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1 romatin structure of breakpoint regions in a common fragile site.
2 essor gene, like FHIT and WWOX, located at a common fragile site.
3 cular demonstration of a germline break in a common fragile site.
4 kpoints of lost regions located in genes and common fragile sites.
5 demonstrate that OPT domains are enriched at common fragile sites.
6 s that resemble those of aphidicolin-induced common fragile sites.
7 ny characteristics similar to those in other common fragile sites.
8 nt known to result in chromosome breakage at common fragile sites.
9  and promotes replication of DNA lesions and common fragile sites.
10 inhibit DNA replication induce expression of common fragile sites.
11 ility regions are the most characteristic of common fragile sites.
12 n secondary structures that are hallmarks of common fragile sites.
13 it gene and asked whether it also contains a common fragile site and if it is unstable in mouse tumor
14       The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environ
15 s evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA rep
16 ty of ORC sites are strongly associated with common fragile sites and recurrent deletions in cancers.
17 toward understanding the genomic features of common fragile sites and the cellular processes that mon
18 14.2, is the most frequently expressed human common fragile site, and allelic losses at FRA3B have be
19 recessive cancer genes, 17 were of sequenced common fragile sites, and 178 were in genomic regions th
20                                              Common fragile sites appear to arise through incomplete
21                                              Common fragile sites are chromosomal loci prone to break
22                                              Common fragile sites are highly unstable regions of the
23                                              Common fragile sites are loci that form chromosome gaps
24                                 In contrast, common fragile sites are present in all individuals and
25                                              Common fragile sites are regions of human chromosomes pr
26                                              Common fragile sites are regions that show elevated susc
27         Our results support a model in which common fragile sites are sequences that initiate replica
28                                              Common fragile sites are specific regions in the human g
29                                              Common fragile sites are specific regions of the genome
30                                              Common fragile sites, as their name implies, are present
31                                          The common fragile site at 3p14.2 (FRA3B) is the most sensit
32                                          The common fragile site at chromosomal band 3p14.2 (FRA3B) i
33            FRA7G is an aphidicolin-inducible common fragile site at human chromosomal band 7q31.2.
34 highly destabilized chromosomes and specific common fragile site breakage.
35                           Thus, the study of common fragile sites can provide insight not only into t
36      The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin
37                                              Common fragile sites (CFS) are chromosomal regions that
38      Although distinct from late-replicating common fragile sites (CFS), the stability of ERFSs and C
39 of hard-to-replicate genomic regions, namely common fragile sites (CFS).
40  loci with DNA secondary structures, such as common fragile sites (CFSs) and palindromic repeats.
41                                  Chromosomal common fragile sites (CFSs) are genetically unstable reg
42                                              Common fragile sites (CFSs) are genomic regions that are
43                                              Common fragile sites (CFSs) are hot spots of chromosomal
44                                              Common fragile sites (CFSs) are large genomic regions pr
45                                              Common fragile sites (CFSs) are loci that preferentially
46                                              Common fragile sites (CFSs) are regions of profound geno
47                                  Chromosomal common fragile sites (CFSs) are unstable genomic regions
48 se cleaves late replication intermediates at common fragile sites (CFSs) during early mitosis to trig
49 n in cervical cancer and the position of the common fragile sites (CFSs) has been observed at both th
50 n in cervical cancer and the position of the common fragile sites (CFSs) has been observed at the cyt
51                                              Common fragile sites (CFSs) represent large, highly unst
52  from genomic deletions and duplications and common fragile sites (CFSs) seen as breaks on metaphase
53 ragile metaphase telomeres that resemble the common fragile sites (CFSs), and the association of sist
54 ol eta is also required for the stability of common fragile sites (CFSs), whose rearrangements are co
55 entially integrates at loci containing human common fragile sites (CFSs).
56 enomic regions, we assessed the stability of common fragile sites, chromosomal loci that are prone to
57                    Thus, this is the largest common fragile site cloned to date.
58                                   With three common fragile sites cloned, their mechanism of expressi
59      We found that aphidicolin (APH)-induced common fragile sites contain more sequence segments with
60                                   FRA7G is a common fragile site containing the candidate tumor suppr
61 cal to prevent mitotic catastrophe following common fragile site expression.
