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1 riod but reached equilibrium after the bloom collapsed.
2 g shelf accelerated, crumbled and ultimately collapsed.
3 vertheless impaired and these spindles often collapsed.
4 ommercial landings of planktivorous sardines collapsed.
5 ction increased steeply as cotton production collapsed.
6  and the membranous vestibular labyrinth was collapsed.
7 are incomplete and sub-genome assemblies are collapsed.
8                               When data were collapsed across all image modifications, a multivariate
9                                Variants were collapsed across CpG islands and their flanking regions
10                                              Collapsed across groups, changes in visceral fat were as
11 , whereas for rarer variants information was collapsed across variants.
12                   However, Treg cell numbers collapsed after LCMV inoculation.
13  switched between cell states initially, but collapsed after repeated transitions, possibly due to th
14 ad, the periplasmic domains of NccX appeared collapsed against the hydrophobic transmembrane segments
15  For rare variants, we applied 2 approaches: collapsed aggregate statistics and joint analysis of var
16     We found that cocaine use for 10 minutes collapsed all three measures of cue-potentiated t-SP bac
17                Many of these deficits can be collapsed along two basic visual dimensions (visual acui
18 profile cases relying on LTDNA evidence have collapsed amid controversy, including the case of Hoey i
19  SERCA in which the Ca(2+) binding sites are collapsed and devoid of divalent cations (E2-PLB).
20 isordered protein regions transition between collapsed and extended conformations under native condit
21 tent with such a dynamic equilibrium between collapsed and extended structures and are best represent
22  Among the two conformations of prothrombin, collapsed and fully extended, histone H4 binds selective
23 of determining the topology of cooperatively collapsed and hidden folded states when these are presen
24              Instead, the formed protrusions collapsed and retracted, bringing the bacteria back to t
25  When the LS interface was grounded the cone collapsed and the MS ion signal was lost, indicating tha
26  always retained in the gas phase, with both collapsed and unfolded species being detected.
27 t, although EEA1(+) endosomes were enlarged, collapsed, and devoid of filamentous-actin and Arp2/3 in
28 sors do not distinguish between native-like, collapsed, and expanded forms of a protein complex, diss
29 the AtCesA7(irx3-5) mutant is also partially collapsed, and we suggest that the small guard cells in
30                   The skull frequently had a collapsed appearance with overlapping sutures and redund
31 equence to characterize the stability of the collapsed aptamer.
32 ts keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positi
33 ly disordered C-terminal arms are relatively collapsed around the tetrameric OB core and collapse fur
34 over time codes were amended, integrated and collapsed as appropriate through the process of analysis
35 vealed that the peptides became increasingly collapsed as the number of glutamine residues increased.
36                                AVLs grew and collapsed at approximately the same rate (P = .275).
37 E PRESENTATION: A 52 year-old diabetic woman collapsed at her home in front of an acquaintance.
38  burden analysis in which variants are first collapsed at the gene level then by Gene Ontology terms.
39                                Mutant pollen collapsed at the time of anther desiccation.
40 d open complexes and extended bubbles, which collapsed back to closed or open complexes, resulting in
41 e formation of pores near the surface of the collapsed beads, offering promising means to tailor comp
42 rs believe that prehistoric Rapa Nui society collapsed because of centuries of unchecked population g
43 pensatory mechanism of the body is partially collapsed because of excessive production of free radica
44 tended clamp configuration as opposed to the collapsed binding mode often observed in other CaM-prote
45 mbranes in the cortex, and the conversion of collapsed bladder membranes into outwardly radiating cor
46 ithm for generating noncalcium images of the collapsed bodies.
47 OA was required to fill indentations between collapsed branches of the restructured aggregates before
48  Inhibition of myosin-II (MII) or Rho-kinase collapsed bridges, whereas extension continued over adhe
49 issions from trapped victims in the voids of collapsed buildings.
50  release, that all marine fisheries would be collapsed by 2048.
51 tra suggest that the lung periphery was more collapsed by obesity in patients with asthma compared wi
52               In contrast, replication forks collapsed by prolonged replication blocks do not restart
53                  Sequence datasets have been collapsed by up to 71%, and the reduced number and impro
54 hermal responsivity; the resulting hydrogels collapsed by up to 95% of their height upon addition of
55 , resulting in p(MMA-stat-GMA), subsequently collapsed by using B(C6F5)3 as catalyst.
