ライフサイエンスコーパス: colonic

1 We examined whether alterations in colonic 5-HT signalling underlie age-related changes in

2 ycine, pointed to their microbial origin and colonic absorption, accounting for 81.0% of excreted met

3 ata suggest that KJT can inhibit AOM-induced colonic ACF formation and might be a useful chemoprevent

4 gnificantly upregulated in majority of human colonic adenocarcinomas tested and colon cancer cell lin

5 growth and progression of Apc (Min/+) mouse colonic adenomas, linked to increased epithelial cell be

6 We quantified the fraction of colonic administered SCFAs that could be recovered in th

7 Systemic availability of colonic-administered acetate, propionate and butyrate wa

8 This study investigated the effects of colonic administration of physiologically relevant SCFA

9 and reducing action potential discharge from colonic afferent nerves.

10 his is evidenced by the activation of murine colonic afferents, and sensitization responses to capsai

11 cell (iPSC) lines from 1 patient with total colonic aganglionosis (with the G731del mutation in RET)

12 a severe form of Hirschsprung disease (total colonic aganglionosis).

13 that causes Hirschsprung disease with total colonic aganglionosis, restored ENCC function.

14 terozygous mice were subjected to a model of colonic anastomotic leakage, and were treated with vehic

15 COX-2 inhibitors have been associated with colonic anastomotic leakage.

16 Utah population and investigate the risk of colonic and extracolonic cancers in family members and t

17 and LPS levels were assessed, in addition to colonic and ileal nitrergic myenteric neuron quantificat

18 =38) by evaluating systemic response and the colonic availability of beta-Cryptoxanthin.

19 Directed modulation of the colonic bacteria to metabolize lactose effectively is a

20 by the human host, they can be fermented by colonic bacteria.

21 y two genes upregulated during growth of the colonic bacterium Bacteroides intestinalis on wheat arab

22 In Bacteroides thetaiotaomicron, a human colonic bacterium, the PULs activated by different pecti

23 The major nutrients available to human colonic Bacteroides species are glycans, exemplified by

24 GFAP::hM3Dq mice, and tested the effects on colonic barrier function and electrogenic ion transport

25 significant decrease of the target genes in colonic biopsies and mesenteric lymph nodes which was ac

26 Colonic biopsies and resected tissue from patients with

27 ction to measure levels of messenger RNAs in colonic biopsies from 60 patients with UC, 50 with CD, a

28 alled B0AT1) were significantly decreased in colonic biopsies from patients with IBD compared with co

29 Colonic biopsies from patients with UC had reduced level

30 both TNBS- and DSS-induced colitis and human colonic biopsies from ulcerative colitis, compared with

31 Human colonic biopsy specimens exposed to G. duodenalis were d

32 Treatment of human colonic biopsy specimens with 8Br-cGMP also activated ca

33 The over-expressed colonic brain-derived neurotrophic factor (BDNF) has bee

34 e preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neonatal rat mode

35 Pulmonary GW-39 human colonic carcinoma microcolonies were induced in athymic

36 However, urinary excretion of 3 colonic catabolites of bacterial origin, most notably, 3

37 gnificant, was also observed with OJ-derived colonic catabolites, which, after supplementation in the

38 avenging mechanisms of quercetin and its six colonic catecholic metabolites (caffeic acid, hydrocaffe

39 nd were capable of polarizing both blood and colonic CD4(+) T cells toward distinct effector fates.

40 While many aspects of Shigella colonic cell invasion are known, crucial gaps in knowled

41 e of Sam68-dependent NF-kappaB activation in colonic cell survival and recovery from extrinsic DNA da

42 fruits of S. nigra are capable of protecting colonic cells against the detrimental effects of oxidati

43 effects of SQ-CDDP NP were assessed in human colonic cells and in mouse models of intestinal cancer.

44 However, our results reveal a colonic community that is mixed at micrometer scales, wi

45 with important health implications for these colonic compartments.

