ライフサイエンスコーパス: combinatorial

1 growing simplicial complexes that are purely combinatorial.

2 an identities in plants are specified by the combinatorial action of homeotic master regulatory trans

3 Dynein's activity is controlled by the combinatorial action of several regulatory proteins.

4 onic development and is achieved through the combinatorial action of transcription factors/co-factors

5 thms of gene expression are generated by the combinatorial action of transcriptional and translationa

6 rvival of developing motor neurons but their combinatorial actions remain poorly understood; to addre

7 strate a modular organization in LC in which combinatorial activation modes are coordinated with proj

8 ll molecule metabolism modulators identified combinatorial activity between a Chk1 inhibitor and chlo

9 Furthermore, the combinatorial activity of Toll and other signaling pathw

10 own that Wnt pathway blockers exhibit potent combinatorial activity with taxanes to inhibit tumor gro

11 to explore the potential utility of a novel combinatorial adeno-associated viral (AAV) gene therapy

12 te-carriers can be adopted to safely deliver combinatorial adjuvants and selectively synergize specif

13 ng dose, treatment duration, requirement for combinatorial agents, and extent of efficacy.

14 for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes

15 ltiple genome-wide epigenomic maps, and uses combinatorial and spatial mark patterns to infer a compl

16 substrate for producing high levels of both combinatorial and temporal diversity in the granule cell

17 in microbial diversity induced by life-long combinatorial antibiotic (ABX) selection pressure in the

18 identification of allergen-specific IgE with combinatorial antibody fragment library technology to an

19 establish unbiased selection from autocrine combinatorial antibody libraries as a robust method to d

20 eted cancer therapies will lead toward novel combinatorial anticancer strategies with improved clinic

21 ane-coated nanogel (RBC-nanogel) system with combinatorial antivirulence and responsive antibiotic de

22 Combinatorial application of six pathway inhibitors indu

23 Overall, this combinatorial approach could be highly effective in clin

24 We investigated a combinatorial approach for the analysis of IgAN-relevant

25 However, published studies using this combinatorial approach have been limited, in that they h

26 Our combinatorial approach introduces a strategy to enhance

27 Finally, this novel, to our knowledge, combinatorial approach may provide a paradigm to enhance

28 We present a combinatorial approach to directly measure R C for large

29 ted here combines a helix abstraction with a combinatorial approach to the RNA folding problem in ord

30 Our combinatorial approach using human, porcine and monkey i

31 For evaluating the repeatability, a combinatorial approach was conducted to verify the consi

32 ecautions must be implemented when designing combinatorial approaches for cancer treatment, because d

33 Much as combinatorial approaches for generating random one-dimen

34 Because combinatorial approaches have not yielded effective drug

35 ore the anti-tumour activity of tivozanib in combinatorial approaches in GBM.

36 sembly processes of these 12 serotypes using combinatorial approaches that involved immunofluorescenc

37 es the feasibility and potential of modular, combinatorial approaches to engineering and analysis of

38 ds to EGFR inhibitors, and suggest potential combinatorial approaches to enhance its therapeutic effi

39 nt state and thereby underscore the need for combinatorial approaches to improve treatment of chemoth

40 Combinatorial approaches will also be critical for comba

41 It is likely that combinatorial approaches with targeted immunotherapies w

42 daptive response and thereby design rational combinatorial approaches.

43 eliorate SMA and demonstrates the promise of combinatorial ASOs for the treatment of neurogenetic dis

44 iological parts that are compatible with DNA combinatorial assembly methods, such as Golden Gate and

45 Combinatorial assembly of IgH and IgL V region exons fro

46 ein 1]) and dynamic recruitment of conserved combinatorial associations of additional regulators in a

47 ce of unknown mutations at target loci using combinatorial BiDz sensors.

48 This revealed conserved combinatorial binding despite sequence divergence, sugge

49 The combinatorial binding patterns of TALE proteins define d

50 Our studies indicate that combinatorial bioactive botanicals from GTPs and BSp are

51 oited for polyketide structural diversity by combinatorial biosynthesis and synthetic biology.

