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1 nits or the spindle checkpoint inhibitor p31(comet).
2 3), an AAA-ATPase known to interact with p31(comet).
3 the mitotic checkpoint-silencing protein p31(comet).
4 s stimulated by the Mad2-binding protein p31(comet).
5 o split at a rate of about 0.01 per year per comet.
6 ng was localized to the "neck" region of the comet.
7 re we report that 288P is a binary main-belt comet.
8 ly progressing comet is followed by a faster comet.
9 ges induced by the rotation and orbit of the comet.
10 ore and/or after being incorporated into the comet.
11 prevents the inhibitory effect of tau on EB comets.
12 f comets were used for the interpretation of comets.
13 han those seen in carbonaceous chondrites or comets.
14 ide-that had not previously been reported in comets.
15 etary dust particles (IDPs) originating from comets.
16 ments of the bulk composition of planets and comets.
17 ss of the role of energetic negative ions in comets.
18 morphology and dynamics of Nck-induced actin comets.
19 present a fraction of the building blocks of comets.
20 ere thought, but not proved, to originate in comets.
21 id not reconstitute dynamic, elongated actin comets.
22 -COU-AA-301, AFFIRM, ELM-PC-5, ELM-PC-4, and COMET-1- ClinicalTrials.Gov identifiers: NCT00638690, NC
24 egates in the near-surface of the nucleus of comet 67P also provides a mechanism for lowering the ten
25 ow bilobate shapes, including the nucleus of comet 67P/Churyumov-Gerasimenko (67P), visited by the Ro
26 ouchdown of the Rosetta lander Philae on the comet 67P/Churyumov-Gerasimenko (67P), we show that no g
28 is the main species observed in the coma of comet 67P/Churyumov-Gerasimenko and water is the major c
30 ement of the D/H ratio in the Jupiter family comet 67P/Churyumov-Gerasimenko by the ROSINA mass spect
33 ctural similarities between the two lobes of comet 67P/Churyumov-Gerasimenko indicate that the early-
36 ity and internal structure of the nucleus of comet 67P/Churyumov-Gerasimenko on the basis of its grav
37 of dune-like patterns at the surface of the comet 67P/Churyumov-Gerasimenko requires conceptual and
38 cecraft has measured the coma composition of comet 67P/Churyumov-Gerasimenko with well-sampled time r
39 observations of water ice on the surface of comet 67P/Churyumov-Gerasimenko, appearing and disappear
40 quired maps of the subsurface temperature of comet 67P/Churyumov-Gerasimenko, at 1.6 mm and 0.5 mm wa
41 situ measurement of N2 in the Jupiter family comet 67P/Churyumov-Gerasimenko, made by the Rosetta Orb
42 e Rosetta spacecraft spent 2 years orbiting comet 67P/Churyumov-Gerasimenko, most of it at distances
43 athered at the Philae landing site Abydos on comet 67P/Churyumov-Gerasimenko, we found the diurnal te
44 ort in situ measurement of O2 in the coma of comet 67P/Churyumov-Gerasimenko, with local abundances r
55 anic matter in the dust particles emitted by comet 67P/Churyumov-Gerasimenko; the carbon in this orga
56 ovided detailed mineralogy of particles from comet 81P/Wild, the fine-grained aggregate component was
67 n caused intracellular oxidative stress, and comet analysis revealed introduction of formamidopyrimid
69 range of fitness values of the mutants, the Comet and Comet-swarm graphs have fixation probability s
72 or the underlying algorithms, implemented in COMET and supported on linux, can be downloaded at the s
73 coronal material; the EUV absorption by the comet and the brightness of the tail suggest that the ma
77 dition, we explored the relationship between COMETs and haplotypes in lymphoblastoid cell lines of Af
78 tion on the structural organization of actin comets and in particular the spatial arrangement of fila
79 molecular clouds, and, more importantly, in comets and in primitive meteorites that have most probab
81 easurably influence the spin rates of active comets and might lead to the splitting of bilobate comet
85 ide the first evidence for regulation of p31(Comet) and demonstrate a previously unknown event contro
88 lotting, annexin-V/propidium iodide binding, comet, and micronuclei assays, showed that the reduction
89 dense clouds or circumstellar regions, some comets, and as a minor component in carbonaceous chondri
92 tion and even solar system formation because comets are considered remnant volatile-rich planetesimal
96 We show here that vapor flow emitted by the comet around its perihelion spreads laterally in a surfa
97 firming this phenomenon, we have revealed by comet assay and currently the most sensitive method of D
100 DNA damage following BPA exposure using the comet assay and immunofluorescence staining, and used ce
101 898E-reconstituted cells, as revealed by the comet assay and IR-induced Rad51 foci formation assay.
