ライフサイエンスコーパス: common lymphoid progenitor

1 ith the reversion event having occurred in a common lymphoid progenitor.

2 s at a developmental stage that precedes the common lymphoid progenitor.

3 rm repopulating activity, HSC quiescence and common lymphoid progenitors.

4 suggesting a differentiation bottleneck for common lymphoid progenitors.

5 e progenitors, hematopoietic stem cells, and common lymphoid progenitors.

6 plays a critical role in the development of common lymphoid progenitors.

7 , developed into lymphoid lineage-restricted common lymphoid progenitors.

8 Here we show that a clonogenic common lymphoid progenitor, a bone marrow-resident cell

9 ILCs derive from common lymphoid progenitors, although the transcriptiona

10 We propose that the common lymphoid progenitor and common myeloid progenitor

11 elopmental intermediate between the upstream common lymphoid progenitor and the downstream NKP, previ

12 of lymphoid-primed multipotent progenitors, common lymphoid progenitors and B cell progenitors, norm

13 In contrast to MPP, common lymphoid progenitors and B lineage cell numbers w

14 Clonogenic common lymphoid progenitors and clonogenic common myeloi

15 also of their downstream progenitors such as common lymphoid progenitors and common myeloid progenito

16 rred via developmental intermediates such as common lymphoid progenitors and common myeloid progenito

17 ymphopoiesis was unaffected, and bone marrow common lymphoid progenitors and hematopoietic stem cells

18 ng heterodimer that stimulates the growth of common lymphoid progenitors and immature B and T lymphoi

19 In bone marrow from mutant mice, common lymphoid progenitors and pre-pro-B cells appeared

20 Ras inhibition impaired proliferation of common lymphoid progenitors and pre-pro-B cells but not

21 hanism resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double

22 mmitted progenitors in both the bone marrow (common lymphoid progenitor) and thymus (proT1) maintain

23 ipheral leukocyte counts, early depletion of common lymphoid progenitors, and a monocytic bias in com

24 ive haematopoietic stem cells, are absent on common lymphoid progenitors, and are upregulated after m

25 tic stem cells, early lymphocyte precursors, common lymphoid progenitors, and early T lineage progeni

26 mphopoiesis at the single cell level: HSPCs, common lymphoid progenitors, and mature B cells.

27 Strikingly, ectopic GATA-1 reprogrammed common lymphoid progenitors as well as granulocyte/monoc

28 s altered, we show that ILC2 generation from common lymphoid progenitors, as well as ILC2 homeostasis

29 f cell-fate-restriction events that occur as common lymphoid progenitors become committed to each of

30 emokine receptor CCR9 by a subset of MPP and common lymphoid progenitors but not hemopoietic stem cel

31 that the observed expression of the IL-7R on common lymphoid progenitors, but not ETPs, results in di

32 bly by influencing lineage commitment from a common lymphoid progenitor cell.

33 f B cells, T cells, natural killer cells and common lymphoid progenitor cells and an enhanced myeloid

34 et (FMD) increases the levels of bone marrow common lymphoid progenitor cells and cytotoxic CD8(+) tu

35 IL-7R is first expressed on common lymphoid progenitor cells and is not detected on

36 The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage d

37 Marrow-derived hematopoietic stem cells, common lymphoid progenitor cells, and developing B and m

38 ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known ab

39 , we sort-purified mouse bone marrow-derived common lymphoid progenitor cells, early thymic progenito

40 ymphocyte development and can be detected in common lymphoid progenitor cells.

41 progenitor cells and the bone marrow-derived common lymphoid progenitor cells.

42 methylated at CpG residues among fetal liver common lymphoid progenitor cells.

43 Our data suggest that common lymphoid progenitor (CLP) cells could be responsi

44 he phenotypic changes of reporter-expressing common lymphoid progenitor (CLP) cells in the bone marro

45 hematopoietic stem cell (HSC) expansion and common lymphoid progenitor (CLP) depletion in a model of

46 t in FOXO1-deficient mice is arrested in the common lymphoid progenitor (CLP) LY6D(+) cell stage.

