ライフサイエンスコーパス: common gamma chain

1 mmon beta chain and IL-2/IL-7/IL-15 receptor common gamma chain.

2 esembles the hematopoietic cytokine receptor common gamma chain.

3 mbination with the interleukin (IL)-receptor common gamma chain.

4 specific chain, and JAK3 is appended to the common gamma chain.

5 rget cells expressing the IL-15Rbeta and the common gamma-chain.

6 of Ccnd3 was dependent on expression of the common gamma-chain.

7 4, and IL-7, through engagement of the IL-2R common gamma-chain.

8 gnaling through cytokine receptors using the common gamma-chain.

9 ans to cells bearing the IL-2Rbeta-chain and common gamma-chain.

10 d expression of the IL-7R alpha-chain or the common gamma-chain.

11 sting of the IL-21 receptor (IL-21R) and the common gamma-chain.

12 ells that expressed the IL-7Ralpha-chain and common gamma-chain.

13 says with cells bearing human IL-15Rbeta and common gamma-chains.

14 alcium mobilization via association with the common gamma-chain, a subunit that transmits signals upo

15 -2 and IL-4 bind to receptors containing the common gamma chain and JAK3.

16 n an expansion of lymphocytes expressing the common gamma chain and the development of CD3(+) T lymph

17 with mutant JAK3 (M511I) for binding to the common gamma chain and thereby suppresses its oncogenic

18 But in sensitized mice lacking the Fc common gamma-chain and B cell-deficient mice, the number

19 Similar defects were present in common gamma-chain and Jak3 KO mice, but not in lambda 5

20 of FcgammaR (through an insufficiency of the common gamma-chains), and the exceptionally slow dissoci

21 vival are regulated by the cytokine receptor common gamma-chain-associated cytokines IL-2, IL-7, and

22 ished by a single amino acid mutation in the common gamma-chain binding site on IL-15.

23 Taken together, our data suggest that common gamma-chain binding-dependent activation of the s

24 The common gamma chain (CD132) is a subunit of the interleuk

25 madelta-17 cells express IL-15Ralpha and the common gamma chain (CD132), yet lack the IL-2/15Rbeta ch

26 express mRNA for IL-7R alpha (CD127) and its common gamma chain (CD132).

27 of variable speed with a few members of the common gamma-chain (CD132) family of cytokines, the spee

28 eptor composed of IL-7Ralpha (CD127) and the common gamma-chain (CD132) to transmit its signal.

29 o T cells expressing IL-2/IL-15Rbeta and the common gamma-chain (CD132), but did not block IL-15 acti

30 coexpression of MDR1 and human IL-2 receptor common gamma-chain cDNAs.

31 egulate TdT and the IL-7R alpha (but not the common gamma-chain) chain.

32 As the IL-2R shares the common gamma-chain component with IL-4, IL-7, and IL-15,

33 gnaling through T cell antigen receptors and common gamma chain cytokine receptors.

34 sion of genes associated with type I IFN and common gamma chain cytokine signaling in CD4 T cell subs

35 protein by effector T cells was dependent on common gamma-chain cytokine activation of the mTOR pathw

36 CD4 help is provided via IL-21 production, a common gamma-chain cytokine closely related to IL-2.

37 1, the most recently described member of the common gamma-chain cytokine family, is produced by activ

38 idence has indicated that CD8 T(mem) use the common gamma-chain cytokine IL-15 for their steady-state

39 e in that IL-2-mediated up-regulation of the common gamma-chain cytokine receptor and perforin, and a

40 that the need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thu

41 by demonstrating gene transfer of the human common gamma-chain cytokine receptor gene (gamma(c)), de

42 of several signaling mediators activated via common gamma-chain cytokine receptors.

43 IL-21, a common gamma-chain cytokine secreted by activated CD4+ T

44 of self ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrea

45 cell cycle proteins are independent of Jak3/common gamma-chain cytokine signals.

46 IL-15 is a common gamma-chain cytokine that has been shown to be mo

47 The response is induced via IL-2 receptor common gamma chain cytokines and a Janus kinase 3 (JAK3)

48 The common gamma chain cytokines interleukin (IL)-2 and IL-7

49 For example, common gamma-chain cytokines (CGCC), such as interleukin

50 cluded bryostatin 1/ionomycin and sequential common gamma-chain cytokines (IL-7/IL-15 + IL-2).

