ライフサイエンスコーパス: commitment

1 -limiting for metabolic activity and lineage commitment.

2 atidylcholine (LysoPC) that regulates sexual commitment.

3 ntiated component of the niche with vascular commitment.

4 pairment of B cell lineage specification and commitment.

5 and experiences are associated with lack of commitment.

6 ge, attitudes, or experiences could threaten commitment.

7 hange over time, with DUSP6 predominating at commitment.

8 sis by controlling the onset and duration of commitment.

9 identified as contributors to escalation of commitment.

10 myeloid and lymphoid haematopoietic lineage commitment.

11 t but increases this fraction for increasing commitment.

12 PB-associated Cdk1-cyclin B to drive mitotic commitment.

13 ial transcription factor for myeloid lineage commitment.

14 s, revealing a role in governing HSC lineage commitment.

15 on is critical for decisions concerning cell commitment.

16 matopoietic stem cell (HSC) self-renewal and commitment.

17 naling accompanying an incomplete neurogenic commitment.

18 back mechanisms control human T-cell lineage commitment.

19 stem cell self-renewal and/or direct lineage commitment.

20 ors that guide ILC lineage specification and commitment.

21 g directly DNA replication and cell division commitment.

22 loss of stemness signatures and by epidermal commitment.

23 on factors from prematurely enacting lineage commitment.

24 eased with elapsing time until the moment of commitment.

25 potency biomarkers, and tri-lineage in vitro commitment.

26 ce gene families and determines sexual stage commitment.

27 ght in the regulation of early hematopoietic commitment.

28 ombined with reduced potential for T lineage commitment.

29 ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

30 d blockage of T3 action during glial lineage commitment.

31 cell-specific gene activated during meiotic commitment.

32 Conversely, DUSP10 expression antagonises commitment.

33 identified RET as a regulator of neurogenic commitment.

34 Both initially undergo similar early neural commitment.

35 ich by contrast is dispensable for T-lineage commitment.

36 LL-Af4 was interlinked with lymphoid lineage commitment.

37 g to repress KLF4 in monocytes undergoing LC commitment.

38 hromatin folding during early neural lineage commitment.

39 nt and decrease this fraction for increasing commitment.

40 s directing B cell lineage specification and commitment.

41 s the importance of intention recognition in commitments.

42 ited impaired function and defective lineage commitment abilities.

43 These results suggest that impairment of Th1 commitment after Ad5 immunization could be due to reduce

44 930 and alr3234 acted most upstream to delay commitment, alr2902 acted next in the pathway to inhibit

45 ncreased slightly and the use of involuntary commitment and acute care decreased slightly after the r

46 isorder, the additional costs of involuntary commitment and acute mental health care exceeded savings

47 and downstream effects, such as involuntary commitment and acute mental health care use.

48 cells may interfere with normal cell lineage commitment and cause the accumulation of undifferentiate

49 ces in memory and activation status, lineage commitment and cytokine expression.

50 w increases the critical fraction for waning commitment and decrease this fraction for increasing com

51 PBC and is characterized by a divergent fate commitment and different signaling pathway predominance.

52 criptional programs control cellular lineage commitment and differentiation during development.

53 Indeed, a skewing of megakaryocyte commitment and differentiation may entail the onset of m

54 Although MRFs are essential for myogenic commitment and differentiation, timely repression of the

55 anscriptional diversification during lineage commitment and differentiation.

56 lian cells and eventually determines lineage commitment and differentiation.

57 of Texas (ERCOT) region in 2011 using a unit commitment and dispatch model (UC&D).

58 r regulator of mESC self-renewal and lineage commitment and document a multilayer regulatory mechanis

59 Using a unit commitment and economic dispatch model, we find flexible

60 nt and the overall relationship between cell commitment and global gene expression changes are still

61 chy in human megakaryocyte/erythroid lineage commitment and highlights the importance of using a comb

62 in stringent gene regulation during lineage commitment and maintenance.

63 transcriptional program required for sexual commitment and maturation is initiated but likely aborte

64 How the thymic environment guides ETP commitment and maturation toward a specific lineage rema

65 variant TCR, which triggers NKT cell lineage commitment and maturation.

66 latory nodes of hESC identity, neuroectoderm commitment and neurogenesis.

67 and progenitor cell differentiation, lineage commitment and organogenesis during mammalian developmen

68 National commitment and ownership, as well as strong coordination

69 ut from roof-top installations, while a unit commitment and real-time economic dispatch (UC-ED) model

70 identify functional targets of Bcl11b during commitment and relate them to other regulomes.

