ライフサイエンスコーパス: compass

1 analysis of antigen-specific T-cell subsets (COMPASS).

2 is methylated by the Set1 complex (Set1C or COMPASS).

3 thought to provide animals with an internal compass.

4 the central complex acts as an internal sky compass.

5 and human cancers, as a key target of SET1B/COMPASS.

6 d no screening to orient with their magnetic compass.

7 ells signal heading direction, rather like a compass.

8 tion rely on the concept of a mental map and compass.

9 , they could not orient using their magnetic compass.

10 head orientation, thus implementing a neural compass.

11 s interaction with the Cps40/Spp1 subunit of COMPASS.

12 sphatase in establishing a PtdIns(3,4,5)P(3) compass.

13 s required for APT to overcome antagonism by COMPASS.

14 Danaus plexippus) use a time-compensated sun compass.

15 a novel catalytic-independent role of SET1B/COMPASS.

16 entral complex, the presumed site of the sun compass.

17 one cross talk as a binding surface for Set1-COMPASS.

18 avigation while using a time-compensated sun compass.

19 server of COMPASS, http://prodata.swmed.edu/compass.

20 egulated by Tyr1052 and the Cps40 subunit of COMPASS.

21 radical-pair processes in the avian magnetic compass.

22 y recruitment of the Cps35 (Swd2) subunit of COMPASS.

23 mally designed as a receptor in a biological compass.

24 he panorama and signals from their sun-based compass.

25 n a straight direction using their celestial compass.

26 entral complex, the presumed site of the sun compass.

27 ator possesses both a sun compass and a moon compass.

28 ferences are selected for the fly's internal compass.

29 as those found in macroscopic gyroscopes and compasses.

30 vigational mechanisms that rely on a map and compasses.

31 er 2010 to 2012, 36 articles were identified compassing 11 sedation scales.

32 ail peptide, suggesting a regulatory role in COMPASS; (2) the affinity of the subunit Spp1 for modifi

33 of risk scanning with the Navigenics Health Compass, a commercially available test of uncertain clin

34 We present COMPASS, a COmputational Model to Predict the developmen

35 that a subunit of Caenorhabditis elegans MLL/COMPASS, a gene activation complex, acts within the DC c

36 to suggest a mechanism for the regulation of COMPASS activity at an actively transcribed gene.

37 gation rate and frequency as well as reduced COMPASS activity.

38 l structural region predictions suggested by COMPASS alignments.

39 hipod Talitrus saltator possesses both a sun compass and a moon compass.

40 clude that nocturnally migrating moths use a compass and an inherited preferred direction to optimize

41 n for this task-a celestial-cue-based visual compass and an optic-flow-based visual odometer-but the

42 ethylation of both histone H3K4 and H3K79 by COMPASS and Dot1 methyltransferases, respectively.

43 ishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.

44 likely to establish part of the internal sun compass and find them highly homologous to those of the

45 ve reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and

46 nce then, it has been demonstrated that Set1/COMPASS and its enzymatic product, H3K4 methylation, is

47 4) implemented by the macromolecular complex COMPASS and its related complexes is associated with tra

48 dly extendible, conceptual framework--like a compass and map--for describing and exploring in neuroin

49 Thus, COMPASS and Mediator are repurposed to promote epigeneti

50 tive interactions between the avian magnetic compass and polarized light, we developed a spatial orie

51 in the regulation of H3K4 trimethylation by COMPASS and that the mutation to phenylalanine (Y1052F)

52 dings suggest that Ras is part of the cell's compass and that the RasGAP-mediated regulation of Ras a

53 directions; they appear to have an internal compass and to respond to turbulence features in the air

54 ive to their final destination using both a "compass" and a "map".

