ライフサイエンスコーパス: combinatorial library

1 the relative permeability of compounds in a combinatorial library.

2 ding interactions of variable fragments in a combinatorial library.

3 e inhibitors of Int from a synthetic peptide combinatorial library.

4 ly diversified positional scanning synthetic combinatorial library.

5 en on a 10,000-membered natural product-like combinatorial library.

6 ration and screening of a 135-member indexed combinatorial library.

7 r two different guests from a single dynamic combinatorial library.

8 reening a reduced dipeptidomimetic synthetic combinatorial library.

9 d to the single-bead analysis of a split-mix combinatorial library.

10 mposition of the individual catalysts in the combinatorial library.

11 operties of de novo proteins from a designed combinatorial library.

12 arative HPLC fractions from a small molecule combinatorial library.

13 ll TAR RNA-binding molecules from an encoded combinatorial library.

14 alenediimide-based aqueous disulfide dynamic combinatorial library.

15 creen of a 2304-member one-bead-one-compound combinatorial library.

16 f thiosemicarbazone exchange to form dynamic combinatorial libraries.

17 ing pairs can be rapidly isolated from large combinatorial libraries.

18 efines a new modular approach to isoindolone combinatorial libraries.

19 ganic materials and as components in dynamic combinatorial libraries.

20 s chemical scaffolds for the construction of combinatorial libraries.

21 ads (about 100 microm) used for synthesis of combinatorial libraries.

22 oyed in the solid-phase synthesis of peptide combinatorial libraries.

23 oughput screening of compound collections or combinatorial libraries.

24 d for OBOC peptidomimetic and small molecule combinatorial libraries.

25 oach to preparing potentially highly diverse combinatorial libraries.

26 ate their usefulness in constructing dynamic combinatorial libraries.

27 ompared with those selected from much larger combinatorial libraries.

28 and efficient strategy for the generation of combinatorial libraries.

29 xes for eight de novo heme proteins from two combinatorial libraries.

30 uld allow direct characterization of massive combinatorial libraries.

31 and cost associated with the purification of combinatorial libraries.

32 nd acetylated synthetic l- and d-hexapeptide combinatorial libraries.

33 he cystic fibrosis phenotype by screening of combinatorial libraries.

34 n of reactants for numerous production-sized combinatorial libraries.

35 y identified by directed evolution involving combinatorial libraries.

36 oad and cost of screening sufficiently large combinatorial libraries.

37 the lectins were identified by screening of combinatorial libraries.

38 ely used to design individual substrates and combinatorial libraries.

39 ive, individual compounds from mixture-based combinatorial libraries.

40 in structure information to generate focused combinatorial libraries.

41 he diversity of acyl hydrazone based dynamic combinatorial libraries.

42 and has enabled easy access to a variety of combinatorial libraries, 2-D macrocycles, and 3-D molecu

43 2 that were discovered by AS-MS screening of combinatorial libraries against the basal form of the pr

44 ingle-chain variable fragment) clones from a combinatorial library against total proteins of Strongyl

45 he isolation of ligand-binding proteins from combinatorial libraries anchored on the periplasmic face

46 le assay holds much promise for screening of combinatorial libraries and compound collections.

47 ere an efficient means to sift through large combinatorial libraries and identify molecules that bloc

48 portable amino acid sequences selected from combinatorial libraries and supporting the assembly, nuc

49 application in the solid-phase synthesis of combinatorial libraries and the in situ screening of the

50 becoming a primary method to screen focused combinatorial libraries and to quantitatively characteri

51 appaB consensus sequence or a bead-bound ODN combinatorial library and adsorption was then assessed u

52 macrocycles that emerge from a small dynamic combinatorial library and compete for a common feedstock

53 tandardized assembly strategy to construct a combinatorial library and express for the first time in

54 is for chemical amplification from a dynamic combinatorial library and lactide can be converted to (M

55 rmined using a positional scanning-synthetic combinatorial library and substrate phage techniques.

