1 gh the in vitro activity of Semaphorin III/D/
Collapsin 1 is clear, recent analyses of two different s
2 of two different strains of semaphorin III/D/
collapsin 1 knockout mice have generated conflicting fin
3 Z1a, a zebrafish homolog of semaphorin III/D/
collapsin 1.
4 To explore the mechanism of
collapsin-
1 action, we expressed and purified a truncate
5 motility and indicate that rac1 may mediate
collapsin-
1 action.
6 ) domain and the basic tail, each potentiate
collapsin-
1 activity.
7 al spreading and are minimally responsive to
collapsin-
1 and myelin.
8 l chemorepellent activity is blocked by anti-
collapsin-
1 antibodies.
9 report a detailed study on the expression of
collapsin-
1 as well as on the distribution of collapsin-
10 Collapsin-
1 belongs to the Semaphorin family of molecule
11 lapsin-2 and -3, are structurally similar to
collapsin-
1 but have different biological activities.
12 Collapsin-
1 can function as a selective chemorepellent f
13 These results suggest that
collapsin-
1 can inhibit EC motility as well as axon moti
14 e of mossy fiber afferents of granule cells,
collapsin-
1 caused most pontine growth cones to collapse
15 y are mediated by NRP1, and that VEGF165 and
collapsin-
1 compete for NRP1-binding sites.
16 Like all family members,
collapsin-
1 contains within its sequence a semaphorin do
17 Collapsin-
1 covalently dimerizes, and dimerization is ne
18 collapsin-
1 expression is detected in regions bordering
19 peripheral portions of the rectal wall when
collapsin-
1 expression retreats from the outer muscle la
20 atterns for mouse semaphorin D/III and chick
collapsin-
1 fusion proteins are indistinguishable from o
21 In an in vitro angiogenesis assay,
collapsin-
1 inhibited the capillary sprouting of EC from
22 Collapsin-
1 inhibited the motility of porcine aortic EC
23 apsin-1-induced collapse of growth cones and
collapsin-
1 inhibition of neurite outgrowth.
24 ventrally projecting muscle afferents become
collapsin-
1 insensitive as they project into the ventral
25 Collapsin-
1 is a member of the semaphorin family of sign
26 Chick
collapsin-
1 is a repellent for specific growth cones.
27 Collapsin-
1 is a secreted glycoprotein that inhibits the
28 this study that (1) the semaphorin domain of
collapsin-
1 is both necessary and sufficient for biologi
29 Collapsin-
1 is expressed in high levels in the ventral h
30 In the early chick brain
collapsin-
1 is expressed in specific regions of the reti
31 lel to, but do not enter, the intestine when
collapsin-
1 is expressed in the adjacent rectal wall.
32 In the periphery,
collapsin-
1 is expressed in the dermamyotome and in ecto
33 In the hindbrain
collapsin-
1 is first expressed in rhombomere 5 and later
34 Our results suggest that
collapsin-
1 may help prevent Remak axons from projecting
35 Here we report the distribution of
collapsin-
1 message as demonstrated by in situ hybridiza
36 We now find that antibodies to
collapsin-
1 neutralize this repellent activity.
37 onneuronal cells, the effects of recombinant
collapsin-
1 on endothelial cells (EC) were examined.
38 In order to test the function of
collapsin-
1 on the migration of neural crest cells, an i
39 Collapsin-
1 or semaphorin III(D) inhibits axonal outgrow
40 gest that the transient dorsal expression of
collapsin-
1 prevents all efferents from entering the cor
41 both the spinal cord and the olfactory bulb,
collapsin-
1 prevents premature entry of sensory axons in
42 Collapsin-
1 protein, the chick ortholog of sema-D, did n
43 Collapsin-
1 rapidly disrupted the formation of lamellipo
44 line phosphatase probe to visualize putative
collapsin-
1 receptors in vitro and in situ.
45 tern of collapsin-1 with the trajectories of
collapsin-
1 responsive axons suggests that in both the s
46 rowth cone structure, neurite elongation, or
collapsin-
1 sensitivity.
47 ns of the rho subfamily might participate in
collapsin-
1 signal transduction.
48 These results suggest that
collapsin-
1 signalling can contribute to the patterning
49 collapse and promoted neurite outgrowth on a
collapsin-
1 substrate.
50 in this study another structural feature of
collapsin-
1 that is necessary for its function.
51 When VEGF165 and
collapsin-
1 were added simultaneously to PAEC/KDR/NRP1,
52 l data suggest that all afferents respond to
collapsin-
1 when they are first confined to the dorsal c
53 Comparing the expression pattern of
collapsin-
1 with the trajectories of collapsin-1 respons
54 ly known as Semaphorin III, Semaphorin D, or
collapsin-
1) is a member of the semaphorin gene family,
55 y known as semaphorin III, semaphorin D, and
collapsin-
1), a secreted subtype of the semaphorin famil
56 ng of chick collapsin-3 and -5 and show that
collapsin-
1, -2, -3, and -5 bind to overlapping but dist
57 inct receptors with different affinities for
collapsin-
1, -2, -3, and -5.
