ライフサイエンスコーパス: collecting duct

1 red protons (mainly in the distal tubule and collecting duct).

2 ibrotic signaling within cells of the kidney collecting duct.

3 lls of the juxtaglomerular apparatus and the collecting duct.

4 I specifically in the principal cells of the collecting duct.

5 protein and regulatory proteins in the renal collecting duct.

6 n-mediated transcriptional regulation in the collecting duct.

7 shed targets of vasopressin signaling in the collecting duct.

8 lial cells, and is localized to the cortical collecting duct.

9 permeability from the proximal tubule to the collecting duct.

10 as kAE1 expression remained unchanged in the collecting duct.

11 e in regulating acid secretion in the kidney collecting duct.

12 reabsorption with sodium reabsorption in the collecting duct.

13 airing responses to vasopressin in the renal collecting duct.

14 in intercalated cells of the inner cortical collecting duct.

15 the expression of POSH in the renal cortical collecting duct.

16 are also expressed in native inner medullary collecting duct.

17 ting step for sodium absorption in the renal collecting duct.

18 ar segments, from the proximal tubule to the collecting duct.

19 er (NDCBE) in beta-intercalated cells of the collecting duct.

20 he highest expression in the inner medullary collecting duct.

21 d MUC1 in the thick ascending limb, DCT, and collecting duct.

22 ecretion, by metering sodium delivery to the collecting duct.

23 ores in principal cells that line the kidney-collecting duct.

24 AQP2 accumulate at the apical surface of the collecting duct.

25 ation by facilitating water transport in the collecting duct.

26 ule, the connecting tubule, and the cortical collecting duct.

27 in principal cells of the connecting tubule/collecting ducts.

28 late S-shaped body stage and the developing collecting ducts.

29 f cells present in the connecting tubule and collecting ducts.

30 che in proximal and distal renal tubules and collecting ducts.

31 ypertonic medullary interstitium mediated by collecting ducts.

32 ding limbs via NO, and water reabsorption in collecting ducts.

33 apical membrane of principal cells along the collecting ducts.

34 al fluid resorbed from the loop of Henle and collecting ducts.

35 from principal cells in distal parts of the collecting ducts.

36 ces proliferation in the epithelium of renal collecting ducts.

37 om patients with proteinuria and observed in collecting ducts.

38 f p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreased expression of

39 of cilia in cultured murine inner medullary collecting duct 3 (mIMCD3) renal cells.

40 pha) in renal tubule-derived inner medullary collecting duct 3 cells and show that PI3K-C2alpha resid

41 ation of E-cadherin in mouse inner medullary collecting duct-3 renal tubular cells.

42 V-ATPase in a polarized rabbit cell line of collecting duct A-type intercalated cell characteristics

43 PAR2 is expressed in kidney collecting ducts, a main site of control of Na(+) and K(

44 Absence of collecting duct AC6 did not alter urinary cAMP excretion

45 -stimulated Na(+) reabsorption in the kidney collecting duct, acting to enhance Na(+),K(+)-ATPase act

46 increased 11,12-EET in the isolated cortical collecting duct, an effect mimicked by inhibiting the an

47 ), papillary type 2 kidney cancer (including collecting duct and medullary RCC) (5%), the microphalmi

48 gl2 is known to be expressed in ureteric bud/collecting duct and metanephric mesenchymal/nephron line

49 CFTR Cl(-) channels on salt handling by the collecting duct and on the functional CFTR-ROMK interact

50 mediate NaCl absorption within the cortical collecting duct and the connecting tubule.

51 ting ENaC-mediated Na(+) reabsorption in the collecting duct and the development of hypertension.

52 and water balance by principal cells of the collecting duct and the regulation of solute and water b

53 ours (leiomyomata) and an aggressive form of collecting duct and type 2 papillary renal cancer.

54 strate plasticity in the fate choice between collecting duct and ureter, and show that an environment

55 ng Hoxb7-driven Cre that is specific for the collecting ducts and a subset of distal tubules.

56 embryonic day 13 in the mouse, mainly in the collecting ducts and both the proximal and distal tubule

57 ical membrane of principal cells in cortical collecting ducts and connecting segments but not in the

58 nels in PCs and ICs of split-opened cortical collecting ducts and connecting tubules.