56 nt cycles, of molecular balances, of dynamic combinatorial libraries, and of crystal structures.

57 ns the carbapenem family comprises a natural combinatorial library, and C-2/C-6 oxidation is associat

58 We report a salicylic acid based combinatorial library approach aimed at binding both act

59 riations in X and Y functionality by using a combinatorial library approach.

60 e by using the positional scanning substrate combinatorial library approach.

61 ognition using an "inverse alanine scanning" combinatorial library approach.

62 Large collections of combinatorial libraries are an integral element in today

63 Dynamic combinatorial libraries are mixtures of compounds that e

64 ll lines can select functional peptides from combinatorial libraries based on the expression of tumor

65 Combinatorial libraries based on these pre-BCR proteins

66 cation of a new software tool CoLibri on 358 combinatorial libraries based on validated reaction prot

67 an RNA aptamer (RNA(11F7t)) selected from a combinatorial library based on its ability to bind facto

68 A posttranslational modification-randomized, combinatorial library based on the first 21 residues of

69 ding protein, N9, obtained by screening of a combinatorial library based on the ultra-stable Sso7d sc

70 ed 10 peptides selected from a 16,384-member combinatorial library based on their ability to permeabi

71 GE to separating and analyzing a complex RNA combinatorial library based on thermal stability, using

72 (TGGE) can be used to separate a simple RNA combinatorial library based on thermal stability.

73 ble to high-throughput screening hit triage, combinatorial library-based affinity optimization, and d

74 roughput analysis of solid-phase synthesized combinatorial libraries by acquiring mass spectra from a

75 er 1,000,000 different peptides derived from combinatorial libraries can activate 172.10, yet the TCR

76 consumes <1 nanomole of each compound, large combinatorial libraries can be subjected to numerous sep

77 Such combinatorial libraries can now also be created and eval

78 the aggregate, our results demonstrate that combinatorial libraries can recapitulate the immune repe

79 To begin to address these issues, we used combinatorial library cloning to isolate pneumococcal po

80 A dynamic combinatorial library composed of racemic hydrazone-base

81 Two targeted chromogenic octapeptide combinatorial libraries, comprised of 38 pools each cont

82 the results of the MCSS calculations, small combinatorial libraries consisting of 10s or 100s of thr

83 A combinatorial library consisting of 32 variants encoding

84 ble Ab fragments (IgE-ScFvs) isolated from a combinatorial library constructed from PBMCs of a grass

85 a simple tripeptide "one-bead one-compound" combinatorial library containing 14 unnatural and 19 nat

86 y examining isobaric dipeptides as well as a combinatorial library containing 27 tripeptides.

87 cribe the design and synthesis of an encoded combinatorial library containing 39,304 unnatural small

88 A phage Fab display combinatorial library containing Fab genes from bone mar

89 owth selection dynamics for Escherichia coli combinatorial libraries created by recursive multiplex r

90 of donor-acceptor [2]catenanes from dynamic combinatorial libraries (DCL) in water.

91 f-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication

92 cally relevant macromolecules from a dynamic combinatorial library (DCL).

93 Dynamic combinatorial libraries (DCLs) are collections of struct

94 Dynamic combinatorial libraries (DCLs) are powerful tools for di

95 Reactive distillation of such dynamic combinatorial libraries (DCLs) isolates the most volatil

96 ow molecular weight acyclic and heterocyclic combinatorial libraries derived from amino acids, peptid

97 We generated a combinatorial library derived from spleen cells of a pat

98 A combinatorial library derived from the 12 best performin

99 of these substructures is common practice in combinatorial library design and has produced leads, the

100 ent, beta-sheet pore-forming peptides from a combinatorial library designed to mimic membrane-spannin

101 scaffold was used as a template in a focused combinatorial library, designed using the NMR SOLVE meth

102 methods for generating aptamers from random combinatorial libraries (e.g., systematic evolution of l

103 ino acids of ABD were randomized to create a combinatorial library enabling selection of high-affinit

104 A small, focused combinatorial library encompassing all possible permutat

105 iostin A (2) suitable for the preparation of combinatorial libraries enlisting only liquid-liquid aci

106 aniline as a nucleophilic catalyst, dynamic combinatorial libraries equilibrate rapidly at pH 6.2, a

107 isolation of full-length IgG antibodies from combinatorial libraries expressed in E. coli.

