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1 2NO's react at each FprA active site in the committed step.
2 s and suggest that sulfation may be an early committed step.
3 s reported so far, the enzymes for the first committed steps all appear to have been recruited direct
5 Thus, GmaR production represents the first committed step for flagella production in L. monocytogen
8 amination of Phe to trans-cinnamic acid, the committed step for the major pathway of Phe metabolism.
9 ylserine synthase (PSS), which catalyzes the committed step for the synthesis of major phospholipids
10 idate phosphatase (PAP), which catalyzes the committed step for the synthesis of triacylglycerol in S
11 Sugar phosphorylation is an indispensable committed step in a large variety of sugar catabolic pat
14 ice, the mRNA for Cyp17, which catalyzes the committed step in androgen synthesis, was down-regulated
16 cloisomerization reaction that serves as the committed step in biosynthesis of the large class of lab
18 geranyl diphosphate to syn-CPP catalyzes the committed step in biosynthesis of these natural products
20 hat these activities occur downstream of the committed step in capsule synthesis and reveal that Cps2
21 Phytoene synthase (PSY) mediates the first committed step in carotenoid biosynthesis; with PSY3 des
27 he reduction of FRP(Vh)-bound FMN is not the committed step in coupling the NADPH oxidation to biolum
29 -phosphate acyltransferase-1 (Ad-GPAT1), the committed step in de novo triacylglycerol synthesis.
30 lass II diterpene cyclase that catalyzes the committed step in edaxadiene biosynthesis, i.e. the prev
31 e-1-carboxylic acid synthase gene, the first committed step in ethylene biosynthesis compared with wi
32 f the Mcm2-7 replicative DNA helicase is the committed step in eukaryotic DNA replication initiation.
33 central metabolic enzyme that catalyzes the committed step in fatty acid biosynthesis: biotin-depend
34 carboxylase (ACC), which catalyzes the first committed step in fatty acid synthesis and consists of t
35 tyl-CoA carboxylase that catalyzes the first committed step in fatty acid synthesis in all organisms.
37 Acetyl-CoA carboxylase catalyzes the first committed step in fatty acid synthesis in all plants, an
44 f the AtCPS1 gene, responsible for the first committed step in GA biosynthesis, was detected exclusiv
47 glutamyl-tRNA reductase) catalyzes the first committed step in heme biosynthesis in the enteric bacte
50 osynthesis inhibitors that inhibit the first committed step in its biosynthesis, condensation of two
51 lutamate synthase (NAGS) catalyzes the first committed step in l-arginine biosynthesis in plants and
52 horibosyltransferase catalyzes the first and committed step in l-histidine biosynthesis in Mycobacter
55 amine deacetylase (LpxC) catalyzes the first committed step in lipid A biosynthesis, the hydrolysis o
58 trate synthase (HCS) catalyzes the first and committed step in lysine biosynthesis in many fungi and
65 e terpene synthases, which often mediate the committed step in particular biosynthetic pathways so th
66 ation reactions that typically represent the committed step in particular biosynthetic pathways, lead
67 mate mutase, the enzyme catalyzing the first committed step in phenylalanine and tyrosine synthesis.
68 ae CKI1-encoded choline kinase catalyzes the committed step in phosphatidylcholine synthesis via the
70 tyl-CoA carboxylase that catalyses the first committed step in prokaryotic fatty acid biosynthesis.
73 (PGHS) is a heme protein that catalyzes the committed step in prostaglandin and thromboxane biosynth
74 nic acid to prostaglandin H(2) (PGH(2)), the committed step in prostaglandin and thromboxane formatio
75 es, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the
76 COX) isozymes, which are responsible for the committed step in prostaglandin biosynthesis, and this h
77 genase (COX) enzymes are responsible for the committed step in prostaglandin biosynthesis, the genera
82 nthase-1 and -2 (PGHS-1 and -2) catalyze the committed step in prostaglandin synthesis and are target
84 2), an enzyme responsible for catalyzing the committed step in prostanoid biosynthesis, is the produc
87 cyclohydrolase-1, which catalyzes the first committed step in pterin biosynthesis, was a rate-limiti
88 ate transcarbamoylase (ATCase) catalyzes the committed step in pyrimidine nucleotide biosynthesis, th
93 sitive mannosidase for catalyzing this first committed step in Saccharomyces cerevisiae We reconstitu
97 ls of serine palmitoyltransferase, the first committed step in sphingolipid synthesis, and increase t
98 mitoyltransferase, responsible for the first committed step in sphingolipid synthesis, further suppor
101 ce this novel reaction constitutes the first committed step in sterol biosynthesis, there has been co
103 s fungi, ATP sulfurylase catalyzes the first committed step in sulfate assimilation to produce APS, w
104 te (APS) reductase (APR) catalyzes the first committed step in sulfate reduction for the biosynthesis
105 osulfate reductase (APR) catalyzes the first committed step in sulfate reduction for the biosynthesis
107 into arabinose 5-phosphate (A5P), the first committed step in the 3-deoxy-D-manno-oct-2-ulosonic aci
108 ral membrane enzyme catalyzing the final and committed step in the acyl-coenzyme A (CoA)-dependent bi
111 ymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-e
113 enicillin N to deacetoxycephalosporin C, the committed step in the biosynthesis of cephalosporin anti
114 xidative ring expansion of penicillin N, the committed step in the biosynthesis of cephamycin C by St
115 se is the rate-limiting enzyme and the first committed step in the biosynthesis of cholesterol in mam
118 hr) to alpha-ketobutyrate and ammonia as the committed step in the biosynthesis of isoleucine (Ile).