104 lated using published potencies based on the comet assay for Chinese hamster ovary cells (assesses th
113 n combination with DNA methylation sensitive comet assay to determine the effects of vitamin B12 or M
114 ense and damage, biomarkers of genotoxicity (comet assay), and behavioral biomarkers (feeding and bur
117 tivation, spontaneous DNA damage by alkaline comet assay, basal micronuclei levels, the number of lar
118 her levels of DNA damage, as assessed by the comet assay, quantification of 8-oxoguanine, and poly(AD
126 foci; DSB levels were determined by neutral comet assay; western blotting was used to evaluate prote
127 ged the induction of DNA damage as judged by Comet assays and gammahistone 2AX (gammaH2AX) and checkp
129 DNA repair as revealed by gammaH2AX foci and comet assays and to the up-regulation of Ku70 and DNA-de
132 ion and genetic instability, as indicated by comet assays that showed increased numbers of DNA-strand
133 ct of Usp and Imu1-3 was assessed by MTT and Comet assays, infection assays, caspase 3/7 activity, fl
134 including active RAS pulldown, reporter and Comet assays, small interfering RNA-mediated depletion o
136 Initially, the solar wind permeates the thin comet atmosphere formed from sublimation, until the size
138 adapter protein p31(comet) We show that p31(comet) binding to the TRIP13 N-terminal domain positions
142 cess is mediated by TRIP13 together with p31(comet), but the mode of their interaction remained unkno
143 wed the separated tails from the head of the comet by increasing applied doses from 0.1 to 1.5 kGy.
144 On 15 and 16 December 2011, Sun-grazing comet C/2011 W3 (Lovejoy) passed deep within the solar c
145 R) spectroscopy, we show that TRIP13 and p31(comet) catalyze the conversion of C-Mad2 to O-Mad2, with
150 o, are examined for the interstellar medium, comets, chondritic meteorites, and terrestrial planets;
151 elegans orthologue of the Mad2 inhibitor p31(comet)(CMT-1) interacts with TRIP13(PCH-2) and is requir
152 rs also genetically interact, as loss of p31(comet)(CMT-1) partially suppressed the requirement for T
154 icrobes in a community, e.g. as predicted by COMETS (Computation of Microbial Ecosystems in Time and
157 hat TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint pro
158 the comet tail have stopped moving; (3) the comet core is held together by a matrix of slime; and (4
159 contain a factor that promotes ATP- and p31(comet)-dependent disassembly of a Cdc20-Mad2 subcomplex
160 d turnover similar to those of N-WASP in Nck comets, did not reconstitute dynamic, elongated actin co
161 ame C-Mad2 interface, which explains how p31(comet) disrupts MCC assembly to antagonize the SAC.
164 DNA decatenation, DNA-Topo cleavage complex, comet, DNA intercalating/unwinding, and Topo IIalpha-med
165 d together by a matrix of slime; and (4) the comets etch trails in the agar as they move forwards.