108 Using peptide combinatorial libraries expressed in yeast, we have scre

109 he synthesis and permeability screening of a combinatorial library, followed by deconvolution of memb

110 e writing fields are used to prepare ternary combinatorial libraries for an efficient stepwise optimi

111 modeling to address issues such as designing combinatorial libraries for an entire class of targets a

112 tic search techniques, and methods to design combinatorial libraries for screening and selection.

113 t of attempts to design structurally diverse combinatorial libraries for the identification of novel

114 Herein we report the use of mixture based combinatorial libraries for the rapid discovery of a ser

115 s have demonstrated the utility of synthetic combinatorial libraries for the rapid identification of

116 By the screening of a combinatorial library for inhibitors of nitric oxide (NO

117 ade of maternofetal transport by screening a combinatorial library for peptides that bind nonendothel

118 n effective chemistry for biological dynamic combinatorial library formation.

119 peptides selected from one-bead-one-peptide combinatorial libraries has been developed.

120 y for "one-bead-one-compound" small molecule combinatorial libraries has been developed.

121 High-throughput screening of combinatorial libraries has evolved from studying large

122 al screening in a huge collection of virtual combinatorial libraries has led to the identification of

123 The combinatorial library/high-throughput screen protocols f

124 h throughput screening of our small molecule combinatorial library identified a class of benzoylnapht

125 ces, which when propagated downstream in the combinatorial library, improve the average quality of th

126 y assembled constructs, or into high-quality combinatorial libraries in only 2-3 d.

127 The possibility of filtering combinatorial libraries in order to maximize the probabi

128 er demonstrates the utility of mixture-based combinatorial libraries in the discovery of novel alpha-

129 ifs for CD4+ T cells using peptide synthetic combinatorial libraries in the positional scanning forma

130 npredictable structures, we prepared dynamic combinatorial libraries in which reversibly binding buil

131 ized and characterized from a single dynamic combinatorial library in water.

132 cell clones to positional scanning synthetic combinatorial libraries is analyzed with a mathematical

133 A new methodology for the construction of combinatorial libraries is described.

134 (iv) The combinatorial library is screened to identify the tighte

135 ivileged scaffold for dehydrogenase-targeted combinatorial libraries, it could also be used in a dire

136 notypic cell-based screen of kinase-directed combinatorial libraries led to the discovery of TWS119,

137 Analysis of separate dynamic combinatorial libraries made from one of six peptide-fun

138 ce of a novel self-replicator from a dynamic combinatorial library made from a threonine containing p

139 A general, combinatorial library method for the rapid identificatio

140 The "one-bead one-compound" (OBOC) combinatorial library method is highly efficient, especi

141 The combinatorial library method should be generally applica

142 The combinatorial library method should be readily applicabl

143 A combinatorial library method was developed to systematic

144 In the "one-bead one-compound" (OBOC) combinatorial library method, each compound bead display

145 In this work, we have developed a novel combinatorial library method, termed "enzyme-catalyzed l

146 Using a positional scanning combinatorial library method, we found that the optimal

147 ed the positional scanning synthetic peptide combinatorial library methodology to screen the p773-782

148 and 6 was identified by using a 352-compound combinatorial library microarrayed in quadruplicates on

149 rther tested using unpurified, mixture-based combinatorial libraries of >1000 compounds, yielding res

150 methods were used to design structure-based combinatorial libraries of antipicornaviral capsid-bindi

151 e strategy described here, we prepared large combinatorial libraries of artificial transcription fact

152 for moulding desired recognition sites uses combinatorial libraries of assemblies that are made of a

