ライフサイエンスコーパス: combining site

1 nd LeuP10, into a depression in the antibody combining site.

2 the encoded proteins to form a polyspecific combining site.

3 lace the antigenic peptide away from the TCR combining site.

4 itopes or differential positioning in the Ag combining site.

5 ll geometry approximating CDRs in the parent combining site.

6 urface that diametrically opposes the normal combining site.

7 Fab')2 molecule containing only a single 7E3 combining site.

8 at binds deeply into a cleft in the antibody-combining site.

9 ete alpha helical segment of the MHC antigen combining site.

10 bility and complexity in the topology of the combining site.

11 op connecting two alpha-helices of the F-box-combining site.

12 n of the polar lactam moiety in the antibody-combining site.

13 e catalytic activity belongs to the antibody combining site.

14 RPAP sequence is immobilized in the antibody-combining site.

15 89), which reorients to form the base of the combining site.

16 , or both chains in forming the 23F-specific combining site.

17 to maintain the structural integrity of the combining site.

18 ructural plasticity in the germline antibody-combining site.

19 wo have indirect effects on the shape of the combining site.

20 ion of the cocaine molecule at their antigen-combining site.

21 so present in eluates which blocked anti-DNA combining sites.

22 using at most one or two gene pairs to form combining sites.

23 s that bind to proteins have relatively flat combining sites.

24 er of different amino acid residues in their combining sites.

25 attern of conserved configurations for their combining sites.

26 tive selection were associated with antibody combining site A or B or the sialic acid receptor bindin

27 gested that the overall shape of the antigen combining site (ACS) of antibodies is correlated with th

28 nce of both anti-DNA and antiidiotypic (anti-combining site) activity in human anti-DNA Id column elu

29 ical with that of WT Ab, suggesting that the combining site adopts a WT conformation.

30 ion between one high-affinity anti-HIV-gp140 combining site and a second low-affinity site on another

31 Ligand recognition was via the alphabetaTCR combining site and involved the identical germline-encod

32 e Trp420 side chain is largely buried in the combining site and that the Asn417 side chain, which is

33 2 formed typical IgG monomers containing two combining sites and a small fraction of a higher-molecul

34 try to monitor both occupancy of surface IgE combining sites and association of antigen with the cell

35 hain Fv clones mimicking physiological VL-VH-combining sites and minority IgV populations with nonphy

36 corresponds to a 2G12 dimer containing four combining sites and present a model for how intermolecul

37 gents with different architectures, antibody combining sites, and linkers.

38 orces that steer the antigen to the antibody-combining site are computed by solving the linearized Po

39 ordered water molecules in the free antibody-combining site are retained and that additional waters a

40 omposed of soluble CD59 fused to an antibody-combining site at the end of CH1, after the hinge (H), a

41 to the transplantation of an intact antibody-combining site between a rodent and a human framework, a

42 -terminal domain extending over the antibody-combining site, blocking entry to large antigens.

43 ic antibody capable of blocking SLE anti-DNA combining sites bound to Id+ affinity columns.

44 antibody possessed a large and deep antigen combining site bounded primarily by the third complement

45 This process changes the antigen combining site by replacing a portion of the original V(

46 egions (CDR) forming the structure of the Ab combining site, CDR3 of heavy chain is the most variable

47 , ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaini

48 mmune disease, and open the possibility that combining site chemical reactivity is a factor driving t

49 of inner strands, thus placing the receptor combining sites close to the sheets.

50 f germline antibodies to adopt more than one combining-site configuration, with both antigen binding

51 The combining site consists of a deep cleft, heavily lined w

52 at the center and at the periphery of the D5 combining site contribute to shape complementarity and e

53 ed distance and flexibility between antibody combining sites correlated with enhanced neutralization

54 am LUDI was used to epitope map the antibody-combining site, correlating peptide reactivity patterns.

