ライフサイエンスコーパス: combination

1 nd who received CBT, pharmacotherapy, or the combination.

2 L for the highest emitting vaporizer/voltage combination.

3 vious studies confirmed the efficacy of this combination.

4 bit immune responses to the antigen-scaffold combination.

5 tive of preclinical sensitivity to this drug combination.

6 ication of the maximum tolerated dose of the combination.

7 rettes plus e-cigarettes was the most common combination.

8 onstrains the landscape of potential genetic combinations.

9 new RXRalpha-based antitumor agents and drug combinations.

10 rresponding synergistic or antagonistic drug combinations.

11 were exposed to a subset of auditory-visual combinations.

12 SP (0.01-1 muM) and IL-33 (1-100 ng/mL) in combination also greatly stimulate TNF secretion (by 4,5

13 all three imager manufacturer-field strength combinations also showed excellent interimager agreement

14 or with 3 different opioid and acetaminophen combination analgesics.

15 hod to be used for fingerprinting and linear combination analysis of known XANES reference compounds.

16 the use of antidementia drugs, alone and in combination, antipsychotics, antidepressants, anxiolytic

17 acute infection and persisted during 7 mo of combination antiretroviral drug therapy (cART).

18 ients with virological failure of first-line combination antiretroviral therapy (ART) containing the

19 sible in vivo, especially in the presence of combination antiretroviral therapy.

20 The combination approach does not seem justified.

21 Alcohol-amine combinations are discussed to the extent that net oxidat

22 tune functionality, but the accessible layer combinations are limited by the crystal chemistries of t

23 These combinations are, however, commonplace in biological tis

24 in combination with the top biomarkers (the combination being our a priori primary endpoint), to pro

25 tabine, and tenofovir alafenamide fixed-dose combination [bictegravir group] and 330 with dolutegravi

26 e technologies and opportunities employed in combination cancer therapy using nucleic acids therapeut

27 omplete responses and 8 partial responses to combination carmustine and O6-benzylguanine treatment.

28 if they were treated for lymphoma, received combination chemotherapy, and did not develop therapy-re

29 e efficacy and safety of a clofarabine-based combination (CLARA) versus conventional high-dose cytara

30 d with current or recent use of various oral combination (estrogen-progestin) contraceptives varied b

31 lectron-transfer dissociation (ETD), and the combinations ETciD and EThcD.

32 Furthermore, cells treated with the drug combination exhibited increased promoter and gene body H

33 Linear combination fitting of extended X-ray absorption fine st

34 Overall, combination fludarabine-melphalan with low-dose TBI afte

35 itted rapid evaluation of over 400 admixture combinations for the oxidative methyl esterification of

36 ged, negatively charged, or neutral) and ten combination forms via hemolysis, cell viability, and Ann

37 nly with regard to layer materials and their combinations (gradient plates) but also with regard to d

38 iated with diarrhoea), and two deaths in the combination group (diarrhoea and urinary sepsis in one p

39 The lithium/sertraline combination group had a significantly higher overall dro

40 80 (40.0%) of 200 participants in the combination group had detectable virus at day 3 compared

41 Performance Test score increased more in the combination group than in the aerobic and resistance gro

42 In very high-risk patients receiving combination haploidentical single-unit cord blood transp

43 criteria using antibiotic and culture order combinations in terms of patient characteristics and out

44 ential on the basis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact in 1,32

45 oaches are used iteratively and in judicious combination, in cognizance of the individual patient's c

46 ) are all potential factors that alone or in combination increase cancer-associated thrombosis.

47 The use of the rivaroxaban plus aspirin combination increased major bleeding compared with the a

48 We evaluated a combination intervention strategy (CIS) targeting preval

49 For each combination it is shown that ions arising from (2)H-labe

50 ) targeted agents, novel immunotherapies and combinations likely will be needed for most subtypes.