71 the gene regulatory network underlying otic commitment and reveal dynamic changes in gene expression

72 tion 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling

73 Car enzymes in regulating mast cell lineage commitment and suggest that Car enzyme inhibitors may po

74 Cell-lineage commitment and terminal differentiation are disrupted, l

75 is an essential mediator of brown adipocyte commitment and terminal differentiation.

76 Hippo signaling, the exact timing of lineage commitment and the overall relationship between cell com

77 The factors controlling precursor commitment and their subsequent maturation and specifica

78 r specialist mental health care, involuntary commitment, and acute mental health care, and annual spe

79 owever, the mechanisms of cell self-renewal, commitment, and functional integration into the tissue r

80 s characteristics, which include compassion, commitment, and passion.

81 mpartment, show a partial block in B lineage commitment, and produce proB cells with aberrant myeloid

82 the LepR(+) population without osteoblastic commitment, and the LepR(+)Runx2-GFP(low) stromal cells

83 ponse, and continued financial and political commitment are all essential to achieving global eradica

84 ur understanding of how the earliest lineage commitments are regulated remains narrow.

85 orchestrates early intramuscular adipogeneic commitment as an anti-adipogenic regulator which acts by

86 ocytes to osteoblasts (and vice versa) after commitment, as assessed by staining, gene expression, an

87 distinct pluripotent states, before lineage commitment at gastrulation.

88 liogenesis, and thereby regulates phenotypic commitment at the point of oligodendrocyte-astrocytic fa

89 is of the exit from pluripotency and lineage commitment at the single cell level, a potential steppin

90 cognitive dissonance result in escalation of commitment behavior in the surgical ICU setting resultin

91 MAIN Escalation of commitment behavior was observed with self-justification

92 t are thought to contribute to escalation of commitment behaviors.

93 rental bond-a relationship of solidarity and commitment between two adults who join their effort to c

94 easing w lowers critical fraction for waning commitment but increases this fraction for increasing co

95 ly record openings increased for involuntary commitment by 96.8% (95% CI, 87.7%-105.9%; P < .001) and

96 TATION: This initiative shows an encouraging commitment by all participants, and suggests that challe

97 This initiative shows an encouraging commitment by all participants, and suggests that challe

98 to the management of STIs reported were low commitment by higher levels of management, few recent ST

99 Commitment by higher management, training in the managem

100 Here, we characterise commitment by integrating transcriptomic and proteomic d

101 scription factors subsequently induce T-cell commitment by repressing residual natural killer (NK)-ce

102 has been increased awareness, interest, and commitment by various specialty societies and organizati

103 tiation is not irreversible and that lineage commitment can be overridden following severe tissue inj

104 common ICU narratives in which escalation of commitment can occur.

105 people's willingness to sign organ donation commitment cards, donate the organs of a deceased relati

106 pithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination towa

107 ssion can lead to drastic changes in lineage commitment, cellular function, and immunity.

108 s database of postmarketing requirements and commitments, ClinicalTrials.gov, and matched peer-review

109 We find that TE specification and commitment coincide and occur at the time of transcripti

110 o increased propensity for terminal myogenic commitment connected to impaired proliferative potential

111 oves that they coexist in different forms of commitment creation.

112 AP2-G expression during this 'commitment cycle' prepares gene expression in nascent me

113 ietic stem cells undergo a number of lineage commitment decisions that ultimately lead to the product

114 wth can be recapitulated if the rate of fate commitment depends on the tissue's stem cell proportion.

115 which appears to be critical for neural fate commitment, depends almost entirely on intracellular sig

116 chestrated by exquisitely timed cell lineage commitment, divisions, migration, and morphological chan

117 inner cell mass lineage restriction and cell commitment during preimplantation development.

118 Here the authors show that a pre-commitment event modulated by the transcription factor,

119 We used kinetic isotope effect (KIE), commitment factor (Cf), and binding isotope effect (BIE)

120 However, the role of lineage commitment factor Bcl11b has been unclear.

121 re we show that Bcl11b, known as a T-lineage commitment factor, is essential for proper expression of

122 N: In the absence of unprecedented political commitment, financial support, and medical advances, the

123 alling for sustained political and financial commitment for the success of malaria elimination as ult

124 ent, and hetP acted most downstream to drive commitment forward.

125 Existing in vitro models induce T cell commitment from human HSPCs; however, differentiation in

126 potent, thereby serving both bookkeeping and commitment functions within relationships.