59 r matrix surrounding the convoluted tubules, collecting ducts and loops of Henle as well as within th

60 The human breast parenchyma consists of collecting ducts and terminal duct lobular units (TDLUs)

61 which promote low water permeability in the collecting ducts and, hence, free water excretion, remai

62 ributes to homeostasis, predominantly of the collecting duct, and regeneration.

63 ifferentiated thick ascending limb of Henle, collecting duct, and stroma; however, it disappeared in

64 mbryonic kidney and liver, in isolated renal collecting ducts, and in an inner medullary collecting d

65 outer and inner medulla, in isolated kidney collecting ducts, and in cultured outer and inner medull

66 PAR2 might control electrolyte transport in collecting ducts, and thereby participate in the regulat

67 he paracellular chloride reabsorption in the collecting duct are not understood.

68 In the principal cells of the renal collecting duct, arginine vasopressin (AVP) stimulates t

69 luorescent protein (GFP) mice identified the collecting duct as a source of kidney MSC-like cells, wi

70 ial cells of proximal and distal tubules and collecting ducts at E17.5 and P0 mouse kidney.

71 eter-like 'trunk' from one end of which true collecting duct branches radiate and induce nephron deve

72 opressin regulates water reabsorption in the collecting duct, but extracellular nucleotides modulate

73 ponent of vasopressin signaling in the renal collecting duct, but the database of known phosphoprotei

74 3R in apical membranes of distal tubules and collecting ducts, but not of proximal tubule.

75 VP) enhances water reabsorption in the renal collecting duct by vasopressin V receptor (VR)-mediated

76 Collecting duct carcinoma (CDC) is a kidney cancer subty

77 ing proteins in aldosterone-treated cortical collecting duct (CCD) cells identified the Rab-GAP, AS16

78 The nephron cortical collecting duct (CCD) is composed of principal cells, wh

79 distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water an

80 mediate sodium reabsorption in the cortical collecting duct (CCD), but the regulatory pathways that

81 the connecting tubule (CNT) and the cortical collecting duct (CCD).

82 The rate of sodium transport by collecting duct (CD) cells varies widely in response to

83 es flow-dependent Ca(2+) signaling in murine collecting duct (CD) cells, suggesting that this channel

84 Ammonia secretion by the collecting duct (CD) is critical for acid-base homeostas

85 n (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed

86 local renal renin-angiotensin system in the collecting duct (CD).

87 Isolated, split-open collecting ducts (CD) from SHR-A3 displayed decreased ba

88 in vitro Homozygous deletion of ILK in renal collecting ducts (CD) of Ilk(fl/fl) ;Pkhd1-Cre mice caus

89 We showed that mice with collecting-duct (CD)-specific ablation of TSC1 (CDTsc1KO

90 ce to delete HNF-1beta specifically in renal collecting ducts (CDs).

91 examined the effects of miRNA suppression in collecting ducts (CDs).

92 r stimulating integrin alpha3beta1-dependent collecting duct cell functions.

93 e of fluorescently loaded ECVs into a kidney collecting duct cell line (mCCDC11) and into primary cel

94 addition, we developed an immortalized renal collecting duct cell line with inactive Pkd2; these cell

95 nases SGK1 and WNK1 were observed in a human collecting duct cell line, while SPAK was unaltered.

96 expression of Period 1 (Per1) mRNA in renal collecting duct cell lines and in the rodent kidney.

97 ession are low, we generated inner medullary collecting duct cell lines that stably express enhanced

98 s, and in cultured outer and inner medullary collecting duct cells (mOMCD1 and mIMCD3).

99 rm V2-receptor-mediated response in cultured collecting duct cells (mpkCCD) from mouse.

100 y expressed in mouse kidney and mouse kidney collecting duct cells (mpkCCD14).

