ライフサイエンスコーパス: colonic mucosa

1 he number of 5-HT-containing EC cells in the colonic mucosa.

2 e interplay between luminal bacteria and the colonic mucosa.

3 lated, and no responses were observed at the colonic mucosa.

4 ubling of prostaglandin E(2) in 15-PGDH null colonic mucosa.

5 sion in biopsy specimens of the rectosigmoid colonic mucosa.

6 and enhanced histopathological damage in the colonic mucosa.

7 ions in T84 cell monolayers and normal human colonic mucosa.

8 solaterally polarized TLR5 response in human colonic mucosa.

9 ecimens but not in the adjacent nonmalignant colonic mucosa.

10 tmentalization of resident proteins in mouse colonic mucosa.

11 copy for determination of DNA methylation in colonic mucosa.

12 ture in rapidly renewing tissues such as the colonic mucosa.

13 the activities of both iNOS and COX-2 in the colonic mucosa.

14 localized inflammation and ulceration of the colonic mucosa.

15 be via modification of apoptotic activity in colonic mucosa.

16 e did not significantly affect the growth of colonic mucosa.

17 diarrhea by invasion and spread through the colonic mucosa.

18 expressed by bacteria resident in the human colonic mucosa.

19 T helper cell-type 1 immune response in the colonic mucosa.

20 twofold upregulation of AT1 receptors in CRF colonic mucosa.

21 y on biopsies from normal and inflamed human colonic mucosa.

22 the putative injurious effects of H2S on the colonic mucosa.

23 gh the actions of toxin A and toxin B on the colonic mucosa.

24 ted in rapidly renewing tissues, such as the colonic mucosa.

25 stric mucosa and is a trophic factor for the colonic mucosa.

26 oduction of elevated amounts of IL-17 in the colonic mucosa.

27 in comparison to the adjacent grossly normal colonic mucosa.

28 as, followed by the gastric, intestinal, and colonic mucosa.

29 d in the middle to upper crypt region of the colonic mucosa.

30 single patient were identified in unembedded colonic mucosa.

31 y toxin A produced acute inflammation of rat colonic mucosa.

32 ificantly higher in colon tumors compared to colonic mucosa.

33 d strongly to samples of jejunal, ileal, and colonic mucosa.

34 with the surface-active phospholipids of the colonic mucosa.

35 s TGF-alpha and TGF-beta expression in human colonic mucosa.

36 ation of innate gamma/delta T17 cells in the colonic mucosa.

37 th crypts, key morphological features of the colonic mucosa.

38 ignificantly higher PGD2 levels than healthy colonic mucosa.

39 leading to a successful colonization of the colonic mucosa.

40 D-1) ligand-expressing cells in normal human colonic mucosa.

41 e located superficially on the rectal and/or colonic mucosa.

42 secretion, inflammation, and necrosis of the colonic mucosa.

43 ssion in controlling inflammation within the colonic mucosa.

44 NA methylation and gene expression in murine colonic mucosa.

45 aining for CD40 in IECs of inflamed ileal or colonic mucosa.

46 tory bowel diseases that commonly affect the colonic mucosa.

47 cell monolayers and sections of normal human colonic mucosa.

48 ssed in colorectal cancers but not in normal colonic mucosa adjacent to the cancer.

49 ot expressed in any of the samples of normal colonic mucosa adjacent to the tumors.

50 gnificant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a con

51 equency of age-related methylation in normal colonic mucosa among the genes hypermethylated in colore

52 nk between the abundance of Fusobacterium in colonic mucosa and adenomas and suggest a possible role

53 rooestrus, an effect mediated by 5-HT in the colonic mucosa and by 5-HT3 receptors.

54 andin F2alpha dehydrogenase (15-PGDH) in the colonic mucosa and colon tumors of male F344 rats.

55 d whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this respon

56 the last AOM or saline injection, and their colonic mucosa and grossly visible colon tumors from rat

57 d an increase of CRTH2-positive cells in the colonic mucosa and high CRTH2 protein content.

58 ly-differentiated adenocarcinomas, in normal colonic mucosa and in human colon cancer cell lines.

59 rmediates also have proliferative effects in colonic mucosa and in some oesophageal cancer cell lines

60 (>35%) and levels of 8-iosoprostane (50%) in colonic mucosa and in tumors.