51 ther studies examining potential benefits of combination lipid-lowering therapy in individuals with C

52 rug partner), this vaccine could be used for combination mass drug administration and a mass vaccinat

53 Their combination may facilitate the triage of candidate compo

54 Specific codons and codon combinations modulate ribosome speed and facilitate prot

55 oviding an elegant and efficient approach to combination nanomedicines.

56 networks are quantitatively analyzed using a combination of 2-D slice analysis and 3-D visualization

57 e genetic correlations between each pairwise combination of 2469 transcripts that are highly heritabl

58 acterize axonal development, we used a novel combination of 3-DISCO technique with 1-photon microscop

59 n these animals are probably maintained by a combination of a conditional strategy and a genetic poly

60 ersality of the code likely results from the combination of a frozen accident, i.e., the deleterious

61 ty, has the potential to achieve the winning combination of a high energy and power density.

62 rk, it was shown for the first time that the combination of a propidium monoazide (PMA) treatment wit

63 Our results show that the combination of activity of several key kinases can predi

64 By using a combination of all methods, 98 mycobacteria were isolate

65 Here we report the first direct combination of all three approaches (CRISPRko, CRISPRi a

66 A combination of alpha and beta provides a tiered system f

67 The efficacy and safety of fixed-dose combination of AM and PQP was comparable to AL for the t

68 he peak-to-peak resolution for each pairwise combination of amino acid ions.

69 The combination of antifungal agents (cinnamon bark oil, zin

70 Combination of ASA and VKA therapy was not associated wi

71 A cascade is defined as the combination of at least two reaction steps in a single r

72 Lastly, combination of AURKA and MEK inhibitors induces a delete

73 Using a combination of biochemistry, electrophysiology, and imag

74 We apply a combination of Biolog phenotype data and fitness data to

75 ression to standard therapy responded to the combination of bortezomib and cytarabine, concomitant wi

76 by dilation, gating by tilt, and gating by a combination of both dilation and tilt.

77 diesel engine and was characterized using a combination of bulk analytical techniques and high resol

78 0.1 wt % provided the most effective minimal combination of carbon substrate and inoculum to drive pH

79 The combination of CHC coating and genetic modification prov

80 In this work, a combination of coarse-grained "Martini" and all-atom sim

81 The combination of dopamine and ketones in a PSR leads to th

82 t is long and complex, typically involving a combination of drugs taken for 6 months.

83 n this study, we introduce a new approach, a combination of EEG and NIRS, to detect driver drowsiness

84 s higher in vegetated sediments because of a combination of enhanced nitrification and higher organic

85 A combination of eol1 with the curly leaf (clf) allele, ca

86 Using a combination of evolutionary analysis, reinforcement lear

87 is truly new and may have broad interest in combination of experimental and computational methods fo

88 plants in very short photoperiods and used a combination of extended nights, continuous light, sucros

89 pression duties, and are likely to reflect a combination of factors including extreme physical exerti

90 Our findings indicate that a combination of factors is required to sensitize these re

91 Regression analyses revealed that this combination of factors significantly accounted for varia

92 We propose that a combination of failed clearance and exaggerated release

93 ral activity in each brain area depends on a combination of feedforward drive (bottom-up from the pre

94 re-driven insulator-metal transition using a combination of first-principles density-functional and m

95 Combination of FUT1 and B3GALT5 revealed that high expre

96 Using a combination of genetic mapping approaches, we show that

97 llowing zygotic genome activation (ZGA), the combination of genomic imbalance and partial genome loss

98 uPcTs-H2O interaction can be tracked using a combination of gravimetric, optical, and electrical sens

99 Using a combination of high-content imaging and a mammalian memb

100 Phenolic compounds were identified by a combination of HPLC-PDA, LC-high resolution MS (LC-HRMS)

101 The combination of ibuprofen and acetaminophen (paracetamol)

102 The combination of immunoprecipitation (IP) with MALDI techn

103 the proteins encoded by these genes using a combination of in vitro biochemical assays and heterolog

104 binning configuration: one model based on a combination of in vivo, ex vivo, and clinical patient in