46 IBD subtypes, including ulcerative colitis, colonic Crohn's disease and ileal Crohn's disease.

47 ined by three groups (ileal Crohn's disease, colonic Crohn's disease, and ulcerative colitis) than by

48 hese risk scores to test the hypothesis that colonic Crohn's disease, ileal Crohn's disease, and ulce

49 sed laser capture microdissection to isolate colonic crypt cells, differentiated surface epithelium,

50 Using normal colonic crypt epithelium as a comparator, we identify en

51 duced the number of mutagen-induced aberrant colonic crypt foci.

52 lar-level model of the healthy and cancerous colonic crypt microenvironments.

53 that priority of gut colonization determines colonic crypt occupancy.

54 al ring geometry of cells (such as that of a colonic crypt), a 2D lattice and a mass-action (complete

55 DCS cells results in loss of stem cells from colonic crypts and disrupts gut homeostasis and colon or

56 inding to epithelial cells distributed along colonic crypts.

57 on model (mouth, stomach, intestine, but not colonic digestion).

58 yses of breast cancer subtypes and different colonic diseases.

59 rformance was observed in patients with poor colonic distension or opacification.

60 Colonic distribution of labeled DNAzyme and inflammation

61 erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver dise

62 40 consecutive subjects diagnosed with acute colonic diverticulitis between January 2004 and May 2008

63 Results Colonic diverticulitis most commonly involved the rectos

64 indings that are predictive of recurrence of colonic diverticulitis.

65 eric nervous system, which may contribute to colonic dysmotility associated with diverticulitis.

66 th respect to driving enteric neuropathy and colonic dysmotility.

67 253 798 patients who underwent colonic endoscopy were identified, of whom 11 944 with i

68 We demonstrate that only a subpopulation of colonic enterocytes which are characterized by apical di

69 bottom, creating an SC signature for normal colonic epithelia (NCE).

70 We examined whether activation of colonic epithelial 5-HT4R protects colons of mice from i

71 orced upregulation of CBS in an adenoma-like colonic epithelial cell line is sufficient to induce met

72 neficial or deleterious consequences for the colonic epithelial cell metabolism and physiology in ter

73 dings implicate CNOT3 in the coordination of colonic epithelial cell self-renewal, suggesting this fa

74 f oxygen by driving the energy metabolism of colonic epithelial cells (colonocytes) toward beta-oxida

75 sion and release of HbetaD1 and HbetaD2 from colonic epithelial cells and mucosal tissues.

76 ion to promote survival and proliferation of colonic epithelial cells during CAC development.

77 levels of cytoplasmic HuR were increased in colonic epithelial cells from patients with IBD, IBD-can

78 apid replenishment of cytoplasmic ATP within colonic epithelial cells in the maintenance of the mucos

79 by the attenuation of cytokine production in colonic epithelial cells in vitro In conclusion, Lactoba

80 CR analysis of miR-31-3p expression in human colonic epithelial cells overexpressing neurokinin-1 rec

81 In response to injury or gut microbes, colonic epithelial cells produce extracellular hydrogen

82 In response to injury, AQP3-depleted colonic epithelial cells showed defective lamellipodia,

83 also called bacillary dysentery, and invade colonic epithelial cells via the T3SS.

84 HCT116 colonic epithelial cells were employed to analyze the in

85 ouse lamina propria mononuclear cells, human colonic epithelial cells, and human peripheral blood mon

86 at EGFR signaling in macrophages, but not in colonic epithelial cells, has a significant role in CAC.

87 te human beta-defensin-1 and -2 secretion by colonic epithelial cells.

88 -22 in mice upregulates Claudin-2 protein in colonic epithelial cells.

89 ase I (Car1) is a gene expressed uniquely in colonic epithelial cells.

90 that bile acids can differentially regulate colonic epithelial HbetaD expression and secretion and d

91 Effect of fecal water on colonic epithelial permeability was also examined.

92 ntact between Gram-negative bacteria and the colonic epithelial surface.

93 represent a major energy source for the host colonic epithelium and enhance epithelial barrier functi

94 aling mechanism of extracellular H2O2 in the colonic epithelium and implicate AQP3 in innate immunity

95 O. formigenes interacts with colonic epithelium and induces colonic oxalate secretion

96 Although the colonic epithelium appears able to face, up to some exte

97 ensitivity in mice, most likely via enhanced colonic epithelium barrier disruption.