51 The most widely recognized pathways, common gamma-chain cytokines and type I IFNs, did not co

52 The common gamma-chain cytokines IL-15 and IL-7 have been sh

53 IL-7 was not unique, because the common gamma-chain cytokines IL-2, IL-4, and IL-15, as w

54 ch that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase

55 nredundant, but IL-4, IL-7, and IL-15, other common gamma-chain cytokines, could sustain Foxp3 expres

56 chronic GVHD, caused by T cells activated by common gamma-chain cytokines, each represent therapeutic

57 Other common gamma-chain cytokines, IL-4, IL-7, or IL-15, do n

58 CD25(+)Foxp3(-) cells to IL-2, but not other common gamma-chain cytokines, resulted in Stat5 phosphor

59 activation with physiologic stimuli such as common gamma-chain cytokines, Toll-like receptor (TLR) 2

60 y cognate peptide stimulation or exposure to common gamma-chain cytokines.

61 Bone marrow-cultured mast cells from common gamma-chain deficient mice, unlike mast cells cul

62 acterization of a new genetic stock of IL-2R common gamma-chain deficient NOD/LtSz-scid (NOD-scid IL2

63 In CD132 (common gamma-chain)-deficient hosts, pmel-1 CD8(+) T cel

64 (SCID/NOD) wild-type or SCID/NOD Fc receptor common gamma chain-deficient (FcRgamma(-/-)) mice.

65 -7Ralpha-chain-deficient (IL-7Ralpha-/-) and common gamma chain-deficient (gammac-/-) mice both exhib

66 s with this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(

67 , whereas B cells were not eliminated in FcR common gamma chain-deficient mice.

68 ese diabetic severe combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mi

69 to control B16F10 tumor growth, but only in common gamma-chain-deficient host mice.

70 Therefore, we used alymphoid Rag- and common gamma-chain-deficient mice as recipients and obse

71 of immunoglobulin G Fc receptor (Fc(gamma)R) common gamma-chain-deficient mice revealed that the cros

72 eport, we examine in detail the role of Jak3/common gamma-chain-dependent cytokines in promoting cell

73 ental requirement for IL-2 and perhaps other common gamma-chain-dependent cytokines to promote select

74 trate a direct impact of IL-2 and IL-15, two common gamma-chain-dependent cytokines, on CD8(+) T-cell

75 ntestinal microbiota, adaptive immunity, and common-gamma chain-dependent signaling.

76 lpha-chain to the shared IL-2/IL-15Rbeta and common gamma-chains displayed on the surface of T cells

77 essed following IRI in immunodeficient RAG-2/common gamma-chain double-knockout mice, suggesting that

78 IL-2 and IL-15 are common gamma-chain family cytokines involved in regulati

79 IL-7, a member of the common gamma-chain family of cytokines, is essential for

80 MyD88 and FcR common gamma-chain (Fcer1g, FcRgamma) elicit proinflamma

81 mma RI, Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid

82 eptor tyrosine-based activation motif on the common gamma chain (FcRgamma).

83 2 and IL-15, a cytokine family that uses the common gamma-chain for signaling.

84 IL-2 receptor beta-chain CD122, forming with common gamma-chain functional high-affinity IL-2 recepto

85 like human XSCID, is due to mutations in the common gamma chain (gamma c) gene and has clinical and i

86 , a disease caused by genetic defects of the common gamma chain (gamma c) that is a shared component

87 Signaling through the common gamma chain (gamma c), a subunit of the receptors

88 consisting of the IL-4R alpha chain and the common gamma chain (gamma c), resulting in a series of p

89 a(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by

90 t mice lacking either the alpha chain or the common gamma chain (gamma(c)) of the IL-7R.

91 this study, we examined whether Jak3 and the common gamma chain (gamma(c)) reciprocally regulate thei

92 iated with the interleukin-2 (IL-2) receptor common gamma chain (gamma(c)) that is activated by multi

93 ld not completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

94 e models, all carrying null mutations of the common gamma chain (gamma(c)).

95 emory T cells expressing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

96 caused by a defect in the gene encoding the common gamma chain (gamma-c) of the receptor for interle

97 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15

98 4 signals through two receptors, IL-4R alpha/common gamma-chain (gamma(c)) and IL-4R alpha/IL-13R alp

99 erous crystal structures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and the

100 The common gamma-chain (gamma(c)) cytokines signal through t

101 view focuses on the role of cytokines of the common gamma-chain (gamma(c)) family in the determinatio

102 here an unliganded receptor structure in the common gamma-chain (gamma(c)) family of receptors and cy

103 The common gamma-chain (gamma(c)) is a functional component

104 The shared common gamma-chain (gamma(c)) of IL-2R and its associate

105 28/CD40 ligand (CD40L) costimulation and the common gamma-chain (gamma(c)) signals, a shared signalin

106 The common gamma-chain (gamma(c)) that functions both in lig

107 ing through cytokine receptors utilizing the common gamma-chain (gamma(c)).