56                                     Notably, collapsed CaM is observed after binding of an extended C
57 hermally responsive component of the pattern collapsed, causing a significant and predictable alterat
58 nts lacked exine deposition and subsequently collapsed, causing male sterility.
59                   Much work has been done on collapsed chains of conjugated semiconducting polymers a
60 iking transition into macroscopic domains of collapsed chains with fractal dendritic morphology.
61 synuclein formed a heterogeneous ensemble of collapsed coil states in an aqueous environment.
62 l that although all three variants remain as collapsed coils in solution, there exist significant str
63 es for small, low trophic-level species have collapsed compared with those for large predators.
64 te corresponds to a slipknot conformation, a collapsed configuration where the C-terminal helix adopt
65 ater thermodynamic binding affinity with the collapsed conformation of polystyrene than with the exte
66             Furthermore, it was found that a collapsed conformation of the polymer is required to ens
67  the human and murine forms that confirm the collapsed conformation reported previously under differe
68 h DNA damage organizes PARP-1 domains into a collapsed conformation that can explain the strong prefe
69 udies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E
70 ded CaM conformation, whereas cSH2 prefers a collapsed conformation.
71                All three osmolytes stabilize collapsed conformations of the ELP and reduce the lower
72   These results suggest that TMAO stabilizes collapsed conformations via a mechanism that is distinct
73 range tertiary interactions leading to Abeta collapsed conformations.
74 ls, assembly of such data usually results in collapsed contigs that represent a variable number of ho
75 ompact ensembles: C (crystal structure), CC (collapsed crystal), and Sph (spherical compact).
76 etition of the cycle was performed until the collapsed cyst wall appeared gray.
77 ew of the selectivity filter backbone in its collapsed deep C-type inactivated conformation, highligh
78  junctions, and that loss of Lnp1 leads to a collapsed, densely reticulated ER network.
79 ole subsites of the open Na(+) complexes are collapsed, distorted, and too small to accommodate indol
80 An Skp2/Cks1 pocket inhibitor preferentially collapsed DKO prostate tumor organoids over AADKO organo
81 e that mammalian RAD52 facilitates repair of collapsed DNA replication forks in cancer cells.
82 a infection at a third, smaller release site collapsed due to the immigration of Wolbachia-free mosqu
83 ve previously shown that F1 TnC is a typical collapsed dumbbell EF-hand protein that accommodates one
84 O values to the modern, and that the monsoon collapsed during periods of weakened AMOC during Heinric
85 e of ultrastable zeolite Y the FAU framework collapsed during phosphatation, due to extraction of fra
86 d Ice Sheet and the West Antarctic Ice Sheet collapsed during the protracted warm period while change
87 onformations where the active site is either collapsed (E*) or accessible to substrate (E).
88 erceived KT knowledge (5-point Likert scale, collapsed empirically to 4 points); we also asked candid
89 esults from aberrant accumulation within the collapsed endosomal compartment, ultimately leading to d
90  However, although TfnR was accumulated with collapsed endosomes, it recycled normally.
91 ecent studies revealed that polar IDPs favor collapsed ensembles in water despite the absence of hydr
92 ne protein-associated protein A (VAP-A) in a collapsed ER network.
93 ptome, and that 90% of the Bcl-6 cistrome is collapsed following Tlr4 activation.
94 f ecosystems in the tropical eastern Pacific collapsed for 2500 years, representing as much as 40% of
95 ntly occur by an active fork converging on a collapsed fork.
96 processing DNA intermediates that arise from collapsed forks and homologous recombination.
97 e gene by CRISPR/Cas9 compromised restart of collapsed forks and led to DNA damage in cells experienc
98                                              Collapsed forks can be rescued by homologous recombinati
99 antly increased levels of markers of stalled/collapsed forks compared to either single homozygote.
100                          At chromosome ends, collapsed forks result in truncated telomeres that must
101 2AX, a marker of DNA double-strand breaks at collapsed forks, and it co-immunoprecipitates with PCNA
102                   RecBCD targets DNA ends at collapsed forks, enabling DNA capture without interferen
103 on forks collide from behind with stalled or collapsed forks.
104 lly dependent upon HR-mediated resolution of collapsed forks.