127 tise our externalization of particular moral commitments generates features of our social interaction

128 immunization exhibited impaired Th1 lineage commitment, generating significantly decreased Th1 respo

129 within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and TBET) in

130 vitro while retaining their tissue-of-origin commitment, genetic stability and potential to different

131 e and field-measurement-based global warming commitment (GWC) for the Philips FDCS were a factor of 8

132 ver, their precise role in regulating B-cell commitment has been the subject of debate.

133 contrast, exit from pluripotency and lineage commitment have not been studied systematically at the s

134 Agreements and commitments have provided a novel mechanism to promote c

135 a functional domain and modulate heterocyst commitment: hetP (alr2818), asl1930, alr2902, and alr323

136 Because lineage commitment hierarchies differ between embryo and adult,

137 tion of DNA methylation enhanced plasma cell commitment in a cell-division-dependent manner.

138 examethasone (Dex), routinely used to induce commitment in CPCs, for 7 days and analysed expression o

139 hat almost exclusively determines cell-cycle commitment in daughter cells.

140 tor Sp7 (osterix) during mesenchymal lineage commitment in mammalian cells.

141 esent study we assessed the rescue of B-cell commitment in mice lacking IL-7 but simultaneously overe

142 s (ICDs) are frequently viewed as a lifelong commitment in that patients are routinely scheduled for

143 nd is essential for self-renewal and lineage commitment in vitro.

144 mics of cis-regulatory contacts upon lineage commitment, including the acquisition and loss of promot

145 activity plays a fundamental role in linking commitment-induced generosity with happiness.

146 convert the UN Sustainable Development Goal commitments into tangible action.

147 ed risk letter and invitation to attend a no-commitment introductory session run by the local SSS (in

148 Reasons for slow progress include inadequate commitment, investment, focus, scale, and quality of imp

149 creates a bistable switch that makes mitotic commitment irreversible [2-4].

150 Escalation of commitment is a business term that describes the continu

151 Lymphoid lineage commitment is an important process in haematopoiesis, wh

152 ty of cis-regulatory elements during lineage commitment is crucial for understanding developmental tr

153 in 3D7 parasites, we found that sexual stage commitment is governed by transcriptional reprogramming

154 monstrated that granulocytic/monocytic (G/M) commitment is marked by Runx1 suppression of genes encod

155 A further wave of commitment is observed following recrudescent asexual pa

156 Because commitment is often irreversible, entry into and progres

157 During development cell commitment is regulated by inductive signals that are ti

158 Tfh-Teff cell fate commitment is regulated by mutual antagonism between the

159 he TEtra circuit indicates how trophectoderm commitment is regulated in human embryogenesis.

160 homologous to mammalian Oct4) drives lineage commitment is unclear.

161 on(s) in early B cell fate specification and commitment is unknown.

162 ansition between the two cell states, termed commitment, is poorly understood.

163 INTERPRETATION: To enhance OPV commitment, it might be useful to consider a multifactor

164 by diminished transcripts of early lymphoid commitment markers.

165 Escalation of commitment may be a contributor to high healthcare costs

166 To clarify lineage commitment mechanisms, we followed developing T cells at

167 genitor states, with the first major lineage commitment occurring in multipotent progenitors, thus gi

168 objective was to determine if escalation of commitment occurs in healthcare settings, specifically i

169 Escalation of commitment occurs in the surgical ICU, resulting in sign

170 f BMP-4 to regulate factors that control the commitment of adipocyte progenitors to an adipogenic pat

171 Here we show that commitment of blood progenitor cells to the erythroid or

172 The commitment of differentiating cells to a specialized fat

173 ancer, and it has the ability to enhance the commitment of embryonic stem cells into skeletal muscle

174 Asia Region (SEAR) in April 2016.The strong commitment of governments and immunization professionals

175 promoter interactome dynamics during lineage commitment of human pluripotent cells.

176 siRNA knockdown of Ezh2 enhanced osteogenic commitment of MC3T3 preosteoblasts.

177 hairpin RNA-mediated MYB knockdown promoted commitment of MEPs to the Mk lineage, further defining i

178 tor of critical checkpoints that dictate the commitment of multipotent precursors to the T cell linea

179 Cell fate choice and commitment of multipotent progenitor cells to a differen

180 ator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor c

181 broadly fall into three domains: the lineage commitment of pluripotent stem cells, the appropriation

182 atf3); however, those required for the early commitment of pre-cDCs toward the cDC2 lineage are unkno

183 tive fashion, enhance the osteogenic lineage commitment of primary mouse and human mesenchymal stem c

184 Our analyses revealed that hematopoietic commitment of PSCs to hematopoietic precursors correlate

185 genes involved in the attraction and lineage commitment of T cell precursors, Foxn1 regulates the exp

186 humans, including the inducible topographic commitment of T cells for skin and inflamed sites.