58 Collapsin-
1, a member of the semaphorin family, activate
59 e the inhibitory properties of CNS myelin or
collapsin-
1, a soluble semaphorin, in chick embryonic mo
60 As demonstrated for
collapsin-
1, CNS myelin-evoked growth cone collapse was
61 unk and hindbrain regions and a receptor for
collapsin-
1, neuropilin-1, is expressed by migrating cre
62 h cone motility normally induced by SEMA-3A (
collapsin-
1, semaphorin III, semaphorin D) and SEMA-3C (
63 Chick
collapsin-
1, the first identified vertebrate member of t
64 Two additional structural domains of
collapsin-
1, the immunoglobulin (Ig) domain and the basi
65 As predicted by the activity profile of
collapsin-
1, the probe binds spinal sensory tracts, vent
66 ction, we expressed and purified a truncated
collapsin-
1-alkaline phosphatase fusion protein (CAP-4).
67 ollapsin-1 as well as on the distribution of
collapsin-
1-binding sites in regions where neural crest
68 These sites provide a substrate for the
collapsin-
1-dependent patterning of non-neuronal tissues
69 When added to crest cells in vitro, a
collapsin-
1-Fc chimeric protein induces morphological ch
70 t cells, an in vitro assay was used in which
collapsin-
1-Fc was immobilised in alternating stripes co
71 h cones, and dominant negative rac1 inhibits
collapsin-
1-induced collapse of growth cones and collaps
72 n of dominant negative rac1 or cdc42 negated
collapsin-
1-induced growth cone collapse and promoted ne
73 th cones collapse in the presence of soluble
collapsin-
1.
74 been identified as a candidate receptor for
collapsin-
1.
75 desensitizing growth cones to CNS myelin or
collapsin-
1.
76 m explants and also by 293T cells expressing
collapsin-
1.
77 We have constructed a chimeric
collapsin-
1/alkaline phosphatase probe to visualize puta
78 Chick
collapsin-
1/human semaphorin III/mouse semaphorin D is b
79 Microscopic gradients of
Collapsin-
1/Semaphorin III/D (Sema III) and myelin-assoc
80 anisms that mediate the repulsive actions of
Collapsin-
1/Semaphorin III/D (Sema III), we searched for
81 1) was recently identified as a receptor for
Collapsin-
1/Semaphorin III/D (Sema III).
82 glycoprotein (MAG) but not by a gradient of
collapsin-
1/semaphorin III/D or neurotrophin-3 (NT-3).
83 n outgrowth, such as netrin-1, netrin-2, and
collapsin-
1/semaphorin-III.
84 To determine whether
collapsin-
1/semaphorin-III/D, a molecule known to repel
85 r secreted members of the semaphorin family,
collapsin-
2 and -3, are structurally similar to collapsi
86 We have completed the cloning of chick
collapsin-
3 and -5 and show that collapsin-1, -2, -3, an
87 , semaphorin III, semaphorin D) and SEMA-3C (
collapsin-
3, semaphorin E) but not that induced by SEMA-
88 In contrast, these four
collapsins all bind recombinant neuropilin with similar
89 The
collapsin and semaphorin family of extracellular protein
90 l cord and olfactory bulb for sensitivity to
collapsin and show that the former are sensitive to coll
91 To determine whether semaphorin/
collapsins could interact with NRP1 in nonneuronal cells
92 uidance that bound members of the semaphorin/
collapsin family.
93 During development, semaphorins (
collapsin,
fasciclin) mediate repulsive and inhibitory g
94 both trunk and hindbrain regions avoided the
collapsin-
Fc-containing substratum.
95 bilised in alternating stripes consisting of
collapsin-
Fc/fibronectin versus fibronectin alone.
96 The semaphorin/
collapsin gene family encodes secreted and transmembrane
97 s, and receptors for netrins and semaphorins/
collapsins have been identified.
98 ch as N-cadherin in optic tectum, semaphorin/
collapsin in spinal cord, and ephrins in cerebral cortex
99 Inhibition of growth cone motility by chick
collapsin is mediated by the intraneuronal protein CRMP-
100 Semaphorins and
collapsins make up a family of conserved genes that enco
101 165), an angiogenesis factor, and semaphorin/
collapsins,
mediators of neuronal guidance.