105 orks, and implicate Metnase in the repair of collapsed forks.
106 s DNA double-strand breaks (DSBs) arising at collapsed forks.
107 ection altogether, thereby licensing NHEJ at collapsed forks.
108 xtended, histone H4 binds selectively to the collapsed form and induces a transition toward a new con
109 ctures from a more open toward a more stable collapsed form by stabilizing tertiary interactions.
110 s of the exine layer, displayed shrunken and collapsed forms, and were unable to germinate when cultu
111 populations possibly indicating the open and collapsed forms.
112                       Megafaunal populations collapsed from 14,800 to 13,700 years ago, well before t
113                                      Intact, collapsed gas vesicles from the cyanobacterium Anabaena
114                                     We use a collapsed Gibbs sampling algorithm for inference.
115 ide backbones, and therefore, backbones form collapsed globular structures in aqueous solvents.
116 st striking of these had the appearance of a collapsed graphite structure, with benzenoid C6 units an
117 verting conformations that are more globally collapsed, hairpin-like, or circular, giving rise to the
118 n the gene-level linkage analysis, using the collapsed haplotype pattern method.
119 , whereas the D2.50 allosteric pocket became collapsed in active GPCR structures.
120                Jag1(Ndr/Ndr) liver organoids collapsed in culture, indicating structural instability.
121 e potential was significantly increased, but collapsed in response to oligomycin, suggesting that the
122 These sites were depleted and the ER network collapsed in syta-1, and both reformed upon rescue with
123 cted under continuous light in the wild type collapsed in the CCA1 overexpressor.
124 ile the upper peak--species that has not yet collapsed in the current wave.
125  under physiological conditions, but rapidly collapsed in the presence of tumor-localized ultrasound
126 wall leads to spherically shaped cells and a collapsed inner membrane sac.
127  of the enzyme to its substrates that may be collapsed inside hydrophobic domains.
128 -protein (LP) diet are normoglycemic despite collapsed insulin secretion.
129 nsistent with formation of a hydrophobically collapsed intermediate state which slowly rearranges to
130 These observations suggest that specifically collapsed intermediate structures with low stability in
131 readers for MCE and 3 readers for SPECT were collapsed into 1 diagnosis per patient per technique and
132                                              Collapsed into a 3-category risk score, major hemorrhage
133 es which have been incorrectly assembled and collapsed into a single copy.
134 he pervasive developmental disorders are now collapsed into a single entity, autism spectrum disorder
135                            The CSF data were collapsed into a single index by the use of weighted mea
136 are variants within a given gene region were collapsed into a single locus and a global P value was c
137 grees ) even when the two one-electron waves collapsed into a single two-electron wave.
138 vel, a validated 11-point mobility scale was collapsed into four categories: nothing in bed, in-bed a
139                           HCT-CI scores were collapsed into four groups and were evaluated in univari
140                       Surprisingly, the TFVs collapsed into lipid droplets after entry into the cell
141 tegories 5 (severe disability) and 6 (death) collapsed into one category (severe disability or death)
142                            When proteins are collapsed into orthologous groups (OGs) the resulting me
143 mation from CRM and transmittance images was collapsed into straightforward single variables; total i
144 according to the new classification and then collapsed into three groups (LEP, ACN/PAP, and MIP/SOL).
145 ive adaptation when responding to blocked or collapsed invader DNA replication.
146 e and the archaeological layer upon which it collapsed, it is clear that the Early Aurignacian occupa
147                 p.Q434del and p.R441P formed collapsed K10 fibers rather than aggregates characterist
148 and display compressed axial cell length and collapsed lamellipodia.
149 thritic knees, afferent lymphatic vessels to collapsed LNs in inflamed knees do not pulse.
150 her fully extended (54 +/- 2 A) or partially collapsed (</=34 A) as seen in the crystal structure.
151 difficult to place sutures correctly through collapsed lumen, making the procedure prone to failure.
152 ell polarities, which might be the cause for collapsed lumina.
153 t maneuver (Sigh) might induce reaeration of collapsed lung regions, possibly decreasing regional lun
154 s, which potentially marks the time when the collapsed masses sliding into river and perhaps even imp
155  of both SAM and magnesium to form the fully collapsed metabolite-bound closed state of the SAM-I rib
156  while vup1 loss-of-function mutants exhibit collapsed morphology of xylem vessel cells.