187 nd engraftment coupled to inadequate cardiac commitment of the adoptively transferred stem cells comp

188 in the regulation of Ras/MAPK signal in the commitment of the precursor cells to adipose tissues.

189 RNA motif to regulate cardiovascular lineage commitment, opening the door for exploring broader roles

190 ed factors deflect CHIR99021-induced lineage commitment over time.

191 h an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, with

192 s modulates the timing and efficiency of the commitment phase of development and note that this work

193 Thus, APC(Cdh1) inactivation is the commitment point when cells lose the ability to return t

194 ultaneously induces self-renewal and myeloid commitment programs via STAT5-dependent and STAT5-indepe

195 grams, to take a cautious approach on supply commitments, putting in place clear allocation criteria

196 he midgut and find that proportion-dependent commitment rate and stem cell scaling can arise phenomen

197 However, the exact reasons impairing their commitment remain elusive.

198 controlling enhancer turnover during lineage commitment remain largely unknown.

199 mes acting in concert with initial cell fate commitment remains poorly characterized.

200 Cell fate commitment represents a critical state transition or "ti

201 T lineage commitment requires the coordination of key transcriptio

202 Sexual commitment requires the transcriptional activation of ap

203 Bcl11b distinguishes discrete components of commitment, resolving how innate lymphoid, myeloid, and

204 tion toward greater regulatory T (Treg) cell commitment, resulting in a more tolerogenic Treg to conv

205 , asked questions of the nurse, and signed a commitment statement affirming their participation.

206 ranging in age from 0 to 23 months signed a commitment statement.

207 issociation from the proteasome prior to the commitment step.

208 A change in commitment strength impacts the critical fraction of pop

209 Committed nodes are assigned a commitment strength, w, defining their willingness to lo

210 ls from Sid4 contribute to the Cut12 mitotic commitment switch.

211 Thus, in addition to promoting Th1 effector commitment, T-bet acts as a repressor in differentiated

212 p53 KO T cells exhibited enhanced glycolytic commitment that correlated with increased proliferation,

213 lear vision, national purpose, and long-term commitment that seeks to take the health of its citizens

214 y behaved conservatively, but at the time of commitment the population activity was similar across bl

215 ough China and India have both shown renewed commitment through national programmes for community-ori

216 Thus Pcid2 controls lymphoid lineage commitment through the regulation of SRCAP remodelling a

217 ition between motor plans and determine when commitment to a choice is made.

218 tations reflect, to some extent, a tentative commitment to a choice.

219 ahlbaum, Hecker, and Kraepelin shared both a commitment to a clinical research agenda for psychiatry

220 s that can block the transition from lineage commitment to a differentiating state in myoblasts and o

221 ing legumes may be driven by an evolutionary commitment to a high N strategy, by higher N availabilit

222 A renewed commitment to a more forward-looking, flexible yet integ

223 The commitment to achieve these targets should be celebrated

224 issue of access, despite the UN's political commitment to address non-communicable diseases and ensu

225 ated receptor gamma expression that controls commitment to adipogenesis and is repressed by Zfp521.

226 ontribution be acknowledged through a shared commitment to alleviate ethically problematic aspects of

227 gain (for increasing) or both (in variable) commitment to an opinion.

228 f bone marrow cells to bone surfaces and the commitment to an osteogenic lineage of these cellsin viv

229 p53 killer (a p53 phosphoform which promotes commitment to apoptosis) in cells characterized by high

230 proteins and, by extension, control cellular commitment to apoptosis.

231 Thus, we conclude that Zeb2 regulates commitment to both the cDC2 and pDC lineages through rep

232 Commitment to building mental health treatment capacity

233 on of environmental bacteria by modulating a commitment to bursts of fast pumping.

234 dence of donor-acceptor distance and forward commitment to catalysis along with steady state and sing

235 isotope effect for heavy F159Y PNP came from commitment to catalysis experiments.

236 ionally, particularly at a time of uncertain commitment to climate change agreements at the national

237 We highlight the many drawbacks of a commitment to compositional representations and describe

238 encing of malaria cultures undergoing sexual commitment to determine the transcriptional changes indu

239 By transiently priming cells for commitment to different lineages, these fluctuations are

240 resulting from CE polarity are required for commitment to differentiated somatic cell fates.

241 is results in the activation of Gad8 and the commitment to differentiation.

242 estable interactions critical for early G2/M commitment to division.