98 eptor 4 (5-HT4R or HTR4) is expressed in the colonic epithelium but little is known about its functio

99 trols; levels of IL28R were increased in the colonic epithelium of patients with IBD and mice with co

100 upregulated the gp130/IL6/Stat3 signaling in colonic epithelium potentially assisted by infiltrating

101 The colonic epithelium provides an essential barrier against

102 may likely affect the homeostatic process of colonic epithelium renewal and the epithelial barrier fu

103 We found that colonic epithelium tissues from patients with IBS have i

104 udy the passage of live bacteria through the colonic epithelium, and determine the role of mast cells

105 -/- mice revealed dedifferentiated and leaky colonic epithelium, and developed invasive adenocarcinom

106 were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organiz

107 Colonic explants were cultured and preserved ex vivo for

108 Exposure to BAR501 increased the colonic expression of IL-10 and TGF-beta mRNAs and the p

109 that the lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and

110 ingle-exon ring finger E3 ligase with strong colonic expression, protects against ulcerative colitis

111 wel wall thickening and infiltration of peri-colonic fat, which were suggestive for stercoral colitis

112 led that both the in vitro digestion and the colonic fermentation caused a pronounced decrease in 3,5

113 re bacterial metabolites produced during the colonic fermentation of undigested carbohydrates, such a

114 e of in vitro gastrointestinal digestion and colonic fermentation on the stability of the polyphenols

115 phenolic contents of SCG that influenced its colonic fermentation.

116 release to simulated gastric, intestinal and colonic fluids, and thus largely enriched the SDS and RS

117 and RNF43 was observed in human hyperplastic colonic foci.

118 The increased colonic FPRL1 expression is associated with severe mucos

119 Colonic FPRL1 mRNA expression was positively correlated

120 In CD patients, colonic FPRL1 mRNA was positively correlated with intest

121 he genetic risk score strongly distinguished colonic from ileal Crohn's disease.

122 peak symptom intensity correlated with peak colonic gas (r = 0.57; P < .05).

123 We hypothesized that bile acids regulate colonic HbetaD expression and aimed to test this by inve

124 INT-777 also stimulated colonic HbetaD1 and HbetaD2 release from wild-type, but

125 f transcription factors and are critical for colonic health.

126 CSA13 inhibited colonic HMG-CoA reductase activity in an FPRL1-dependent

127 This indicates that colonic hypersensitivity to distension, rather than exce

128 xpression levels of MAGI3, PTEN, and TJP1 in colonic IBD as well as UC mucosa, and between inflammati

129 mation and increased expression of PTPN22 in colonic IBD mucosa, was observed.

130 ole of inward rectifier K(+) conductances in colonic ICC that might contribute to regulation of membr

131 (Kir 6.1) and Kcnj11 (Kir6.2) were found in colonic ICC.

132 rmeability, colonic mucosal destruction, and colonic IL-1beta expression.

133 ed tomography, to postmortem measurements of colonic immune cell infiltration.

134 ells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the pres

135 virulence during host transit and subsequent colonic infection.

136 In response to dextran sodium sulfate, colonic infiltration of neutrophils and inflammatory cyt

137 REG3A TG mice developed only mild colonic inflammation after exposure to 2,4,6-trinitroben

138 LNs, and identify pDC as active sentinels of colonic inflammation and/or microbial dysbiosis.

139 ed to resolve dextran sulfate sodium-induced colonic inflammation as a result of defects in dendritic

140 ng from dextran sulfate sodium (DSS)-induced colonic inflammation led to a significant decrease of th

141 Likewise, colonic inflammation related to prolonged exposure to mo

142 nt results in a "leaky" gut, predisposing to colonic inflammation that is facilitated by microbial dy

143 deletion significantly increased gastric and colonic inflammation, respectively, and enhanced M1 acti

144 ral step in visceral sensitization following colonic inflammation, thereby identifying spinal G-CSF a

145 12 deficiency in mice caused increased basal colonic inflammation, which led to a less-diverse microb

146 inflammatory responses in a murine model of colonic inflammation.

