ライフサイエンスコーパス: commensal

1 tella sp. and Butyricimonas sp., another gut commensal.

2 trasting with a reduced abundance of aerobic commensals.

3 ing the challenges of cultivating fastidious commensals.

4 reduced colonization of potential beneficial commensals.

5 ocalize to HFs, a primary reservoir for skin commensals.

6 ly affiliated PCs, recognized mucus-embedded commensals.

7 decreasing pathogen richness and increasing commensal abundance.

8 ficant but imperfect homology to segments of commensal Acinetobacter phage viruses.

9 all obligate anaerobic bacteria, while oral commensal aerobes, including aerotolerant ones, such as

10 eus in the context of its biology as a human commensal and a life-threatening pathogen.

11 Staphylococcus aureus is both a commensal and a pathogen, and USA300, a strain that is u

12 ural products produced by certain strains of commensal and extraintestinal pathogenic Escherichia col

13 onization by Streptococcus gordonii, an oral commensal and opportunistic pathogen of animals and huma

14 Both commensal and pathogenic bacteria are capable of produci

15 The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microo

16 Mammalian hosts interface intimately with commensal and pathogenic bacteria.

17 g infection, we infected EEC aggregates with commensal and pathogenic bacteria: Lactobacillus crispat

18 and contributes to our understanding of how commensal and pathogenic E. coli colonise their environm

19 ent utilization of host sialic acids by both commensal and pathogenic E. coli strains.

20 iruses of the family Tectiviridae can infect commensal and pathogenic Gram-positive and Gram-negative

21 nts with IBS have increased translocation of commensal and pathogenic live bacteria compared with con

22 a class switching and SIgA responses against commensal and pathogenic microbes.

23 the host cellular networks to figure out how commensal and pathogenic microbiota modulate the host si

24 The even distribution of the system among commensal and pathogenic phytobacteria suggests that the

25 This secretion system is commonly found in commensal and pathogenic plant-associated bacteria.

26 metazoan gut harbours complex communities of commensal and symbiotic bacterial microorganisms.

27 humans are continuously exposed to different commensals and pathogens in sequential and mixed infecti

28 diverse host-associated bacteria, including commensals and pathogens with known anti-inflammatory pr

29 e is a dynamic environment inhabited by both commensals and pathogens.

30 The gut harbors many symbiotic, commensal, and pathogenic microbes that break down and m

31 play between potential pathogens, protective commensals, and the host immune system may facilitate th

32 ota, appropriate mucosal T cell responses to commensal antigens must be established.

33 These microbial commensals are essential to skin health and can potentia

34 , IgA responses against oral antigen and gut commensals are impaired.

35 ommunities, however, the protective roles of commensals are largely under recognized and poorly under

36 Although commensals are not required for T1D progression, germ-fr

37 S and increased survival of oxygen-sensitive commensal bacteria (Faecalibacterium prausnitzii and Ros

38 ere found using the device developed between commensal bacteria (no infection) and bacteria inoculate

39 ucociliary clearance and overgrowth of nasal commensal bacteria accompanied by neutrophil exudation.

40 , underpins competition among pathogenic and commensal bacteria alike.

41 a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens.

42 ely shape the symbiotic relationship between commensal bacteria and mammalian hosts.

43 e may promote ecological competition between commensal bacteria and pathogenic species.

44 tic signalling molecules may be common among commensal bacteria and that manipulation of microbiota g

45 with these VH4-34-encoded IgG clones binding commensal bacteria antigens.

46 Whether mutation and selection among commensal bacteria are associated with infection is unkn

47 Commensal bacteria are believed to have important roles

48 Commensal bacteria are known to provide colonization res

49 We have assembled a consortium of commensal bacteria belonging to the Clostridiales order,

50 conclude that serine proteases derived from commensal bacteria can directly impact the excitability

51 rom host and environmental factors, and many commensal bacteria can produce multiple capsule types.