47 nsistent with multilineage progenitor (MLP), common lymphoid progenitor (CLP), and B lineage-restrict

48 NFIL3 was required in the common lymphoid progenitor (CLP), and was essential for

49 ive DDT decreased the numbers of MPP-derived common lymphoid progenitor (CLP), common myeloid progeni

50 ne of these developmental intermediates, the common lymphoid progenitor (CLP), which can give rise to

51 The number of common lymphoid progenitors (CLP) and their pre-pro-B an

52 est, there was heterogeneity among canonical common lymphoid progenitors (CLP) in bone marrow.

53 ow multipotent progenitors (MPP) switch into common lymphoid progenitors (CLP) or common myeloid prog

54 id-primed multipotential progenitors (LMPP), common lymphoid progenitors (CLP), and B/T cell precurso

55 n protein renders functionally defined HSCs, common lymphoid progenitors (CLP), and precursor B-lymph

56 D44(Hi) and similar in some respects to the "common lymphoid progenitors" (CLP) identified by others.

57 eviously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2, coexist in

58 Strikingly, >50% hGM-CSFR+ common lymphoid progenitors (CLPs) and >20% hGM-CSFR+ pr

59 which generate fewer than normal numbers of common lymphoid progenitors (CLPs) and common myeloid pr

60 ed lymphopenia and substantial reductions of common lymphoid progenitors (CLPs) and lymphoid precurso

61 rkably, CD11a was critical for generation of common lymphoid progenitors (CLPs) and lymphoid-primed m

62 studies using highly enriched populations of common lymphoid progenitors (CLPs) and MPs from the bone

63 al of 2 putative thymus seeding populations, common lymphoid progenitors (CLPs) and multipotent proge

64 )CD27(+) subset is predominantly composed of common lymphoid progenitors (CLPs) and multipotent proge

65 tment point when NK progenitors develop from common lymphoid progenitors (CLPs) and that E4bp4 must b

66 Common lymphoid progenitors (CLPs) are descended from HS

67 Common lymphoid progenitors (CLPs) are lymphoid-lineage-

68 Common lymphoid progenitors (CLPs) are the first bone ma

69 the V(D)J recombinase is active as early as common lymphoid progenitors (CLPs) but not in the upstre

70 Common lymphoid progenitors (CLPs) clonally produce both

71 hroid but not lymphoid genes, whereas single common lymphoid progenitors (CLPs) coexpress T and B lym

72 We now show that common lymphoid progenitors (CLPs) from mice with active

73 th which hematopoietic stem cells (HSCs) and common lymphoid progenitors (CLPs) from neonates and adu

74 f both Rac1 and Rac2 inhibited production of common lymphoid progenitors (CLPs) in bone marrow and su

75 ) haematopoietic progenitor cells (LSKs) and common lymphoid progenitors (CLPs) in bone marrow.

76 s) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (B

77 l embryonic stem (ES) cells fail to generate common lymphoid progenitors (CLPs) resulting in a comple

78 In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the in

79 showed that the extrathymic precursors were common lymphoid progenitors (CLPs) that included CD19(-)

80 The number of common lymphoid progenitors (CLPs) were not affected; ho

81 ulated the proliferation of pre-pro-B cells, common lymphoid progenitors (CLPs), and colony-forming u

82 rified HSCs, multipotent progenitors (MPPs), common lymphoid progenitors (CLPs), and common myeloid p

83 p to 1000-fold toward cells with features of common lymphoid progenitors (CLPs), and lymphoid differe

84 egakaryocyte-erythrocyte progenitors (MEPs), common lymphoid progenitors (CLPs), and pro-T and pro-B

85 on CpG sites throughout the genome for MPPs, common lymphoid progenitors (CLPs), common myeloid proge

86 tion with common myeloid progenitors (CMPs), common lymphoid progenitors (CLPs), granulocyte-macropha

87 phoid lineage-committed progenitors, such as common lymphoid progenitors (CLPs), maintain a latent my

88 We found that both the common lymphoid progenitors (CLPs), shown here and elsew

89 that of lin(-)Sca1(low)kit(low)IL7Ralpha(+) common lymphoid progenitors (CLPs), their cloning effici

90 r CXCR4 in MPPs reduced differentiation into common lymphoid progenitors (CLPs), which decreased lymp

91 plantation of low numbers of highly purified common lymphoid progenitors (CLPs)-a rare population of

92 promote early B lineage differentiation from common lymphoid progenitors (CLPs).