121 oyl)-GlcNAc deacetylase (LpxC) catalyzes the committed step in the biosynthesis of lipid A and is the
123 tylase], the enzyme that catalyzes the first committed step in the biosynthesis of lipid A, block the
124 ruginosa, we focused on inhibiting the first committed step in the biosynthesis of lipid A, the deace
126 Acetyl-CoA carboxylase catalyzes the first committed step in the biosynthesis of long-chain fatty a
127 -P, G3P) acyltransferase catalyses the first committed step in the biosynthesis of membrane phospholi
128 hine decarboxylase (ODC) catalyzes the first committed step in the biosynthesis of polyamines, and it
130 ndoperoxide H synthases (PGHSs) catalyze the committed step in the biosynthesis of prostaglandins and
132 ) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isopre
133 (HOs) to form biliverdin IXalpha (BV) is the committed step in the biosynthesis of the phytochrome (p
135 ntothenate kinase (PanK) catalyzes the first committed step in the biosynthetic pathway in B. anthrac
136 specific phytoene synthase (PSY1), the first committed step in the carotenoid biosynthesis pathway.
137 phosphorylation of choline by ATP, the first committed step in the CDP-choline pathway for phosphatid
138 f Mg(2+) into protoporphyrin IX is the first committed step in the chlorophyll biosynthetic pathway.
141 nylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, coupl
143 tases are key enzymes that perform the first committed step in the denitrification process and reduce
144 syl diphosphate, is the product of the first committed step in the enzymatic synthesis of a range of
145 on of squalene synthase represents the first committed step in the formation of cholesterol, making i
146 mation of the germacradienol seems to be the committed step in the formation of geosmin, the characte
147 1,3,4-trisphosphate 5/6-kinase is the first committed step in the formation of higher phosphorylated
148 ylcanadine catalyzed by CYP82Y1 as the first committed step in the formation of noscapine in opium po
149 ydroxymandelate synthase (HMS) catalyzes the committed step in the formation of p-hydroxyphenylglycin
150 estrial plants where they catalyze the first committed step in the formation of phenylpropanoids, onl
151 tional zinc metalloenzyme that catalyzes the committed step in the formation of the proinflammatory m
153 e-utilizing enzymes that carry out the first committed step in the formation of tryptophan, folate, a
154 hosphate synthase, which catalyzes the first committed step in the gibberellin biosynthetic pathway.
156 ets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essenti
157 aryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for i
158 acyl-condensing enzymes, catalyzes the first committed step in the mevalonate pathway and is a potent
159 reductoisomerase (IspC) catalyzes the first committed step in the mevalonate-independent isopentenyl
160 ly regulated through inhibition of the first committed step in the pathway catalyzed by dihydrodipico
161 amidotransferase (GFAT) catalyzes the first committed step in the pathway for biosynthesis of hexosa
163 ase-1 (Gpat1), which catalyzes the first and committed step in the pathway of glycerolipid synthesis.
164 ylserine synthase, the enzyme catalyzing the committed step in the pathway, activity was regulated by
165 absence is the characterization of the first committed step in the pathway, namely the 3-hydroxylatio
169 n of chalcones to chiral (S)-flavanones is a committed step in the production of plant flavonoids, co
170 yl)-N-acetylglucosamine by LpxC is the first committed step in the Pseudomonas aeruginosa biosyntheti
171 nylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone an
172 erolphosphate synthase (Pgs1p) catalyses the committed step in the synthesis of cardiolipin (CL).
174 Acetyl-CoA carboxylase catalyzes the first committed step in the synthesis of long chain fatty acid
176 he CKI1-encoded choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine v
178 mbled that of pgs1Delta strains, lacking the committed step in the synthesis of phosphatidylglycerol
179 (COX)-1 and COX-2, which catalyze the first committed step in the synthesis of prostaglandins via se
180 bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, throm
182 transferase, EC 2.5.1.7) catalyzes the first committed step in the synthesis of the bacterial cell wa
183 MD from Pseudomonas aeruginosa catalyzes the committed step in the synthesis of the exopolysaccharide
184 tidylglycerophosphate synthase catalyzes the committed step in the synthesis of the mitochondrial pho
185 ng putrescine N-methyltransferase, the first committed step in the synthesis of the nicotine pyrrolid
188 known), and these enzymes often mediate the committed step in their particular biosynthetic pathway.
190 e phytyltransferase (HPT) performs the first committed step in this pathway, the phytylation of HGA.
