ライフサイエンスコーパス: collagen IV

1 necrosis factor-alpha or cell attachment to collagen IV.

2 on of cellular fibronectin, collagen III and collagen IV.

3 ondrial ROS production (DCF and MitoSOX) and collagen IV.

4 mmunobeads recognizing either laminin 332 or collagen IV.

5 factor (CDAF) that is processed from alpha1 collagen IV.

6 the only BMP ligand in Drosophila that binds collagen IV.

7 ith magnetic beads coated with antibodies to collagen IV.

8 hanism of BMP shuttling that is catalyzed by collagen IV.

9 culature was dual stained with isolectin and collagen IV.

10 of Perlecan, which counters constriction by Collagen IV.

11 es, polymerizing, and binding to nidogen and collagen IV.

12 mbrane, as mirrored by an increase in plasma collagen IV.

13 to the membrane of Caco-2 cells spreading on collagen IV.

14 l epithelial cell spreading and migration on collagen IV.

15 ulation of Caco-2 spreading and migration on collagen IV.

16 oodpasture auto-antigen, the alpha3 chain of collagen IV.

17 anoma cells did not affect their adhesion to collagen IV.

18 o both native and recombinant NC1 domains of collagen IV.

19 s by integrin signaling when cells attach to collagen IV.

20 nderlying chain selection in the assembly of collagen IV.

21 n, cell aggregation, or protease cleavage of collagen IV.

22 re beta1 integrin and adhere more rapidly to collagen IV.

23 Fas-dependent apoptosis by interaction with collagen IV.

24 t mediate chain selection in the assembly of collagen IV.

25 dly on hyaluronic acid than on collagen I or collagen IV.

26 tes the formation of covalent cross-links in collagen IV.

27 xtracellular matrix proteins fibronectin and collagen IV.

28 I, but interrupted linear basal staining for collagen IV.

29 bodies against K3, Cx43, integrin beta1, and collagen IV.

30 the formation of sulfilimine cross-links in collagen IV.

31 FIX binds tightly to collagen IV.

32 in, heparin, bovine serum albumin, mucin, or collagen IV.

33 2-mediated crosslinking of basement membrane collagen IV.

34 of elevated glucose on deposition of FN and collagen IV.

35 o kinds of alloantibodies against allogeneic collagen IV.

36 The aggregated platelets released collagen IV, a critical BL component, onto the PAR4-AP-m

37 d of an IOL placed on a membrane coated with collagen IV, a major constituent of the lens capsule.

38 regates and in addition showed focal loss of collagen IV, a principal component of basal lamina.

39 Collagen IV accumulation in HG was markedly reduced in H

40 etic mice, Sema3a(+) exacerbates laminin and collagen IV accumulation in Kimmelstiel-Wilson-like glom

41 r signal-regulated kinase (ERK1/2, p38), and collagen IV accumulation in mesangial cells.

42 cell proliferation and increased glomerular collagen IV accumulation that is reversed by antioxidant

43 lointerstitial total collagen and glomerular collagen IV accumulation) benefits were seen upon dual t

44 on in ROCK activity, albuminuria, glomerular collagen IV accumulation, and urinary collagen IV excret

45 induced phosphorylation of these targets and collagen IV accumulation.

46 se induces FN assembly, which contributes to collagen IV accumulation.

47 h islets seeded onto scaffolds adsorbed with collagen IV achieved euglycemia fastest and their respon

48 ), a receptor tyrosine kinase that acts as a collagen IV adhesion receptor.

49 D mutation in the collagen domain of COL4A2 (collagen IV alpha chain 2) in a family displaying porenc

50 neys showed significantly less expression of collagen IV, alpha-smooth muscle actin, and other marker

51 product of the alpha1alpha2alpha1 network of collagen IV (alpha1alpha2alpha1(IV) truncated protomer)

52 ngle T cell epitope pCol(28-40) derived from collagen IV alpha3 chain not only induced severe GN in W

53 membrane disorder caused by mutations in the collagen IV alpha3, alpha4, or alpha5 genes that results

54 The dragnet gene, drg, encodes collagen IV(alpha5) (Col4a5), a basement membrane compon

55 nce the production of another novel chain of collagen IV, alpha5(IV) collagen, and SU5416 failed to r