55 ting as a critical regulator of the cellular compass, and identify them as potential targets for anti

56 required for the incorporation of Cps35 into COMPASS, and increasing the level of ubiquitylated H2B i

57 ion complex Paf1, the histone methylase Set1-COMPASS, and the translation-related Trm112 dimers are a

58 t God's beliefs as a moral compass, but that compass appears especially dependent on one's own existi

59 all H3K4 trimethylations implemented by MLL2/COMPASS are functionally equivalent.

60 mechanisms that underlie the avian magnetic compass are still poorly understood.

61 companies who elected to purchase the Health Compass at a discounted rate.

62 d in behavioral tests: it is an "inclination compass" based on the inclination of the field lines rat

63 hat honeybees remember visual panoramas in a compass-based coordinate frame, linking together stored

64 or-navigation strategy (i.e., use a specific compass bearing without compensating for displacement).

65 e antennae are important for the inclination compass because they appear to contain light-sensitive m

66 Monarchs might also use a magnetic compass because they possess two cryptochromes that have

67 ex (CX) is likely the site of the actual sun compass, because neurons in this brain region are tuned

68 onoubiquitination may not directly stimulate COMPASS but rather works in the context of the PAF and R

69 se inferences about God's beliefs as a moral compass, but that compass appears especially dependent o

70 at promoters of bivalent genes, Mll2 (KMT2B)/COMPASS can also implement H3K4me3 at a subset of non-TS

71 COMPASS can mono-, di-, and trimethylate H3K4, but trans

72 The COMPASS chromatin complex, which trimethylates lysine 4

73 n by the Polycomb (Pc), Trithorax (Trx), and Compass chromatin modifier complexes.

74 lecular pathway driven by mutant p53 and the COMPASS chromatin-modifying complex that is amenable to

75 together in the monarch time-compensated sun compass circuit.

76 ates the activity of the chromatin modifying COMPASS complex (complex proteins associated with Set1)

77 thylation is mediated by the Set1-containing COMPASS complex and is regulated in trans by prior ubiqu

78 By analyzing strains lacking specific COMPASS complex members or containing H2B mutations that

79 alytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 methylation

80 Set1 functions as part of the COMPASS complex to mono-, di-, and tri-methylate H3K4.

81 me H3K4-trimethylated through an alternative COMPASS complex.

82 x group (TrxG) protein MLL1 found within its COMPASS (complex associated with SET1)-like complex is a

83 ption start sites to recruit the Wdr82-Set1A/COMPASS (complex of proteins associated with Set1) compl

84 o-, di-, and trimethylated by members of the COMPASS (complex of proteins associated with Set1) famil

85 Mutations and translocations within the COMPASS (complex of proteins associated with Set1) famil

86 Although MLL/COMPASS (complex of proteins associated with Set1) famil

87 Of the six members of the COMPASS (complex of proteins associated with Set1) famil

88 Cps35/Swd2 within COMPASS (complex of proteins associated with Set1) is co

89 , including H3K4me1, are implemented by Set1/COMPASS (complex of proteins associated with Set1), ther

90 phila homolog, Trithorax, which exist within COMPASS (complex of proteins associated with Set1)-like

91 of a distinct surface that affects only Set1-COMPASS (complex proteins associated with Set1)-mediated

92 methylases, including Set1A/B, forming human COMPASS complexes, and MLL1-4, forming human COMPASS-lik

93 open a new line of investigation into clock-compass connections that may extend widely to other inse

94 or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated

95 suggest ways in which the performance of the compass could have been optimized by evolution, (iii) ma

96 y insects exploit skylight polarization as a compass cue for orientation and navigation.

97 lity to use the magnetic field as a map; the compass cue(s) used by eels was not investigated.

98 e beetles use a wide repertoire of celestial compass cues.

99 persist in using a celestial body for their compass, day or night.

100 oci, generation of catalytically mutant MLL2/COMPASS demonstrated that H3K4me3 implemented by this en

101 c genealogy community, have already used DNA Compass, demonstrating its utility.

