ライフサイエンスコーパス: combinatorially

1 se residues are not specified and are varied combinatorially.

2 heart tissue, involves two components acting combinatorially.

3 chains were not constrained and were varied combinatorially.

4 molecular interactions that are readily used combinatorially.

5 suggesting that these miRNAs might function combinatorially.

6 ors that bind DNA and modulate transcription combinatorially.

7 y, individual members of which are expressed combinatorially.

8 nergic neurons, en masse or a subset defined combinatorially.

9 tion factors that regulate these changes act combinatorially.

10 evels, which allows the pathways to function combinatorially.

11 were found among the HSC clones even though combinatorially 54 groups were possible.

12 otic cells is complex and is orchestrated by combinatorially acting transcription factors.

13 Here, we engineer a combinatorially activated T cell circuit in which a synt

14 ally control some differentiation events and combinatorially affect others.

15 A key insight is that activators often work combinatorially, allowing signal integration.

16 The effect of individually and combinatorially altering these nine cysteines was examin

17 ssue, Wnt family members are often expressed combinatorially, although the significance of this is no

18 factory bulb network that can reproduce both combinatorially and temporally sparse mitral cell codes.

19 can be used to pre-encode skeletal diversity combinatorially and thereby generate such small molecule

20 vidually but are also capable of functioning combinatorially as a pattern.

21 hese results suggest that these proteins can combinatorially assemble into distinct 9-1-1 clamps that

22 BAF53b is combinatorially assembled into polymorphic complexes wit

23 hat dendritic outgrowth requires a family of combinatorially assembled, neuron-specific chromatin rem

24 ese results suggest that KIF3 family members combinatorially associate to power anterograde axonal tr

25 tic process by which a diverse repertoire of combinatorially assorted cytokine gene expression patter

26 al-specific gene expression may be regulated combinatorially, but the transcriptional mechanisms gove

27 lation pattern of this reporter is regulated combinatorially by a set of nine maternally supplied RBP

28 ic and that its activities can be controlled combinatorially by different inhibitory ligands.

29 red together, odors appear to be represented combinatorially by dynamical neural assemblies, defined

30 ere that arterial specification is regulated combinatorially by Notch signaling and SoxF transcriptio

31 Odor perceptions are encoded combinatorially by ORs and can be altered by slight chan

32 7), Cys(379), and Cys(408), were substituted combinatorially by Ser.

33 The pattern of Pn.p cell fusion is regulated combinatorially by two genes of the C. elegans Hox gene

34 synthesized on a programmable microarray and combinatorially cloned into a single scFv framework for

35 A combinatorially complete data set consists of studies of

36 lving mostly single and double mutants, or a combinatorially complete subgraph involving only two ami

37 gments (IRES modules) that independently and combinatorially contribute to overall IRES activity.

38 hanisms by which distinct signaling pathways combinatorially control proliferation during organogenes

39 This pathway is combinatorially controlled by at least two genes that ha

40 ast, the pathways of sulfur assimilation are combinatorially controlled by five transcriptional regul

41 , epoxide-functionalized block polymers were combinatorially cross-linked with a diverse library of a

42 rotonergic silencing, only one mapped to the combinatorially defined subset.

43 g the yeast galactose network as a model, we combinatorially deleted one of the two copies of its fou

44 implemented for high-throughput screening of combinatorially developed organic protective coatings fo

45 copic system for high-throughput analysis of combinatorially developed protective organic coatings ar

46 Recruitment of combinatorially distinct AP-1 complexes to these element

47 ut suggest that inhibitory circuits assemble combinatorially during odor presentations.

48 , we show that the four ETS factors function combinatorially during vascular and hematopoietic develo

49 This was accomplished by combinatorially editing the genome via gene deletions an

50 ate in molecular detail how protein kinase A combinatorially effects a key developmental switch.

51 structural variants in a complex mixture of combinatorially engineered Escherichia coli lipid A.

52 ough the simultaneous mapping of millions of combinatorially engineered genomes at single-cell resolu

53 Do the ligands act combinatorially, ensuring appropriate three-dimensional

54 eton Skel(left floor rhod right floor)(P) is combinatorially equivalent to Skel( left floor rhod righ

55 We selected 29 candidate genes to combinatorially express in Nicotiana benthamiana (tobacc

56 progress has been made in understanding how combinatorially expressed transcription factors control

57 n unbiased oligonucleotide library it should combinatorially identify energetically preferred hybridi

58 that these tuning modules can be implemented combinatorially in a predictable manner to further impro

59 te that TRiC contacts full-length substrates combinatorially in a subunit-specific manner.

60 sion patterns is evident; thus, XTHs may act combinatorially in determining wall properties of specif

61 this region are each necessary and function combinatorially in ERK-activated transcription.

62 t, while Prd can use its DNA-binding domains combinatorially in order to achieve different DNA-bindin

63 rotein structural information is pre-encoded combinatorially in polypeptide sequences, thus making it

64 s cells and are expressed stochastically and combinatorially in single neurons.