105 A combination of interventions targeting multiple steps in

106 The combination of ion intercalation with redox reactions of

107 ectively, our study illustrates the powerful combination of iPSCs and genome editing technologies for

108 Here, a combination of kinetic, thermodynamic, and in situ spect

109 RETATION: The rate of cure with a fixed-dose combination of ledipasvir-sofosbuvir for patients with a

110 This phenomenon is facilitated by the combination of low electronic heat capacity and large pl

111 The combination of low thermal conductivity and good transpo

112 Patients with the combination of M41L + L210W + T215rev showed full human

113 ts and Methods This phase I study tested the combination of M6620 and topotecan in 3-week cycles usin

114 SCOP development concluded in 2009, using a combination of manual curation and highly precise automa

115 geted MS to validate and evaluate the simple combination of metabolites that effectively predict ADG.

116 We use a combination of molecular dynamics simulation and atomic

117 performance similar to that of the standard combination of morphologic sequences for the detection o

118 We addressed this by using a combination of mouse strains differing in their ability

119 'epigenomics signal algebra' that allows the combination of multiple activation and repression epigen

120 l vegetation change has been controlled by a combination of multiple forcings, such as tectonics, sea

121 A combination of multiple patient-reported outcomes measur

122 Decidedly, the combination of our recently isolated 12-connected (12-c)

123 f this study support the efficacy of a fixed combination of pepsin and amino acid hydrochloride for t

124 as significantly higher than two-dimensional combination of PGI/II-HpAb (0.786, P < 0.001), PGI/II-OP

125 The area under ROC from three-dimensional combination of PGI/II-HpAb-OPN (0.826) was significantly

126 This combination of phosphorylation and acetylation of FOXO3a

127 A combination of phylogenetic analyses, gene silencing, an

128 Our approach also validates the promising combination of plant engineering with microbial chassis

129 Most patients with acquired TTP respond to a combination of plasma exchange and rituximab, but some d

130 A combination of PolyPhen-2, SNPs&GO, MutPred, MutationTas

131 Effect of integrating optimized combination of pretreatment with packaging on shelf life

132 The combination of probiotics, vitamins, and biological agen

133 Using a combination of protein characterization, expression and

134 A combination of proteins mucin-5AC and prostate stem-cell

135 Our results suggest that a combination of R402Q and S192Y with a deleterious mutati

136 hat contribute to THV thrombosis through the combination of retrospective clinical data analysis and

137 Through a combination of rigorous experimental screening and in si

138 a day (dolutegravir group) or a three-tablet combination of ritonavir-boosted atazanavir plus coformu

139 Here by using a combination of RNA splicing, transcription, and protein

140 alyst for the dimerization of ethylene has a combination of selectivity and activity that surpasses t

141 A combination of seven plasma metabolite biomarkers readil

142 This prediction was validated by a combination of simulation experiments of Ras overexpress

143 We show that a combination of single nicks in the target gene and donor

144 Combination of site-specific incorporation of a clickabl

145 In all cases, the combination of small feature size and optimal shape prov

146 To the best of our knowledge, through combination of solid-state metathesis, guest incorporati

147 A combination of solid-state NMR and circular dichroism ex

148 The powerful combination of static and dynamic structural probes enab

149 and hypophosphite specificity results from a combination of steric selection and the presence of a P-

150 anning transcript interaction are based on a combination of structural and sequence components of the

151 The combination of structure-based hit identification and su

152 This combination of techniques also enabled us to relate chan

153 Thus, mastic oil, as a combination of terpenes, exerts growth inhibitory effect

154 the improvement is due to the optimized NBC combination of the complementary information from both c

155 The combination of the proteasome inhibitor bortezomib with

156 y threefold compared to LC-MS alone due to a combination of the reduction of chemical noise and separ

157 Our method is a novel combination of the strength of probabilistic graphical m

158 ism, different size-control strategies (or a combination of them) provide efficient buffering of size