147 ering the disease activity index, decreasing colonic inflammatory lesions by 4-fold, and suppressing

148 Colonic infusions of SCFA mixtures, in concentrations an

149 Before and for two hours after colonic infusions, indirect calorimetry was performed an

150 s of adiponectin and AdipoR1 interactions in colonic injury following dextran sulfate sodium treatmen

151 r novel subgroups characterised by differing colonic involvement.

152 aFeEDTA, thereby possibly reflecting greater colonic iron absorption.

153 gested that this occurs because increases in colonic iron adversely affect the gut microbiome in that

154 ese interventions produce large increases in colonic iron because the absorption of their high iron d

155 of classically activated macrophages in the colonic lamina propria and worsened the severity of infl

156 B and T lymphocytes residing in the human colonic lamina propria, encountered by Shigella upon its

157 f IL-6-producing macrophages in the inflamed colonic lamina propria.

158 tly greater severity of small intestinal and colonic lesions and were significantly more likely to ha

159 There were 73 premalignant colonic lesions diagnosed in 56 cases (tubular adenoma,

160 colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease

161 Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the

162 nd (b) sorted tumor-associated and -resident colonic macrophage subpopulations defined a distinct TAM

163 In a human tissue microarray, colonic macrophages demonstrated robust EGFR activation

164 R1 is expressed in circulating monocytes and colonic macrophages, and its activation promotes a IL-10

165 ty in mice promotes the growth of endogenous colonic malignancies and of human colorectal cancer cell

166 inal pressure patterns using High Resolution Colonic Manometry during a baseline period and in respon

167 In vitro, HCOs express colonic markers and contained colon-specific cell popula

168 bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of

169 ected free radicals indicate that catecholic colonic metabolites constitute an efficient group of mor

170 However, the influence of CKD on the colonic microbial metabolism is largely unknown.

171 in the gastrointestinal tract and liver) and colonic microbial metabolism.

172 as the most prevalent interconversion by the colonic microbiota and was not related to the butyrate-p

173 We found hREG3A to alter the colonic microbiota by decreasing levels of ROS.

174 Sialidases produced by some members of the colonic microbiota can promote the expansion of several

175 indicate that stressor exposure affects the colonic microbiota during challenge with C. rodentium, a

176 cus bromii is a dominant member of the human colonic microbiota that plays a 'keystone' role in degra

177 y of microorganisms, collectively termed the colonic microbiota, which has an important role in human

178 Hesperetin-3'-O-glucuronide and the colonic microbiota-derived catabolite 3-(3'-hydroxy-4'-m

179 e and extensively metabolized, mainly by the colonic microbiota.

180 Focal-leaks detected in HT-29/B6 colonic monolayers were verified for native tissue using

181 tion of ENSC into the colon rescues impaired colonic motility with formation of extensive networks of

182 Assessment of colonic motor dysfunction is rarely done because of inad

183 l6, Tnf, and IL1alpha gene expression in the colonic mucosa and reduced the amounts of proinflammator

184 ransit, the profile of the microbiota in the colonic mucosa could discriminate patients with constipa

185 Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subt

186 eq from both the small intestinal mucosa and colonic mucosa of healthy control mice or those exhibiti

187 avitation, can be used to deliver RNA to the colonic mucosa of living mice.

188 n be used to deliver mRNAs and siRNAs to the colonic mucosa of mice and knock down expression of targ

189 lized microinjection of PMN-MPs into wounded colonic mucosa was sufficient to impair epithelial wound

190 This study assessed the structure of the colonic mucosa-associated microbiota in mice exposed to

191 Stressor exposure significantly affects the colonic mucosa-associated microbiota, and exacerbates Ci

192 he number of 5-HT-containing EC cells in the colonic mucosa.

193 lated, and no responses were observed at the colonic mucosa.

194 ation of innate gamma/delta T17 cells in the colonic mucosa.

195 to be important factors in the regulation of colonic mucosal barrier function and inflammation.