52 Commensal bacteria co-exist on the mucosal surfaces of a

53 ting that, as is widely found in amphibians, commensal bacteria confer protection against this pathog

54 trate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XI

55 Commensal bacteria contribute to immune homeostasis in t

56 d influenza A virus infection occurring upon commensal bacteria eradication is efficiently overturned

57 Although obligate anaerobic commensal bacteria have been associated with colonizatio

58 Reintroduction of commensal bacteria in a murine model of enterococcal col

59 terial activity and that S Typhimurium kills commensal bacteria in a T6SS-dependent manner.

60 ow HIV infection might change the balance of commensal bacteria in the gut.

61 bacteria dialog whereby selective subsets of commensal bacteria interact with dendritic cells to faci

62 We propose that binding of free SC to commensal bacteria is a key and conserved mechanism for

63 tion between the mammalian immune system and commensal bacteria is necessary to limit chronic inflamm

64 vars and other common respiratory pathogenic/commensal bacteria of pigs.

65 eliminary study examined the contribution of commensal bacteria on neutrophil location across the too

66 Commensal bacteria protect against invading pathogens us

67 Site-specific commensal bacteria provide key signals ensuring host def

68 It has been shown in the mouse that oral commensal bacteria significantly contribute to clinicall

69 nzae (NTHi) are closely related upper airway commensal bacteria that are difficult to distinguish phe

70 Staphylococci are commensal bacteria that colonize the epithelial surfaces

71 nsal segmented filamentous bacteria or human commensal bacteria that induce intestinal TH17 cells wer

72 However, the specific commensal bacteria that promote host resistance and immu

73 017) define a precise, limited consortium of commensal bacteria that restores resistance to colonizat

74 studies revealed that IL17A synergized with commensal bacteria to trigger Ikkepsilon phosphorylation

75 s infectivity without affecting host cell or commensal bacteria viability.

76 population specialized in the containment of commensal bacteria when gut barriers are breached.

77 Overall, our data suggest that defined gut commensal bacteria with a propensity to induce TH17 cell

78 interest, such as lipid structures found in commensal bacteria, are emphasized.

79 , maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in re

80 udy investigates the interaction of tSC with commensal bacteria, pathogenic bacteria and a fungal pat

81 n gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interac

82 Commensal bacteria-free animals have thymocyte maturatio

83 inal selection whereby MHCII(+) ILC3 deletes commensal bacteria-reactive CD4 T cells.

84 ltaneously or individually in live anaerobic commensal bacteria.

85 epletes multiple immunologically significant commensal bacteria.

86 nted filamentous bacteria, but also by other commensal bacteria.

87 systemic dysbiosis of aerobic and anaerobic commensal bacteria.

88 also partially eliminate naturally existing commensal bacteria.

89 which recognizes the products of intestinal commensal bacteria.

90 t likely by enabling pathogens to outcompete commensal bacteria.

91 s disease susceptibility in mice depleted of commensal bacteria.

92 se from mouse liver, including reactivity to commensal bacteria.

93 exposed continuously to dietary antigens and commensal bacteria.

94 eyer's patches and produced IgAs reactive to commensal bacteria.

95 ith broad-spectrum antibiotics which disrupt commensal bacteria.

96 Relish response to both enteropathogenic and commensal bacteria.

97 ch has the unwanted side effect of depleting commensal bacteria.

98 Collectively, our data reveal a unique host-commensal-bacteria dialog whereby selective subsets of c

99 Immunization strategies against commensal bacterial pathogens have long focused on eradi

100 e BBM dynamically responds to pathogenic and commensal bacterial signals can define intestinal homeos

101 s (MAMs) are abundant in both pathogenic and commensal bacterial species, mediate early attachment to

102 which is composed of diverse populations of commensal bacterial species, provides resistance against

103 We show that Staphylococcus epidermidis, a commensal bacterium in the human skin microbiome, produc

104 ter actinomycetemcomitans is a Gram-negative commensal bacterium of the oral cavity which has been as

105 d for interbacterial antagonism by the plant commensal bacterium Pseudomonas protegens Consistent wit

106 Propionibacterium acnes is a skin commensal bacterium that contributes to the development

107 hanism by which S. aureus transitions from a commensal bacterium to an invasive pathogen.