159 Together with experimental results, a combination of theoretical modeling and atomistic simula

160 By using a combination of theory and experiments, we show that epit

161 The time is ripe for a fruitful combination of these findings with two other long-runnin

162 The combination of these new technologies allows us, for the

163 nitrogen as drift gas and also agree with a combination of this equation with Blanc's law when using

164 fied as having sustained minor injury by the combination of three standard criteria including: presen

165 monitors or estimated indirectly through the combination of time-activity and meteorological data set

166 physical model for this behavior involving a combination of tranverse diffusion through the tissue an

167 The "tubulin code"-a combination of tubulin isotypes and tubulin post-transla

168 obtain an integrated view, we apply here the combination of two complementary experimental techniques

169 these new retroelement copies result from a combination of two mechanisms, of which the first preven

170 It comprises a novel combination of two powerful technologies: deep convoluti

171 catalytic power of Au(I) in BC stems from a combination of two sources: stereoelectronic assistance

172 The combination of two-dimensional radiation hydrodynamic an

173 th provides the basis for a highly desirable combination of ultrahigh sensitivity and SLIM SUPER high

174 A combination of virus resistance, HA interaction, and mol

175 ne pulverization was made possible through a combination of: (1) prodigious bite forces (8,526-34,522

176 n subgroups-defined a priori by all possible combinations of 11 demographic and clinical factors (age

177 t epithelial cells were treated with various combinations of BEV and RES.

178 e to deal with networks containing different combinations of binary, categorical, or numerical attrib

179 ers in each cancer type to determine whether combinations of biomarkers can be used as predictors of

180 Antibiotic treatment with combinations of clindamycin and rifampicin, or ertapenem

181 Patients had undergone imaging with various combinations of color photography, fluorescein angiograp

182 n paradigm, this was unaffected by different combinations of cross-modal feature, suggesting that fea

183 tem function by demonstrating that different combinations of functional traits can act to maximize AN

184 We tested the effects of different combinations of gene knockout, including arsenate reduct

185 n requirements is to use naturally occurring combinations of growth factors.

186 xperimental values of lycopene with selected combinations of independent variables were 8.20-59.17mg/

187 find that most Kenyon cells integrate random combinations of inputs but that a subset receives stereo

188 tion into a burst/pause pattern results from combinations of intrinsic ion conductances, inhibitory a

189 rs through the administration of synergistic combinations of latency reversing agents (LRAs), such as

190 The unique combinations of light responses in each strain gives ris

191 We therefore used different combinations of maternal and embryo SERT Ala56 genotypes

192 ongenital malformations can be manifested as combinations of phenotypes that co-occur more often than

193 ce de novo proto-peptides containing broader combinations of prebiotically plausible monomers.

194 Combinations of questionnaire items improved the predict

195 ng via the tip followed by retraction; (iii) combinations of surfing and retraction; or (iv) sweeping

196 ated nine 2-year scenarios with all possible combinations of the driest ("dry"), wettest ("wet"), and

197 ndings underscore the importance of specific combinations of transcription factors and coregulators i

198 Different combinations of TRMs add to a core TRM, broadly found ac

199 properties are compared and analyzed for two combinations of voltage amplitudes and frequencies: 7 kV

200 ese agents may be part of doublet or triplet combinations, or incorporated into intensive strategies

201 Several protein combinations outperformed hemoglobin in discriminating C

202 help discover clinically relevant biomarker combinations pivotal for understanding cardiovascular di

203 curred in 8/346 (2.3%) patients who received combination prophylaxis versus 4/100 (4.0%) patients who

204 search for synthetic lethality and optimise combination protocol designs.

205 study, we examine a DNA and adenovirus (Ad5) combination regimen targeting guanylyl cyclase C (GUCY2C

206 However, not every virus-antibody combination results in complete neutralization of the in

207 cin and rifampicin, or ertapenem followed by combination rifampicin, moxifloxacin, and metronidazole

208 DG ALDLT with ABOi and ABOc graft combination seems to be a feasible option for expanding

209 te and cross-compare multiple drugs and drug combinations simultaneously in living tumors and across

210 ffectiveness of individual components of the combination strategy.