157 rs, a single dose of several anti-VEGF drugs collapsed MV to form glomeruloid microvascular prolifera
158 on parallel to the lipid bilayer sealing the collapsed Na(+) ion pocket and linking the agonist with
159                 As existing communities have collapsed, new ones have become established, fundamental
160 ume corresponding to different newborn sizes collapsed on top of each other.
161 nar jointing, and show how these data can be collapsed onto a single master scaling curve.
162 e distributions of local cell volumes can be collapsed onto a universal curve using the predicted k-g
163 reveal that the evolutionary dynamics can be collapsed onto master curves governed by three essential
164 ure also reveals that the capping domain had collapsed onto the active site containing the Ser-101-Hi
165 stratification and colocalization within the collapsed OPL, although both are atrophic and the spatia
166      After ejection, the extended phage tail collapsed or disassembled, which allowed resealing of th
167 ubules, whereas scattered glomeruli appeared collapsed or featured signs of fibrosis along Bowman's c
168 riA, the initiator of replication restart on collapsed or misassembled replication forks, blocks the
169 lower peak formed by populations of recently collapsed or newly introduced species while the upper pe
170 an be forced together by the ECM producing a collapsed orientation of the talin dimer.
171 zing constant and cannot be aggregated (i.e. collapsed) over time to make space-only inference.
172 ersity with 1867 core proteins and a paralog-collapsed pan-genome size of 11,694 proteins.
173 d unlignified, thin-walled xylem fibers with collapsed parenchyma cells around the vessels.
174 an elaborate capillary plexus with an empty, collapsed PAS-positive lens capsule in the pupillary reg
175 n without long-range magnetic order, and the collapsed phase shows nearly zero thermal expansion.
176 ph speed was observed in vessels afferent to collapsed PLN (P < 0.05).
177 atically increased to 9.92 +/- 1.79 cmH2O in collapsed PLN.
178 e in mice with wild-type (WT), expanding and collapsed PLN.
179 A is prometaphase arrest with characteristic collapsed polar polo spindle.
180 ransfer to the lowest-energy chromophores in collapsed polymer chains that adopt a highly ordered mor
181 ons between Au cores being very large in the collapsed polymer state, setting up a tightly compressed
182                        The essential role of collapsed polymers in achieving anisotropic growth makes
183 cle surfaces with locally defined domains of collapsed polymers.
184  stationary in lymphatic vessels afferent to collapsed popliteal LNs.
185 ulations predict a channel-like shape with a collapsed pore, which is supported by the AFM channel im
186 he selectivity filter no longer assumes the "collapsed," presumed inactivated, conformation in low K(
187 hains predicts the crowding effects only for collapsed protein chains.
188 we excluded randomized controlled trials and collapsed protocols, guidelines, and bundles into one ca
189 povolemic cardiac arrest, the ventricles are collapsed rather than dilated.
190 n the DNA structures resembling a stalled or collapsed replication fork and its interactions with RAD
191 ge of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DS
192 rvation of the genetic integrity, restart of collapsed replication forks and telomere maintenance.
193 B3 maintains genomic stability at stalled or collapsed replication forks by facilitating fork restart
194 pathway participates in repair of stalled or collapsed replication forks during DNA replication, lead
195 egation at meiosis and the repair of stalled/collapsed replication forks in mitotic cells.
196           Replication stress from stalled or collapsed replication forks is a major challenge to geno
197 ions are needed to load Gp41 onto nascent or collapsed replication forks lacking clusters of Gp32 and
198 f stalled replication forks and HR repair of collapsed replication forks require two distinct RAD51-m
199 te repair of damaged chromosomes, restart of collapsed replication forks, and telomere maintenance.
200 slocalization to DSBs occurred at stalled or collapsed replication forks, concurrent with a significa
201 s hypersensitivity to ionizing radiation and collapsed replication forks, increased Rad52 foci, defec
202                SMARCAL1-deficient cells show collapsed replication forks, S-phase cell cycle arrest,
203 ind DNA structures encountered at stalled or collapsed replication forks, such as ssDNA-double-strand
204 zymes play in the response of cells to DSBs, collapsed replication forks, telomere dysfunction, and m
205 d17, which enhance recombinational repair of collapsed replication forks, we demonstrate that USP20 d
206 AD51-dependent HR is triggered for repair of collapsed replication forks, without apparent restart.
207 re, MMEJ is used to repair DSBs generated at collapsed replication forks.