102 h butterfly possesses a time-compensated sun compass dependent upon a circadian clock in the antennae

103 gh addition of this limited genetic model to COMPASS did not improve prediction of progression of MCI

104 es often depart from the release site in the compass direction they were bent on before their capture

105 tation mechanism uses a time-compensated sun compass during both the migration south and the remigrat

106 als), identifying such abilities as magnetic compasses, electrosensitivity, polarization vision, and

107 ings regarding the properties of the PcG and COMPASS families and the insight they provide into the e

108 py30, which are all common components of the COMPASS family from yeast to human.

109 ngboard for the functional dissection of the COMPASS family members and their role in the regulation

110 This structural arrangement suggested that COMPASS family members function as exo-methylases, which

111 d that individual inactivation of the MLL1-4/COMPASS family members has little effect on early Hox ge

112 ation-sequencing (ChIP-seq) of this class of COMPASS family members in both human HCT116 cells and mo

113 There are six COMPASS family members in mammals, two of which, MLL3 (G

114 While humans have six COMPASS family members, Drosophila possesses a represent

115 osophila possesses three and humans bear six COMPASS family members, each capable of methylating H3K4

116 chanism controlling the activity of the KMT2/COMPASS family of lysine methyltransferases.

117 at the Trithorax-related (Trr) branch of the COMPASS family regulates enhancer activity and is respon

118 e Trithorax group (TrxG) proteins within the COMPASS family, which are highly mutated in a large numb

119 s a cytoplasmic function for a member of the COMPASS family, which could be harnessed for therapeutic

120 molecular characterization of the Drosophila COMPASS family.

121 ation is thus shown to be a highly regulated compass for mechanosensitive migration.

122 o use a light-dependent inclination magnetic compass for orientation in the absence of directional da

123 ignificance of light <420 nm for inclination compass function was not considered in previous monarch

124 f results, extensions and generalizations of compass graphs and our HapCompass framework.

125 we report the first evidence that nocturnal compass-guided insect migrants use a turbulence-mediated

126 -Cas9 genetic knockouts, we demonstrate that COMPASS H3K4 methyltransferase family members differenti

127 The avian magnetic compass has been well characterized in behavioral tests:

128 Theoretical descriptions of this compass have thus far been unable to account for the hig

129 rectional sails were set and obesity was the compass heading.

130 The COMPASS-HF (Chronicle Offers Management to Patients with

131 which have pre-defined core regions, against COMPASS, HHalign and PSI-BLAST, using structure superpos

132 erformance to state-of-the-art tools such as COMPASS, HHsearch and PRC.

133 -3gamma promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-

134 uripotency factor NANOG to recruit the DPY30-COMPASS histone modifiers onto key developmental genes.

135 alters the recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/

136 Radical pairs, indeed, can act as a magnetic compass; however, the cryptochrome photoreaction pathway

137 ibe a recently improved public web server of COMPASS, http://prodata.swmed.edu/compass.

138 s of cytokine production, we demonstrate how COMPASS improves characterization of antigen-specific T

139 rized light and the light-dependent magnetic compass in an animal.

140 etoreception of the light-dependent magnetic compass in birds is suggested to be mediated by a radica

141 s the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism i

142 he HD signal plays a causal role as a neural compass in navigation.

143 pass, likely located in the brain and a moon compass in the antennae.

144 may be suited to stabilize the internal sky compass in the central complex of the locust.

145 sition of the sun) are integrated in the sun compass in the midbrain central complex region.

146 atory birds are unable to use their magnetic compass in the presence of urban electromagnetic noise.

147 Although there is only one COMPASS in yeast, Drosophila possesses three and humans

148 on, integrity, and overall stability of Set1-COMPASS independent of H2Bub1.

149 ng a role of this receptor in modulating sky-compass information and/or higher sensor-motor control.

150 lli of E. imperialis could provide sensitive compass information for navigation in the rainforest and

151 ract with structures that represent maps and compass information to compute and constantly control na

152 neurons can convey both map information and compass information.

153 irection from its nest through odometric and compass information.

