ライフサイエンスコーパス: collectin

1 L (SP-D/MBLneck+CRD) to create a novel human collectin.

2 se structures on gp120 are the target of the collectin.

3 zing Abs but did not increase sensitivity to collectins.

4 We focused on collectin-11 (CL-11), a pattern recognition molecule tha

5 ed how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by

6 The interface between collectin-11 and L-fucose, in both the recipient and the

7 In particular, collectin-11 has been shown to engage L-fucose at sites

8 Collectin-11, a soluble C-type lectin expressed in renal

9 Mannose-binding lectin (MBL)/ficolin/collectin-11-associated protein-1 (MAP-1) is a recently

10 that MAP-1 can compete with the MBL/ficolin/collectin-11-associated serine proteases (MASPs) in bind

11 , a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has been identified.

12 tion and proliferation factor-1 (NPDC1), and collectin-12 (COLEC12).

13 C1q and the collectins alone were adequate to trigger amebic phagocy

14 The collectins also bind to bacteria, the usual source of nu

15 uggesting a specific interaction between the collectin and beta(1-->6)-glucan.

16 Because members of the collectin and pentraxin families of serum proteins bind

17 ily with structural similarities to the lung collectins and functional similarities to C1q.

18 , and suggest important interactions between collectins and HNPs in the host response to viruses and

19 ant and/or natural forms of SP-D and related collectins and HNPs were tested for antiviral activity a

20 vels that were comparable with the authentic collectins and that the N-terminal interchange converted

21 a1 integrin is a novel receptor for multiple collectins and the C1q complement protein.

22 glycosylation sites on HA for sensitivity to collectins and to neutralizing Abs.

23 olved in host defense, including complement, collectins, and other antimicrobial proteins.

24 structure analysis for engineering effective collectin antivirals as in vivo therapeutics.

25 Collectins are a family of innate immune proteins that c

26 In conclusion, we show that collectins are a new class of proteins that bind free DN

27 Collectins are composed of four major structural domains

28 uctures previously thought to be targets for collectins are important in shielding the more vulnerabl

29 enhance removal of apoptotic cells, and that collectins are integral, organ-specific components of th

30 To test the possibility that the collectins are ligands that stimulate E. histolytica pha

31 Collectins are pattern recognition molecules of the inna

32 The collectins are proteins with collagen tails and globular

33 Collectins are secreted collagen-like lectins that bind,

34 To quantify relationships among collectins, bacteria, and inflammation in early cystic f

35 efense mechanisms include components such as collectins, beta-defensins, lactoferrin, and complement,

36 Here we show that collectins bind DNA from a variety of origins, including

37 binding and competition studies suggest that collectins bind nucleic acid via their CRDs as well as b

38 ty, suggesting that requirements for optimal collectin binding to influenza virus and bacteria differ

39 Distinctive functional properties of collectin collagenous domains and CRDs can be exploited

40 Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney

41 nt proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head doma

42 aggregating activity, activities of chimeric collectins containing the N-terminal and collagen domain

43 Thus collectins could play particularly important roles in se

44 We conclude that relative collectin deficiency occurs early in CF airways and is i

45 s decrement was attributed to killing of the collectin-exposed yeast since it failed to grow on agar

46 factant proteins A and D (SP-A and SP-D) are collectins expressed in the airway and alveolar epitheli

47 1q because mannose-binding lectin, a related collectin, failed to upregulate Mer expression and funct

48 s an innate immune mediator belonging to the collectin family known to bind to the surfaces of many v

49 Surfactant protein D (SP-D) is a collectin family member with demonstrated immunomodulato

50 In mammals, collectin family members (e.g., mannose-binding lectin [

51 Recently, a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has

52 rfactant protein-D (SP-D) is a member of the collectin family of C-type lectins that is synthesized i

53 ins A (SP-A) and D (SP-D) are members of the collectin family of calcium-dependent lectins and are im

54 t protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing

55 nglutinin are closely related members of the collectin family of host defense lectins.

56 rfactant protein D (SP-D) is a member of the collectin family of innate defense proteins.

57 rfactant protein A (SP-A) is a member of the collectin family of innate host defense molecules expres

58 Surfactant protein (SP) D is a member of the collectin family of innate immune molecules that plays a

59 These results suggest that the entire collectin family of innate immune proteins (including C1

60 annose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells an

61 protein A (SP-A), a pulmonary member of the collectin family of proteins, facilitates the rapid clea

62 similarities between C1q and members of the collectin family of proteins, including pulmonary surfac

63 MBL is a member of the collectin family of proteins, which binds to oligomannos

64 MBL is a member of the collectin family with structural similarities to the lun

65 (SP-A) is a hydrophilic glycoprotein of the collectin family, and its main function is related to ho

66 arbohydrate binding, a characteristic of the collectin family, and specific interactions with lipid m

67 surfactant protein D (SP-D), a member of the collectin family, is an innate immune molecule critical

68 Mannan-binding lectin (MBL), a member of the collectin family, is known to have opsonic function, alt

69 humoral pattern recognition molecules in the collectin family, namely surfactant proteins D and A (Sp

70 surfactant protein A (SP-A), a member of the collectin family, plays an important role in innate immu

71 Surfactant protein A (SP-A), a member of the collectin family, selectively binds to Pneumocystis cari

72 urfactant protein-D (SP-D), a member of the "collectin" family, has been shown to play a role in inna

73 Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus.

74 This serum collectin has been shown to activate complement when bou

75 The collectins have been shown to have a role in host defens

76 factant protein D, the other known pulmonary collectin, in response to GBS instillation.