153 a1-BAR interaction, we functionally screened combinatorial libraries of BAR in which active site resi

154 or chemical synthesis and screening of large combinatorial libraries of bicyclic peptides displayed o

155 lay vector, pComBov, for the construction of combinatorial libraries of bovine Ig antigen-binding fra

156 DNA shuffling generates combinatorial libraries of chimeric genes by stochastica

157 AutoClickChem can be used to produce large combinatorial libraries of compound models for use in vi

158 Large combinatorial libraries of cyclic peptides can now be ro

159 ersity by synthesizing one-bead-one-compound combinatorial libraries of cyclic tetrapeptide analogues

160 Combinatorial libraries of de novo amino acid sequences

161 Recent experiments with combinatorial libraries of de novo proteins have demonst

162 Through the screening of combinatorial libraries of dimeric iminodiacetic acid di

163 from the Sargasso Sea were determined using combinatorial libraries of dipeptides and N-acyl derivat

164 ction of protein binders from highly diverse combinatorial libraries of DNA-encoded small molecules i

165 tural homology to the immunoglobulin domain, combinatorial libraries of FN3 designed to date have pri

166 coded by genes assembled stochastically from combinatorial libraries of gene segments.

167 h-throughput screening and/or selection from combinatorial libraries of gene switch and circuit varia

168 tion without destroying it altogether, seven combinatorial libraries of green fluorescent protein var

169 ITCHY) is a novel tool for the generation of combinatorial libraries of hybrid proteins independent o

170 method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase a

171 Here, we study combinatorial libraries of La(2-x)Sr(x)CuO4-La2CuO4 bila

172 r segments are then ligated together to form combinatorial libraries of long uninterrupted open readi

173 s an in silico prescreen to generate focused combinatorial libraries of mCherry mutants.

174 ulation of bacteria can efficiently generate combinatorial libraries of new strains.

175 Combinatorial libraries of non-biological polymers and d

176 represents a powerful strategy for creating combinatorial libraries of open reading frames that dist

177 anization of membrane proteins and to screen combinatorial libraries of peptides for members that int

178 lices of membrane proteins and for screening combinatorial libraries of peptides for members that int

179 Combinatorial libraries of peptides such as those displa

180 l fidelity, it may be possible to synthesize combinatorial libraries of peptides that contain multipl

181 Screening of nonisotopic reagents used combinatorial libraries of peptidyl compounds, and the r

182 haracterization of large, chemically diverse combinatorial libraries of peptoids (N-substituted oligo

183 ve been shown to interact with proteins, and combinatorial libraries of peptoids have been useful in

184 naproxen and ibuprofen were measured for two combinatorial libraries of polymers prepared in the pres

185 evelop AIDS vaccine components, we generated combinatorial libraries of recombinant human rhinoviruse

186 dentification of cyclic peptide ligands from combinatorial libraries of reversible cyclic depsipeptid

187 ection of de novo heme proteins derived from combinatorial libraries of sequences designed to fold in

188 Combinatorial libraries of synthetic and natural product

189 then filtered and prioritized, and finally, combinatorial libraries of target molecules were synthes

190 hesis of individual cyclic depsipeptides and combinatorial libraries of these compounds is proposed,

191 Chemically synthesized combinatorial libraries of unmodified or modified nuclei

192 method involves the comparative screening of combinatorial libraries of unnatural, synthetic molecule

193 ional regulatory domains, we developed large combinatorial libraries of zinc finger transcription fac

194 A small combinatorial library of 10 structurally related phenyle

195 A mixture-based combinatorial library of 14-membered macrocycles was syn

196 The combinatorial library of 20 compounds gave several compo

197 Using a combinatorial library of 24 GMS hosts and 26 guest molec

198 A combinatorial library of 400 inhibitors has been synthes

199 A combinatorial library of 400 serine protease inhibitors

200 1 nonreactive moieties, resulting in a small combinatorial library of 72 fragment-like compounds.

201 acted and used as scaffolds for generating a combinatorial library of 7912 tetrapeptides.