154 y the position of the sun, this cue provides compass information.

155 , 6], suggesting that the use of a celestial compass is a general and perhaps ancient capability of i

156 COMPASS is a method for homology detection and local ali

157 COMPASS is a profile-based method for the detection of r

158 DNA Compass is a website designed to empower the public by e

159 METHODS AND Compass is an open-label randomised trial of 5-yearly HP

160 COMPASS is available as open-source software.

161 In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a posttranslatio

162 sotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than ex

163 , implying that the light-dependent magnetic compass is intrinsically polarization sensitive.

164 The use of this inclination compass is light-dependent utilizing ultraviolet-A/blue

165 Whether H3K4 methylation by Set1A/COMPASS is required for ESC maintenance and during diffe

166 Instead, we demonstrate that SET1A/COMPASS is required for full transcriptional activation

167 Although Mll2/COMPASS is required for H3K4me3 implementation on thousa

168 The multiprotein complex Set1/COMPASS is the founding member of the histone H3 lysine

169 are H3K4 methyltransferases; however, dSet1/COMPASS is the major monoubiquitination-dependent H3K4 d

170 This light-dependent magnetic compass is thought to be mediated by cryptochrome protei

171 This compass keeps track of their paces and turns and updates

172 mediated by key components of the Trithorax/COMPASS-like and Polycomb group complexes together with

173 zed array of microtubules that bundle into a compass-like arm that appears to anticipate the directio

174 thyltransferases are conserved components of COMPASS-like co-activator complexes.

175 functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and have identified the mi

176 and gene expression by cooperating with the COMPASS-like complex to increase H3K4 trimethylation at

177 t1A and Set1B and MLL1 to MLL4, are found in COMPASS-like complexes capable of methylating H3K4.

178 protein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively

179 iated with Set1), there are three classes of COMPASS-like complexes in Drosophila that could carry ou

180 ht into the redundancy and specialization of COMPASS-like complexes in mammals and provide evidence f

181 rr and its human homologs, the MLL3 and MLL4/COMPASS-like complexes, as enhancer histone H3 lysine 4

182 e Drosophila homolog of the mammalian Mll3/4 COMPASS-like complexes, can function as a major H3K4 mon

183 COMPASS complexes, and MLL1-4, forming human COMPASS-like complexes.

184 epresentative of the three subclasses within COMPASS-like complexes: dSet1 (human SET1A/SET1B), Trx (

185 the lncRNA Hottip/HOTTIP, members of the MLL/COMPASS-like H3K4 methylases, which regulate chromatin i

186 subsurface contaminant gradients, providing compass-like information about the contaminant gradient,

187 ature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Tr

188 e Leukemia 2 (MLL2/ALR), a core component of COMPASS-like nuclear receptor coactivator complexes.

189 can occur in the context of Trr or mammalian COMPASS-like proteins deficient in H3K4 monomethylation

190 entical paths to the same side of actin in a compass-like spinning motion demonstrating a symmetrical

191 dies have shown that neurons which fire in a compass-like way--head direction cells--are present befo

192 lunar and solar orientation apparatus; a sun compass, likely located in the brain and a moon compass

193 For migratory monarchs, the inclination compass may serve as an important orientation mechanism

194 The sun compass mechanism involves the neural integration of sky

195 We reasoned that the time-compensated compass mechanism that enables solar orientation of T. s

196 cal reference to calibrate other cues in the compass mechanism.

197 absent small or homeotic discs 1 (ASH1), and Compass member SET1 histone methyltransferases were O-Gl

198 lso known as complex associated with Set1 or COMPASS) methylates histone H3 on lysine 4, with differe

199 Memory requires a remodeled form of the Set1/COMPASS methyltransferase lacking Spp1, which dimethylat

200 ntaining protein 5 (WDR5), a core subunit of COMPASS/MLL family histone H3 lysine 4 methyltransferase

201 We propose a "compass" model according to which protrusive and contrac

202 hylation patterns at some loci or in certain COMPASS mutants.

