ライフサイエンスコーパス: collision-induced dissociation

1 large numbers of product ions resulted from collision induced dissociation.

2 [4-(trimethylammonio)phenyl]acetic acid upon collision induced dissociation.

3 inct signature fragmentation patterns during collision induced dissociation.

4 osaccharide product ions generated following collision-induced dissociation.

5 multiple reaction monitoring mode (MRM) with collision-induced dissociation.

6 for subsequent fragmentation via low energy collision-induced dissociation.

7 mass spectrometry using ion trap multistage collision-induced dissociation.

8 aled that the NTA moiety can be detached via collision-induced dissociation.

9 em mass spectrometry product ion scans using collision-induced dissociation.

10 ragment ion (m/z 44, CH(3)CH=NH (+)(2)) upon collision-induced dissociation.

11 eptides to be sequenced without the need for collision-induced dissociation.

12 different from those obtained in low-energy collision-induced dissociation.

13 thus, undergo a neutral loss of 129 Da under collision-induced dissociation.

14 temperatures), as well as at high in-source collision-induced dissociation.

15 nated ions, from GBPs in the gas phase using collision-induced dissociation.

16 confirmed via tandem mass spectrometry using collision-induced dissociation.

17 rmative product ions arising from ozone- and collision-induced dissociation.

18 ying the fragmentation patterns produced via collision-induced dissociation.

19 a combination of lower- and enhanced-energy collision-induced dissociation.

20 re characterized by subsequent isolation and collision-induced dissociation.

21 A hybrid collision induced dissociation/193 nm UVPD (CID/UVPD) ap

22 Upon collision-induced dissociation, 4 undergoes decarboxylat

23 or preservation of the formed Se-S bond upon collision-induced dissociation), a feature that is usefu

24 dentical modification sites were observed by collision-induced dissociation analysis for the neonicot

25 ments of the modified AChBP were analyzed by collision-induced dissociation and Edman sequencing of r

26 em mass spectrometry on an LTQ-Orbitrap with collision-induced dissociation and high-energy collision

27 cessfully applied to ion-molecule reactions, Collision-induced dissociation and infrared multiphoton

28 Collision-induced dissociation and site-directed mutagen

29 confirmed via tandem mass spectrometry using collision-induced dissociation and supported by exact ma

30 need for conducting MS(3) or sequential CID (collision-induced dissociation)- and ETD (electron trans

31 elucidation of lipids is often achieved via collision induced dissociation, and lithium-lipid adduct

32 loss of CO(2) or H(2)O from the anions upon collision-induced dissociation; and (2) the fragment ion

33 y high, such that collisional scattering and collision-induced dissociation are expected to underlie

34 characteristic fragmentation pattern during collision induced dissociation as amine-reactive sulfoxi

35 f a peptide molecular ion to lose HNE during collision-induced dissociation-based fragmentation is in

36 Characteristic ionization and collision induced dissociation behaviors were observed d

37 The collision-induced dissociation cells located in front of

38 ent of the charge-state distribution and the collision-induced dissociation channels.

39 s of tandem mass spectra (MS/MS) obtained by collision induced dissociation (CID) and 351 nm ultravio

40 A comparison of this technique is made with collision induced dissociation (CID) and electron captur

41 nked peptides are detected and identified by collision induced dissociation (CID) and ETD with linear

42 enerated by UVPD were compared to those from collision induced dissociation (CID) and higher energy c

43 ingolipids and gangliosides in comparison to collision induced dissociation (CID) and higher energy c

44 The adjusted collision induced dissociation (CID) conditions generate

45 n of radical directed dissociation (RDD) and collision induced dissociation (CID) following separatio

46 dissociation (UVPD) at 193 nm is compared to collision induced dissociation (CID) for sequencing and

47 w focusing ionization (DEFFI) with in-source collision induced dissociation (CID) for the mass spectr

48 investigated, and we report on parent ions, collision induced dissociation (CID) fragment ions, redu

49 Due to observed collision induced dissociation (CID) fragmentation ineff

50 of electron-transfer dissociation (ETD) and collision induced dissociation (CID) fragmentation.