62                                              Common fragile sites form gaps at characteristic chromos
63 es of RET/PTC rearrangements, are located in common fragile sites FRA10C and FRA10G, and undergo DNA
64 ative tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1, i
65 the cloning of WWOX, a gene that maps to the common fragile site FRA16D region in chromosome 16q23.3-
66 e that WWOX may span the yet uncharacterized common fragile site FRA16D region.
67 3.3-24.1, a chromosome region that spans the common fragile site FRA16D.
68 ontig of >1 Mb across the second most active common fragile site, FRA16D (16q23.2).
69 omain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of
70         The 16q23.2 breakpoint transects the common fragile site, FRA16D, providing a molecular demon
71               The FHIT gene, which spans the common fragile site FRA3B, has been shown to produce abe
72 scripts in a variety of tumors and spans the common fragile site FRA3B.
73 e gaps and breaks and breaks at the specific common fragile sites FRA3B and FRA16D were significantly
74 such independent integrations into 3p14.2, a common fragile site (FRA3B).
75    One putative target, 3p14.2, contains the common fragile site, FRA3B, a hereditary renal carcinoma
76 tidine triad gene (FHIT) encompasses a human common fragile site, FRA3B, that is susceptible to envir
77 involved in the fragility of the most active common fragile site, FRA3B.
78  within the FHIT gene, which encompasses the common fragile site, FRA3B.
79 ated that the DNA probe for D7S522 spans the common fragile site FRA7G at 7q31.
80                Thus for the first two cloned common fragile sites, FRA7G and FRA3B, there is an assoc
81 31.1-31.2, a region that contains one of the common fragile sites, FRA7G.
82                                              Common fragile sites frequently coincide with the locati
83                                 The study of common fragile sites has its roots in the early cytogene
84 romosome structure, no biological effects of common fragile sites have been convincingly shown, altho
85 f cell cycle checkpoints and DNA repair, and common fragile sites have provided insight into understa
86 ntriguing component of chromosome structure, common fragile sites have taken on novel significance as
87 teresting component of chromosome structure, common fragile sites have taken on novel significance as
88 somal band 3p14.2, FRA3B, is the most active common fragile site in the human genome.
89 FRA3B, has been described as the most active common fragile site in the human genome.
90  chromosomal band 3p14.2, is the most active common fragile site in the human genome.
91 n chromosomal band 3p14.2 is the most active common fragile site in the human genome.
92    FRA3B at 3p14.2 is the most active of the common fragile sites in the human genome and is expresse
93 Parkin maps to FRA6E, one of the most active common fragile sites in the human genome, it represents
94 orts the role of DNA secondary structures in common fragile site instability, provides a systematic m
95 Thus, the physical relationship of Fhit to a common fragile site is similar to that observed with the
96 f CCG repeats, the mechanism responsible for common fragile sites is unknown.
97       FRA3B is the most frequently expressed common fragile site localized within human chromosomal b
98      This work further demonstrates that the common fragile sites may play an important role in cance
99                 Recent findings suggest that common fragile sites may serve as markers of chromosome
100                    Correspondingly, genes at common fragile sites may sustain elevated levels of DNA
101 ues were associated with cancer breakpoints, common fragile sites, microRNA, and cancer-related genes
102 gene and is the most highly expressed of the common fragile sites observed when DNA replication is pe
103 t 3p14.2 is the most highly expressed of the common fragile sites observed when DNA replication is pe
104  3p14-p12 interval known to contain the most common fragile site of the human genome (FRA3B), the FHI
105      The 3p14.2 region spans the most active common fragile site of the human genome, encompassing a
106  oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located
107                          The distribution of common fragile sites parallels the positions of neoplasi
108                                              Common fragile sites predispose to specific chromosomal
109 rspersed nuclear element 1s, suggesting that common fragile sites serve a function.
110 l cycle checkpoint kinases, CHK1 and CHK2 on common fragile site stability in human cells.
111 ing chromosome stability, and in particular, common fragile site stability.
112 wn genomic loci/regions include centromeres, common fragile sites, subtelomeres, and telomeres.
113 dentification of a sequence element within a common fragile site that increases chromosome fragility.
114 ristics are possibly intrinsic properties of common fragile sites that may affect their replication a
115 mal abnormalities occurred preferentially at common fragile sites upon conditional Hus1 inactivation.
116 o learn about the general characteristics of common fragile sites, we investigated the chromatin stru
117 ngements in tumors are often associated with common fragile sites, which are specific genomic loci pr

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