52 ar metabolic engineering system is used in a combinatorial biosynthetic approach toward alleviating t

53 These studies expand our view of the combinatorial biosynthetic potential available in bacter

54 itive to sequencing relationships, and their combinatorial capacities, most saliently in the domain o

55 ndexed Hi-C (sciHi-C), a method that applies combinatorial cellular indexing to chromosome conformati

56 Dynamic combinatorial chemistry has proven to be a useful tool i

57 ticular interest in combination with ceramic combinatorial chemistry to generate a library of e.g. cu

58 tems allow both for achieving complexity, by combinatorial chemistry, and addressing it, by switching

59 emistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical

60 Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adeno

61 How combinatorial chromatin modification states are recogniz

62 ogression of prostate cancer is modeled as a combinatorial circuit.

63 Our data support the use of combinatorial clinical therapies exploiting robotic devi

64 mino acid sequence and prenyl group define a combinatorial code for lipid binding that extends beyond

65 transcription factors (TFs) participate in a combinatorial code for RGC type specification, but their

66 A combinatorial code of neuropeptides acts on the circuit

67 We reveal a combinatorial code of TFs, cell surface molecules, and d

68 mossy fiber inputs and are thought to form a combinatorial code useful for pattern separation and lea

69 While a combinatorial code was initially found to reprogram soma

70 However, little is known about how combinatorial complexity among JAZ-TF interactions maint

71 ctions in granules is challenging because of combinatorial complexity in the number of potential mole

72 Despite the combinatorial complexity of gene regulation, its quantit

73 ta with a enumeration algorithm based on the combinatorial constraints defined by the underlying phyl

74 We describe a combinatorial CRISPR interference (CRISPRi) screening pl

75 ic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robus

76 as been recognized that mutations may impose combinatorial defects in CFTR channel biology.

77 time and, finally, generating individual and combinatorial deletions to a set of five conserved genes

78 consequence, further investigation of MN/NP combinatorial delivery strategies is warranted.

79 Furthermore, combinatorial detection of IL-6 and Cortisol in human sw

80 Further in vivo studies revealed the combinatorial diets of GTPs and BSp significantly inhibi

81 Combinatorial disruption of B-cell receptor signalling a

82 show that realistic input patterns constrain combinatorial diversity by producing redundant combinati

83 We found that GrC combinatorial diversity saturates quickly as mossy fiber

84 ined how GCL architecture contributes to GrC combinatorial diversity.

85 The high affinity of the combinatorial domain 11 Fc fusion proteins functioned as

86 criptional programs that correlated with the combinatorial 'dose' of the transcription factors IRF8 a

87 hese combinations, we developed an efficient combinatorial drug screening method called the Feedback

88 entified, and these patterns replicated with combinatorial drugs at 75% precision.

89 Combinatorial ECMs composed of collagen IV + heparan sul

90 These data suggest that optimal combinatorial ECMs enhance endothelial differentiation,

91 These results suggest a combinatorial effect of drug and physical therapy interv

92 Here, we demonstrate that the combinatorial effect of suboptimal SMN antisense oligonu

93 penetrance in autoimmune models, including a combinatorial effect with other risk variants.

94 in-transcending targets that had synergistic combinatorial effects in vitro, while studies in an ende

95 ting the paucity of wet-bench data regarding combinatorial effects of ABA and internal node activatio

96 Combinatorial effects of drug pairs often vary even for

97 We sought to investigate potential combinatorial effects of epigenetic bioactive botanicals

98 ved from their cells of origin and allow for combinatorial effects upon recipient cells.

99 oretical work on the granule cell layer as a combinatorial expander, where each granule cell represen

100 Combinatorial expansion by the cerebellar granule cell l

101 C populations that support both temporal and combinatorial expansion.

102 ient when the solution space is large due to combinatorial explosion of adjustable parameters or for

103 me-scale networks remains challenging due to combinatorial explosion of EMs in complex networks.