56 In addition to dysregulation of collagen IV, Alport GBM contains aberrant laminins, whic

57 We observed that collagen IV also stimulated Src-dependent phosphorylatio

58 is required for sulfilimine formation within collagen IV, an event critical for BM assembly and tissu

59 viking/collagen IV and betaPS-integrin are known to promote tis

60 llel to perlecan and in opposition to viking/collagen IV and betaPS-integrin to keep CNS lineages roo

61 tegrin interacts with two different ligands, collagen IV and CDH17, using two different binding sites

62 Other molecular (collagen IV and connective tissue growth factor) and his

63 ntrast, the processed form of LOXL2 binds to collagen IV and crosslinks the 7S domain.

64 cess that involves deposition of laminin and collagen IV and de-nitrosylation of laminin.

65 ockdown cells revealed increased adhesion to collagen IV and decreased invasion through the Matrigel.

66 rosis, mesangial expansion, and ECM protein (collagen IV and fibronectin) accumulation as well as inc

67 extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collage

68 Collectively, we conclude that collagen IV and its variant, spongin, are primordial com

69 lomerular basement membrane (GBM) components collagen IV and laminin 10 and 11.

70 Immunofluorescent staining of collagen IV and laminin and electron microscopy analysis

71 urthermore, glomerular nodules overexpressed collagen IV and laminin extensively.

72 degradation and structural reorganization of collagen IV and laminin secreted and deposited by HOSE c

73 heet of basement membrane composed mainly of collagen IV and laminin, and it is believed that the bas

74 that contains tissue-restricted isoforms of collagen IV and laminin.

75 oted euglycemia, yet required more time than collagen IV and less time than serum.

76 trated a 2-fold increase in the levels of BM collagen IV and LOX, key determinants of capillary BM st

77 and differentiated into SMCs when seeded on collagen IV and maintained in differentiation media.

78 ansmission microscopy and immunostaining for collagen IV and MMP-9 were used to examine the effects a

79 enesis decreases proliferation and increases collagen IV and MT-MMP expression.

80 ver, in Col4a3(-/-) Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited Ig

81 ion, respectively) Caco-2 sheet migration on collagen IV and noticeably inhibited lamellipodial exten

82 Collagen IV and pan-laminin were present in the disorgan

83 Our results uncover incorporation of Collagen IV and Perlecan into BMs as a major determinant

84 ation, altered peritracheal distributions of collagen IV and Perlecan, misregulated ASP growth, and a

85 transcriptome and available genomic data for collagen IV and peroxidasin.

86 The resulting upregulation of alpha1 collagen IV and production of Arresten by the tumor cell

87 ow that p53 induces the expression of alpha1 collagen IV and release of Arresten-containing fragments

88 1 knockdown decreased melanocyte adhesion to collagen IV and shifted melanocyte localization in a man

89 tiating P. aeruginosa keratitis by degrading collagen IV and upregulating chemotactic cytokines/chemo

90 We first established a protocol using collagen IV and VEGF to drive the functional differentia

91 hesion of both fetal and adult beta-cells to collagen IV and vitronectin also results in the marked s

92 pendent adhesion of fetal beta-cells to both collagen IV and vitronectin induces significant glucose-

93 Fibronectin and collagens IV and I protein levels were elevated in both

94 connective tissue growth factor (CTGF), and collagens IV and VI found in diabetic wild-type mice was

95 sylated proteins (mucin, soybean peroxidase, collagen IV, and avidin) were compared with those of the

96 own to bind decay-accelerating factor (DAF), collagen IV, and carcinoembryonic antigen-related cell a

97 ses Col4a2 and intracellular accumulation of collagen IV, and decreases the proteolytic release of co

98 (4) significant accumulation of perivascular collagen IV, and fibrin deposits (5) significantly incre

99 affinities to extracellular matrix proteins, collagen IV, and fibronectin.

100 eases in the levels of glomerular TGF-beta1, collagen IV, and fibrosis only in WT diabetic mice.