101 imensional polarized cultures of mouse renal collecting duct cells and mice treated with clinically r

102 lia were elongated in proximal tubule cells, collecting duct cells and parietal cells of the remainin

103 nctions of Adam10 in determining the fate of collecting duct cells are more complex than those of a s

104 thium initiated proliferation of mouse renal collecting duct cells but also increased the G2/S ratio,

105 Furthermore, collecting duct cells derived from laminin-deficient kid

106 In vitro, Grhl2-deficient collecting duct cells displayed increased paracellular f

107 mRNA in acutely isolated rat inner medullary collecting duct cells ex vivo and ET-1 peptide in rat in

108 s lacking PC2, NEK8-depleted inner medullary collecting duct cells exhibited a defective response to

109 Collecting duct cells expressing this mutation had moder

110 Collecting duct cells from mutant mice have abnormal pri

111 -type cells, PC1-depleted immortalized renal collecting duct cells had higher levels of integrin-beta

112 g ureteric bud developed kidney agenesis and collecting duct cells had severe cytoskeletal, adhesion

113 required for sgk1-regulated ENaC activity in collecting duct cells has yet to be established.

114 the apical plasma membrane of mouse cortical collecting duct cells in response to vasopressin.

115 nockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of hydrogen peroxi

116 LRRK2 protein is predominantly localized to collecting duct cells in the rat kidney, with much lower

117 rtical, outer medullary, and inner medullary collecting duct cells in vitro.

118 teric branching and cell cycle regulation in collecting duct cells in vivo Although in vitro data ind

119 the amount of AQP2 in exosomes released from collecting duct cells is physiologically regulated and e

120 ioles and glomerular cells and HIF-1alpha in collecting duct cells of the adult kidney.

121 Aldosterone and endothelin-1 (ET-1) act on collecting duct cells of the kidney and are important re

122 F-beta type II receptor deletion in cultured collecting duct cells resulted in excessive integrin alp

123 apical membrane of aldosterone-stimulated A6 collecting duct cells revealed that the open probability

124 rom HeLa and mouse principal kidney cortical collecting duct cells significantly decreases cell motil

125 Here, we use deep DNA sequencing in mouse collecting duct cells to ask whether vasopressin signali

126 ic screen in mouse principal kidney cortical collecting duct cells using a GST-SNX27 fusion construct

127 polyomavirus was detected within the graft's collecting duct cells using quantitative polymerase chai

128 Here we showed that in mouse kidney collecting duct cells, claudin-4 functioned as a Cl(-) c

129 In cultured collecting duct cells, enhanced apical Na(+) entry incre

130 apical Na(+) availability in cultured mouse collecting duct cells, enhanced apical Na(+) entry invar

131 In kidney collecting duct cells, filamentous actin (F-actin) depol

132 ways in the vasopressin signaling network of collecting duct cells, involving several kinases not gen

133 In mouse collecting duct cells, knockdown of KLHL3 profoundly inc

134 n vitro uptake of exosomes by renal cortical collecting duct cells, most studies of human urinary exo

135 NA profiling (Affymetrix) in mouse mpkCCDc14 collecting duct cells, revealing expression of 25 TRs th

136 In the collecting duct cells, the assembly of claudin-4 into TJ

137 gmented epithelial and mouse inner medullary collecting duct cells-3.

138 ion and barrier formation in Grhl2-deficient collecting duct cells.

139 F-actin dynamics in polarized mouse cortical collecting duct cells.

140 nduced by desmopressin stimulation of kidney collecting duct cells.

141 sustains water and Na(+) transport in renal collecting duct cells.

142 nces ENaC activity in aldosterone-stimulated collecting duct cells.

143 mbrane of aldosterone-stimulated mpkCCD(c14) collecting duct cells.

144 can alter Na(+) transport in mouse cortical collecting duct cells.

145 mic analysis of exosomes from mouse cortical collecting duct cells.

146 plasma membrane exosomes from mouse cortical collecting duct cells.

147 result of an autoimmune insult on the kidney collecting duct cells.

148 ce of the aquaporin-2 water channel in renal collecting duct cells.

149 d decrease alpha-ENaC expression in cortical collecting duct cells.

150 sociation with autoantibodies against kidney collecting duct cells.

151 primarily cultured rat renal inner medullary collecting-duct cells and microarray analysis to identif

152 and claudin-4, -7, and -8 as determinants of collecting duct chloride permeability.