211 ponents within 1 minute of AMF exposure, and combination studies of antibiotics and AMF demonstrate a

212 templating, self-templating, and multimethod combination synthesis.

213 prim-sulfamethoxazole in a single fixed-dose combination tablet), 12 weeks of fluconazole, 5 days of

214 sensory information, in such categorical cue combination tasks.

215 estimate the null distribution of the Fisher combination test statistic.

216 pment and commercialization of point-of-care combination tests capable of detecting markers of infect

217 Artemisinin-based combination therapies (ACTs) are the mainstay of the cur

218 e, causing high failure rates of artemisinin combination therapies in some areas.

219 Mycophenolate mofetil (MMF) and combination therapies including MMF, at serum trough lev

220 recent studies highlighting the potential of combination therapies recruiting both innate and adaptiv

221 Preliminary studies of DAA combination therapies suggest improved response rates, a

222 xic effects of PARP inhibition, and point at combination therapies to potentiate PARP inhibitor treat

223 zid monotherapy, rifampicin monotherapy, and combination therapies with 3 to 4 months of isoniazid an

224 clinically relevant biomarkers and trials of combination therapies.

225 eted drugs and potentially for the design of combination therapies.

226 y should be conducted prior to proceeding to combination therapies.

227 ivity are desired as high-value partners for combination therapies.

228 tio [OR] 2.23, 95% CI 1.59-3.12); p<0.0001), combination therapy (1.53, 1.13-2.07; p=0.054), and have

229 I, 0.27-0.55), and 14 in patients exposed to combination therapy (IR, 0.95; 95% CI, 0.45-1.45).

230 We stratified analyses of combination therapy according to INCREMENT-CPE mortality

231 cin plus 1 other antipseudomonal beta-lactam combination therapy at 1 of 6 large children's hospitals

232 with a modest increase in artemisinin-based combination therapy coverage (3.56 percentage point incr

233 c denervation alone in 18 (3%) patients, and combination therapy in 166 (27%) patients.

234 s warrant the clinical investigation of this combination therapy in patients with NF1 mutant melanoma

235 amantadine (100 mg), and ribavirin (600 mg) combination therapy or oseltamivir monotherapy twice dai

236 s within 10 days of acute coronary syndrome, combination therapy seemed to be more effective than mon

237 ors and proved safer and more effective than combination therapy using unmodified myxoma and systemic

238 (28.1%) received beta-lactam plus macrolide combination therapy.

239 ported anti-PD-L1 plus olaparib or cediranib combination therapy.

240 In combination, these results raise several opportunities f

241 In a subset of odor combinations, this history-dependent processing was usef

242 hain pairs encoded by the TRAV27/TRBV19 gene combination to recognize this relatively featureless pep

243 e kinase and reveals the potential for using combination treatment with CDK4/6 inhibitors and PD-1-PD

244 Using this combination, we examined an amyloid form of Sup35NM that

245 Starting infections with different segment combinations, we found that the relative abundance of ea

246 lly depends on three dimensionless parameter combinations, which represent myosin-dependent contracti

247 MTD was 20 mg of carmustine applied once in combination with 2 daily doses of 120 mg/m2 of O6-benzyl

248 onstrate that a radio-frequency deflector in combination with a dipole spectrometer not only allows f

249 ted stirring system, a Meinhard nebulizer in combination with a heated single-pass spray chamber, and

250 In synergistic combination with a Lewis acid that helps sequestering th

251 In this work, an analytical methodology in combination with a low power benchtop total reflection X

252 In combination with a novel means of irradiation of the int

253 provides a robust AP detection algorithm in combination with a standardized AP parameter analysis ov

254 urther established that FI-HSV-2 alone or in combination with adjuvants as well as adjuvanted subunit

255 ultimate, generally applicable SC, which in combination with all kinds of ion-selective membranes (I

256 ies of high-resolution MS (HRMS) alone or in combination with all-ion-fragmentation (AIF), data-indep

257 and further defined as positive for CD26 in combination with an aberrant lack of cKIT expression.