104 The combinatorial explosion of various alterations on a prot

105 Combinatorial expression of betalain-related genes also

106 Here, we demonstrate that, in rodents, the combinatorial expression of secretagogin (Scgn), specifi

107 Combinatorial expression of select members across famili

108 We examined the role of combinatorial extracellular matrix (ECM) proteins on end

109 eparately engineered and then assembled in a combinatorial fashion via click chemistry.

110 ings: (i) VH and VL gene sequences pair in a combinatorial fashion without detectable pairing restric

111 gs show that HLHS can arise genetically in a combinatorial fashion, thus providing a new paradigm for

112 transcriptional bursting individually allows combinatorial fine-tuning of the level of MHC class I ge

113 (Abeta) aggregates can be discriminated by a combinatorial fluorescent molecular sensor.

114 Combinatorial fluorescent protein expression in germline

115 This was used in a combinatorial format to study the effects of cytokines o

116 ings establish the first molecular model for combinatorial GABAAR assembly in vivo and reveal an asse

117 Currently, no molecular model exists for combinatorial GABAAR assembly in vivo.

118 raries of structurally diverse scaffolds via combinatorial gene assembly as well as to afford rapid i

119 latform, we demonstrate both synergistic and combinatorial gene expression in human cells.

120 Combining genetic deletion and combinatorial gene expression of Pfma cluster genes, we

121 ng technologies are being harnessed to probe combinatorial gene functions in functional genomics stud

122 the massively parallel screening of barcoded combinatorial gene perturbations in human cells and tran

123 These data indicate the efficacy of a new combinatorial gene therapy aimed at rescuing DA function

124 s on cadherins and protocadherins, we used a combinatorial gene-editing strategy in multiple cell lin

125 CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strat

126 Combinatorial genetic screening using CRISPR-Cas9 is a u

127 This resource allows single-target or combinatorial genetic screens to be carried out at scale

128 establishes a general strategy for multiplex combinatorial genome engineering in eukaryotes.

129 l of oligonucleotides rapidly produced large combinatorial genomic diversity >10(5).

130 We provide evidence that combinatorial HDACi/(+)-JQ1 treatment spurs synergistic

131 n/Src signaling contributes to resistance to combinatorial HER2 and PI3K inhibition.

132 We further use combinatorial-iChIP to illuminate aspects of the Set2-RP

133 This approach identified patient-specific combinatorial immune signatures consisting of high-resol

134 ficity, an RNA-based AND gate that generates combinatorial immunomodulatory outputs only when both pr

135 Here, we evaluate 219 combinatorial implementations of the most commonly used

136 e failures is much more difficult due to the combinatorial increase in possible sets of initially fai

137 We present single-cell combinatorial indexed Hi-C (sciHi-C), a method that appl

138 Here, we present single-cell combinatorial indexed sequencing (SCI-seq) as a means of

139 Our results demonstrate that combinatorial indexing is a generalizable strategy for s

140 se of model organisms; and a new single-cell combinatorial indexing RNA sequencing approach.

141 s or nuclei, termed sci-RNA-seq (single-cell combinatorial indexing RNA sequencing).

142 solve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcrip

143 of a novel KDM5i compound and suggests that combinatorial inhibition along with DAC represents a new

144 nd PI3K/mTOR signaling pathways, we identify combinatorial inhibition of the MAPK/mTOR pathway as a p

145 d the efficacy and synergism of all possible combinatorial inhibitions of eleven currently targetable

146 uripotent progenitors, a process governed by combinatorial inputs from numerous signaling cascades th

147 Here we show that combinatorial inputs from temporal and spatial axes gene

148 tors can be used in the same cell to achieve combinatorial integration of environmental cues, includi

149 o target cancer with enhanced specificity by combinatorial integration of multiple expression markers

150 erapies is hindered by poor understanding of combinatorial integrin function in the epidermis.