153 The mammalian collecting duct comprises principal and intercalated cel

154 e post-MI, the remodeling and dysfunction of collecting ducts contribute to the development of chroni

155 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeos

156 Mutant kidneys developed collecting duct cysts by postnatal day 5, with rapid cys

157 revealed cystogenesis in distal tubules and collecting ducts, decreased ciliogenesis in cyst cells,

158 he late connecting tubule and early cortical collecting duct demonstrated that Ba2+-sensitive apical

159 Collecting duct-derived ET-1 regulates salt excretion an

160 Thus, talins are essential for kidney collecting duct development through mechanisms that exte

161 is, whereas tubule epithelia, except for the collecting duct, did not.

162 AT(1A) receptors in epithelial cells of the collecting duct directly modulate aquaporin-2 levels and

163 n deletion of the complex A gene Ift140 from collecting ducts disrupted, but did not completely preve

164 Ammonium secretion by the collecting duct epithelia accounts for the majority of u

165 ncreased ENaC current in Xenopus oocytes and collecting duct epithelia and enhanced ENaC abundance at

166 report that nephric duct, ureteric bud, and collecting duct epithelia express high levels of grainyh

167 expressed in the kidney proximal tubule and collecting duct epithelia, where it has an important rol

168 ular interconnection between the nephron and collecting duct epithelia.

169 aC current in Fischer rat thyroid and kidney collecting duct epithelia.

170 In mouse renal intermedullary collecting duct epithelial (mIMCD3) cells transduced wit

171 ta indicate a direct functional link between collecting duct epithelial barrier characteristics, whic

172 ver, the functional relevance of this strong collecting duct epithelial barrier is unresolved.

173 In collecting duct epithelial cells, Grhl2 inactivation imp

174 aBalphaDeltaN in renal proximal, distal, and collecting duct epithelial cells.

175 reduction of Notch activity in Adam10 mutant collecting duct epithelium and the similar reduction of

176 The collecting duct epithelium forms tight junctions compose

177 phron precursor cells closest to the nascent collecting duct epithelium leads to an active cell invas

178 on, distal cells break into the lumen of the collecting duct epithelium, suggesting that an invasive

179 lasticity and imply a role for such cells in collecting duct formation and, possibly, repair.

180 la and these cells continue to contribute to collecting duct formation during homeostasis.

181 ed renin formation by principal cells of the collecting ducts forms Ang I from AGT thus increasing An

182 oad resource for additional investigation of collecting duct function.

183 l kinases not generally accepted to regulate collecting duct function.

184 Precystic collecting ducts had an increased mitotic index, suggest

185 ation events in isolated rat inner medullary collecting duct (IMCD) suspensions.

186 Mice lacking the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and u

187 s NO production in the renal inner medullary collecting duct (IMCD), the segment with the greatest en

188 reported the presence of an inner medullary collecting duct (IMCD)-specific enhancer region in the 5

189 ployed proteomic analysis of inner medullary collecting ducts (IMCD) from rats fed with a potassium-f

190 rentially expressed genes in inner medullary collecting duct (IMCD3) cells grown under isotonic and h

191 nd activity in the intercalated cells of the collecting duct impaired acid-base regulation by the kid

192 ifically eliminate AT(1A) receptors from the collecting duct in mice (CD-KOs).

193 iption of microRNA (miR) 802 in the cortical collecting duct in mice.

194 the similar reduction of PC/IC ratios in the collecting ducts in mice deficient for mindbomb E3 ubiqu

195 Vasopressin controls transport in the renal collecting duct, in part, by regulating transcription.

196 ch in BMP4 promotes differentiation of early collecting ducts into uroplakin-positive, unbranched, ur

197 gase CHIP is highly expressed throughout the collecting duct; is modulated in abundance by vasopressi

198 ured cells or in vivo in rat kidney medullar collecting ducts led to the activation of ERK1/2 through

199 Collecting ducts make up the distal-most tubular segment

200 in ZO-1, collagen type IV, as well as UB and collecting duct markers, rearranged during transfection

201 d by epithelial principal cells of the renal collecting duct may be responsible for a large portion o

202 iting TGF-beta receptor-mediated function in collecting ducts may exacerbate renal fibrosis by enhanc

203 NOX4 silencing in a mouse collecting duct (mCCD(cl1)) cell line increased TGF-beta

204 ne to alter miR expression in mouse cortical collecting duct (mCCD) epithelial cells.