55 oids are inserted more deeply into the 1E9dm combining site, creating more hydrophobic contacts that

56 function of L5 in the mitotic kinesin Eg5 by combining site-directed mutagenesis of L5 with transient

57 By combining site-directed mutagenesis with femtosecond spe

58 By combining site-directed mutagenesis, biochemical assays,

59 By combining site-directed mutagenesis, heterologous expres

60 sidues for oxygen diffusion were verified by combining site-directed mutagenesis, rapid kinetics expe

61 S55-3 and S55-5 have combining sites distinct from anti-lipid A antibodies pr

62 ortion of the Ig sequence for determining Ab combining site diversity, our data provide the molecular

63 providing a significant contribution to TCR combining site diversity.

64 A minimal conserved motif in the pristine Ag-combining site essential for multispecificity and Ag bin

65 of amino acid sequence convergence in the Ag combining sites exhibited by members of independent clon

66 The antibody-combining site features a long (22 amino acid residues)

67 aDeltaG(Ala-WT) >or= 1 kcal/mol) that formed combining site features critical to the affinity of the

68 or "preconfigured flexibility" by modulating combining site flexibility.

69 lic acid is an essential element of the mZP3 combining site for sperm.

70 -linked oligosaccharides located at the mZP3 combining site for sperm.

71 ency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and

72 demonstrate that evolution localized the Ab-combining site from a heterogeneous ensemble of conforma

73 The variety of combining sites generated by diversification within indi

74 pears to occur through reorganization of the combining site geometry in a manner that optimizes the b

75 peptide binding complements the shape of the combining site groove much better than pentasaccharide b

76 Despite the low affinity of the polyreactive combining site, heteroligation demonstrably increases th

77 The structure of the antigen combining site in the complex is nearly identical to tha

78 r nonadditivity will be observed only if the combining sites in both associating proteins involve lar

79 The number of bound IgE combining sites in excess of the number of bound antigen

80 require a structural fitness of the antibody combining site involving heavy and light chain variable

81 ural mimicry of the DENV E epitope by the E1 combining site is achieved via the formation of numerous

82 The TCR combining site is relatively flat except for a deep hydr

83 tation of the cyclic peptide in the antibody-combining site is rotated by 180 degrees compared to the

84 A key feature of the antibody-combining site is the protruding, finger-like long CDR H

85 anti-anti-idiotypic mAb GH1002 through their combining sites is extremely tight and intricate, closel

86 ctable change in the microenvironment of the combining site, it did alter the kinetic parameters of b

87 The more flexible combining sites likely result from longer HCDR3 loops an

88 and equilibrium dialysis suggested two sugar-combining sites located in subdomains 1 alpha and 2 gamm

89 c antibodies are characterized by an antigen-combining site mediating specific interactions with two

90 nificant changes in the configuration of the combining site occur upon binding of hapten to the germl

91 tact residues, it is possible to reorder the combining site of a high affinity antibody, resulting in

92 have examined the plasticity of the antigen-combining site of a high-affinity antibody.

93 ymorphonuclear neutrophils; effect on the Ab-combining site of Abs; and in vivo inflammatory activity

94 s initially started in 1970 to determine the combining site of antibodies based on the available amin

95 s initially started in 1970 to determine the combining site of antibodies based on the available amin

96 (CDRs) located in the center of the antibody combining site of C6.5, a human single-chain Fv (scFv) i

97 alanine substitutions were introduced in the combining site of D1.3, and their effects on affinity fo

98 ubstitutions in 9 out of 21 positions in the combining site of E5.2 involved in contacts with D1.3 an

99 The antigen combining site of HuCC49DeltaCH2 is very similar, but no

100 The combining site of RA6.3 was epitope mapped using a novel

101 -imidazole cofactor is incorporated into the combining site of the aldolase antibody 38C2.

102 Comparative analysis of the groove-like combining site of the toxin-bound anti-AahII Fab and pla

103 benzoic acid molecule was sequestered in the combining site of the unliganded antibody.

104 linked oligosaccharides located at the sperm combining site of zona pellucida glycoprotein mZP3.