151 s identify a novel physiological context for combinatorial integrin signaling, laying the foundation

152 The combinatorial interaction of a receptor kinase and a mod

153 ew that transporter ubiquitylation relies on combinatorial interaction rules such that alpha-arrestin

154 ian promoters is restricted by unpredictable combinatorial interactions between constituent transcrip

155 insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE protei

156 d apply it in a multiplex fashion to analyse combinatorial interactions between sets of miRNA respons

157 Combinatorial interactions of transcription factors and

158 the expression level of Ctip2 by CThPN, via combinatorial interactions with other molecular controls

159 Through combinatorial interrogation, we find that simultaneous r

160 Here we use combinatorial labeling of zebrafish cranial neural crest

161 finding eigenvectors and eigenvalues of the combinatorial Laplacian.

162 ve been shown to interact with proteins, and combinatorial libraries of peptoids have been useful in

163 Dynamic combinatorial libraries that equilibrate under thermodyn

164 he diversity of acyl hydrazone based dynamic combinatorial libraries.

165 y identified by directed evolution involving combinatorial libraries.

166 ganic materials and as components in dynamic combinatorial libraries.

167 f thiosemicarbazone exchange to form dynamic combinatorial libraries.

168 ely used to design individual substrates and combinatorial libraries.

169 ding protein, N9, obtained by screening of a combinatorial library based on the ultra-stable Sso7d sc

170 ce of a novel self-replicator from a dynamic combinatorial library made from a threonine containing p

171 acted and used as scaffolds for generating a combinatorial library of 7912 tetrapeptides.

172 We screened an existing combinatorial library of engineered ubiquitin variants f

173 eps of the method are 1) initial design of a combinatorial library of N-methylated analogues of the s

174 We built a combinatorial library of NOR gates that directly convert

175 HyCoSuL is a combinatorial library of tetrapeptides containing amino

176 s, SNAG-mGluR2 restores patterned vision and combinatorial light response diversity provides a new lo

177 gulated TF genomic distribution and define a combinatorial logic for heterotypic TF regulation of dif

178 s the following stages: (i) preparation of a combinatorial M13 phagemid (PM) library expressing varia

179 ecruited to transcribing genes, operate in a combinatorial manner in targeting the Rpd3S complex to h

180 These TFs act in a combinatorial manner to bind sequence-specific DNA withi

181 multiple metabolic engineering targets in a combinatorial manner.

182 Combinatorial mapping of chromatin occupancy and transcr

183 anularity that then must be operated upon by combinatorial mechanisms and rules (i.e., decomposition/

184 multitude of unrelated functions or whether combinatorial mechanisms can explain its multifaceted ex

185 ctionally redundant, and it also unveils the combinatorial mechanisms involved in the tissue-selectiv

186 signaling are buffered, at least in part, by combinatorial mechanisms.

187 Here, we report a combinatorial metabolic engineering strategy based on an

188 ll, we comprehensively assess the effects of combinatorial mismatches between guide RNA (gRNA) and ta

189 Combinatorial mixtures of detrimental and beneficial bac

190 domain in Tiam1 GEF regulation and suggest a combinatorial model for GEF inhibition and activation of

191 floral whorl, together with BEN We propose a combinatorial model for patterning the B- and C-function

192 Combinatorial mutagenesis demonstrated that hydrophobic

193 Results from a series of LAT constructs with combinatorial mutations of tyrosine residues reveal a pr

194 nd provide a striking example of the shared, combinatorial nature of molecular pathways that underlie

195 Protein design algorithms enumerate a combinatorial number of candidate structures to compute

196 ologous enhancers with conserved or diverged combinatorial occupancy.

197 ted by Hallem and Carlson and shown that the combinatorial odor code supplied by the fruit fly antenn

198 as a binary constrained optimization and the combinatorial optimization is relaxed as a convex-concav

199 able molecular strategy for construction and combinatorial optimization of highly efficient K(+)-sele

200 We formulate our underlying combinatorial optimization problem as an integer linear

201 Solving combinatorial optimization problems is challenging.

202 samplers from the ground-state manifolds of combinatorial optimization problems.