101 rticipates in regulation of cell adhesion on collagen IV, and is required for maximal PAK1 kinase act

102 llular matrix proteins-including collagen I, collagen IV, and laminin V-to modulate intercellular Eca

103 TA-6 correlates with the loss of Disabled-2, collagen IV, and laminin, markers for epithelial cell ty

104 ment membrane (BM) constituents, laminin 10, collagen IV, and nidogen-2 (but not perlecan) are consid

105 factor-beta1 (TGF-beta1), fibronectin (FN), collagen IV, and p21/WAF1Cip1 (p21) were analyzed.

106 icate a functional connection between Br(-), collagen IV, and peroxidasin.

107 th invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasm

108 that the structural and genomic features of collagen IV are homologous to those of non-bilaterian an

109 e using lysozyme and RGD-alpha3NC1 domain of collagen IV as model proteins in vitro.

110 opy after immunohistochemically staining for collagen IV basement membrane markers, in addition to ex

111 The collagen IV binding receptor integrin alpha1beta1 has be

112 A collagen IV binding-deficient Dpp mutant signals at long

113 n this article, we show that adhesion by the collagen IV-binding integrin alpha1beta1 unexpectedly in

114 Culture on collagen IV, but not on laminin, rendered HLE-B3 cells r

115 Conditioned medium from LECs cultured on collagen IV, but not TC plastic, protected cells culture

116 281) fusion protein bound to fibronectin and collagen IV, but not to collagen I.

117 Collagen IV, but not vitronectin, induces comparable res

118 gh p130cas siRNA inhibited cell spreading on collagen IV by 33%, three different paxillin siRNAs did

119 integrin consistent with the modification of collagen IV by hypochlorous (HOCl) and hypobromous acids

120 bilized the expression of full-length alpha1 collagen IV by upregulation of alpha(II) prolyl-hydroxyl

121 n as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is

122 he 7/10/22 subfamily and broadly distributed collagen IV chains (alpha1/2) promote clustering of syna

123 Synapse-specific collagen IV chains (alpha3-6) accumulate only after syna

124 at intermolecular epitope spreading to other collagen IV chains also was induced.

125 our previous studies, establish that the six collagen IV chains are organized into three canonical pr

126 tress arising from defective localization of collagen IV chains in human podocytes contributes to the

127 Assembly of collagen IV chains into heterotrimeric molecules and net

128 ted by pathogenic anti-GBM alloantibodies to collagen IV chains present in the renal allograft but ab

129 d bone-morphogenetic protein-4 and growth on collagen IV-coated plates.

130 n FN surfaces but spread 3x greater on rigid collagen IV-coated surfaces than soft.

131 nt-related gene changes, including decreased collagen IV (COL4A1, COL4A2) and ephrinA1 (EFNA1).

132 or the effects of FA on fibronectin (FN) and collagen IV (Coll IV) expression.

133 protein quantification showed a dominance of collagen IV, collagen I, and laminin isoforms in the glo

134 aran sulfate chains were integrated into the collagen IV-containing network.

135 nd extracellular matrix components (laminin, collagen IV) correlate with tissue softening.

136 (trans), microvessel volume, and circulating collagen IV correlated with duration of overall survival

137 ucture and proposed biosynthetic function in collagen IV cross-linking.

138 structural requirements of LOXL2 that enable collagen IV crosslinking.

139 ent in vivo was associated with increases in collagen IV, decreases in laminin, and varied changes in

140 An inhibitor of FN matrix assembly prevented collagen IV deposition, demonstrating dependence of coll

141 gen VI anchorage, in turn leading to reduced collagen IV deposition.

142 ne, excessive ROS production, and consequent collagen IV deposition.

143 foot processes, lowered proteinuria, lowered collagen IV deposits in the mesangial matrix, diminished

144 Here we report that a novel collagen IV derived biomimetic peptide inhibits breast c

145 We also show that incorporation of Collagen IV determines organ shape, first by mechanicall

146 orms of the major ECM components laminin and collagen IV did not reproduce the effect; or (3) inhibit

147 The protective effect of culture on collagen IV diminished with decreasing cell density.

148 stress are potential therapeutic options for collagen IV diseases including haemorrhagic stroke.

149 be suppressed by loss of the ECM components collagen IV (EMB-9) and fibulin (FBL-1).