108 rough the receptor subunit IL-2Rbeta and the common gamma-chain (gamma(c)).

109 e IL-15R complex that consists of IL-2Rbeta, common gamma-chain (gamma(c)-chain), and a specific chai

110 n the X-linked gene IL2RG, which encodes the common gamma chain, gamma c, of the leukocyte receptors

111 umans and dogs results from mutations in the common gamma-chain, gamma c, which is a common component

112 a-chain that specifically binds IL-7 and the common gamma-chain, gamma(c), which is also a component

113 Cytokines that use the common gamma chain gammac are critical for lymphoid deve

114 deficient mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and carrying a human st

115 combination-activating gene 2 (Rag2) and the common gamma chain (gammac) (Rag-gammac(-/-)), which lac

116 hematopoietic cells that associates with the common gamma chain (gammac) and is required for signalin

117 leukin 2 (IL-2) and IL-15 signal through the common gamma chain (gammac) and through IL-2 receptor be

118 eficiency (XSCID) is due to mutations in the common gamma chain (gammac) gene and is identical clinic

119 Interestingly, common gamma chain (gammac) knockout mice have been show

120 The anti-common gamma chain (gammac) mAb CP.B8 is shown to inhibi

121 by mutations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukin

122 he alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.

123 restricted to interleukins that recruit the common gamma chain (gammac) receptor, including IL-9.

124 odest reduction in surface expression of the common gamma chain (gammac) that associates with JAK3.

125 kinase that specifically associates with the common gamma chain (gammac), a shared subunit of recepto

126 The common gamma chain (gammac), a subunit of the interleuki

127 through cytokine receptors that utilize the common gamma chain (gammac), such as those for IL-2, IL-

128 The common gamma chain (gammac)-binding cytokine interleukin

129 However, Foxp3 lethality was prevented by common gamma chain (gammac)-dependent cytokine signals t

130 Common gamma chain (gammac)-receptor dependent cytokines

131 We show that common gamma chain (gammac)-using cytokines, namely IL-2

132 r for IL-7 is heterodimeric, consisting of a common gamma chain (gammac, encoded by Il2rg) and an alp

133 with SCID caused by mutations affecting the common gamma-chain (gammac) cytokine signaling pathway a

134 kinase, AP-1, and NF-kappaB, as well as the common gamma-chain (gammac) cytokine-receptor-induced si

135 Tim-3 was induced by the common gamma-chain (gammac) cytokines IL-2, IL-7, IL-15,

136 resent in mice lacking both the Rag2 and the common gamma-chain (gammac) genes (Rag2(-/-)gammac(-/-))

137 R alpha-chain; IL-7Ralpha is paired with the common gamma-chain (gammac) in the IL-7 receptor complex

138 The common gamma-chain (gammac) is a key component of multip

139 The common gamma-chain (gammac) plays a central role in sign

140 LP and TGF-beta) that did not signal via the common gamma-chain (gammac) receptor but that, like IL-7

141 The common gamma-chain (gammac), a subunit of the IL-2R, is

142 ing via cytokine receptors that comprise the common gamma-chain (gammac), i.e., the receptors for IL-

143 ncies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptor

144 tasis of natural killer (NK) cells relies on common gamma-chain (gammac)-dependent cytokines, in part

145 by CD28/CD154 costimulatory signals and the common gamma-chain (gammac; a shared signaling element b

146 IL-4 signals through the type I (IL-4Ralpha/common gamma-chain [gammac]) and the type II (IL-4Ralpha

147 aling pathways utilizing a cytokine receptor common gamma chain, gammac, and the tyrosine kinase Jak3

148 and human XSCID are caused by defects in the common gamma chain, gammac, of receptors for interleukin

149 es share a component of their receptors, the common gamma chain, gammac.

150 ction from cytokine receptors containing the common gamma-chain, gammac.

151 ng alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors.