105 r understand how the relatively flat antigen-combining sites of antibodies interact with the concave

106 Possible interactions of fullerenes with the combining sites of IgG are discussed based on the physic

107 In contrast, the combining sites of the unliganded mouse and humanized an

108 igenic features, usually associated with the combining sites, of other antibodies.

109 ctin has two different types of carbohydrate-combining sites: one type for oligomannoses, which prefe

110 Antibody 38C2 features a large hydrophobic-combining site pocket with a highly nucleophilic lysine

111 The hapten complex revealed a combining site pocket with high shape complementarity to

112 origins that generate two markedly different combining-site pockets that are complementary both in sh

113 The 7A9 antigen combining site presents a groove resembling the structur

114 Insights into the evolution of antibody-combining sites provided by this and other structural st

115 Rs, which use an Ab-like structure to form a combining site, recognize molecular complexes consisting

116 The combining site residues of complexed Fab HyHEL-63 exhibi

117 proteins through essentially the same set of combining site residues.

118 Based on a molecular model of the combining site, residues at the base (Arg98 and Asp108)

119 pyramid array for intravesicular analysis by combining site-selective dielectrophoresis (DEP) and Ram

120 extended turn conformation within the BR55-2 combining site, serving to overlap the peptides with the

121 ave analysed antigen-contacting residues and combining site shape in the antibody Fv and Fab crystal

122 secondary structure and may contain similar combining site shapes.

123 idues which are located centrally within the combining site; some less central CDR residues are only

124 nes encode a substantial element of antibody combining site specificity, there is scant evidence for

125 alyzed for VH-D-J(H) gene usage and antibody combining site structure.

126 s been developed and applied to the antibody combining site surfaces.

127 alactosides, it has an extended carbohydrate-combining site that exhibits highest specificity and aff

128 The reorganization of the combining site that was nucleated by hapten binding is f

129 series of architectures for the b12 and 4E10 combining sites that differed in size, valency, and flex

130 D) domain-swapped structure with two aligned combining sites that facilitates recognition of its carb

131 In the combining site, the grafted CDRs retained conformational

132 bonds in an elongated groove in the antibody-combining site through interactions with Complimentarity

133 PAK-13, which would allow the same antibody combining site to accommodate either trans or cis topolo

134 thod for selection and evolution of antibody combining sites using antibody-ribosome-mRNA (ARM) compl

135 We have also sequenced the combining sites (variable regions) of the antibodies and

136 ted that release of CRM107 from the antibody combining site was fast, and its toxic action was unimpe

137 The combining site was found to be relatively flat, like oth

138 s (DeltaG degrees (nonel)) at the anti-ssDNA combining site was used for the estimation of the specif

139 Significant inhibition of SLE APAD combining sites was observed with eluates from anti-DNA

140 o distinctly different types of carbohydrate-combining sites was purified from tubers of Xanthosoma s

141 ues that potentially interact with the RA6.3 combining site were identified by data base screening us

142 Antibody combining sites were fully occupied at pH 5.5, partially

143 with an Fd region known to generate a Hib PS-combining site when paired with an A2-Arg(95a)-Jkappa1 V

144 nsive structural rearrangements occur in the combining site, where residue H47 acts as a specificity

145 or the core oligosaccharide is buried in the combining site, which explains the lack of LPS recogniti

146 or the core oligosaccharide is buried in the combining site, which explains their inability to recogn

147 Within the antibody-combining sites, which are dominated by the protrusion o

148 nds revealed a considerably altered antibody-combining site with a closed binding pocket.

149 The riboflavin is located in the antigen-combining site with its isoalloxazine ring stacked betwe

150 tigen is bound in the middle of the antibody combining site with most of the six complementarity-dete

151 ular region of DAF was joined to an antibody combining site with specificity for the hapten dansyl, a

152 body 93F3 Fab' at 2.5A resolution revealed a combining site with two lysine residues, including LysL8

153 This diversity of combining sites within B cell clones supports the propos