203 oloring of graphs, belonging to the class of combinatorial optimization, represents one such problem.

204 t problems in computing, such as large-scale combinatorial optimizations, by exploiting different ope

205 patiotemporal profiles, generating a complex combinatorial output with time- and space-dependent effe

206 Odor identity is encoded by combinatorial patterns of activated glomeruli, the initi

207 Combinatorial patterns of histone modifications regulate

208 ernel of apricot, based on equalisation with combinatorial peptide ligand libraries (CPLLs), SDS-PAGE

209 es as high-dimensional molecular readouts of combinatorial perturbations provide a detailed view of g

210 Combinatorial perturbations to dietary casein protein an

211 e will be widely applicable for the study of combinatorial phenotypes.

212 This simple technique enables combinatorial polymer synthesis in microtiter plates on

213 Combinatorial polyvalent contacts of histone-binding dom

214 annotating transposon mutant collections by combinatorial pooling and next-generation sequencing.

215 Using simple combinatorial pooling, a highly oversampled collection o

216 The method uses manual 4D combinatorial pooling, next-generation sequencing, and a

217 s with At-NF-YB and At-NF-YC, broadening HFD combinatorial possibilities in terms of trimerization, D

218 ions, which expands our understanding of the combinatorial post-transcriptional control of gene expre

219 arkov model (HMM) that explicitly models the combinatorial presence or absence of each mark.

220 oint Selection (TPS) method that solves this combinatorial problem in a principled and practical way.

221 lenge in understanding their assembly is the combinatorial problem of a non-random selection of a ful

222 This is especially true for combinatorial protein design algorithms, which aim to se

223 ide a useful tool for the molecular study of combinatorial protein-RNA recognition in RNA regulation.

224 We have developed an integrated combinatorial Raman-Active Nanoprobe (RAN) system combin

225 n is leading to the development of optimized combinatorial reactivation and immune surveillance strat

226 r, our findings establish a critical role of combinatorial readout in maintaining chromatin organizat

227 Bromodomain cassette in ZMYND8 mediated the combinatorial recognition of H3K4me1-H3K14ac and H3K4me0

228 Our study suggests that a combinatorial regimen targeting the vasculature, GSCs, a

229 Our work shows how evolution of combinatorial regulation allows for rapid expansion of a

230 Although combinatorial regulation is a common feature in gene reg

231 Combinatorial regulation is highly probable in dictating

232 straightforward model for the development of combinatorial regulation of biological processes in nucl

233 ibility, evolutionary conservation, and pCRE combinatorial relationships in machine learning models a

234 organization that allows for both unique and combinatorial sampling by central relay neurons.

235 but 'orphan' functions, that enable the full combinatorial scope of dimeric signaling receptors encod

236 Using a combinatorial screen in yeast, we engineered an optogene

237 resented methodology holds great promise for combinatorial screening of stem-cell and multicellular-s

238 To increase the efficiency of combinatorial screening, we employ orthogonal Cas9 enzym

239 As additional large combinatorial screens become available, this methodology

240 Due to the large combinatorial search space, unambiguous identification o

241 argets in the network through a network-wide combinatorial search.

242 The peptide originates from combinatorial selection and enables precise modulation o

243 t suitable for high-throughput synthesis and combinatorial sequence screening.

244 estive system development is orchestrated by combinatorial signaling interactions between endoderm an

245 Using a combinatorial small-molecule screen, we previously ident

246 ations has been challenging due to the large combinatorial space involved and the subtle relationship

247 Last, we use our combinatorial staining approach to demonstrate that rheu

248 and may have potential as a key component in combinatorial strategies for spinal repair.