150 ch involves degradation or reorganization of collagen IV (EMB-9), whereas FBL-1 opposes GON-1 by stab

151 microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental archit

152 nity of the extracellular alpha1 I domain to collagen IV enhances outside-in signaling by potentiatin

153 dermal-epidermal junction, we propose that a collagen-IV-enriched DEJ may, in part, explain its well-

154 immunization with native forms of allogeneic collagen IV exclusively elicited antibodies to quaternar

155 erular collagen IV accumulation, and urinary collagen IV excretion compared with untreated db/db mice

156 for diabetic vs. treated) and a reduction in collagen IV expression following sTbetaRII.Fc treatment

157 Collagen IV expression was increased in sinusoidal endot

158 decreased BMPR2 and downstream signaling and collagen IV expression.

159 Follicle epithelia mutant for integrin or collagen IV fail to rotate and elongate, which results i

160 re was significantly increased expression of collagen IV, fibronectin, and laminin mRNA in Cfh(-/-) g

161 helial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin that assemble to a

162 Depositions of collagen IV, fibronectin, and laminin were also greatly

163 ct combinations of collagen I, collagen III, collagen IV, fibronectin, and laminin.

164 d that in vivo ITF2357 decreased collagen I, collagen IV, fibronectin, integrin alphaVbeta3 expressio

165 of lactide and glycolide were adsorbed with collagen IV, fibronectin, laminin-332 or serum proteins

166 llagen III as well as mixtures of collagen I/collagen IV/fibronectin as having a positive effect on L

167 In these mice, intact collagen IV from murine GBM was not immunogenic.

168 We also provide in vivo evidence that collagen IV functions as a scaffold to promote shuttling

169 als at longer range in vivo, indicating that collagen IV functions to immobilize free Dpp in the embr

170 To evaluate the origins of collagen IV further, we transplanted embryonic kidneys f

171 agen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrat

172 ar matrix proteins fibronectin, laminin, and collagen IV have been shown to function as receptors for

173 Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collage

174 able to compete for the alpha1 I domain from collagen IV (IC(50) approximately 3 mum), GFOGER is much

175 sue from P1 and P2 was found to have reduced collagen IV immunoreactivity at the muscle basement memb

176 The sclerotic index values, density of collagen IV immunoreactivity in the microvasculature and

177 munoreactivity and protected against loss of collagen IV immunoreactivity.

178 ific covalent sulfilimine bonds to reinforce collagen IV in basement membranes.

179 We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural

180 the N- and C-termini of agrin, laminin, and collagen IV in mouse and human GBM revealed a highly ori

181 was identified as the isoform cross-linking collagen IV in mouse embryonal PFHR-9 cells.

182 Enhanced breakdown of collagen IV in the basal lamina and of fibrillar collage

183 for laminin 5, positive linear staining for collagen IV in the basement membrane, and diffuse staini

184 llagen III in the liver and collagen III and collagen IV in the heart; this is induced by HF feeding.

185 resulted in markedly decreased deposition of collagen IV in the mesangium and less beta-galactosidase

186 itions under which Arresten is released from collagen IV in vivo or whether the protein functions in

187 ood vessels, localized to the same region as collagen IV, in 2 representative human tissues: liver an

188 Intriguingly, defective collagen IV incorporation into the dermal BM was observe

189 Collagen IV incorporation into the matrix was also incre

190 mKL promoted cell adhesion to collagen IV, increased FAK and Akt phosphorylation, and

191 tion proteins, did not affect degradation of collagen IV induced by the tMCAO, but altered cell types

192 human alpha3 noncollagenous (NC1) domain of collagen IV inhibits angiogenesis and tumor growth.

193 Collagen IV is a family of 6 chains (alpha1-alpha6), tha

194 Moreover, collagen IV is absent in unicellular sister-groups.

195 endent release of bioactive NC1 domains from collagen IV is critical for integrating collagen IV synt

196 Our analysis also revealed that mutant collagen IV is degraded via the proteasome.

197 overed that the extracellular matrix protein collagen IV is important for BMP gradient formation.

198 es and the vascular basement membrane marker collagen IV is mislocalized, suggesting that ECs fail to

199 We found with this method that Collagen IV is synthesized by the fat body, secreted to

200 on the expression and function of the major collagen IV isoform alpha1(IV), and pathological effects

201 here is a novel strain-specific alternative collagen IV isoform switch that is associated with the d

202 y GBM components (fibronectin, laminins, and collagen IV isoforms), or podocyte integrins could be ob

203 matrix molecules (collagen I, collagen III, collagen IV, laminin and fibronectin) on cellular differ

204 MTM cells expressed TM markers, including collagen IV, laminin, and alpha-smooth muscle actin.

205 matrix structure and composition in terms of collagen IV, laminin, and fibronectin.