196 phine induced increases in gut permeability, colonic mucosal destruction, and colonic IL-1beta expres

197 D2 from epithelial cell monolayers and human colonic mucosal tissue in vitro In contrast, ursodeoxych

198 n dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense

199 ostasis in healthy carriers is maintained by colonic mucus, the major constituent of which is the gly

200 contraction and relaxation, respectively, in colonic muscle cells.

201 nterstitial cells of Cajal (ICC) from murine colonic muscles express genes encoding inwardly rectifyi

202 gs show that ICC, when isolated freshly from colonic muscles, expressed a Ba(2+) -sensitive, inwardly

203 ive, inwardly rectifying K(+) conductance in colonic muscles.

204 ctance is active under resting conditions in colonic muscles.

205 g resting potentials and the excitability of colonic muscles.

206 on of resting potentials and excitability of colonic muscles.

207 a into severe clinical manifestation such as colonic necrosis-if intestinal barrier dysfunction, eg,

208 rmethylation, occur more frequently in early colonic neoplasia than previously believed, and identify

209 nt with their role in the earliest stages of colonic neoplasia, 75% of the loci harboring methylation

210 changes to modulate gene expression in early colonic neoplasia.

211 for medically refractory disease or to treat colonic neoplasia.

212 r colon cancer, diverticular disease, benign colonic neoplasm, and ulcerative colitis/regional enteri

213 Sox2 expression was investigated in colonic neurons of human patients with Clostridium diffi

214 m colitis (CC) was induced in adult mice and colonic neurons were quantified.

215 % of P2Y1-positive and 100% of P2Y2-positive colonic neurons, consistent with reduced afferent fiber

216 nscripts in nearly all retrogradely labelled colonic neurons, suggesting redundancy in function.

217 Both DSS and CC led to increased colonic neurons.

218 A conorphin agonist inhibited colonic nociceptors in a mouse tissue model of chronic v

219 o develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryo

220 Here we report the differentiation of human colonic organoids (HCOs) from hPSCs.

221 the induction of swelling of the jejunal and colonic organoids.

222 nteracts with colonic epithelium and induces colonic oxalate secretion, thereby reducing urinary oxal

223 alate excretion and stimulated (>42%) distal colonic oxalate secretion.

224 eed to identify the derived factors inducing colonic oxalate secretion.

225 ssed control mice, during challenge with the colonic pathogen C. rodentium.

226 ract infection, one other neoplasms, and two colonic perforations) and one died due to sepsis.

227 concentrations may, in addition, affect the colonic pH and osmolarity, which are known to affect col

228 ctors influencing the delicate regulation of colonic pH, including epithelial water absorption, nutri

229 e sialic acid side chain, which can occur at colonic pH, may serve as a switch controlling EstA-assis

230 Here, we investigate how colonic physiology impacts bacterial growth, which ultim

231 Colonic polyps were found in one-half of the patients an

232 llected data from patients with more than 10 colonic polyps, recruited in 2008-2009 from 24 hospitals

233 s in Spain for a study of causes of multiple colonic polyps.

234 Absence of colonic pouch was the only independent factor of pelvic

235 In humans, increased colonic production of the SCFA propionate acutely reduce

236 However, evidence of an effect of colonic propionate on the human brain or reward-based ea

237 On average, 6% of colonic propionate was incorporated into glucose.

238 Here we dissect cell fate transitions during colonic regeneration in a mouse dextran sulfate sodium (

239 ients over 75 years with ASA I-II undergoing colonic resection, and the largest cost increase in pati

240 TNF-alpha treatment of colonic rho(0) cells augmented IL-8 expression by 9-fold

241 Thus, we generated colonic rho(0) cells with reduced mitochondrial function

242 Colonic RORg(+) Treg frequencies increased in mice lacki

243 iRNA expression patterns in the normal human colonic SC niche to understand how cancer stem cells (CS

244 fect of (2) on h/rCRF-induced stimulation of colonic secretory motor activity and urocortin 2-induced

245 enolic metabolite and SCFAs profiles in each colonic segment, with important health implications for

246 (DT) and adjacent tissue (AT) from the same colonic segment.

247 after endoscopic visualization of sequential colonic segments, which were re-examined for discordant

248 ion of the transplanted cells were made from colonic smooth muscle cells in recipient mice.