249 unosuppressive effects of RT as we delineate combinatorial strategies to boost the former at the expe

250 re limited overall than at acute stages, our combinatorial strategy in the chronically injured animal

251 This combinatorial strategy remarkably enhanced integration b

252 nism and paves the way for a rationale-based combinatorial strategy to improve the efficacy of MAPKi.

253 This study paves way for a combinatorial strategy to treat as well as prevent adver

254 back and front interfaces optimized through combinatorial studies and demonstrate record open-circui

255 Combinatorial studies with immune checkpoint blockade ha

256 When compared with high-throughput combinatorial studies without computational prioritizati

257 idated workflow that may be applied to other combinatorial studies, both in animals and humans.

258 Upon combinatorial substitution of these glycine residues to

259 ing unnatural amino acids such as the hybrid combinatorial substrate library (HyCoSuL), which uses bo

260 Since the number of combinatorial TALE-VAS pairs is virtually unlimited, thi

261 orable as CD19, we developed a generalizable combinatorial targeting strategy fulfilling stringent ef

262 onal ablation of single genes and allows for combinatorial targeting.

263 Additionally, we show that combinatorial TcPAb preparations can be used to treat co

264 e we show that mass cytometry with multiplex combinatorial tetramer staining can identify and charact

265 Combinatorial therapeutic approaches are an imperative t

266 rovides rationale and proof of concept for a combinatorial therapeutic attack on Notch-dependent canc

267 the clinical implications include a need for combinatorial therapeutic strategies that account for th

268 These findings reveal novel combinatorial therapeutic strategies to realize the pote

269 Thus, a combinatorial therapeutic strategy that targets the PI3K

270 SMA animal models, and suggests a potential combinatorial therapeutic strategy to efficiently treat

271 another, is a powerful tool to select potent combinatorial therapies and predict connectivity between

272 ne treatment, creating unique NQO1-selective combinatorial therapies for specific cancers.

273 B may present novel opportunities to develop combinatorial therapies to improve existing therapies fo

274 Thus, combinatorial therapies using MEK or BRD4 inhibitors tog

275 est that it may be possible to develop novel combinatorial therapies with PBD- and tubulysin-based AD

276 gs about challenges in identifying effective combinatorial therapies.

277 ablish a computational framework to optimize combinatorial therapy in silico We constructed a detaile

278 This combinatorial therapy may be applicable to a much wider

279 ality and to propose potentially efficacious combinatorial therapy regimens.

280 xenograft model of endometrial cancer, this combinatorial therapy resulted in a marked inhibition of

281 Importantly, our combinatorial therapy resulted in tumor regression, incl

282 Thus, two enhancers integrate combinatorial transcription factor input, feedback and r

283 effect of bortezomib and present this novel combinatorial treatment against colorectal cancer.

284 ceptor agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 agoni

285 ses in aggressive brain tumors.Significance: Combinatorial treatment of glioblastoma with temozolomid

286 n the chip, and used the GBM chip to perform combinatorial treatment of Pitavastatin and Irinotecan.

287 Our results showed that this combinatorial treatment re-sensitized ERalpha-dependent

288 ide the selection of compounds to be used in combinatorial treatment strategies.

289 Combinatorial treatment using BRAF and MEK inhibitors re

290 This study sought to implement a novel combinatorial treatment utilizing losartan, previously s

291 Supporting this, combinatorial treatment with N-acetyl-l-cysteine and cat

292 a cells, which will guide the development of combinatorial treatment with radiotherapy for patients w

293 rs into subsets and developed individualized combinatorial treatments for two subtypes with distinct

294 Combinatorial treatments with 3,4-DAP and VGCC agonists

295 This anticorrelation demonstrates how a combinatorial tubulin code written in two different post

296 ognise their RNA and protein partners by the combinatorial use of several RNA binding domains.

297 We propose that the combinatorial use of transcription factors enables the s

298 Specifically, we used a combinatorial viral technique to express diphtheria toxi

299 A semi-combinatorial virtual approach was used to prepare pepti

300 Combinatorial Wnt and BMP signaling was mediated by Smad