77 Exposure of yeast to either collectin induced a dose-dependent decrease in [3H]leuci

78 novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and CL-11), and collectin plac

79 e proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 and MASP-3, respec

80 nding of mannan-binding lectin, ficolins, or collectin kidney 1 (CL-K1, alias CL-11) to suitable micr

81 lex, MBL-associated serine protease (MASP)-3/collectin-L1/K1 hetero-oligomer, which impacts cardiac n

82 tins, such as mannose-binding lectin and the collectin-like C1q, have been shown to bind to apoptotic

83 f native CL-K1 from plasma, we observed that collectin liver 1 (CL-L1) was copurified.

84 Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and

85 In contrast, the collectin mannose binding lectin C (MBL-C) but not MBL-A

86 We now demonstrate that the serum collectins mannose-binding lectin (MBL) and conglutinin

87 The role that collectin (mannose-binding protein) may play in the host

88 Because these collectins may bind and opsonize bacteria and viruses, d

89 Collectins may therefore play an important role in decre

90 of AMos from inhibition of AC uptake by lung collectins may, in part, explain the beneficial role of

91 rn recognition molecules, i.e., those of the collectin MBL-C, are involved in the Aspergillus-lectin

92 e role of CR1 as a cellular receptor for the collectin MBL.

93 re more susceptible than smooth strains, and collectin-mediated growth inhibition was partially block

94 f the organism and that Hc gains asylum from collectin-mediated killing by rapid entry into pulmonary

95 These results indicate that collectin-mediated viral aggregation per se may be an im

96 The model may also be relevant to collectin multimers.

97 To further assess the importance of lung collectin N-terminal domains in surfactant structure and

98 quired for the permeabilizing effects of the collectins on model bacterial membranes.

99 ), collectin kidney 1 (CL-K1 and CL-11), and collectin placenta 1 (CL-P1), were discovered.

100 Collectins play important roles in host defense against

101 Soluble defense collagens including the collectins play important roles in innate immunity.

102 the 16-fold excess in tissue, but the total collectin pool in lavage is still significantly reduced.

103 On the basis of homology with other collectins, potential functions for SP-D include roles i

104 hat the group of collagenous lectins (termed collectins) present in blood and pulmonary surfactant pl

105 Surfactant protein-D (SP-D) is a collectin produced in the distal lung airspaces that is

106 anism through which opsonization of IAV with collectins protects neutrophils against the deactivating

107 rotein D (SP-D) are high abundance pulmonary collectins recently implicated in apoptotic cell clearan

108 The roles of these three collectins remain largely unknown.

109 Deletion of the E. coli OmpA gene from a collectin-resistant smooth E. coli strain enhanced SP-A

110 an increased capacity to inhibit a partially collectin-resistant strain of IAV.

111 toneal Mos that had not been exposed to lung collectins showed delayed, but not rapid, increase in AC

112 take by alveolar macrophages (AMos) via lung collectin signaling through signal regulatory protein al

113 e also had substantial increases in the lung collectin SP-D, including significant amounts of an S-ni

114 These data suggest that the pulmonary collectins SP-A and SP-D facilitate the resolution of in

115 We have recently shown that collectins SP-A, SP-D, and mannose binding lectin recogn

116 targeted mice that two surfactant-associated collectins (SP-A and SP-D) may serve in these roles and

117 The lung collectins, SP-A and SP-D, are important components of t

118 The collectins, SP-A and SP-D, play distinct roles during ba

119 Surfactant protein A (SPA), a lung-specific collectin, stimulates macrophage chemotaxis.

120 Thus, we conclude that collectins such as SP-A and SP-D reduce the generation o

121 Other collectins, such as mannose-binding lectin and the colle

122 We hypothesized that collectins, such as pulmonary surfactant proteins (SPs)

123 We hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the

124 da and opsonization of F. novicida with lung collectin surfactant protein A (SP-A) increased bacteria

125 bohydrate recognition domains (CRDs) of lung collectin surfactant protein D (SP-D) recognize sugar pa

126 pretreatment of peritoneal Mos with the lung collectin surfactant protein D inhibited AC uptake, and

127 cytokine production, and proteolysis of the collectin surfactant protein-D (SP-D).

128 The pulmonary collectins surfactant protein (SP)-A and SP-D play impor

129 ns of IAV are generally not inhibited by the collectins surfactant protein D or mannose binding lecti

130 The collectins surfactant-associated protein A (SP-A) and SP

131 The lung collectin, surfactant protein A (SP-A), has emerged as a

132 The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are invo

133 ficantly less in SP-A than in the homologous collectins, surfactant protein D, and mannose-binding pr

134 y, we investigated the role of the pulmonary collectins, surfactant proteins (SP) A and D, in the cle

135 The N-terminal domains of the lung collectins, surfactant proteins A (SP-A) and D (SP-D), a

136 The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), h

137 irect antimicrobial actions of the pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D).

138 The pulmonary collectins--surfactant proteins A (SP-A) and D (SP-D)--p

139 mediated at least in part by the collagenous collectin tail domain.

140 particles coated with C1q, MBL, or purified collectin tails were phagocytosed more efficiently than

141 and purified human C1q, MBL, and collagenous collectin tails.

142 and D are innate immune pattern recognition collectins that contain fibrillar collagen-like regions

143 fic because no, or minimal, binding to other collectins was found.

144 ral and functional similarities with soluble collectins, we hypothesized the existence of a fluid-pha

145 Mice in which endogenous pulmonary collectins were replaced with D/A were developed by huma

146 s of ligand recognition, the interactions of collectins with complement cascades, and the association

147 RDs can be exploited to generate novel human collectins with potential for therapy of influenza.

148 acquired alterations in the levels of active collectins within the airspaces and distal airways may i