205 In this study murine kidney collecting duct (mCCDC11) cells were used to demonstrate

206 red murine cell model of the inner medullary collecting duct (mIMCD-3 cells) via transactivation of e

207 a (alpha-ENaC) gene in mouse inner medullary collecting duct mIMCD3 cells and mouse kidney.

208 ulture model that uses mouse inner-medullary collecting duct (mIMCD3) cells to generate epithelial sp

209 In mouse inner medullary collecting duct (mIMCD3) cells, Dragon generated BMP sig

210 - and Vps33b-deficient mouse inner medullary collecting duct (mIMDC-3) cells expressed membrane prote

211 In the renal collecting duct, mineralocorticoids drive Na(+) reabsorp

212 collecting ducts, and in an inner medullary collecting duct mouse cell line.

213 In collecting duct (mpkCCD) cells, acetazolamide reduced th

214 changes in the nuclear proteome of cortical collecting duct (mpkCCD) cells.

215 of the Wolffian duct and progenitor for the collecting duct network in the kidney, but they do devel

216 embrane of principal cells from the cortical collecting duct obtained from mice.

217 have found that deletion of claudin-8 in the collecting duct of mouse kidney caused hypotension, hypo

218 proximal tubule through the inner medullary collecting duct of rat kidneys.

219 alpha-Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base

220 The paracellular pathway in the collecting duct of the kidney is a predominant route for

221 In the cortical collecting duct of the kidney, sgk1 regulates sodium tra

222 le genes involved in sodium transport in the collecting duct of the kidney.

223 ane staining of beta1 was reduced throughout collecting ducts of AE1-null mouse kidney, where increas

224 GDIalpha is highly expressed in the cortical collecting ducts of mice and rats, and its expression is

225 ending limbs, distal convoluted tubules, and collecting ducts of mice.

226 gans, including the airways of the lung, the collecting ducts of the kidney, and the ducts of the mam

227 hannel present in the principal cells of the collecting ducts of the kidneys that are responsible for

228 secreting cells in the renal outer medullary collecting duct (OMCD) and in gastric parietal cells.

229 on within the connecting tubule and cortical collecting duct, or gave aldosterone and NaHCO(3) plus a

230 These results expand the known list of collecting duct phosphoproteins and highlight the utilit

231 l data, we expanded the size of the existing collecting duct phosphoproteome database from 367 to 118

232 rvations of papillary stem cell activity and collecting duct plasticity and imply a role for such cel

233 of papillary epithelial cells comprising the collecting duct predominantly but also the loop of Henle

234 llular and paracellular transport, while the collecting duct primarily facilitates transcellular tran

235 ng/trafficking mutant, and length defects in collecting duct primary cilia, the organelle central to

236 olateral membranes in two different cortical collecting duct principal cell lines and in cortical col

237 enhanced AQP2 apical membrane expression in collecting duct principal cells and reduced urine volume

238 dietary Na(+) intake and aldosterone levels, collecting duct principal cells are exposed to large var

239 importance of insulin receptors expressed in collecting duct principal cells for ENaC activity.

240 ng duct principal cell lines and in cortical collecting duct principal cells in mouse kidney tissue.

241 nockdown of RhoGDIalpha in cultured cortical collecting duct principal cells increased ENaC subunits

242 sulin receptor (InsR KO) specifically in the collecting duct principal cells.

243 plasma membrane of polarized murine cortical collecting duct principal cells.

244 ar feedback response and/or direct effect on collecting duct principal or intercalated cells may unde

245 heterogeneous, low-level transfection of the collecting duct, proximal tubule, distal tubule, interst

246 overexpression enhanced proliferation in the collecting ducts, reduced the size of epithelial duct lu

247 f AT(1) receptors in epithelial cells of the collecting duct regulate water reabsorption, we used Cre

248 onditional inactivation of integrin-beta1 in collecting ducts resulted in a dramatic inhibition of Pk

249 Patch-clamp analysis of split-open cortical collecting ducts revealed no difference in baseline acti

250 ordings from principal cells of rat cortical collecting ducts revealed similar inhibitory effects of

251 d provide an alternative explanation for the collecting duct's role in PHA-II.