258 ntly (aOR, 5.58 [95% CI, 2.03-15.36]) and in combination with an additional metabolic risk factor (hy

259 only produce analgesia when administered in combination with an opioid.

260 unosuppressive treatments, glucocorticoid in combination with bDMARDs and synthetic disease-modifying

261 High-throughput UV-vis titrations in combination with chemical double-mutant cycles (DMCs) ha

262 r for the use of Notch pathway inhibitors in combination with chemotherapy in select patients with sm

263 as a single agent, and more so when used in combination with cisplatin+pemetrexed, the current stand

264 In combination with clinical data MRI has moderate prognost

265 perimental models and can be safely given in combination with currently approved PAH therapies.

266 site-associated DNA sequencing (RADseq), in combination with demographic inference methods, are impr

267 STM measurements in combination with density functional theory (DFT) calcula

268 The electrical and optical measurements, in combination with density functional theory calculations,

269 ods, including egg, milk, soy, and wheat, in combination with exercise, were all negative.The results

270 ndrially targeted agent, MitoQ, alone and in combination with first line therapy for DKD.

271 he antagonist and increased only slightly in combination with GIP, whereas it increased fivefold duri

272 inflammatory role, SP and its metabolites in combination with insulin-like growth factor-1 are shown

273 d sialoglycan ligand recognizing Siglec-8 in combination with integrin blocking antibodies, pharmacol

274 GF release by HPMCs is controlled by IL-6 in combination with its soluble receptor (IL-6 trans-signal

275 B1, OATP1B3, and OATP1A2, either alone or in combination with MDR1, significantly transported doxorub

276 ated biphenyls (PCBs) and applied to cVMS in combination with measurements to explore their bioaccumu

277 We studied CPI-613 in combination with modified FOLFIRINOX (oxaliplatin at 65

278 was established at 500 mg/m(2) when used in combination with modified FOLFIRINOX in patients with me

279 Of note, SNF1 deletion in combination with MSN2 and MSN4 deletion resulted in addi

280 ble sensors for the analyte or biosensors by combination with NADH producing enzymes.

281 Previous studies have examined cue combination with natural categories (e.g., phonemes), pr

282 The unusual auxetic behaviour in combination with other remarkable properties of monolaye

283 nhibition exhibited increased sensitivity in combination with PIK3CA inhibition.

284 However, in combination with reductions of food wastage and food-com

285 In combination with results from a range of in silico funct

286 he recommended phase 2 dose of venetoclax in combination with rituximab was 400 mg.

287 ased to 49.8 and 93.2 nmol/L when treated in combination with rubone, demonstrating a reversal of pac

288 roduction, stimulation of HPMCs with IL-6 in combination with sIL-6R promoted VEGF expression and sec

289 ate transcriptomic and proteomic analysis in combination with simultaneous manual curation to achieve

290 he IL-1 family of cytokines, administered in combination with SP (1 microM), markedly increase (by 1,

291 dy we used high-throughput RNA sequencing in combination with systems-based computational approaches

292 pothesized that an elevated mutation load in combination with T cell clonal dominance among intratumo

293 desirable impact is effectively prevented by combination with T-cell immune agonist immunotherapies r

294 Used in combination with the ACE-R, it provided additional value

295 mily of proteins (KDM5i), either alone or in combination with the DNA-demethylating agent 5-aza-2'-de

296 These results, in combination with the high levels of exposure, indicate a

297 This finding, in combination with the striking up-regulation of CD3, CD8

298 e State Scale)) by themselves, as well as in combination with the top biomarkers (the combination bei

299 Here, we use gene expression patterns in combination with weighted gene coexpression networks and

300 n, and potentially extendable to other metal combinations) with a wide variety of compositions and si