202 t led to changes in substrate specificity, a combinatorial library of approximately 6000 maltose bind

203 e and 2,2'-oxybis(ethylamine) form a dynamic combinatorial library of at least nine members.

204 A combinatorial library of beads bearing cell- and molecul

205 highly efficacious cellular activity, from a combinatorial library of bidentate benzofuran salicylic

206 azobenzene building block produced a dynamic combinatorial library of cyclic oligomers, while multibu

207 eported the design and characterization of a combinatorial library of de novo beta-sheet proteins tha

208 ward achieving these goals, we constructed a combinatorial library of de novo proteins designed to fo

209 High-throughput screening of a combinatorial library of diamidophenols yielded lead com

210 A combinatorial library of dipeptide N-acylethylenediamine

211 We screened an existing combinatorial library of engineered ubiquitin variants f

212 A recent screen of a combinatorial library of fluorescent compounds discovere

213 istics of vaccine candidates isolated from a combinatorial library of human rhinoviruses displaying t

214 and experimental binding free energies for a combinatorial library of inhibitors of cathepsin D (CatD

215 (iii) A combinatorial library of linked binding elements is prep

216 We expressed a combinatorial library of monomeric M-CSF (M-CSFM) single

217 eps of the method are 1) initial design of a combinatorial library of N-methylated analogues of the s

218 roach: implementing and evaluating in vivo a combinatorial library of nanoparticles with distinct phy

219 We built a combinatorial library of NOR gates that directly convert

220 in, for example, plasma, is incubated with a combinatorial library of peptide ligands synthesized on

221 ify specific receptor-binding compounds in a combinatorial library of peptoids displayed on beads.

222 A combinatorial library of polyenes, based on (-)-stipiami

223 Described herein is the synthesis of a combinatorial library of potential proapoptotic agents a

224 A combinatorial library of quinone-polyamine conjugates de

225 The identification of such ligands in a combinatorial library of RNA ligands is reported.

226 andem repeat is important for generating the combinatorial library of saccharides that are necessary

227 profilin's essential properties, we built a combinatorial library of ScPFY variants containing eithe

228 solfataricus; Sso7d-hFc was isolated from a combinatorial library of Sso7d mutants using yeast surfa

229 The preparation of a large combinatorial library of such compounds is also discusse

230 urfactants, we designed and screened a large combinatorial library of surfactant formulations, which

231 HyCoSuL is a combinatorial library of tetrapeptides containing amino

232 n-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII

233 d by our group, allowing the generation of a combinatorial library of tri-substituted purines by the

234 Mixture-based combinatorial libraries offer a cost-effective alternati

235 Mixture based synthetic combinatorial libraries offer a tremendous enhancement f

236 aradigm established for screening an encoded combinatorial library on polymeric support, an ECLiPS li

237 To design diverse combinatorial libraries or to select diverse compounds t

238 =0.85 similar to one already chosen for the combinatorial library or in the screening set.

239 In silico screening of combinatorial libraries prior to synthesis promises to b

240 endent assays: positional-scanning synthetic combinatorial library profiling and multiplex substrate

241 Protein combinatorial libraries provide new ways to probe the de

242 e synthesis of positional-scanning synthetic combinatorial libraries (PS-SCL) that does not depend on

243 is the use of positional scanning synthetic combinatorial libraries (PS-SCLs).

244 T-cells and a positional scanning synthetic combinatorial library (PS-SCL) was used to analyze and r

245 Using the positional scanning-substrate combinatorial library (PS-SCL) we determined that TcAtg4

246 mixture-based positional-scanning synthetic combinatorial library (PS-SCL) with the alpha4/4-conotox

247 High-throughput assays using mixture-based combinatorial libraries represent a unique, highly effic

248 s suggesting that the Fabs selected from the combinatorial library represented a varied anti-DbpB imm

249 Positional scanning synthetic combinatorial libraries revealed Kaposi's sarcoma-associ

250 utilized for the initial purification of the combinatorial library samples containing unreacted amine

251 In the optimized LLE method, crude combinatorial library samples were dissolved in a water-

252 pplied to the cleanup of some representative combinatorial library samples with greater than 98% amin

253 tant for numerous applications, ranging from combinatorial library screening and protein engineering

254 Combining computational design, combinatorial library screening and rational mutagenesis

255 acid residues from positional scan synthetic combinatorial library screening data were synthesized.