203 To help illuminate the neural basis of sun compass navigation, we examined the neuronal composition

204 dentified a protein complex that acts like a compass needle to guide magnetic orientation in animals.

205 n such familiar settings as the lodestone in compass needles and the hard drive in computers.

206 r recordings from neurons in the monarch sun compass network reveal responses tuned to specific E-vec

207 ysiology, we show that polarized-light-based compass neurons and optic-flow-based speed-encoding neur

208 preferences are reflected in the activity of compass neurons in the brain.

209 Compass neurons in the central complex of diurnal beetle

210 rates for the necessary interactions between compass neurons in the central complex, a prominent stru

211 ombine with the neurons' connectivity to the compass neurons to create an elegant mechanism for updat

212 generated a standardized version of the sun compass neuropils, providing reference volumes, as well

213 l reactions are responsible for the magnetic compass of migratory birds.

214 thereby, retains the "docking site" for Set1-COMPASS on chromatin to maintain its stable chromatin as

215 mutation, while Cps40 is stably assembled in COMPASS on chromatin, demonstrating that Tyr1052- and Cp

216 conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to huma

217 lling the neuronal mechanisms underlying sun compass orientation and in identifying the genetic compl

218 le and may also augment time-compensated sun compass orientation for appropriate directionality throu

219 re necessary for proper time-compensated Sun compass orientation in migratory monarch butterflies, th

220 tematically altered the time-compensated sun compass orientation of the bees, with a mean anticlockwi

221 nce for roles in polarized light vision, sky compass orientation, and integration of spatial informat

222 zed light modulated light-dependent magnetic compass orientation, i.e., how the birds perceive the ma

223 he neuronal network that underlies celestial compass orientation.

224 provide the primary timing mechanism for Sun compass orientation.

225 head polarized light near the zenith for sky compass orientation.

226 Sun compass output is time compensated by circadian clocks i

227 P bears a fundamental resemblance to the sky-compass pathway, a visual navigation circuit described i

228 DNA Compass presents the relevant genotypes of the user side

229 ntifying protein homologs (BLAST, PSI-BLAST, COMPASS, PROF_SIM, RANKPROP and their variants) on two d

230 ul applied, for instance, as embodied in the Compass program described above in "Shape from Surfaces"

231 We show that a large shift in the sun-compass rapidly induced by general anesthesia does not a

232 her-level methylations reflect not only Set1/COMPASS recruitment but also multiple rounds of transcri

233 Cells lacking Set1 lose COMPASS recruitment but show increased promoter cross-li

234 d, associated with each such snapshot, a sun-compass-referenced home vector derived from dead reckoni

235 d on describing the neuroarchitecture of sun-compass-related brain regions and outlining their homolo

236 Such a compass representation was recently discovered in a neur

237 The stimulus responsible for compass resetting has been identified as a reduction in

238 A construct compassing residues S212-P259 and containing the TMD and

239 alytic pocket that are capable of regulating COMPASS's activity.

240 n machinery and Cps35/Swd2 function to focus COMPASS's H3K4me3 activity at promoter-proximal regions

241 and the Composite Autonomic Symptoms Scale (COMPASS)-select (a measure of autonomic symptoms and aut

242 S II 26.4 (8.8) versus 25.4 (10.5; p=0.764); COMPASS-select 43.5 (18.7) versus 42.8 (19.6; p=0.835).

243 sessed by change in UMSARS I, UMSARS II, and COMPASS-select, was modest.

244 The primary detection mechanism of this compass sense is uncertain but appears to involve the qu

245 een put forward as the basis of the magnetic compass sense of migratory birds.

246 ds, endowing migratory birds with a magnetic compass sense.

247 otein thought to be responsible for magnetic compass sensing in migratory birds and a variety of magn

248 is essential for its operation as a chemical compass sensor.

249 e viability of a cryptochrome-based magnetic compass sensor.