51 Da) or thiocholine thiolate (-119 Da) during collision induced dissociation (CID) in tandem mass spec

52 Collision induced dissociation (CID) is a widely used te

53 This strategy consists in using collision induced dissociation (CID) multistage mass spe

54 In step 1 of the catalytic cycle, collision induced dissociation (CID) of [(phen)M(O2CCH3)

55 Isolation followed by collision induced dissociation (CID) of singly charged p

56 Collision induced dissociation (CID) of the even-electro

57 Collision induced dissociation (CID) of these phosphoryl

58 oxo bond of uranyl, UO2(2+), was achieved by collision induced dissociation (CID) of UO2(N3)Cl2(-) in

59 th data-independent multiplexed nonselective collision induced dissociation (CID) on a time-of-flight

60 A method of performing collision induced dissociation (CID) on the charge-reduc

61 Either collision induced dissociation (CID) or ion/ion reaction

62 rmulas to fluorinated surfactant ions, while collision induced dissociation (CID) spectra assisted st

63 rform well on certain types of spectra [e.g. Collision Induced Dissociation (CID) spectra of tryptic

64 f a selected precursor ion), drift time, and collision induced dissociation (CID) spectrum.

65 mass spectrometry (MS/MS) experiments using collision induced dissociation (CID) were employed for i

66 f dityrosine cross-linked Abeta(1-16), using collision induced dissociation (CID), higher-energy coll

67 based on exact mass shifts while a combined collision induced dissociation (CID), higher-energy coll

68 Upon subsequent "soft" collision induced dissociation (CID), highly abundant z-

69 of electron transfer dissociation (ETD) and collision induced dissociation (CID), in combination wit

70 estigated with multiple techniques including collision induced dissociation (CID), infrared multiphot

71 The commonly used activation method, collision induced dissociation (CID), often provides lim

72 high-energy collision dissociation (HCD) and collision induced dissociation (CID), provided the compl

73 Upon Collision Induced Dissociation (CID), several spectromet

74 contrast to slow heating techniques such as collision induced dissociation (CID), the cleavage prope

75 However, unlike collision induced dissociation (CID), which has been stu

76 erimented with adding in a parallel ion trap collision induced dissociation (CID)-MS(2) data acquisit

77 which are not typically observed by ion trap collision induced dissociation (CID).

78 ce information than the conventional TOF-TOF collision induced dissociation (CID).

79 equence information relative to conventional collision induced dissociation (CID).

80 ibility of chip-based nanoESI HCT multistage collision-induced dissociation (CID MS(n)) for polysialy

81 modifications were identified by low-energy collision-induced dissociation (CID) (40 V), and the typ

82 bserved includes characteristic fragments of collision-induced dissociation (CID) (b/y/a fragments) a

83 culosis (Mtb) CYP142A1 were assessed through collision-induced dissociation (CID) and collision-induc

84 em mass spectrometry (MS/MS) methods such as collision-induced dissociation (CID) and electron transf

85 sed of any number (limited by ion signal) of collision-induced dissociation (CID) and electron transf

86 acterization of IgG1kappa than does top-down collision-induced dissociation (CID) and electron transf

87 Collision-induced dissociation (CID) and electron-induce

88 In the analysis of MCF7 cell lysate, we show collision-induced dissociation (CID) and electron-transf

89 ith complementary fragmentation modes (e.g., collision-induced dissociation (CID) and electron-transf

90 ng" threshold fragmentation methods, such as collision-induced dissociation (CID) and infrared multip

91 Simultaneous transmission mode collision-induced dissociation (CID) and ion/ion proton

92 ir deprotonated form, from the protein using collision-induced dissociation (CID) and subjecting them

93 al mobility-selected ions prior to in-source collision-induced dissociation (CID) and time-of-flight

94 er-energy collisional dissociation (HCD) and collision-induced dissociation (CID) are employed to pro

95 dem mass spectrometry (MS(n)) analysis using collision-induced dissociation (CID) as the fragmentatio

96 ng a 1 Da mass isolation window, followed by collision-induced dissociation (CID) at 1.5 keV in a col

97 series of on-board traps in which we perform collision-induced dissociation (CID) at pressures in the

98 Therefore, the collision-induced dissociation (CID) behavior of the (AA

99 s spectrometry, ion mobility separation, and collision-induced dissociation (CID) can be used to fina

100 Collision-induced dissociation (CID) causes preferential

101 Beam-type collision-induced dissociation (CID) data of intact glyc

102 ces to create a local database against which collision-induced dissociation (CID) data of modified ol

103 a therapeutic cyclic peptide, exhibits poor collision-induced dissociation (CID) efficiency for mult

104 Combining RAPTOR with IM-MS and collision-induced dissociation (CID) enables us to inter

105 oth electron-transfer dissociation (ETD) and collision-induced dissociation (CID) experiments are imp

106 This technique correlates product ions in collision-induced dissociation (CID) experiments of susp

107 n their mass spectral analyses to complement collision-induced dissociation (CID) experiments.