61 ant decrease in COX-2 expression both in the colonic mucosa and in tumors.

62 ignificant recruitment of neutrophils to the colonic mucosa and increased colonic myeloperoxidase (MP

63 antibody-treated mice had severely inflamed colonic mucosa and increased rather than decreased expre

64 shigellosis, by invading and destroying the colonic mucosa and inducing a robust inflammatory respon

65 ) plays a critical role in the protection of colonic mucosa and is essential to restitution after epi

66 Colonic mucosa and mesenteric lymph nodes from Ccl17-def

67 Such interactions are concentrated at the colonic mucosa and provide energy for the host epitheliu

68 l6, Tnf, and IL1alpha gene expression in the colonic mucosa and reduced the amounts of proinflammator

69 ely express class II MHC molecules in normal colonic mucosa and that they are distinct from professio

70 colon carcinogenesis, both in the uninvolved colonic mucosa and the fecal colonocytes.

71 le of bacterial flagellin using native human colonic mucosa and the mouse colitis model of dextran su

72 Fifty-seven pairs of matched normal colonic mucosa and tumor specimens from patients with co

73 CXCR2 ligands were elevated in inflamed colonic mucosa and tumors and induced MDSC chemotaxis.

74 yeloid-derived suppressor cells (MDSCs) into colonic mucosa and tumors in a mouse model of colitis-as

75 gher in colon tumors than in the surrounding colonic mucosa, and also increased levels of these enzym

76 and ERbeta isoforms in colon tumors, normal colonic mucosa, and colon cancer cell lines.

77 tation, develop adenomas in normal-appearing colonic mucosa, and in the process usually acquire a mut

78 downregulated in IBD patients with inflamed colonic mucosa, and in trinitrobenzene sulphonic acid (T

79 nsitional epithelium of the urinary bladder, colonic mucosa, and mammary epithelium of the adult mous

80 ntly reduced (P < 0.05) colonic Folbp1 mRNA, colonic mucosa, and plasma folate concentration.

81 s compared with its expression in uninvolved colonic mucosa, and that YAP and beta-catenin localize t

82 The principal functions of the colonic mucosa are to act as a barrier to the luminal co

83 e the role of hypermethylation in the normal colonic mucosa as a possible precursor lesion, we studie

84 an underlying process of instability in the colonic mucosa as measured by DNA fingerprinting and flu

85 the last AOM or saline injection, and their colonic mucosa, as well as the grossly visible colon tum

86 This study assessed the structure of the colonic mucosa-associated microbiota in mice exposed to

87 Stressor exposure significantly affects the colonic mucosa-associated microbiota, and exacerbates Ci

88 ed in carcinomas; compared to that of normal colonic mucosa, Bax immunointensity was reduced in only

89 lysis to compare gene expression patterns in colonic mucosa between ZBP-89(DeltaInt) and C57BL/6 wild

90 despite the lack of bacterial attachment to colonic mucosa beyond peak hyperplasia.

91 Proliferation and apoptosis of the colonic mucosa both changed in a protransformational dir

92 d protein expression were absent from normal colonic mucosa but were up-regulated during experimental

93 The colonic mucosa, but not neurons, was found to express li

94 revealed that Id2 was undetectable in normal colonic mucosa, but occurs in 40% of primary tumors and

95 stantially higher in the rat jejunum than in colonic mucosa by a mean (SE) factor of 51.0 (13.2) for

96 K-1R, possesses antiapoptotic effects in the colonic mucosa by activating Akt, which prevents apoptos

97 in peripheral blood and at the duodenal and colonic mucosa by flow cytometry.

98 Fluorescence images of colonic mucosa can be collected endoscopically, and dysp

99 pecific modulation of CRHR2 signaling in the colonic mucosa can promote restoration of the epithelium

100 gastrointestinal tract, with regard to human colonic mucosa cells cultured in vitro.

101 S production, compared with the nonmalignant colonic mucosa cells, NCM356.

102 Unlike the normal colonic mucosa, cells of the inflamed colonic mucosa hav

103 kinase and total membrane PKC activities in colonic mucosa compared to saline treatment in all dieta

104 Chronically inflamed Gialpha2-/- colonic mucosa contains patchy hypoxia, with increased c

105 ransit, the profile of the microbiota in the colonic mucosa could discriminate patients with constipa

106 Homeostasis of the colonic mucosa depends on balancing cell proliferation w

107 derived chemokine production, whereas intact colonic mucosa did not respond to flagellin.