249 depolarization of freshly dispersed ICC and colonic smooth muscles, suggesting that this conductance

250 Colonic stenting was introduced for palliation of malign

251 vation of amylosome components between human colonic strains from three different continents and a R.

252 elopment of punctate vascular lesions on the colonic surface, which corresponded to changes observed

253 hat COX-2 inhibitors should be avoided after colonic surgery, and administration of PGE2 might be fav

254 essential for intestinal wound healing after colonic surgery, possibly via its effects on angiogenesi

255 To study the effects of COX-2 on colonic surgical wound healing.

256 nduced secondary IFN-gamma overproduction by colonic T cells, leading to prolonged gut inflammation.

257 Studies in colonic T84 cell monolayers revealed that barrier disrup

258 R was used to investigate mRNA expression in colonic tissue and dorsal root ganglion (DRG) cells isol

259 t LAMB4 localizes to the myenteric plexus of colonic tissue and patients harboring LAMB4 variants exh

260 rmeants, including microparticles, deep into colonic tissue ex vivo.

261 Rat colonic tissue exhibited no abnormal histopathological e

262 cally damaged small intestinal and ascending colonic tissue showed a comparably high expression level

263 transplantation, the SERT expression in the colonic tissue was significantly upregulated, and the co

264 oteins in the small intestinal and ascending colonic tissue.

265 nosed as having positive inclusion bodies in colonic tissue.

266 mal adult rat small intestinal and ascending colonic tissue.

267 lls of small intestinal as well as ascending colonic tissue.

268 using microelectrodes on a small segment of colonic tissue; however, little is known if such measure

269 n of GATA3 did not develop colitis and their colonic tissues did not produce inflammatory cytokines (

270 rostasin are significantly down-regulated in colonic tissues from human subjects with active ulcerati

271 Relative colonic TNF-alpha and IL-1beta mRNA levels were calculat

272 TNBS- and DSS-induced colitis and increased colonic TNF-alpha, CXCL10, and chemokine (C-C motif) lig

273 lites (0.2%) derived mainly from rutin after colonic transformation and absorption were also detected

274 on, which in turn is associated with delayed colonic transit and constipation.

275 review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Consti

276 raphic variables, diet, constipation status, colonic transit, and methane production (measured in bre

277 ferences are caused by variations in diet or colonic transit, or are associated with methane producti

278 After adjusting for diet and colonic transit, the profile of the microbiota in the co

279 WD and this was also associated with delayed colonic transit.

280 able of performing studies of defecation and colonic transit.

281 expression of c-MYC, RPL11 and RPL5 in mouse colonic tumor cells irrespective of MDM2(C305F) mutation

282 uggest that IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a

283 f IRE1alpha prevented the colitis-associated colonic tumorigenesis in mice.

284 on of beta-catenin, a key factor that drives colonic tumorigenesis, through activating pancreatic ER

285 bitory role in the growth and development of colonic tumors.

286 multisite/other recurrence with right-sided colonic tumors.

287 ased the number and size of colon tumors and colonic uptake of [(18)F]-fluorodeoxyglucose by positron

288 orally associated increase in mesenteric and colonic vascularity with an increase in mean signal inte

289 orally associated increase in mesenteric and colonic vascularity with an increase in mean signal inte

290 ereas more species appeared in the ascending colonic vessel for accession PM09.812.

291 tients and controls whereas inulin increased colonic volume and gas in both.

292 is a rare inflammatory process involving the colonic wall secondary to fecal impaction with high morb

293 Conclusion Maximum colonic wall thickness and subjective severity of acute

294 tis recurrence were determined to be maximum colonic wall thickness in the inflamed segment (hazard r

295 To silence Wnt-5a in vivo, intra-colonic wall Wnt-5a silencing RNA was used.

296 hich diverticuli, or outpouching through the colonic wall, become inflamed.

297 lae, or herniation of the mucosa through the colonic wall, develop.

298 allows mimicking active contractions of the colonic wall.

299 and migration of enterocytes adjacent to the colonic wounds in a process involving FPR1 and intestina

300 Administration of IL28 to mice with induced colonic wounds promoted mucosal healing.