108 spectrometry (MS(3)) strategy consisting of collision-induced dissociation (CID) followed by 193 ult

109 the advantages of online mobility separated collision-induced dissociation (CID) followed by high re

110 gh resolution FTICR mass spectrometry and by collision-induced dissociation (CID) following nuclease

111 le of surface-induced dissociation (SID) and collision-induced dissociation (CID) for Fourier transfo

112 tched peptide pairs by further comparing the collision-induced dissociation (CID) fragment ions.

113 accomplished by comparison of the in-source collision-induced dissociation (CID) fragmentation patte

114 be determined by matching their experimental collision-induced dissociation (CID) fragmentation spect

115 cation of compounds was possible by standard collision-induced dissociation (CID) fragmentation spect

116 2) spectra, linear ion trap MS(2), in-source collision-induced dissociation (CID) fragmentation, and

117 uced adduct loss was the dominant feature of collision-induced dissociation (CID) fragmentation, but

118 rom the column with 95% acidic acetonitrile, collision-induced dissociation (CID) generates a series

119 having intrachain peptides were subjected to collision-induced dissociation (CID) in an ion trap, a-,

120 Nonselective collision-induced dissociation (CID) is a technique for

121 The chemistry of peptide fragmentation by collision-induced dissociation (CID) is currently being

122 ow well the experimental MS/MS spectrum from collision-induced dissociation (CID) is explained by the

123 Collision-induced dissociation (CID) is the dominant met

124 A detailed comparison of ETD and collision-induced dissociation (CID) modes showed that E

125 D MS) are almost equivalent to conventional, collision-induced dissociation (CID) MS(2) spectra.

126 s are available to be sequenced with routine collision-induced dissociation (CID) MS/MS experiments a

127 The collision-induced dissociation (CID) of a range of depro

128 e understanding and control of the in-source collision-induced dissociation (CID) of analytes is impo

129 s in the interface of tandem-TIMS results in collision-induced dissociation (CID) of avidin tetramers

130 To simulate the collision-induced dissociation (CID) of different charge

131 t work has shown that fragments generated by collision-induced dissociation (CID) of disaccharides ca

132 s a model, we studied the characteristics of collision-induced dissociation (CID) of disulfide-bonded

133 , and protonated crown, H(+)(18C6), from the collision-induced dissociation (CID) of four proton boun

134 Furthermore, tandem MS analysis (MS/MS) via collision-induced dissociation (CID) of glycopeptides in

135 Collision-induced dissociation (CID) of MALDI-generated

136 y of tandem mass spectra for the widely used collision-induced dissociation (CID) of peptide ions.

137 We show that collision-induced dissociation (CID) of pHis peptides pr

138 Collision-induced dissociation (CID) of phosphopeptides

139 Spectral fingerprints: Collision-induced dissociation (CID) of protonated pepti

140 Remarkably, collision-induced dissociation (CID) of the HMTD, TATP,

141 HDX measurements and collision-induced dissociation (CID) of the intermediate

142 Collision-induced dissociation (CID) of the resulting de

143 Collision-induced dissociation (CID) of these cationic m

144 of dipolar excitation to opposing rods, for collision-induced dissociation (CID) of trapped ions.