108 ifies new T6SS effectors employed by a plant commensal bacterium to antagonize its competitors and br

109 tition assays revealed that the dominant HGM commensal Bacteroides ovatus was out-competed by B. anim

110 by pure sulfatase or the sulfatase-producing commensal Bacteroides thetaiotaomicron decreased binding

111 ystem is the key determinant of the pathogen/commensal balance and has selected for adaptations that

112 a large Tn5 transposon mutant library of the commensal Bifidobacterium breve UCC2003 that was further

113 inhabits the nasopharynx as a member of the commensal biofilm.

114 physiology and provide a framework to study commensal biofilms in higher organisms.

115 & Microbe, Paharik et al. (2017) find that a commensal blocks Staphylococcus aureus colonization by p

116 Staphylococcus aureus is a human commensal but also has devastating potential as an oppor

117 we show that streptomycin treatment depleted commensal, butyrate-producing Clostridia from the mouse

118 hesin MAM(HS) facilitates retention of a gut commensal by attachment to mucin.

119 Identification of disease-modulating commensals by microbe-phenotype triangulation may be mor

120 In the related human commensal C. glabrata, Pho4 is required but Pho2 is disp

121 Certain commensals can utilize mucins as an energy source, thus

122 nce of pathogenic organisms and tolerance of commensal cells, including but not limited to human allo

123 By combining models of commensal colonization in antibiotic-treated and germ-fr

124 S. pneumoniae established effective commensal colonization, and influenza virus coinfection

125 neumococcal disease without interfering with commensal colonization, thus specifically targeting dise

126 ent T helper 17 (Th17) cells developed via a commensal colonization-independent mechanism.

127 Staphylococcus epidermidis is normally a commensal colonizer of human skin and mucus membranes, b

128 oid homeostasis and suggest perturbations of commensal communities can influence steady-state regulat

129 and could help SIgA to anchor highly diverse commensal communities to mucus.

130 ft from cataloging individual members of the commensal community to understanding their contributions

131 igh levels of IFNgamma after transfer of the commensal community.

132 e of bifidobacteria, and possible beneficial commensals, confirmed the prebiotic value of these xyloo

133 We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that t

134 e unique and important responses elicited by commensal-derived surface macromolecules(3-5).

135 This systemic alteration of murine gut commensal diversity may be the cause or the consequence

136 tric epithelium, CCR decline, and subsequent commensal dysbiosis and epithelial dysplasia along the G

137 pecifically prevents age-related metaplasia, commensal dysbiosis and functional decline in old guts,

138 PPARalpha deficiency in mice led to commensal dysbiosis in the gut, resulting in a microbiot

139 f conventional C3H/HeN adult mice with 10(9) commensal E coli induced visceral hypersensitivity.

140 thus one of the prime adherence targets for commensal E. coli Mucin gels impeded the motility of E.

141 Complementary studies using commensal E. coli strains as model organisms indicated t

142 the capacity of the mucus barrier to retain commensal E. coli.

143 ansion of facultative Proteobacteria such as commensal E. coli.

144 Thus, commensal enteric fungi safeguard local and systemic imm

145 ote SGG colonization of the gut by replacing commensal enterococci in their niche.

146 The human commensal enterotoxigenic Bacteroides fragilis (ETBF) is

147 Certain commensal Escherichia coli contain the clb biosynthetic

148 lance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a

149 Certain strains of commensal Escherichia coli harbor the 54-kb clb gene clu

150 ivalent adhesion molecule (MAM) from the gut commensal Escherichia coli HS (MAM(HS)), which contains

151 More co-trimoxazole resistance in commensal Escherichia coli isolated from stool samples w

152 stingly, the combined IS treatment enabled a commensal Escherichia coli to flourish, and dramatically

153 cous layer that provides the habitat for the commensal flora and the inner mucous layer that protects

154 Finally, colonization of commensal flora by fecal material transplantation into g

155 th fHbp-containing vaccines could affect the commensal flora have yet to be established.