108 this context, flagellin exposure to injured colonic mucosa due to DSS administration in mice resulte

109 pists spend at least 7 minutes examining the colonic mucosa during colonoscopy withdrawal to optimize

110 sed intestinal bleeding, higher apoptosis of colonic mucosa, elevated expression of cytokines and che

111 nd are cytoprotective for cytokine-activated colonic mucosa ex vivo.

112 large intestinal loops were distended, with colonic mucosa exhibiting an aberrant growth pattern and

113 vivo model system that utilizes sealed human colonic mucosa explants and demonstrate in both the ex v

114 s from prostate, colon, and airway and human colonic mucosa expressed mRNA encoding PAR(2), trypsinog

115 sin and its receptor are elevated in the rat colonic mucosa following toxin A administration.

116 focus) and adjoining, microscopically normal colonic mucosa from 10 colon cancer patients for the pre

117 Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subt

118 protein expression in morphologically normal colonic mucosa from 13 healthy subjects, 9 patients with

119 leum and determine whether it protects human colonic mucosa from C. difficile toxins.

120 In colonic mucosa from CD patients, Vdelta2 T cell producti

121 ), and colonic-like cells (HT29-Cl.19A), and colonic mucosa from diseased and control patients were u

122 lines and 409 colorectal tissues [21 normal colonic mucosa from healthy individuals (N-N), 160 prima

123 t junctions, and expression was increased in colonic mucosa from individuals with Crohn's disease.

124 lation and dephosphorylation was observed in colonic mucosa from irritable bowel disease patients.

125 Colonic mucosa from JAM-A(-/-) mice had normal epithelia

126 S and nitrotyrosine was examined using human colonic mucosa from normal bowel, ulcerative colitis, Cr

127 Colonic mucosa from offspring of MD-supplemented mothers

128 Colonic mucosa from patients with UC revealed dramatic,

129 lpha and TGF-beta expression was assessed in colonic mucosa from patients with ulcerative colitis, pa

130 Ag in colorectal cancers, in adjacent normal colonic mucosa from these patients, and in the human col

131 Colonic mucosa from wild type (WT) and Tlr2(-/-) C57BL/6

132 Colonic mucosa harvested at weeks 1, 12, and 36 and colo

133 normal colonic mucosa, cells of the inflamed colonic mucosa have these genetic alterations before the

134 und with respect to RNA expression in normal colonic mucosa; however, an intronic SNP (IVS10-88) in C

135 to Peyer's patch M cells, ileal mucosa, and colonic mucosa in a rabbit model of diarrhea caused by e

136 munostaining was greater than that of normal colonic mucosa in only 3 of 30 (10%) carcinomas and, in

137 inutes) reduced the contact angle of the rat colonic mucosa in vitro as well as in vivo when administ

138 velopment of malignant transformation in the colonic mucosa includes disruption in the equilibrium be

139 gic inflammatory changes in the duodenal and colonic mucosa including villus blunting, increased lami

140 EGF pretreatment of normal colonic mucosa inhibited ion transport responses to carb

141 Colorectal tumours transplanted onto the colonic mucosa invade and metastasize to specific target

142 Neutrophil infiltration of the colonic mucosa is a hallmark of Clostridium difficile to

143 at endothelial ID1 up-regulation in inflamed colonic mucosa is an adaptive response that modulates th

144 expression of interleukin 17 (IL-17) in the colonic mucosa is associated with colonic inflammation a

145 thylation in the MLH1 promoter in the normal colonic mucosa is closely associated with age and the de

146 The proximal colonic mucosa is constantly exposed to high concentrati

147 large population of commensal bacteria, the colonic mucosa is normally hyporesponsive to these poten

148 nt LOI was present in both tumors and normal colonic mucosa, it is possible that hypermethylation cre

149 regulation of KAI1, from the normal adjacent colonic mucosa (KMS 193) to the primary tumor (KMS 72; P