145 Here we utilize multigenerational collision-induced dissociation (CID) on a miniature mass

146 y is used to disperse product ions formed by collision-induced dissociation (CID) on the basis of cha

147 o allows direct comparison with conventional collision-induced dissociation (CID) on the same instrum

148 ided more structural information than either collision-induced dissociation (CID) or low-energy ECD,

149 spectrometry (MS/MS) strategies coupled with collision-induced dissociation (CID) or radical-driven f

150 charged ions, we show the advantage of using collision-induced dissociation (CID) post-UVPD: radical

151 We found that the high efficient collision-induced dissociation (CID) procedure could be

152 on, whereupon dehydration of the complex via collision-induced dissociation (CID) produces a Schiff b

153 uire significantly more time to acquire than collision-induced dissociation (CID) spectra (>100 ms),

154 eaks with the same parent ion of m/z 463 and collision-induced dissociation (CID) spectra as the two

155 ial electron transfer dissociation (ETD) and collision-induced dissociation (CID) steps, in which ETD

156 ed FA complex cations fragment upon ion-trap collision-induced dissociation (CID) to generate product

157 emethylated PC anions fragment upon ion trap collision-induced dissociation (CID) to yield products t

158 structure-indicative fragments generated by collision-induced dissociation (CID) together with a flo

159 ion trap mass spectrometer capable of source collision-induced dissociation (CID) was used to complet

160 VPD) produces complementary fragmentation to collision-induced dissociation (CID) when implemented fo

161 yed to perform collisional activation and/or collision-induced dissociation (CID) with good transmiss

162 The most commonly used activation method, collision-induced dissociation (CID) with low-mass targe

163 on in the Na(+)(Asn) complex by studying its collision-induced dissociation (CID) with Xe using a gui

164 related adducts and fragments from in-source collision-induced dissociation (CID), (2) in-depth evalu

165 havior of pyrophosphorylated peptides during collision-induced dissociation (CID), a data dependent n

166 ed using standard mass spectrometry, such as collision-induced dissociation (CID), and data analysis

167 tion-ion mobility-mass spectrometry (IM-MS), collision-induced dissociation (CID), and hydrogen/deute

168 ors using the five fragmentation techniques: collision-induced dissociation (CID), beam-type CID (HCD

169 fragmentation methods and two combinations: collision-induced dissociation (CID), beam-type CID (HCD

170 m mass spectrometry (MS/MS) with alternating collision-induced dissociation (CID), ETD, and higher-en

171 hase liquid chromatography and fragmented by collision-induced dissociation (CID), followed by IMS an

172 mass spectra of glycopeptides resulting from collision-induced dissociation (CID), higher-energy C-tr

173 proach that combines mass spectrometry (MS), collision-induced dissociation (CID), ion mobility (IM),

174 In contrast to collision-induced dissociation (CID), IRMPD offered the

175 Reliant on low-energy collision-induced dissociation (CID), traditional ESI-MS

176 in analysis by electrospray ionization (ESI)-collision-induced dissociation (CID)-FTICR MS was applie

177 With the use of a hybrid collision-induced dissociation (CID)-higher energy C-tra

178 ( m-CPBA) epoxidation reaction coupling with collision-induced dissociation (CID)-MS/MS strategy prov

179 verse library of compounds by ESI-low-energy collision-induced dissociation (CID)-MS/MS using quadrup

180 peptide backbone information was provided by collision-induced dissociation (CID)-MS3 fragmentation.

181 etry (IR-MALDI-o-TOF MS) in combination with collision-induced dissociation (CID).

182 l ion family, was investigated by low-energy collision-induced dissociation (CID).

183 ombining ion mobility spectrometry (IMS) and collision-induced dissociation (CID).

184 nt peptide backbone fragmentation when using collision-induced dissociation (CID).

185 in the ion-trap and submitted to sequential collision-induced dissociation (CID).

186 s by electron-capture dissociation (ECD) and collision-induced dissociation (CID).

187 ive activation method than the commonly used collision-induced dissociation (CID).

188 complex of human transthyretin, generated by collision-induced dissociation (CID).

189 ce and complicated fragmentation behavior in collision-induced dissociation (CID).

190 MS/MS), with product ion spectra produced by collision-induced dissociation (CID).

191 oaches using MALDI-MS/MS involve high-energy collision-induced dissociation (CID).

192 ent ion deuterium incorporation pattern upon collision-induced dissociation (CID).

193 ent of collision-induced unfolding (CIU) and collision-induced dissociation (CID).

194 and (iii) to characterize the species using collision-induced dissociation (CID).

195 d peptic peptides that were identified using collision-induced dissociation (CID).

