LIS1 binding, and increasing

266 with and without a C-terminal, alpha-helical coiled-coil domain respond similarly to the osmolality.

267 rotein (ORF1p), which contains an N-terminal coiled-coil domain responsible for cytoplasmic retention

268 The mutation deletes the coiled-coil domain responsible for polymerization into t

269 HA2 subunit, and a K58I mutation in the HA2 coiled-coil domain significantly altered the pH of activ

270 Novel variants affecting the conserved coiled-coil domain, so far exclusively found in fALS exo

271 Finally, a GFP fusion of the coiled-coil domain stabilizes Nrdp1 and potentiates ErbB

272 mical shift perturbation in SH2, DBD and the coiled-coil domain, suggesting conformational changes in

273 ionally, we identified a polymorphism in the coiled-coil domain that appears to affect TRIMCyp expres

274 assembling tetrameric C-terminal cytoplasmic coiled-coil domain that underlies channel assembly and t

275 I IFN, STAT2 is serine phosphorylated in the coiled-coil domain that when phosphorylated can negative

276 Instead, the N-terminal ELKS coiled-coil domains that bind to Liprin-alpha and Bassoo

277 Cp110 in ciliation are generated in part by coiled-coil domains that mediate preferential binding to

278 However, when the coiled-coil domain (the AChR-binding domain of rapsyn) i

279 TRIOBP-1, finding it to possess two distinct coiled-coil domains: the central and C-terminal domains.

280 xpanding the hydrophobic surface area of the coiled-coil domains through introduction of the bulky le

281 Addition of the BD or dimerization/coiled coil domains to G-DID rescued plasma membrane tar

282 in growth cones, mediated by binding of the coiled-coil domain to myosin-VI.

283 ral protein cage by appending a C4-symmetric coiled-coil domain to the protein through a short, flexi

284 shown that both Hec1 and Nuf2 utilize their coiled-coil domains to form a functional dimer; however,

285 structures that uses short de novo designed coiled-coil domains to mediate assembly.

286 Leu-324 to Leu-352, but not the entire first coiled-coil domain, to ensure overall stability of the N

287 Mutations that disrupt the TRPP2 coiled-coil domain trimer abolish the assembly of both t

288 Importantly, the mutant coiled coil domain was more efficacious than the wild ty

289 Positive residues around the C-terminal coiled-coil domain were required for membrane binding.

290 Reductions in the size of the BST-2 coiled-coil domain were tolerated as well.

291 attached at positions on the motor and neck coiled-coil domains were used to reconstruct the positio

292 oth protein interaction domains (VHS and the coiled-coil domains) were required for the increased TNF

293 short and primarily controlled by its basic-coiled-coil domain, whereas the nucleolar residence of N

294 ap revealed that CD2AP consists of a central coiled-coil domain, which forms the tetramer interface,

295 of Mtss1 in response to PDGF also involves a coiled-coil domain, which is essential for a proper dist

296 er models between the linker domain HAMP and coiled-coil domains, which is supported by experimental

297 kinase activity, suggesting that a designed coiled coil domain with enhanced binding to Bcr-Abl and

298 coiled-coil motif or substituting the BST-2 coiled-coil domain with a heterologous coiled-coil motif

299 ized middle domain that is predicted to be a coiled-coil domain with multiple helices.

300 This interaction involves a coiled-coil domain within the lumenal domain.