191 ncoded by the hemA gene, catalyzes the first committed step in this pathway, which is the reduction o
192 myl-tRNA reductase (GTR) catalyzes the first committed step in this pathway, which is the reduction o
195 densation of HGA and phytyl diphosphate, the committed step in tocopherol biosynthesis, is catalyzed
197 second sugar to the repeat unit and, as the committed step in type 2 repeat unit synthesis, is predi
199 s of the collagen triple-helix is one of the committed steps in ECM turnover, we envisioned modulatio
200 se the hydrolysis of collagens is one of the committed steps in ECM turnover, we have investigated se
205 o-head" terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: t
206 yltransferase activities represent the first committed steps in the biosynthesis of a large number of
207 te synthase (DHBPS) catalyzes one of the two committed steps in the riboflavin pathway and converts d
210 e enantiomers, and thus represents the first committed step involved in bacterial cell wall biosynthe
211 om glutamate by a pathway in which the first committed step is catalyzed by the hemA gene product, gl
212 agnesium into protoporphyrin IX as the first committed step of (bacterio)chlorophyll biosynthesis.
217 denylosuccinate synthetase that controls the committed step of AMP biosynthesis, but vertebrates have
218 Adenylosuccinate synthetase governs the committed step of AMP biosynthesis, the generation of 6-
220 Acetolactate synthase (ALS) is the first committed step of branched-chain amino acid biosynthesis
221 isozymes that effectively catalyze the first committed step of branched-chain amino acid biosynthesis
222 which encodes the enzyme that catalyzes the committed step of cardiolipin (CL) synthesis, results in
225 e synthetase, which participate in the first committed step of de novo AMP biosynthesis and/or the pu
227 n of a mixture of abietadiene isomers as the committed step of diterpenoid resin acid biosynthesis.
231 yzes hydroxylation of L-ornithine, the first committed step of ferrichrome and ferrichrome A biosynth
232 hate of GTP to form PEP and GDP as the first committed step of gluconeogenesis and glyceroneogenesis.
234 otic activity of Akt requires only the first committed step of glucose metabolism catalyzed by hexoki
236 hofructokinase-1 (PFK-1) catalyzes the first committed step of glycolysis and is regulated by a compl
241 Isoflavone synthase catalyzes the first committed step of isoflavone biosynthesis, a branch of t
242 ne synthase, the enzyme catalyzing the first committed step of isoflavonoid biosynthesis, various cha
245 he deacetylase that catalyzes the second and committed step of lipid A biosynthesis in Escherichia co
246 pendent deacetylase LpxC catalyzes the first committed step of lipid A biosynthesis in Gram-negative
248 inc-dependent deacetylase LpxC catalyzes the committed step of lipid A biosynthesis in Gram-negative
250 of LpxC, the enzyme that catalyzes the first committed step of lipid A synthesis, were highly elevate
253 ) and cytochrome c efflux, the essential and committed step of mitochondrial regulated apoptosis.
259 -methyltransferase (PMT) catalyzes the first committed step of nicotine biosynthesis, converting putr
261 The data conclusively show that the first committed step of nonactin biosynthesis is the coupling
264 osphotransferase, EC 2.7.1.82) catalyzes the committed step of phosphatidylethanolamine synthesis via
265 oxyphenylpyruvate dioxygenase catalyzing the committed step of plastoquinone and tocopherol biosynthe
268 xygenases COX-1 and COX-2 catalyze the first committed step of prostaglandin synthesis from arachidon
270 .2 of Escherichia coli), which catalyzes the committed step of pyrimidine biosynthesis, is allosteric
272 drogenase (PHGDH), which catalyzes the first committed step of serine biosynthesis, is overexpressed
278 ization of farnesyl diphosphate in the first committed step of the biosynthesis of gossypol, a phytoa
279 yl-CoA carboxylase (ACC) catalyzes the first committed step of the fatty acid synthetic pathway.
280 he 'gatekeeper' of glycolysis, catalyses the committed step of the glycolytic pathway by converting f
283 ndered JA deficient by silencing the initial committed step of the JA biosynthesis pathway, they are
284 1-deoxy-D-xylulose 5-phosphate in the first committed step of the MEP pathway is catalyzed by 1-deox
286 hylerythritol 4-phosphate (MEP) in the first committed step of the MEP pathway of isoprenoid biosynth
288 ng of limonene synthase, which catalyzes the committed step of the pathway, demonstrated a direct cor
289 tose to L-galactose 1-phosphate in the first committed step of the Smirnoff-Wheeler pathway to plant
290 -phosphate synthase that catalyzes the first committed step of the uridine 5'-diphospho-N-acetyl-gluc
292 anyl transferase (HGGT), which catalyzes the committed step of tocotrienol biosynthesis, were isolate
294 LG13 and DPAGT1 that catalyses the first two committed steps of asparagine-linked protein glycosylati
295 ingolipid pathway, and it indicates that the committed steps of the Bacteroides and eukaryotic sphing
297 gnize neurosporene and to catalyze the first committed step on the myxoxanthophyll biosynthesis pathw
300 to the plateau potential that represents the committed step toward the initiation of a motor program.
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