150 KAI1 was expressed at high levels in normal colonic mucosa (KMS 226) but was expressed at lower leve

151 AI1 expression in the transition from normal colonic mucosa (KMS 237) to adenoma (KMS 174) to carcino

152 Anion transport by the colonic mucosa maintains the hydration and pH of the col

153 Reduced hydrophobic integrity of the colonic mucosa may contribute to TNBS-induced colonic in

154 ated STn antigen expression in nondysplastic colonic mucosa may presage the development of neoplasia

155 endent TLR stimulation of CMFs in the normal colonic mucosa may reinforce these cells' anti-inflammat

156 ose per gram) and in antigen-positive normal colonic mucosa (mean, ~0.03 percentage injected dose per

157 drops in transepithelial resistance in human colonic mucosa mounted in Ussing chambers were reversed

158 termined by immunostaining samples of normal colonic mucosa(n=23), transitional normal mucosa adjacen

159 how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and

160 Affymetrix U133 + gene chips on normal human colonic mucosa (NR), adenomas (ADs), and colorectal carc

161 ute 1 alpha OHase mRNA concentrations in the colonic mucosa of 44 individuals without cancer, and in

162 th factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) p

163 expression, and it is present in the normal colonic mucosa of about 30% of patients with colorectal

164 iR-503# were downregulated in the uninvolved colonic mucosa of AOM rats.

165 Correspondingly, colonic mucosa of cathelicidin-deficient mice exhibited

166 a (PPARG) expression was reduced in inflamed colonic mucosa of CD patients with active disease.

167 ker ICAM-1 was also expressed earlier in the colonic mucosa of DSS-treated IRE1beta(-/-) mice, indica

168 Although CD4 T cells were detected in the colonic mucosa of GF recipients, no inflammation was obs

169 However, the levels of cGMP in colonic mucosa of guanylin null mice were significantly

170 eq from both the small intestinal mucosa and colonic mucosa of healthy control mice or those exhibiti

171 broblast lines derived from normal-appearing colonic mucosa of hereditary nonpolyposis CRC individual

172 The colonic mucosa of hGAS mice contained greater numbers of

173 ft in differentiation was seen in the normal colonic mucosa of humans with LOI.

174 e P (SP) were significantly increased in the colonic mucosa of IBS patients.

175 p-regulation of IL-33 and eosinophils in the colonic mucosa of inflammatory bowel disease patients ve

176 , a marker of ER stress, was elevated in the colonic mucosa of IRE1beta(-/-) mice, and, when exposed

177 ased expression of claudin-10 and -15 in the colonic mucosa of JAM-A(-/-) mice and in JAM-A small int

178 avitation, can be used to deliver RNA to the colonic mucosa of living mice.

179 n be used to deliver mRNAs and siRNAs to the colonic mucosa of mice and knock down expression of targ

180 ion was drastically decreased in vivo in the colonic mucosa of mice devoid of MyD88.

181 to compare changes in gene expression in the colonic mucosa of mice that express a human progastrin t

182 nomic consequences of Tlr2 deficiency in the colonic mucosa of mice to gain insights into biological

183 on of cathelicidin increased in the inflamed colonic mucosa of mice with DSS-induced colitis compared

184 use model, we show that Jak3 is expressed in colonic mucosa of mice, and the loss of mucosal expressi

185 We investigated the expression of EBI3 in colonic mucosa of normal control subjects, patients with

186 ontrol patients without cancer showed LOI in colonic mucosa of only two of sixteen cases (12%, P < 0.

187 Ten E. coli strains were isolated from the colonic mucosa of patients in the acute phase of UC.

188 nd the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for s

189 erve as a viable strategy for protecting the colonic mucosa of patients with CDI.

190 ibroblasts in inflamed colons of mice and in colonic mucosa of patients with Crohn's disease.

191 rophils and macrophages) was elevated in the colonic mucosa of patients with ICL.

192 ormal repair by creating focal wounds in the colonic mucosa of prostaglandin-deficient mice.

193 ation of polymorphonuclear leukocytes in the colonic mucosa of rabbits infected with the EHEC espF mu

194 ion of angiogenic factors are evident in the colonic mucosa of rats with colitis and patients with in

195 BR1 in the RNA derived from normal-appearing colonic mucosa of sporadic CRC cases.

196 cing B cells exist primarily in the diseased colonic mucosa of TCR-alpha-/- mice.