156 gulated by small molecules provided by diet, commensal flora, environmental pollutants, and metabolis

157 nasopharynx, and vagina all have associated commensal flora.

158 estricted community of cultivable intestinal commensals from protected into susceptible mice decrease

159 c-treated and germ-free mice, using cultured commensals from the Actinobacteria, Bacteroidetes, Firmi

160 r, these results indicate that disruption of commensal fungal populations can influence local and per

161 The protective benefits of commensal fungi are mediated by mannans, a highly conser

162 Here, we show that commensal fungi can functionally replace intestinal bact

163 Thus, we tested whether a community of commensal gastrointestinal bacteria derived from a healt

164 Mycoplasma hominis is a commensal genitourinary tract organism that can cause in

165 Furthermore, we found that depletion of the commensal genus Neisseria and the species Streptococcus

166 Mouse and cell-based models demonstrate that commensal GPR119 agonists regulate metabolic hormones an

167 assess changes in resistance patterns of the commensal Gram-positive microbiota.

168 ey decrease abundances of beneficial barrier commensal gut bacteria (e.g., bifidobacteria and lactoba

169 al health benefits through interactions with commensal gut bacteria.

170 We have pioneered the use of the commensal gut bacterium Bacteroides ovatus for the oral

171 universally distributed enzyme that enables commensal gut microbes and human pathogens to dehydrate

172 parasite infections exert on populations of commensal gut microbes of veterinary species is a field

173 The molecular underpinnings defining commensal gut microbiota immunomodulatory actions on phy

174 complex interactions among epithelial cells, commensal gut microorganisms, and immune cells.

175 testinal inflammation, mucosal immunity, and commensal homeostasis.

176 e permitting the establishment of beneficial commensal host-microbe relationships.

177 se studies typically generate a long list of commensals implicated as biomarkers of disease, with no

178 Accessory pathogens, while inherently commensal in a particular microenvironment, nonetheless

179 ic networks underlying colonization by a gut commensal in its native host environment, including some

180 is head-on, discovering a naturally existing commensal in mice that induces gammadeltaT cell-mediated

181 coli is a common human pathogen, but also a commensal in multiple environmental and animal reservoir

182 The role of these nasal commensals in host innate immunity is largely unknown, a

183 ractions between opportunistic pathogens and commensals in the pathogenesis of dental caries.

184 l germ-free flies were fed their own natural commensals (including the probiotic Lactobacillus planta

185 robiome, highlighting the roles of the major commensals, including bacteria, fungi and bacteriophages

186 show that during hair follicle development, commensals induce regulatory T cell migration to the ski

187 Commensal interactions between the enteric microbiota an

188 AS6 as a key immunological regulator of host-commensal interactions in the oral epithelium.

189 Commensal intestinal microbes are collectively beneficia

190 In vitro, tSC present in mucus coats trout commensal isolates such as Microbacterium sp., Staphyloc

191 ines and by the administration of beneficial commensal Lachnospiraceae isolates.

192 equired for GBS to transition from a mucosal commensal lifestyle to bloodstream invasion, we performe

193 cacy of an engineered bacterium expressing a commensal MAM on its surface in preventing pathogen atta

194 This study reveals mechanisms for commensal-mediated gut-lung crosstalk and dual TCR-based

195 ndividuals and body sites, with several core commensal members commonly shared among individuals at t

196 ned a nearly complete genome of the archaeal commensal Methanobrevibacter oralis (10.2x depth of cove

197 vant demonstrates competitive advantages for commensal mice in long-term settlements.

198 iated with a dysregulated immune response to commensal micro-organisms in the intestine.