152 rm of human SCID, is due to mutations in the common gamma chain gene (gamma-c) that encodes an essent

153 her cytokines sharing the IL-2R beta- and/or common gamma-chains (i.e., IL-15, IL-4, and IL-7) do not

154 autonomously or in collaboration with other common gamma chain (IL-4 and IL-7) and IL-6/IL-12 family

155 The IL-2R common gamma-chain (IL-2Rgamma) is shared by receptors f

156 other cytokine receptor chains including the common gamma-chain, IL-2Rbeta, or the IL-2Ralpha, IL-4Ra

157 t mice bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, inv

158 utation in the interleukin 2 (IL-2) receptor common gamma chain (IL2rg(null)) into mice that were alr

159 or encoding the human interleukin 2 receptor common gamma chain (IL2RG) gene and the efficient deriva

160 ice expressing mutations in the IL2-receptor common gamma chain (IL2rg) gene, including NOD-scid IL2r

161 roduced IFN-gamma, was T cell-, B cell-, and common gamma-chain-independent, and required IL-4Ralpha

162 ich signals through receptors containing the common gamma chain, induced expression of IL-10 in the I

163 iller (NK) cells and in SCID/NOD Fc receptor common gamma chain knockout (FcRgamma-/-) mice.

164 se diabetic severe combined immunodeficiency common gamma chain knockout-bone marrow-liver-thymus hum

165 he binding of IL-13 to IL-13Ralpha1, neither common gamma-chain nor IL-13Ralpha1 contributed signific

166 opoietic cells and binds specifically to the common gamma chain of a subfamily of cytokine receptors

167 s a tyrosine kinase that associates with the common gamma chain of cytokine receptors and is recurren

168 ciency (XSCID) is caused by mutations of the common gamma chain of cytokine receptors, gamma(c).

169 In addition, we show that mice lacking the common gamma chain of Fc receptors (FcgammaRI, Fcepsilon

170 protection by infecting mice deleted for the common gamma chain of FcRs.

171 y of IL-4 and was largely independent of the common gamma chain of the IL-2, IL-4, IL-7, IL-9, and IL

172 cross-linking CD28, or signaling through the common gamma chain of the interleukin-2 receptor on T ce

173 infection of either BALB/c mice lacking the common gamma-chain of Fc receptors (FcgammaR(-/-)) or mi

174 ations of the FcgammaRIII alpha-chain or the common gamma-chain of FcepsilonRI and FcgammaRI/III, we

175 Although mice deficient in the common gamma-chain of the FcgammaR did not show clinical

176 ors, a complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralp

177 y FcgammaRI, FcgammaRIII, FcgammaRIV, or FcR common gamma chain, or inhibitory FcgammaRIIB.

178 and SCID bearing a null mutation in the IL-2 common gamma chain receptor (NSG) mice as animal models

179 Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymo

180 nterleukin (IL) 7, a constitutively produced common gamma chain receptor cytokine, to the survival of

181 Cytokines, particularly those of the common gamma chain receptor family, provide extrinsic si

182 oexpressed and functions in synergy with the common-gamma chain receptor family.

183 ce IL-1R1 expression by signals via TCRs and common gamma-chain receptors was essential for naive CD4

184 Cytokine receptors that utilize the common gamma chain signal through the lymphocyte-specifi

185 cell features are induced in CTCL T cells by common gamma chain signaling cytokines such as IL-2 and

186 duction below threshold levels necessary for common gamma chain signaling.

187 IL-21 is a member of the common gamma-chain signaling family of cytokines.

188 e (Rag) 2(-/-) splenocytes but not Rag2(-/-) common gamma chain(-/-) splenocytes.

189 Cytokines that signal through the common gamma-chain suppressed T(reg) cell-induced apopto

190 fs, whereas PIR-A pairs with the Fc receptor common gamma chain to form an activating receptor comple

191 iated disease and associates with either the common gamma-chain to form the type I IL-4R or with the

192 Other common gamma-chain-utilizing cytokines were unable to in

193 knocking out the immunoglobulin Fc receptor common gamma chain where the effect is greatest on chron

194 IL2RG encodes the common gamma chain, which is part of several interleukin

195 However, no cell line expressed IL-2R common gamma-chain, which is known to be shared with IL-

196 to bind with the shared IL-2/IL-15Rbeta and common gamma-chains, which activate signaling pathways o

197 CLPs express IL-7 receptors, which share the common gamma chain with IL-2 receptors, IL-7 cannot init

198 ow progenitors lacking the cytokine receptor common gamma-chain yields leukemogenic pre-B cells that