65 rtant facial social judgements are processed combinatorially in the amygdala.

66 n of the two factors allows them to function combinatorially in the regulation of cardiac gene expres

67 The pyknons arrange combinatorially in the untranslated and coding regions o

68 factors and Semaphorin/Plexin repellents to combinatorially increase Mical-mediated F-actin disassem

69 thesis of aromatic amino acid derivatives by combinatorially inserting multiple T7 promoters simultan

70 SKY is based on cohybridization of combinatorially labeled chromosome-painting probes with

71 ants of nanoparticles can be manufactured in combinatorially large sets, varying by only one transpor

72 ylome suggested that RIP and DNA methylation combinatorially maintain G. sinense genome stability by

73 port analysis of complex mixtures of lipid A combinatorially modified during development of vaccine a

74 using peptide arrays containing a library of combinatorially modified histone peptides.

75 l changes targeted throughout the genome and combinatorially optimize complex (multigenic) traits usi

76 Thus, CRX combinatorially orchestrates the transcriptional network

77 haromyces cerevisiae laboratory backgrounds, combinatorially perturbed in histidine, leucine, methion

78 ns is a broad host range plant pathogen that combinatorially recognizes diverse host molecules includ

79 local sampling also produced GrCs that were combinatorially redundant, even when input diversity was

80 me2, AR and FoxA1 within the same CTCF block combinatorially regulate a subset of distally located an

81 r and a heptad of transcription factors that combinatorially regulate genes in HSCs.

82 ulsatile transcription factors Msn2 and Mig1 combinatorially regulate their target genes through modu

83 coherent sets of functionally related mRNAs combinatorially regulated by common RBPs.

84 lar analysis of ThrbCRM1 revealed that it is combinatorially regulated by the Otx2 and Onecut1 transc

85 ow that podocyte expression of some genes is combinatorially regulated by two transcription factors i

86 In Saccharomyces cerevisiae, we combinatorially replace all regulatory network promoters

87 is of plasticity: the sets of genes that are combinatorially selected by exogenous and endogenous env

88 Combinatorially selected defense peptides, previously sh

89 Newly developed algorithms deconvolved combinatorially selected ions to identify and quantify P

90 We demonstrate that a combinatorially-selected dodecapeptide and its variants

91 LA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) combinatorially specify the identity of Arabidopsis flor

92 many mechanistic step types that were later combinatorially spread in catalytic history.

93 le with respect to individual traits but are combinatorially strong.

94 ss this need, we view bio-ontologies more as combinatorially structured databases than facilities for

95 The transplastomic plants were then combinatorially supertransformed with cassettes for all

96 activity and pioneer factor function can be combinatorially suppressed.

97 , a large number of dipeptide aldehydes were combinatorially synthesized and manually evaluated for t

98 ing both commercially available polymers and combinatorially synthesized cross-linked polymers.

99 A combinatorially synthesized RNA ligand and a cocaine ana

100 Pools of related dipeptide aldehydes were combinatorially synthesized, and the most active pool wa

101 ng protein 2 (MECP2) restoration for RTT and combinatorially target factors in the interactome of Xis

102 tumor suppressor and provide a rationale for combinatorially targeting proto-oncogenic tyrosine kinas

103 ent findings suggest that these TFs are used combinatorially to code for cellular determination in th

104 of olfactory receptors (ORs), which are used combinatorially to detect different odorants and encode

105 hways to control gene expression and can act combinatorially to enforce or reverse epigenetic marks i

106 ronmental signals, which are often processed combinatorially to generate particular phenotypic respon

107 ronmental signals, which are often processed combinatorially to generate specific genetic responses.

108 infection, whereas TLR7 and TLR9 contribute combinatorially to immune responses as infection progres

109 a mechanism by which secreted morphogens act combinatorially to induce the stable expression of targe

110 der set of potent therapeutic tools that act combinatorially to inhibit metastatic prostate cancer.

111 The leg gap genes act combinatorially to initiate the expression of the Notch

112 structure was tuned both systematically and combinatorially to select optimal vectors.

113 born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct

114 ises the possibility of gene targeting PSIP1 combinatorially with CCR5 for HIV-1 cure.

115 The cis-acting elements function combinatorially with documented examples of synergism, a

116 (ii) demonstrate that Mcm1-Fkh2 can function combinatorially with other activators to yield late M/G(

117 turnover or repressing translation, and act combinatorially with other regulatory proteins.

118 of hematopoiesis GATA-1 and GATA-2 function combinatorially with Scl/TAL1, another key regulator of

119 h the number of possible intermediates grows combinatorially with the number of subunits in the capsi

120 an upstream activator of Dpp and Wg, Ci acts combinatorially with them to activate D/V-h expression.

121 The second-order neuron L3 acts combinatorially with two previously known inputs, L1 and

122 ct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in spec

123 ests that Mcm ATPase active sites are formed combinatorially, with Walker A and B motifs contributed