199 Thus, HF morphogenesis, commensal microbe colonization, and local chemokine prod

200 Therefore, this commensal microbe might participate in NMO pathogenesis.

201 Neisseria meningitidis is a commensal microbe that colonizes the human nasopharynx b

202 e ecological homeostasis of gastrointestinal commensal microbes and contribute to diarrheal disease a

203 Studying the interactions between commensal microbes and host intestinal tissue networks i

204 ed during development, independently of both commensal microbes and osmotic stress.

205 BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly reg

206 nates had reduced skin Tregs indicating that commensal microbes augment Treg accumulation.

207 Commensal microbes colonize the skin where they promote

208 p microdevice was used to coculture multiple commensal microbes in contact with living human intestin

209 enefits, the contributions of other types of commensal microbes remain poorly defined.

210 nal tract and maintains close proximity with commensal microbes that reside within the intestinal lum

211 thods to quantify shifts in the diversity of commensal microbes throughout the gastrointestinal tract

212 usobacterium nucleatum are well-studied oral commensal microbes with pathogenic potential that are in

213 bacterial infection of the uterus driven by commensal microbes, an alteration likely explaining the

214 ggest that diet, hyperlipidemia, pollutants, commensal microbes, and pathogenic infections can all af

215 Moreover, from this community of commensal microbes, Faecalibacterium prausnitzii strain

216 ents and metabolites, and an environment for commensal microbes.

217 event pathogen invasion and dissemination of commensal microbes.

218 re required to establish immune tolerance to commensal microbes.

219 We investigated T-cell reactivity to commensal microbial antigens using proliferation assays

220 It harbor multiple commensal microbial communities at different body sites,

221 in-induced pathology without harming healthy commensal microbial flora.

222 UDCA, a commensal microbial metabolite, abrogates senescence in

223 ings provide direct evidence that a resident commensal microbiome exists on the ocular surface and id

224 Recent evidence suggests the commensal microbiome regulates host immunity and influen

225 equiring immune control, including a diverse commensal microbiome, ongoing damage from mastication, a

226 molecules related to indole and derived from commensal microbiota act in diverse phyla via conserved

227 7 cells, which are actively regulated by the commensal microbiota and can be selectively stimulated b

228 ly challenged environment keeping intestinal commensal microbiota at bay and defending against invadi

229 dies have demonstrated that manipulating the commensal microbiota can prevent and treat various infec

230 can develop at the gingiva independently of commensal microbiota colonization.

231 These findings imply that the commensal microbiota exert important influences on the e

232 We show that indoles from commensal microbiota extend healthspan of diverse organi

233 growth and competition between pathogens and commensal microbiota for host resources.

234 We report the commensal microbiota has anti-anabolic effects suppressi

235 osteoclast-precursors in vitro, indicate the commensal microbiota induces sustained changes in RANKL-

236 Shifts in the commensal microbiota may explain observed variations in

237 , in specific-pathogen-free mice suggest the commensal microbiota's anti-osteoblastic actions are med

238 nd germ-free mice were used to delineate the commensal microbiota's immunoregulatory effects on osteo

239 Candidate mechanisms mediating commensal microbiota's pro-osteoclastic actions include

240 The commensal microbiota, comprising microbes that colonize

241 hypervariable region 4 poorly captures skin commensal microbiota, especially Propionibacterium.

242 estinal plasma cells to coat and contain the commensal microbiota, yet the specificity of these antib

243 ed interactions between immune cells and the commensal microbiota.

244 its production requires the presence of the commensal microbiota.

245 the immune deficiency pathway in response to commensal microbiota.

246 th a myriad of other organisms, that is, the commensal microbiota.