206 extract (Adipogel) comprising ECM proteins (collagen IV, laminin, hyaluronan, and fibronectin) and i

207 The protein expression of collagen-IV, laminin, claudin-5, occludin, and zonula oc

208 P-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion.

209 vessel volume, and the change of circulating collagen IV levels, all after a single dose of cediranib

210 g glucose-mediated oxidative modification of collagen IV lysine residues rescued the alterations in c

211 y reduced collagen production on plastic and collagen IV matrices; whereas non-collagen protein produ

212 tein predominantly localized adjacent to the collagen IV matrix during cellular attachment.

213 ce the function of transplanted islets, with collagen IV maximizing graft function relative to the ot

214 Importantly, we demonstrate the presence of collagen IV NC1 domains in developing tissue.

215 re detected within the assembly interface of collagen IV NC1 domains isolated from renal ECM of diabe

216 Furthermore, recombinant collagen IV NC1 domains rescue branching morphogenesis a

217 IV, and decreases the proteolytic release of collagen IV NC1 domains.

218 MN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/

219 The predominant collagen IV network is composed of triple helical protom

220 pha5(IV) heterotrimer, which forms the major collagen IV network of the glomerular basement membrane

221 inforcing sulfilimine cross-links within the collagen IV network, an event essential to basement memb

222 rt GBM is effective at restoring the missing collagen IV network, slowing kidney disease progression,

223 -helical molecules of the alpha3alpha4alpha5 collagen IV network.

224 Collagen IV networks are ancient proteins of basement me

225 Collagen IV networks are present in all metazoa and unde

226 Collagen IV networks are present in all metazoans as com

227 important structural cross-linking domain of collagen IV networks that provide mechanical stability t

228 r, the mechanism whereby podocytes adhere to collagen IV networks, a major component of the glomerula

229 The reinforcement extends to other types of collagen IV networks, and it underlies the cryptic natur

230 us (NC1) hexamers, key connection modules of collagen IV networks, are modified via oxidation and chl

231 modifications of renal ECM, and specifically collagen IV networks, contribute to functional protein d

232 molecular machinery that forms cross-linked collagen IV networks, which are essential for glomerular

233 ical protomers, reinforcing the stability of collagen IV networks.

234 n IV deposition, demonstrating dependence of collagen IV on FN matrix.

235 iloxane) chamber and coating a thin layer of collagen IV on top of the electrode surface.

236 specific activity toward triple helices from collagen IV or V.

237 Failure of hemocyte migration, loss of collagen IV, or abrogation of BMP signaling results in t

238 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in

239 fected mice and correlated with staining for collagen IV; PMN was a source of MMP-9.

240 Cs are seated on a well formed human laminin/collagen IV-positive basement membrane, and are surround

241 ell death, and basement membrane constituent collagen IV production were examined in an organotypic d

242 ericytes with TNF-alpha and IL-17A augmented collagen IV production, similar to in vivo remodeling.

243 se inhibits cell proliferation and increases collagen IV production.

244 ed proliferation and migration and increased collagen IV production.

245 ble factors released by the LECs cultured on collagen IV protect LECs from Fas-dependent apoptosis.

246 After binding of Dpp/Scw and Sog to collagen IV, protein interactions are remodeled, generat

247 5R, which binds better than wild-type FIX to collagen IV, provides better hemostasis than wild-type F

248 rabbit anti-VWF, rat ani-CD105, rabbit anti-collagen IV, rat anti-ICAM-2, rabbit anti-desmin, and ra

249 ecause the molecular mechanisms whereby this collagen IV receptor mediates endothelial cell functions

250 We have previously observed that collagen IV regulates Caco-2 intestinal epithelial cell

251 ient recombinant laminins, with retention of collagen IV, reiterating the basement membrane (BM) chan

252 othelial denudation, exposing the underlying collagen IV-rich basal lamina, which promotes both intra

253 tended to localize in close proximity to the collagen IV-rich basement membranes of either the airway

254 mbrane from the lens capsule of the eye is a collagen IV-rich matrix that can easily be extracted and

255 evelopment and architecture found within the collagen IV scaffold of basement membranes (BMs).