166 and mechanical material properties determine comet evolution and even solar system formation because
167 osed ice was observed a short time after the comet exited local winter; following the increased illum
168 othesis that an extraterrestrial (ET) event (comet explosion) triggered Younger Dryas changes in temp
169 nstrate that attenuating the affinity of p31(Comet) for Mad2 by phosphorylation promotes SAC activity
171 GBS methylomes into blocks of comethylation (COMETs) from which lost information can be recovered in
175 milarities with the detected coma species of comet Halley suggest the presence of a radiation-induced
178 that points to a nonbiogenic origin, such as comet impact plume condensates in what may be very rapid
181 he approximately 750,000 known asteroids and comets in the Solar System is thought to have originated
182 emical Markers to Estimate Time-progression (COMET) in idiopathic pulmonary fibrosis study were follo
185 counting several O2 production mechanisms in comets, including photolysis and radiolysis of water, so
188 onchoalveolar lavage obtained as part of the COMET-IPF (Correlating Outcomes with Biochemical Markers
192 composition of the neutral gas comas of most comets is dominated by H2O, CO and CO2, typically compri
197 an important process in the evolution of the comet, leading to cyclical modification of the relative
202 s (PROSE), conjunctival replacement surgery (COMET), limbal stem cell transplantation and kerotoprost
203 functional TRIP13 residues that mediate p31(comet)-Mad2 binding and couple ATP hydrolysis to local u
204 ally, phosphorylation of Ser-102 weakens p31(Comet)-Mad2 binding and enhances p31(Comet)-mediated byp
205 bility of TRIP13(PCH-2) to disassemble a p31(comet)/Mad2 complex, which has been well characterized i
210 r algorithm outperforms the state-of-the-art CoMEt method in terms of discovering mutually exclusive
213 AAA-ATPase and the Mad2-binding protein p31(comet) Now we have isolated from extracts of HeLa cells
214 re remarkably similar to thetaf observed for comet nuclei and measured values of other rigid aggregat
215 suggested here would preferentially decimate comet nuclei during migration to the inner solar system,
220 y to investigate the internal structure of a comet nucleus, providing information about its formation
224 he object is spectrally red, consistent with comets or organic-rich asteroids that reside within the
228 s of the rotational breakup of the main-belt comet P/2013 R3, although that was indirect and poorly c
234 ), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindl
238 was incorporated into the nucleus during the comet's formation, which is unexpected given the low upp
247 that Eribulin increases the frequency of EB3 comet "splitting," transient events where a slow and err
250 fitness values of the mutants, the Comet and Comet-swarm graphs have fixation probability strictly la
252 We propose a mechanism for the initiation of comet tail assembly and two scenarios that occur either
254 rongly suggested by a remarkable increase in comet tail formation and H2A.X phosphorylation in HNE-tr
255 important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-
256 p2/3 complex through mutagenesis all inhibit comet tail formation and reduce the size and number of a
260 tail'; (2) they move when other cells in the comet tail have stopped moving; (3) the comet core is he
264 oteins to assemble an Arp2/3-dependent actin comet tail to power its movement through the host cell.
265 other S. aureus cells behind them forming a comet 'tail'; (2) they move when other cells in the come
266 ion we have simulated the structure of actin comet tails as well as the tracks adopted by baculovirus
268 Several pathogens induce propulsive actin comet tails in cells they invade to disseminate their in
269 ography to visualize the 3D structure of the comet tails in situ at the level of individual filaments
270 ixture was insufficient to disassemble actin comet tails in the presence of physiological F-actin con
271 protein 1 is sufficient to disassemble actin comet tails in the presence of physiological G-actin con
272 the three-dimensional architecture of actin comet tails propelling baculovirus, the smallest pathoge
273 vitro, this system creates polarized, motile comet tails that associate by antiparallel filament bund
275 in cytoskeleton of its host cells such that "comet tails" are assembled powering its movement within
276 displaying prominent accumulation on actin "comet tails" that emanate from focal adhesions in stretc
277 he formation of Listeria monocytogenes actin comet tails, thereby implicating it in actin assembly.
278 ck SH3 domains at the membrane induces actin comet tails--dynamic, elongated filamentous actin struct
280 Both the conventional phenotypic alkaline comet test and the newly developed quantitative toxicoge
281 ith the phenotypic DNA damage endpoints from comet tests, suggesting that the molecular genotoxicity
282 present state, but it may be a Halley-family comet that entered the resonance through an interaction
284 n a subset of the asteroids called main-belt comets, the sublimation of excavated volatiles causes tr
287 ary matter and the potential contribution of comets to inner-planet atmospheres are long-standing pro
288 ved building blocks of life by meteorites or comets to planet Earth are discussed in this Perspective
290 Twenty-five minutes after Philae's initial comet touchdown, the COSAC mass spectrometer took a spec
293 AD2 with the help of the adapter protein p31(comet) We show that p31(comet) binding to the TRIP13 N-t
297 surface of media in structures that we term 'comets', which advance outwards and precede the formatio
298 ics in the gas phase are similar to those in comets, which suggests an even higher relative abundance
299 h combining single-cell gel electrophoresis (comet) with fluorescence in situ hybridization (FISH) th
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