252 ntercalated cells (A-ICs) within the nephron collecting duct sense infecting Gram-negative bacteria,

253 tic kidney disease, precystic Ift140-deleted collecting ducts showed normal centrosomal positioning a

254 Here, we report that collecting duct-specific deletion of an epithelial trans

255 porin-2-Cre recombinase transgene to achieve collecting duct-specific gene targeting.

256 We developed renal collecting duct-specific GSK3beta knockout mice to deter

257 In contrast, coincident collecting duct-specific knockout of polycystin-1 and AC

258 Collecting duct-specific knockout of polycystin-1 caused

259 ients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, wher

260 , physiologically, showed a kidney- and even collecting-duct-specific expression, including secreted

261 ney-like organoids - complete with nephrons, collecting ducts, stroma, and vasculature - from induced

262 opmental mechanism giving rise to a distinct collecting duct subpopulation.

263 was appropriately increased in the medullary collecting duct, suggesting a localized inhibition in th

264 anion-selective paracellular pathway in the collecting duct, suggesting a mechanism for coupling chl

265 ng interstitial population into the neonatal collecting duct, suggesting that such intercalation may

266 found that HDAC7 is expressed in the kidney collecting duct, supporting a potential role for this hi

267 the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephro

268 ement of gamma1 laminins for assembly of the collecting duct system basement membrane, in which immob

269 egulatory pathways in the distal nephron and collecting duct system have helped to better our underst

270 lectrolytes and acid-base homeostasis in the collecting duct system of the kidney require an overlapp

271 t TRPV4 is highly expressed along the entire collecting duct system where it appears to function as a

272 strong expression of TRPV4 along the entire collecting duct system with highest levels at the apical

273 xpression and flow-dependent function in the collecting duct system.

274 d stalk-enriched gene sets in the developing collecting duct system.

275 eric bud formation and within the developing collecting duct system.

276 pressed in the kidney with dilatation of the collecting ducts, systemic hypertension, and progressive

277 rin 2 (Aqp2)(+) principal cells (PCs) in the collecting ducts that was accompanied by a proportional

278 all cells within the nephron other than the collecting duct through a mesenchyme-to-epithelial trans

279 pressin modulates sodium reabsorption in the collecting duct through adenylyl cyclase-stimulated cycl

280 the symmetry of the system, causing a nearby collecting duct to develop into a uroplakin-positive, br

281 ction-associated barrier components, reduced collecting duct transepithelial resistance, and defectiv

282 oping nephrons arranged around a symmetrical collecting duct tree that has no ureter.

283 Mutation of Dlg1 in urothelium and collecting ducts (via HoxB7-Cre or Pax2-Cre) and in neph

284 croperfusion of cortical and outer medullary collecting ducts, was unaffected in mutant mice.

285 PG synthase type 1 play a role in decreasing collecting duct water permeability and increasing water

286 understanding of the molecular regulation of collecting duct water permeability.

287 ), which localizes to principal cells of the collecting duct, we developed mice lacking Dot1l in Aqp2

288 helial sodium channel (ENaC) in the cortical collecting duct, we tested whether dietary potassium mod

289 he proximal tubule and intercalated cells of collecting ducts, we observed coexpression of ActRIIA, D

290 CC and changes in sodium transport along the collecting duct were also observed.

291 n which epithelial cells in the nephrons and collecting ducts were labeled with enhanced yellow fluor

292 ated into the aquaporin 2-positive medullary collecting duct when microinjected into the kidneys of n

293 r of principal and intercalated cells of the collecting duct where it inhibits K(+) secretion and sti

294 that NaCl loss originated from the cortical collecting duct, where activity of both the epithelial s

295 laterally in alpha-intercalated cells of the collecting duct, where it is functionally coupled with a

296 AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrat

297 experiments of principal cells of split open collecting ducts, where ENaC open probability was increa

298 decreased slightly in the cortical/medullary collecting duct, whereas BK channel abundance increased

299 e corrective response is orchestrated in the collecting duct, which has several transporters integral

300 inantly at the level of aquaporin 2-positive collecting ducts with tubular epithelial and basement me