197 ents (44%), as well as in the matched normal colonic mucosa of the patients with LOI in their cancers

198 Microarray analysis revealed that the colonic mucosa of ZBP-89(DeltaInt) mice had reduced leve

199 ntifiedmicroscopically in the grossly normal colonic mucosas of rodents treated with colon carcinogen

200 ssed inflammatory cell infiltration into the colonic mucosa ( P < .05) and prevented mortality.

201 on at the DMR0 compared with matched, normal colonic mucosa (P < .0001; N = 51).

202 In the colonic mucosa, PPARgamma expression occurs throughout t

203 The colonic mucosa presumably has an efficient means of deto

204 -releasing hormone receptor 2 (CRHR2) in the colonic mucosa promotes inflammation during acute coliti

205 Analyses of sLe(a) in human colonic mucosa revealed minimal expression in noninflame

206 cancer patients, and in virtually no normal colonic mucosa samples of 50 human subjects with no hist

207 epigenetic changes normally occurring in the colonic mucosa shortly before adulthood could be importa

208 Microarray analysis of colonic mucosa showed distinct changes in gene expressio

209 sed clinical disease compared with controls, colonic mucosa showed less injury and increased epitheli

210 In patients with active CD, inflamed colonic mucosa showed significantly higher COX2 and L-PG

211 Confocal microscopic studies of rat colonic mucosa showed that the pericryptal sheath surrou

212 ncy Gag epitope-specific CD8+ T cells in the colonic mucosa than in the peripheral blood.

213 ered profiles of gene expression in the flat colonic mucosa that exhibited heterogeneity among the mi

214 antigen-presenting cells in the normal human colonic mucosa that suppress proliferation of activated

215 r to have a mutator phenotype present in the colonic mucosa that underlies the process of tumorigenes

216 We demonstrate that, in intact human colonic mucosa, the flagellin/TLR5 response occurs only

217 aintain the pool of resident Mvarphis in the colonic mucosa, the homeostatic regulation of Mvarphi in

218 that leptin, which is increased in inflamed colonic mucosa, triggers colonic expression of hPepT1 vi

219 unofluorescence and Western blot analyses of colonic mucosa validated the systemic cytokine patterns

220 The oxidation rate of H(2)S by colonic mucosa was 10,000 times greater than the reporte

221 Following cecal intubation, the colonic mucosa was carefully inspected during withdrawal

222 In response to DSS, nearly 60% of the entire colonic mucosa was destroyed in knockout and wa-1 mice,

223 Integrin expression in normal human colonic mucosa was determined by using indirect immunofl

224 Messenger RNA (mRNA) from jejunal and colonic mucosa was isolated, and transcript levels of sc

225 e also noted that the miRNA induction in the colonic mucosa was mirrorred in the mucus layer fecal co

226 MIN was found in 50% of UC patients whose colonic mucosa was negative for dysplasia, 46% of those

227 No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making

228 Colonic mucosa was obtained from 9 patients who received

229 phospholipids, contact-angle analysis of the colonic mucosa was performed after the luminal exposure

230 ity was more than or equal to that of normal colonic mucosa was significantly lower in carcinomas tha

231 lized microinjection of PMN-MPs into wounded colonic mucosa was sufficient to impair epithelial wound

232 model for Shigella flexneri invasion of the colonic mucosa was used to monitor the infectious proces

233 erns of HIV type 1 (HIV-1) RNA isolated from colonic mucosa were compared with those from the plasma

234 Colonic mucosa were harvested at weeks 1, 12, or 36, and

235 n plasma, and histopathologic changes in the colonic mucosa were monitored in untreated and muTF-Ab-t

236 nical disease and histological damage to the colonic mucosa were significantly less severe in GC-C(-/

237 AG kinase and membrane PKC activities in the colonic mucosa when compared to LFCO and HFFO groups.

238 Shigella invades the colonic mucosa, where it initiates an acute inflammation

239 ying process of genomic instability in their colonic mucosa whereas UC patients who are dysplasia-fre

240 y in both their dysplastic and nondysplastic colonic mucosa, whereas instability was not present in t

241 pathic, chronic inflammatory disorder of the colonic mucosa, which starts in the rectum and generally

242 is shown to be selectively upregulated in UC colonic mucosa with active inflammation.