256 ely, our findings establish that the triad-a collagen IV scaffold with sulfilimine cross-links, perox

257 ysine residues to structurally reinforce the collagen IV scaffold, a function critical for basement m

258 A collagen IV scaffold, a major component, is essential fo

259 domain, a structural domain that stabilizes collagen IV scaffolds in the basement membrane.

260 confers critical structural reinforcement to collagen IV scaffolds.

261 Collagen IV sensitizes tubule cells to localized BMP gui

262 Our results show that the collagen IV sheet anchors secreted factors at the surfac

263 Mouse mesangial cells plated on MGO-modified collagen IV showed decreased adhesion and migration.

264 Chemotaxis assays through collagen IV showed more efficient migration of Itga1(-/-

265 Cells plated on glucose-modified collagen IV showed reduced proliferation and migration a

266 tein receptor type 2 (BMPR2) and its target, collagen IV, signaling of the phosphorylated form of the

267 ease by Tsg through specific disruption of a collagen IV-Sog interaction.

268 Collagen IV stainings were negative in both controls and

269 demonstrated normal patterns of laminin and collagen IV subunit expression.

270 The collagen IV sulfilimine cross-link and its catalyzing en

271 r an order of magnitude of stiffness values, collagen IV surfaces lead to enhanced motility compared

272 on geometrical patterns of poly-L-lysine and collagen IV, surrounded by nonadhesive regions of bovine

273 from collagen IV is critical for integrating collagen IV synthesis and proteolysis with epithelial pr

274 bstitutions have enhanced down-regulation of collagen IV synthesis, which is mediated by the ERK/MAPK

275 Moreover, systemic administration of collagen IV targeted Ac2-26 NPs (in as low as 1 microg p

276 actic-co-glycolic acid)-b-polyethyleneglycol collagen IV-targeted polymers.

277 Previously, we reported the engineering of collagen IV-targeting nanoparticles (NPs) and demonstrat

278 lymeric NPs were surface functionalized with collagen IV-targeting peptides and loaded with paclitaxe

279 In collagen I and collagen IV (targets for MMP1 and MMP3, respectively) su

280 study in vivo the biogenesis and assembly of Collagen IV, the main constituent of BMs, we used a GFP-

281 hough the cells adhered to the BrM component collagen IV, these cells preferentially adhered to lamin

282 tein functionality, including the ability of collagen IV to interact with glomerular mesangial cells.

283 e microelectrodes in the MEA was coated with collagen IV to promote cell adhesion and further single-

284 h blood vessels (labeled with an antibody to collagen IV) to measure the coverage of vessel walls by

285 LNNd was found to mediate laminin binding to collagen IV, to bind to galactosyl sulfatide, and to sel

286 In older pancreases, collagen IV, V and VI were present throughout the islet-

287 st that Src may regulate Caco-2 migration on collagen IV via both p130cas and paxillin but that Src p

288 nset disease were studied with antibodies to collagens IV, VIIIA1, VIIIA2, fibronectin, and laminin.

289 ing VNC, the extracellular matrix components Collagen IV, Viking and Peroxidasin are not deposited ar

290 ion to vitronectin, laminin, collagen-I, and collagen-IV was not affected.

291 To identify collagen IV, we first evaluated defect-free erupted teet

292 on and localization of Ki-67, caspase-3, and collagen IV were examined by immunohistochemistry.

293 e basement membrane components laminin V and collagen IV were severely diminished.

294 , alpha-Actinin), and the basement membrane (Collagen IV), were down-regulated upon SRF depletion.

295 a its N-terminal CUB domains, interacts with Collagen IV, which enhances Tolloid activity towards its

296 oteins that contain this amino acid, such as collagen IV, which is an important structural component

297 Integrin alpha1beta1 binding to collagen IV, which is mediated by the alpha1-inserted (I

298 Incubation of collagen IV with pathophysiological levels of either the

299 ucts, and in a zymography assay, reaction of collagen IV with products of A2E photodegradation result

300 substrate, but fails to crosslink insoluble collagen IV within the extracellular matrix.