256 This work presents the first approach on combinatorial library screening for heparin/heparan sulf

257 Previous combinatorial library screening has shown that FHA1 stro

258 st two-hybrid techniques, we first performed combinatorial library screening of "monobodies" (small a

259 Combinatorial library screening of yeast-displayed mutag

260 After combinatorial library selection on EGFR ligands, a panel

261 cid based peptidic receptors, derived from a combinatorial library, served as the cross-reactive sens

262 for the chymotrypsin-like active site via a combinatorial library strategy.

263 describe a novel stepwise fluorophore-tagged combinatorial library synthesis and competitive fluoresc

264 We selected peptide aptamers from combinatorial libraries that disrupted cell-cycle arrest

265 Dynamic combinatorial libraries that equilibrate under thermodyn

266 creenings were performed with triazine-based combinatorial libraries that include various linkers as

267 tion of antibody agonists from intracellular combinatorial libraries that transdifferentiate human st

268 This approach has been used to characterize combinatorial libraries that were synthesized for a vari

269 Specifically, a combinatorial library that examined eight potentially im

270 entification of nine-residue peptides from a combinatorial library that inhibit the intracellular dim

271 Abandoning large combinatorial libraries, the focus has shifted to small,

272 ng billions of antibody variants in tailored combinatorial libraries, they are particularly applicabl

273 We have previously used mixture-based combinatorial libraries to identify hexapeptides that tr

274 strates will prove beneficial when designing combinatorial libraries to screen for artificial TOMMs t

275 We have used synthetic peptide combinatorial libraries to screen for hexapeptides that

276 have devised a method of using intracellular combinatorial libraries to select antibodies that contro

277 Screening 37 different mixture-based combinatorial libraries totaling more than five million

278 designing and filtering potentially massive combinatorial libraries using structural information of

279 ating stable and unstable RNA sequences from combinatorial libraries using temperature gradient gel e

280 isolated in a high throughput screening of a combinatorial library using bacterially made Omi-(134-45

281 rapidly prepared a high-quality beta-peptide combinatorial library via a split-and-mix strategy.

282 A positional scan synthetic combinatorial library was constructed based on the three

283 galanin and the tripeptidomimetic galnon, a combinatorial library was formulated, synthesized, and s

284 A combinatorial library was prepared and used to identify

285 ptimization process, a divergent and focused combinatorial library was synthesized using a polymer-su

286 Using a combinatorial library we identified analogs of G(talpha)

287 Using selection from synthetic combinatorial libraries, we enhanced its affinity by >10

288 Using combinatorial libraries, we generated synthetic binding

289 collections for one-bead-one-compound (OBOC) combinatorial libraries, we have developed hnuSABR (Ligh

290 By screening synthetic peptide combinatorial libraries, we have identified two related

291 ing high throughput inhibitor screens with a combinatorial library, we have identified two novel clas

292 Four "one-bead one-compound" (OBOC) combinatorial libraries were designed, synthesized, and

293 These combinatorial libraries were separated and characterized

294 In this study, combinatorial libraries were used in conjunction with ul

295 ibility of DCC, single compounds and a small combinatorial library were prepared via the Fischer indo

296 We predicted that combinatorial libraries with alternative base compositio

297 on across compositional variations mapped on combinatorial libraries with minimal computational cost.

298 We have interfaced these hydrazone dynamic combinatorial libraries with two isozymes from the gluta

299 or the design and development of much larger combinatorial libraries with varied physicochemical prop

300 A combinatorial library with dipeptide linkers emanating s