208 newly replicated DNA at active, stalled, and collapsed replication forks.
209 Pif1 interfere with DNA replication, causing collapsed replication forks.
210 uired for chromosome integrity and repair of collapsed replication forks.
211 uits CtIP to transiently stalled, as well as collapsed, replication forks on chromatin.
212 xpanded, flexible "open" configuration and a collapsed, rigid "closed" one.
213 m the damaged well both before and after the collapsed riser pipe was removed.
214 ngraved and ocre-stained undersurface of the collapsed rockshelter ceiling from Abri Castanet, Dordog
215                                          The collapsed RuBisCO folding intermediate binds to the lowe
216 sulted from substitution with proline, which collapsed S1 subsite specificity such that only substrat
217 esembles high-density water, with a strongly collapsed second coordination shell.
218 t the cliff overhanging the Chauvet cave has collapsed several times since 29 ka until the sealing of
219 es, in which the 2 sedentary conditions were collapsed, showed an intake that was 178 kcal (95% CI: 8
220                   The resulting product is a collapsed single-stranded DNA molecule with tandem repea
221 he last 50 years leaving only 2% of the pre-collapsed size, consistent with the population collapses
222 tion: (1) severe microcephaly with partially collapsed skull; (2) thin cerebral cortices with subcort
223 signed three-helix-bundle protein that forms collapsed, stable molten globules but lacks a uniquely f
224      Magnesium biases the landscape toward a collapsed state (preorganization) by coordinating pseudo
225 l will transition from a hydrated state to a collapsed state above ~40 degrees C.
226 rements are dominated by the escape from the collapsed state accessed after counterion condensation.
227  suggest simultaneous formation of a compact collapsed state and secondary structure.
228          In contrast, NF-LM gels remain in a collapsed state for P < P(c) and transition to the gel-c
229 ow potassium and low pH, suggesting that the collapsed state is structurally similar to the inactivat
230 llapsed states, and the heterogeneity in the collapsed state makes it feasible to split alpha-synucle
231 s the key factor in the stabilization of the collapsed state of ELPs in D(2)O compared with H(2)O.
232 ions, Gnd(+) was also found to stabilize the collapsed state of the ELP when paired with SCN(-), whic
233 f stabilizing CD-I salt bridges results in a collapsed state of the Kir domain.
234 ter interface and was found to stabilize the collapsed state of the macromolecule when paired with we
235 cation were both found to be enriched in the collapsed state of the polymer.
236                                          The collapsed state was favored because the Gnd(+) cross-lin
237 rotic Mottle Virus capsid transitions to the collapsed state without substantial local structural alt
238 xFG repeat sequences adopts a disordered but collapsed state.
239 vation, proceeds via a state similar to this collapsed state.
240  a dynamic transition of the particle to the collapsed state.
241 ransitions between glacial, intermediate and collapsed states are relatively rapid, taking one to sev
242 pH, whereas G1-G2 and residues 28-161 prefer collapsed states in Ca(2+)-free conditions at pH 8.
243 biquitins, it had no effect on the resulting collapsed states that are essential precursors of the fo
244 transitions between amorphous, wave-like and collapsed states with an intermittent regime between the
245 ontains residual secondary structures in the collapsed states, and the heterogeneity in the collapsed
246 ged intense overexploitation, especially for collapsed stocks, not only delays rebuilding but also su
247               We conclude that CaBP4 forms a collapsed structure around the IQ motif in Cav1.4 that w
248 uggesting the existence of a "sandwich"-like collapsed structure in which the tail enables the close
249             The mechanical rigidity of these collapsed structures may exceed the functional ability o
250 contain a significantly higher proportion of collapsed structures when the tail is present.
251 nsic preference of polypeptide backbones for collapsed structures.
252 t that polyQ chains form mechanically stable collapsed structures.