196 Thus, an online LC-MS strategy combining collision-induced dissociation (CID-MS(2)), electron-tra

197 Collision-induced dissociation (CID-MS/MS) revealed diff

198 hat subunits E and G are most easily lost in collision-induced dissociation, consistent with a periph

199 nteraction, as determined by energy-resolved collision-induced dissociation cross-section experiments

200 The positive ion collision induced dissociation data from (D(0), D(4), D(

201 C-trap dissociation" (HCD), i.e., beam-type collision-induced dissociation data into the database se

202 gmentation of natural peptides using dynamic collision-induced dissociation (DCID), a novel fragmenta

203 LC-MS/MS-based collision-induced dissociation demonstrated isopeptide b

204 idation steps, including the combined use of collision-induced dissociation/electron transfer dissoci

205 Accurate mass measurements and post IM collision induced dissociation experiments allowed us to

206 Collision induced dissociation experiments and Kendrick

207 Collision-induced dissociation experiments conducted in

208 Vc(50) values determined via collision-induced dissociation experiments enabled the e

209 ass-selected dications is probed by means of collision-induced dissociation experiments which reveal

210 he implementation of front-end higher energy collision-induced dissociation (fHCD) on a benchtop dual

211 , ion mobility separation arrival times, and collision-induced dissociation fingerprints of HMO anion

212 The use of FAIMS-selected in source collision induced dissociation (FISCID) yields fragmenta

213 We demonstrate a strategy employing collision-induced dissociation for phosphopeptide discov

214 Collision-induced dissociation Fourier Transform ion cyc

215 Accurate mass measurements of diagnostic collision-induced dissociation fragment ions and heavy i

216 re elucidation based upon the application of collision induced dissociation fragmentation mechanisms.

217 bclasses of these peaks were determined from collision-induced dissociation fragmentation patterns, h

218 peptide ions were subsequently fragmented by collision-induced dissociation, from which the sequence

219 n electrospray tandem mass spectrometry with collision-induced dissociation has been used for charact

220 S(2) fragment precursor ions for high-energy collision induced dissociation (HCD) MS(3) analysis in a

221 on induced dissociation (CID), higher-energy collision induced dissociation (HCD), electron transfer

222 -DESI probe at 10 mum/s, while higher-energy collision-induced dissociation (HCD) spectra were acquir

223 e subsequently activated by CID, high-energy collision-induced dissociation (HCD), or UVPD.

224 gh Energy Collision Dissociation) only, CID (Collision Induced Dissociation)/HCD (High Energy Collisi

225 The method utilized in-source collision induced dissociation in conjunction with multi

226 tor is that AMPP amides undergo considerable collision-induced dissociation in the analyte portion ra

227 spectrometry (MS/MS) product ion scans using collision-induced dissociation in the negative ion mode.

228 A combination of mass spectrometry, collision-induced dissociation, ion mobility mass spectr

229 with tandem mass spectrometry using ion trap collision-induced dissociation (IT-CID) and negative ele

230 lowed by sustained off-resonance irradiation collision-induced dissociation, it was possible to deter

231 and mouse brain sections and confirmed with collision induced dissociation/liquid extraction surface

232 ions and acquisition of structure-diagnostic collision-induced dissociation mass spectra, while minim

233 ilyl-derivatized compounds together with the collision-induced dissociation mass spectra; gas and liq

234 alysis we have identified, by exact mass and collision-induced dissociation mass spectrometry (MS/MS)

235 Collision-induced dissociation mass spectrometry (MS/MS)

236 matrix-assisted laser desorption ionization-collision-induced dissociation mass spectrometry and pol

237 Collision-induced dissociation mass spectrometry of the

238 al similarity, SDS-PAGE stability assays and collision-induced dissociation mass spectrometry reveale

239 assigned state of charge was confirmed by a collision-induced dissociation measurement.

240 Collision-induced dissociation measurements of unknown G

241 Here we report new insights into the collision-induced dissociation mechanism of protein asse

242 re of a given glycopeptide was determined by collision-induced dissociation MS/MS fragmentation, and

243 C/UV-MS, UPLC/UV-MS, rapid-resolution LC-MS, collision-induced dissociation MS/MS, and numerical simu

244 and sphingoid backbone (SB) was inferred by collision-induced dissociation multiple-stage mass spect

245 ectrophoresis, dynamic light scattering, and collision-induced dissociation nanoelectrospray ionizati

246 ipt we harvest an overlooked property of the collision induced dissociation of amino acid adducts to

247 basis of matching fragment ions derived from collision induced dissociation of peptides, which are do

248 s no published experimental determination of collision induced dissociation of PFAMs.