102 The distribution of
collapsin mRNA is consistent with it playing a role in t
103 Cypin contains zinc binding,
collapsin response mediator protein (CRMP) homology, and
104 rial enzymes and shares some similarity with
collapsin response mediator protein (CRMP), a cytoplasmi
105 Recently, we reported
collapsin response mediator protein (CRMP)-2 as an endog
106 Here we describe a role for
collapsin response mediator protein (Crmp-2), a neuronal
107 nnels, but the observation that LCM binds to
collapsin response mediator protein 2 (CRMP-2) suggests
108 n be suppressed by inhibiting the binding of
collapsin response mediator protein 2 (CRMP-2) to CaV2.2
109 Collapsin response mediator protein 2 (CRMP2) binds to m
110 ere, we tested if modification of the axonal
collapsin response mediator protein 2 (CRMP2) by a small
111 The axon guidance and outgrowth protein
collapsin response mediator protein 2 (CRMP2) has been l
112 Collapsin response mediator protein 2 (CRMP2) is traditi
113 We have recently shown the key role of
collapsin response mediator protein 2 (CRMP2), a phospho
114 -nociceptive peptide derived from the axonal
collapsin response mediator protein 2 (CRMP2), a protein
115 such as adenomatous polyposis coli (APC) and
collapsin response mediator protein 2 (CRMP2), support a
116 d class was the microtubule bundling protein
Collapsin Response Mediator Protein 2 (CRMP2).
117 lly modified versions of the binding partner
collapsin response mediator protein 2 (CRMP2).
118 In particular, we identified
collapsin response mediator protein 2 (CRMP2/DPYSL2), a
119 umulated exceptional levels of isoaspartate:
collapsin response mediator protein 2 (CRMP2/ULIP2/DRP-2
120 ceptors identified a novel NMDAR interactor,
collapsin response mediator protein 2, which preferentia
121 eled by (R)-9 compared with (S)-9, including
collapsin response mediator protein 2.
122 affecting tubulin dynamics via its substrate
collapsin response mediator protein 2.
123 We previously identified
collapsin response mediator protein 4 (CRMP4) as a prote
124 ncluding brain lipid binding protein (BLBP),
collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx
125 p34cdc2,
collapsin response mediator protein 4 (CRMP4), doublecor
126 Collapsin response mediator protein 5 (CRMP5) belongs to
127 efined despite the documented involvement of
collapsin response mediator protein and molecule interac
128 u RNA-binding proteins, neuronatin, Racgap1,
collapsin response mediator protein-1, synaptotagmin-1,
129 n of downstream targets of mTORC1, including
collapsin response mediator protein-2 (CRMP-2), in the n
130 Here we have identified the
collapsin response mediator protein-2 (Crmp2) as an inte
131 uding Alzheimer's disease and schizophrenia:
collapsin response mediator protein-2/dihydropyrimidinas
132 Two families of cytoplasmic proteins,
collapsin response mediator proteins (CRMPs) and molecul
133 Collapsin response mediator proteins (CRMPs) are cytosol
134 Collapsin response mediator proteins (CRMPs) specify axo
135 Collapsin response mediator proteins 5 (CRMP5) belongs t
136 The rat
collapsin response-mediated protein 4 (rCRMP-4) is a mem
137 "-IgG [23kDa, recoverin]) and optic neuritis
collapsin response-mediated protein 5 (CRMP-5-IgG [62kDa
138 y markers of small-cell carcinoma, including
collapsin response-mediated protein 5 (CRMP5) IgG (26%)
139 wn 62-kd neuronal cytoplasmic protein of the
collapsin response-mediator family.
140 r myelopathy of uncertain cause demonstrated
collapsin response-mediator protein 5 IgG.
141 ll carcinoma, their frequency being ANNA-1 >
collapsin response-mediator protein-5 > amphiphysin > Pu
142 Other serological markers, such as
collapsin response-mediator protein-5 -IgG and amphiphys
143 Collapsin response-mediator protein-5 autoimmune myelopa
144 commonly small-cell lung carcinoma and after
collapsin response-mediator protein-5 IgG detection).
145 alitis (n = 1) or neuromyotonia (n = 1), and
collapsin response-mediator protein-5-IgG with optic neu
146 s have highlighted the dynamic expression of
Collapsin-
Response-Mediator Proteins (CRMPs) in neuronal
147 Based on
collapsin'
s expression patterns we tested axons extendin
148 e semaphorin E and 49% identity with chicken
collapsin/
semaphorin D.
149 Members of the
collapsin/
semaphorin family play an important role in cr
150 al to human neuropilin-1, a receptor for the
collapsin/
semaphorin family that mediates neuronal cell
151 Semaphorins/
collapsins were characterized in part on the basis of th
152 in and show that the former are sensitive to
collapsin whereas the latter are not.
153 ilin is mediated by the carboxy third of the
collapsins,
while the semaphorin domain confers their un