247 esity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites modulate immuno

248 Commensal microorganisms (the microbiota) live on all th

249 ession is a sterile response, independent of commensal microorganisms and not associated with activit

250 mpounding the challenge, the majority of our commensal microorganisms are not close relatives of Esch

251 T-cell responses to commensals might support intestinal homeostasis, by prod

252 We engineered a commensal murine Escherichia coli strain to detect tetra

253 of available genomes has indicated that some commensal Neisseria species also contain genes that pote

254 The data reveal the earliest known commensal niche for house mice in long-term forager sett

255 utside of the hospital, most probably in the commensal niche, and that drug resistance is not a prima

256 Escherichia coli is a commensal or pathogenic bacterium that can survive in di

257 t affect the overall growth of S. mutans and commensal oral bacteria, and selectively inhibit the bio

258 pathogen Chlamydia trachomatis evolved as a commensal organism of the human gastrointestinal (GI) tr

259 arbon receptor, Janus kinase inhibitors, and commensal organisms also in trials for topical applicati

260 our approach, we used it to identify several commensal organisms that induce intestinal expression of

261 into the microbiome suggest that modulating commensal organisms within the gut or lung may also be a

262 and maintenance of virulence in recombining commensal organisms.

263 ry disease characterized by dysbiosis of the commensal periodontal microbiota.

264 ents allowed house mice to establish durable commensal populations that expanded with human societies

265 ) and experimental human colonization with a commensal, potentially probiotic E. coli bacteriuria str

266 he most well-studied lifestyle for viruses), commensal (probably the most common lifestyle), and mutu

267 Population trends for commensal rodents are the subject of interest and specul

268 s by which the host senses virulent, but not commensal, S. aureus to trigger inflammation remain uncl

269 nant mice that had been colonized with mouse commensal segmented filamentous bacteria or human commen

270 to measure the dynamic relationship between commensal sialidase activity and liberation of mucosal s

271 Here, we show that the commensal species Neisseria cinerea expresses functional

272 but did not disperse biofilms formed by the commensal species Streptococcus sanguinis or Streptococc

273 ocytogenes infection and identify intestinal commensal species that, by enhancing resistance against

274 We characterize the capability of commensal species to cleave and transport mucin-associat

275 l to affect carriage of N. cinerea and other commensal species.

276 is, and showed that this organism elicited a commensal-specific interleukin-17 response from gammadel

277 The commensal-specific response drove neutrophil recruitment

278 needed to confirm whether colonization with commensal staphylococci modulates skin immunity and atte

279 In particular, commensal staphylococci were significantly less abundant

280 lysates from non-ZPS-encoding relatives or a commensal strain of Bacteroides cellulosilyticus in whic

281 biota reconstitution, we identified a single commensal strain that corrects oxytocin levels, LTP, and

282 iverse microbiome and loss of protective gut commensal strains (of the family Lachnospiraceae) and a

283 olic exchange between two bacterial species, commensal Streptococcus gordonii and pathogenic Streptoc

284 enhances nutrition to relationships that are commensal, symbiotic, or parasitic.

285 Neisseria meningitidis is a human commensal that can also cause life-threatening meningiti

286 Candida albicans is a ubiquitous mucosal commensal that is normally prevented from causing acute

287 te that important interactions occur between commensals that can impact disease outcomes and potentia

288 rward loop in which NLRP12 promotes specific commensals that can reverse gut inflammation, while cyto

289 If the interaction is mutualistic or commensal, there is no buffering and only monotonic toxi

290 athogen colonization and may instead allow a commensal to expand.

291 des thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals a

292 del of ocular surface disease to reveal that commensals were present in the ocular mucosa and had fun

293 age of fungi, maintaining this organism as a commensal while minimizing the risk of damage to host ti

294 e host's mucosal immune system must tolerate commensals while fighting pathogens.

295 te of Ain Mallaha, house mice displaced less commensal wild mice during periods of heavy occupational

296 Bifidobacteria are common gut commensals with purported health-promoting effects.

297 Most endophytes act as commensals without any known effect on their plant host,

298 nistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to

299 esent a complete genome assembly of the skin commensal yeast Malassezia sympodialis and demonstrate h

300 The most common sebaceous skin commensal yeasts are the basidiomycetes, Malassezia.