250 an provide the primary signal for a magnetic compass sensor.

251 n still be expected to be viable as magnetic compass sensors.

252 dical pairs currently postulated as magnetic compass sensors.

253 es the butterfly to set its time-compensated compass south in the autumn, then north in the spring fo

254 mation to select a direction, whereas in the compass step the animal maintains that heading [3,4].

255 and potentially independent 'map step' and 'compass step' of animal navigation.

256 Inspired by natural "nano shell" and "nano compass" structures, cell nanomodification can be develo

257 The COMPASS subunits contain a number of domains that are co

258 To investigate how the Set1 and COMPASS subunits establish the methylation states of H3K

259 This compass system uses information extracted from sun-deriv

260 dical pairs on the directional response of a compass system.

261 r, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to rom

262 , we identify PP1/NIPP1 as a novel molecular compass that controls directed cell migration via upregu

263 Cells have an internal compass that enables them to move along shallow chemical

264 hat migratory insects may also rely on other compasses that use night sky cues or the Earth's magneti

265 ave frequently been regarded as an internal 'compass' that can be used for navigation, although there

266 he complex of proteins associated with Set1 (COMPASS) that is responsible for the methylation of lysi

267 ratory birds have a light-dependent magnetic compass, the mechanism of which is thought to involve ra

268 t representation of skylight cues in the sun compass throughout the day.

269 The sun compass timing elements reside in light-entrained circad

270 Danaus plexippus) use a time-compensated Sun compass to aid navigation to their overwintering grounds

271 utterflies (Danaus plexippus) use a magnetic compass to aid their fall migration has been lacking fro

272 Migrants use a time-compensated sun compass to determine directionality during the migration

273 se an antenna-dependent time-compensated sun compass to direct their northward flight.

274 l heading, providing an animal with a neural compass to guide ongoing spatial behavior.

275 this context, a directing group serves as a compass to guide the transition metal to C-H bonds by us

276 rants indeed possess an inclination magnetic compass to help direct their flight equatorward in the f

277 Danaus plexippus) use a time-compensated sun compass to migrate to their overwintering grounds in cen

278 iapause, and they use a time-compensated sun compass to navigate during the long journey south.

279 Danaus plexippus) use a time-compensated sun compass to navigate from eastern North America to their

280 navian visitors and still use their internal compass to navigate to the Basin.

281 yphis fortis use an odometer and a sun-based compass to provide input for path integration (PI).

282 ansferase Set1/complex associated with Set1 (COMPASS) to promoter-proximal RNA polymerase II.

283 information with output from their internal compass, to compensate for the deflection.

284 ment of the modifying enzymes, Rad6/Bre1 and COMPASS, to genes.

285 sequencing (RNA-seq) analysis pipeline, RNA CoMPASS, to investigate the presence of ectopic organism

286 The primary outcome of the COMPASS trial was the occurrence of myocardial infarctio

287 , 2016, 27 395 patients were enrolled to the COMPASS trial, of whom 24 824 patients had stable corona

288 ovided new insights into the mechanisms some compasses use for maintaining a constant bearing during

289 al strategy relies on a time-compensated sun compass, used by diurnal insects, for which neural circu

290 COMPASS uses a Bayesian hierarchical framework to model

291 ther insects use idiothetic information, sky compasses, visual cues, and odor trails.

292 The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4) methyla

293 Set1/COMPASS was the founding member and is the only H3K4 met

294 tional requirements of this complex chemical compass, we have created a family of simplified, adaptab

295 on the multiple-instance learning method of Compass, where a physical model of a binding site is ind

296 Here we report that SET1B/COMPASS, which is essential for cell survival, surprisin

297 ation cues at sunset to calibrate a magnetic compass, which is subsequently used for orientation duri

298 charomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the simi

299 we address this by introducing the software COMPASS, which, by combining automated resonance assignm

300 he head-direction (HD) system functions as a compass, with member neurons robustly increasing their f