243 tion (Paper 2 of this Series) and increasing commitment to early childhood development (Paper 1 of th

244 Commitment to either fate is determined during the prece

245 the use of these methods does not require a commitment to either gene-like cultural inheritance or t

246 Its unwavering commitment to eradicate polio has been vital to the succ

247 d that 61% of the countries that have made a commitment to FP2020 exceeded pre-FP2020 expectations fo

248 hematopoietic precursor cell activation and commitment to granulocyte lineage development.

249 species (ROS) serve as a prime signal in the commitment to hematopoiesis in both mammals and Drosophi

250 Strong political and technical commitment to improve equity-sensitive information syste

251 provision of services must include a strong commitment to improve the safety and quality of care.

252 French Hepato-Pancreato-Biliary-centers made commitment to include all patients undergoing elective h

253 oaches used to assess faculty competence and commitment to lifelong learning across missions.

254 f disease, and a woman's preferences, with a commitment to long-term follow-up.

255 ng such progress was the Government's strong commitment to long-term strategies to ensure access to d

256 , point-of-care guidance with ASCO's abiding commitment to methodologic rigor in guideline developmen

257 ns are part of the same folding funnel, with commitment to one structure or the other occurring only

258 We aimed to determine caregivers' commitment to OPV in districts of Afghanistan at high ri

259 come another chronic disease, where lifelong commitment to pharmacologic control is the paradigm.

260 interested in research than men; women lose commitment to research as their education and training p

261 leaders, peer support, and an organizational commitment to safe, open cultures, may improve safety vo

262 more than 1% of bacterial genomes; however, commitment to strand exchange was believed to occur afte

263 genic risk of cancer, based on an uninformed commitment to the 70-y-old linear no-threshold hypothesi

264 )CD8(+) double-positive thymocytes and their commitment to the CD4(+)CD8(-) single-positive stage are

265 Progressive commitment to the DC lineage also occurs intrathymically

266 engagement in the thymus has initiated their commitment to the gammadeltaT1 lineage.

267 means of identifying group members, ensuring commitment to the group, facilitating cooperation, and m

268 hancer accessibility was a key mechanism for commitment to the iNKT cell lineage.

269 Commitment to the innate lymphoid cell (ILC) lineage is

270 Csf1r expression coincides with the earliest commitment to the macrophage lineage, Csf1r-EGFP bone ma

271 in NK cell numbers when added at the time of commitment to the NK cell lineage.

272 antagonizing lateral induction and promoting commitment to the non-sensory fate.

273 g environment, (2) psychological safety, (3) commitment to the organization, (4) senior management su

274 F directs human mesenchymal stem cell (hMSC) commitment to the osteoblast lineage and modulates Wnt/b

275 ies of secretory progenitor cells undergoing commitment to the Paneth or enteroendocrine lineages, wh

276 SE cells expressed markers suggesting their commitment to the SE lineage.

277 tmarketing observational cohort study, was a commitment to the US Food and Drug Administration to ass

278 l tuberculosis community to make a sustained commitment to tuberculosis transmission science.

279 Commitment to ubiquitination is dictated primarily by co

280 r number of guidelines while maintaining its commitment to using the rigorous development methods tha

281 ctives at local scales while aiding national commitments to addressing ongoing global challenges.

282 xamine recent scientific progress and global commitments to early childhood development.

283 made 14 recommendations that require ongoing commitments to eradication of infectious disease and inc

284 y major corporations and countries have made commitments to purchase or produce only "sustainable" pa

285 n of reaction kinetics, isotope effects, and commitment-to-catalysis based on experiment and theory s

286 maturation to the T cell lineage but enacts commitment toward the myeloid cells.

287 sis, thereby coupling cell adhesion and fate commitment, two fundamental aspects of developmental bio

288 nscious memory due to irreplaceable neuronal commitment under general anesthesia and support the noti

289 differentiation from pluripotency to lineage commitment, using an unbiased single-cell transcriptomic

290 Here we study the effect that making commitment variable has on the dynamics of the system.

291 ic (career calling, meaning, engagement, and commitment) variables, with the goal of understanding ho

292 shed: (1) generating awareness and political commitment via global communications and advocacy; (2) i

293 actors governing B lineage specification and commitment was highly divergent between B-1 and B-2 prog

294 adhesion formation and osteochondral lineage commitment was observed as a function of both feature di

295 In addition, the potential for T lineage commitment was radiation sensitive with aging.

296 nduced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on hematopoie

297 tionships between all four genes relating to commitment were revealed by deleting them individually a

298 Flp1/Clp1 departure can then support mitotic commitment when Cdk1-cyclin B activation at the SPB is c

299 This model limitation is rigid commitment which never changes.

300 ike (iPL)" cells, which can maintain lineage commitment while undergoing controlled expansion.