249 from the fact that conventional, low energy collision-induced dissociation of even-electron lipid io

250 coli) soluble protein lysate using ion trap collision-induced dissociation of intact protein ions fo

251 ies on knowledge of the products produced by collision-induced dissociation of peptide ions.

252 Collision-induced dissociation of the [OT - 3H + Cu](-)

253 The collision-induced dissociation of the charge-inverted co

254 Collision-induced dissociation of the triply tagged, tri

255 For tandem MS analysis, collision-induced dissociation often led to facile palmi

256 data-dependent acquisition mode, using both collision-induced dissociation or electron capture/trans

257 molecule that can be selectively cleaved by collision-induced dissociation or UV light.

258 ther, we identify an unprecedented symmetric collision-induced dissociation pathway that we link dire

259 as ions, was successfully demonstrated using collision-induced dissociation performed on the deproton

260 metabolite fragmentation patterns, following collision-induced dissociation, provides a valuable tool

261 performance of fHCD and resonance excitation collision-induced dissociation (RE-CID) in terms of inje

262 mass spectrometry (LC/MS/MS) separation, and collision-induced dissociation sequencing.

263 During collision induced dissociation, some natural products ex

264 based on sustained off-resonance irradiation collision-induced dissociation (SORI-CID).

265 ine-resolved in Orbitrap Elite higher-energy collision-induced dissociation spectra recorded with a 9

266 s directly from intact N-linked glycopeptide collision-induced-dissociation spectra.

267 gas-phase disassembly patterns as studied by collision-induced dissociation, surface-induced dissocia

268 Modified RNAs are analyzed by MS using collision-induced dissociation tandem mass spectrometry

269 e to identify a number of proteins by use of collision-induced dissociation tandem mass spectrometry

270 Sequential collision-induced dissociation tandem mass spectrometry

271 We report the first collision-induced dissociation tandem mass spectrometry

272 an HNE molecule in the prescan acquired via collision-induced dissociation tandem mass spectrometry

273 ainst phosphate loss in phosphopeptides upon collision-induced dissociation tandem mass spectrometry

274 sequences of the proteins were determined by collision-induced dissociation tandem mass spectrometry,

275 avage rates in a mass spectrometer employing collision-induced dissociation tandem mass spectrometry.

276 of library octasaccharides using low-energy collision-induced dissociation tandem mass spectrometry.

277 can structure within a glycopeptide from its collision-induced dissociation tandem mass spectrum.

278 ing sodium adducts of the GAGs to low-energy collision-induced dissociation tandem MS.

279 human cerebellum and upon use of low-energy collision-induced dissociation tandem MS.

280 ied cytosines are determined using threshold collision-induced dissociation (TCID) techniques.

281 modified cytosines are measured by threshold collision-induced dissociation (TCID) techniques.

282 6) is determined using competitive threshold collision-induced dissociation (TCID) techniques.

283 vely) utilizing an energy-resolved threshold collision-induced dissociation technique.

284 Threshold collision-induced dissociation techniques are employed t

285 Upon collision-induced dissociation, the modified peptides re

286 When given energy via collision-induced dissociation, the system is capable of

287 as subjected to mass-to-charge selection and collision induced dissociation to remove the acyl group,

288 product and neutral loss signals obtained by collision-induced dissociation to a user-defined white l

289 The FAIMS-in-source collision induced dissociation-TOFMS (FISCID-MS) method

290 rand siRNA anions was studied using ion trap collision-induced dissociation under various activation

291 Peptides were fragmented with collision-induced dissociation using isolation windows o

292 Collision-induced dissociation was demonstrated by duty

293 Collision-induced dissociation was performed on both the

294 Fragmentation spectra of HMOs using collision-induced dissociation were studied to obtain th

295 he unreacted precursor ions are subjected to collision induced dissociation which yields b/y- and c/z

296 e and predictable fragmentation pattern upon collision induced dissociation, which enables the chemo-

297 the response of each peak to weak in-source collision induced dissociation, which increases the peak

298 diation fogwater samples were analyzed using collision induced dissociation with ultrahigh-resolution

299 The application of collision-induced dissociation with liquid chromatograph

300 However, in such experiments, collision-induced dissociation yields restricted informa