253                    PATIENT: A 15-yr-old male collapsed suddenly after ingesting an unknown substance
254 ow that there are populations of swollen and collapsed t-ts, patches of SR tangling, and disorder wit
255 in which the boxes are brought together in a collapsed, tail-mediated assembly, which is in dynamic e
256  and ambient pressure: PI with a nonmagnetic collapsed tetragonal (cT) phase at low temperature and P
257       This suggests a possible tetragonal to collapsed tetragonal phase transition.
258  three phases (orthorhombic, tetragonal, and collapsed tetragonal) coexist between TS=95 K and 45 K.
259 the tetragonal (T), orthorhombic (O) and the collapsed-tetragonal (cT) phases in the structural phase
260 on mechanism, the tetragonal/orthorhombic-to-collapsed-tetragonal phase transformation.
261 ization (latrunculin-A, jasplakinolide) also collapsed the actomyosin network.
262 ealed rare metastable intermediates that had collapsed the haematopoietic stem cell/progenitor gene e
263 a maximal concentration of nigericin (5 mum) collapsed the pH gradient and abolished flash activity.
264 rboxylates such as pyruvate and acetate also collapsed the pH gradient and were also inhibitory, wher
265 ansporters and may also be targets because 1 collapsed the proton motive force in membrane vesicles.
266 ng microanatomy, whereby some alveoli remain collapsed throughout the breath cycle while their more c
267 ound forms reveals that the mutated loop has collapsed, thus hindering ATP binding.
268           The CT scan measures the amount of collapsed tissue that regains inflation.
269 tance, lung weight, normally aerated tissue, collapsed tissue, and lung and chest wall elastances wer
270 red hyperfine interactions (apparent triplet collapsed to a doublet) relative to [1'-(1)H]-F(2)CDP.
271  not influence nitrogen uptake, and biofilms collapsed to a single dominant species.
272 t the two one-electron waves in acetonitrile collapsed to a single two-electron wave in a RTIL such a
273                             Risk scores were collapsed to form statistically distinct low-, moderate-
274                             Risk scores were collapsed to form statistically distinct low-, moderate-
275 have accelerated the cooling of matter as it collapsed to form the first stars and galaxies, and woul
276 ating a long-term trend from more frequently collapsed to more glaciated states, dominant 40-kyr cycl
277 t rearrangements: one pair of S6 helices has collapsed towards the central pore axis and the other S6
278 between three double-labeled mutants, in the collapsed transient state, were determined and compared
279 relatively rigid, irreversibly adsorbed, and collapsed upon air drying, as demonstrated by combined q
280 efined by the Rietveld method is a partially collapsed variant of SiO(2) beta-cristobalite, space gro
281 Gnd(+)) salts influence the stability of the collapsed versus uncollapsed state of an elastin-like po
282 mages were able to depict bone marrow in the collapsed vertebral bodies, especially in those with les
283 and 2) a fall-in fragment that fell into the collapsed vesicle to expand the fusion pore.
284  can be shear-thin delivered to the lumen of collapsed vessels (where it distends the vessel) and the
285 ts with the lowest amounts of lignin exhibit collapsed vessels and yield penalties.
286 ulation but was (largely) the consequence of collapsed vessels.
287  mucosal immune responses, Treg cell numbers collapsed via multiple pathways, including blockade of T
288     Fundus characteristics included abnormal collapsed vitreous, macular atrophy, and a tesselated fu
289                                     However, collapsed WASHout endosomes harbored segregated subdomai
290 work in the southern Southwest grew and then collapsed, whereas networks became more fragmented in th
291  have aberrant lymphatic sinus that appeared collapsed, with reduced numbers of lymphocytes.
292 nt of founders' personality; all communities collapsed within a year of achieving it.
293 system engineers, but their populations have collapsed worldwide because of overfishing and habitat d
294 plants that fail to grow normally because of collapsed xylem cells in the vascular system.
295  (KAK) gene that suppressed dwarfism and the collapsed xylem character, the cause of decreased hydrau
296                  However, suppression of the collapsed xylem phenotype in esk1 kak double mutants was
297 haliana) irregular xylem (irx) mutants, with collapsed xylem vessels and dwarfed stature, highlighted
298 that has a constitutive drought syndrome and collapsed xylem vessels, along with low acetylation leve
299 al mutant exhibits severe growth defects and collapsed xylem, demonstrating the importance of wall po
300 e best compromise between overdistention and collapsed zones was arbitrarily defined as the lowest pr

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