93 d compare multipotent progenitors (MPPs) and common lymphoid progenitors (CLPs).

94 inappropriate induction of Gata1 in HSCs and common lymphoid progenitors (CLPs).

95 and Flt3 ligand (FL) in pDC development from common lymphoid progenitors (CLPs).

96 the earliest lymphoid-committed progenitors (common lymphoid progenitors [CLPs]) and CMPs and their p

97 Common lymphoid progenitors could not be identified in t

98 trathymic T lineage-committed cells, whereas common lymphoid progenitors did not.

99 ously described lymphoid progenitors such as common lymphoid progenitors express TdT and relatively h

100 tors and Lin(-)Sca-1(+)cKit(Lo)IL-7Ralpha(+) common lymphoid progenitors from adult marrow efficientl

101 2L/L-selectin+ progenitors (LSP), as well as common lymphoid progenitors from C57BL6-Thy1.1-RAG-1/GFP

102 GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded inves

103 PU.1 disruption in common lymphoid progenitors, however, did not prevent th

104 Although we know they develop from a common lymphoid progenitor in the bone marrow (BM), the

105 regenerated the thymus and were superior to common lymphoid progenitors in magnitude and frequency o

106 provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoie

107 ILC2s arise from common lymphoid progenitors in the bone marrow, are depe

108 ates that all newly made ILCs originate from common lymphoid progenitors in the bone marrow.

109 ucer cell progenitors in the fetal liver and common lymphoid progenitors in the bone marrow.

110 population of B/NK bipotent precursors among common lymphoid progenitors in the fetal liver and the b

111 stem, such as common myeloid progenitors and common lymphoid progenitors, increase the production of

112 required for the in vivo differentiation of common lymphoid progenitors into ILC lineage-restricted

113 progenitor (Lin-Sca1+Kit+ Flt3+) as well as common lymphoid progenitor (Lin-Sca1+CD117(lo)CD127+) po

114 itro proliferation and/or differentiation of common lymphoid progenitors, pre-pro-B cells, and hemato

115 Moreover, early lymphoid progenitors and common lymphoid progenitors produced significant numbers

116 from hematopoietic stem cells did not alter common lymphoid progenitor production but severely reduc

117 downstream multipotent progenitors (MPP) and common lymphoid progenitors rapidly generated T cells fo

118 scription signatures of E2A- and HEB-ablated common lymphoid progenitors significantly overlap.

119 hat extended to hematopoietic stem cells and common lymphoid progenitors, spared T cells and enhanced

120 -) mice is completely blocked at the LY6D(-) common lymphoid progenitor stage.

121 We have identified a clonogenic common lymphoid progenitor that can differentiate into T

122 The existence of a common lymphoid progenitor that can only give rise to T

123 Furthermore, unlike common lymphoid progenitors that readily generate B cell

124 contrast to the previously described murine common lymphoid progenitor, the alpha chain of the recep

125 hat mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted pr

126 ed factor that blocks B lymphopoiesis at the common lymphoid progenitor to preproB cell stage.

127 the adipocyte-derived factor occurred at the common lymphoid progenitor to preproB cell stage.

128 lymphoid-primed multipotent progenitors and common lymphoid progenitors to the thymus decreases more

129 cell differentiation potential of HNF1A(-/-) common lymphoid progenitors was severely impaired in vit

130 competent myeloid but not lymphoid cells, as common lymphoid progenitors were decreased, and peripher

131 epression, operative in both fetal and adult common lymphoid progenitors, where T cell potential is s

132 ILCs are generated from common lymphoid progenitors, which are subsequently comm

133 e in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are di