ライフサイエンスコーパス: competitive binding

1 nds to receptors in trigeminal neurons using competitive binding.

2 complex formation prompted investigation of competitive binding.

3 ence data suggest based on a model of direct competitive binding.

4 e analyzed for contributions to interspecies competitive binding.

5 cyclin A-Cdk2 from inhibition by p27 through competitive binding.

6 duce the effects of CD30-targeting agents by competitive binding.

7 tyrosine phosphorylation of WBP2 and TAZ/YAP competitive binding.

8 locus of the antibody and the percentage of competitive binding.

9 ally act to displace interacting proteins by competitive binding.

10 placement of ATMND from 38-GC as a result of competitive binding.

11 tive estrogen receptor modulator (SERM) with competitive binding activity against estradiol for estro

12 oughout the human genome, often resulting in competitive binding activity at nearby or overlapping ci

13 ing by one-half, indicating that RNCs have a competitive binding advantage.

14 nm, lambda(em)=400 nm) of c-SAHA due to its competitive binding against other HDAC inhibitors, and s

15 se were all present could be modeled using a competitive binding algorithm.

16 Results from fluorescence spectroscopic and competitive binding analyses indicated that the specific

17 Competitive binding analyses revealed that alpha-FhbB Ab

18 Competitive binding analysis and mutagenesis reveals a u

19 Using competitive binding analysis with nonlabeled competitor

20 This interaction was confirmed by competitive binding analysis, in which the addition of e

21 Competitive binding and [(35)S]GTPgammaS functional assa

22 says that measure recombinant Hsp90 (rHsp90) competitive binding and changes in rHsp90 conformation.

23 re the diversity of the internal sites using competitive binding and DNase I protection assays and sh

24 aluated for activity at the H(4) receptor in competitive binding and functional assays.

25 Competitive binding and internalization experiments were

26 Competitive binding and kinetic studies with exosite mut

27 Further competitive binding and mutational analysis showed that

28 on in the transfectants were confirmed using competitive binding and particle exclusion assays.

29 toluene below its saturation level revealed competitive binding and resulted in an average increase

30 ions that impact gene expression by enabling competitive binding and switching between transcription

31 Competitive binding and transcription assays demonstrate

32 Both titration and competitive binding approaches were performed prior to a

33 4-D, was found to be 50-fold selective in a competitive binding assay and 100-fold selective in a tr

34 measured in a fluorescence polarization (FP) competitive binding assay and are active in human cancer

35 osis proteins (XIAP) with a Ki of 61 nM in a competitive binding assay and directly antagonizes the X

36 erivatives 6-11 were tested in vitro using a competitive binding assay and ex vivo using a rat aortic

37 Liquiritigenin showed ERbeta selectivity in competitive binding assay and isoliquiritigenin was equi

38 d to have >50% inhibition at 100 nM in a CB1 competitive binding assay and were further characterized

39 alutamide, mifepristone, DHT, and R1881 in a competitive binding assay as compared to wild-type AR LB

40 s (Ki values) for inhibitors in the FP-based competitive binding assay conditions, and accordingly, a

41 The competitive binding assay demonstrated that both SarAr-S

42 Analysis of 2 by flow cytometry and competitive binding assay demonstrates that immunoconjug

43 Using a newly developed competitive binding assay dependent upon the reassembly

44 The Fe3O4 NP-based competitive binding assay detected ATP and pyrophosphate

45 cells and was inactive in a [(3)H]astemizole competitive binding assay for hERG liability screening.

46 A competitive binding assay gave a dissociation constant o

47 A displacement competitive binding assay indicates that DOTA-IO-RGD con

48 results obtained indicated that the FP-based competitive binding assay performs correctly as designed

49 Important effects of surface chemistry and competitive binding assay protocol on the sensitivity of

50 ose concentrations when implemented within a competitive binding assay system.

51 ted structural analogues were evaluated in a competitive binding assay to breast cancer cell lysate a

52 In addition, a competitive binding assay to detect cardiac Troponin I (

53 nat)Ga-/(nat)Lu-PSMA I&T was determined in a competitive binding assay using LNCaP cells.

54 The unlabeled peptides were evaluated in a competitive binding assay using PC-3 prostate cancer cel

55 4h, and 4s are similar, as confirmed by the competitive binding assay where the ability of the ligan

56 In a competitive binding assay with a Eu-labeled probe based

57 ounds using GPCR arrays was examined using a competitive binding assay with BT-NT and unlabeled neuro

58 dal compounds were assessed by a radioligand competitive binding assay with the use of cytosolic AR p

59 idin/4'-hydroxyazobenzene-2-carboxylic acid) competitive binding assay, and fluorescence correlation

60 ally were tested experimentally in an MCH-R1 competitive binding assay, and six novel chemotypes as l

61 assay, EC(50) = 20 nM) and binding affinity (competitive binding assay, K(i) = 25 nM).

62 In a fluorescence competitive binding assay, the selective ligand binding

63 ARgamma-ligand binding domain in a PPARgamma competitive binding assay.

64 s for PSMA were determined by screening in a competitive binding assay.

65 ion of the small molecule as well as using a competitive binding assay.

66 lpha(v)beta5 was evaluated in a heterologous competitive binding assay.

67 ity in a [(3)H]histamine radiolabeled ligand competitive binding assay.

68 led NDP-alpha-MSH and was used to optimize a competitive binding assay.

69 PSMA inhibition constants were evaluated by competitive binding assay.

70 with reported values measured by an indirect competitive binding assay.

71 es' biorecognition capabilities for use in a competitive binding assay.

72 the applied nonradioactive 96-well plate TTR competitive binding assay.

73 finity for the Hsp90 ATP binding site in the competitive binding assay.

74 compounds were synthesized and evaluated in competitive binding assays and an androgen receptor tran

75 By performing competitive binding assays and expressing truncated NS1

76 These findings are supported by results of competitive binding assays and the similarity of the x-r

77 nists are 10-50-fold selective for ERbeta in competitive binding assays and up to 60-fold selective i

78 ide analogues of M6G and C6G was examined by competitive binding assays at mu, delta, and kappa opioi

79 Competitive binding assays based on the lectin Concanava

80 f label-free real-time optical biosensors in competitive binding assays by epitope binning a panel of

81 ar alpha-syn in vivo, but we show that SIL23 competitive binding assays can be used to screen additio

82 Competitive binding assays confirm binding to specific t

83 T20/C37 competitive binding assays confirmed that T20 interacts

84 Finally, based on these observations, competitive binding assays for these three small analyte

85 Competitive binding assays in the lateral septum showed

86 However, gel shift and competitive binding assays indicated that the JRL domain

87 In vitro competitive binding assays revealed a preferred binding

88 Competitive binding assays revealed that clone 47 also s

89 Consistent with these results, competitive binding assays revealed the following relati

90 Competitive binding assays strongly suggest that EGCG do

91 We present evidence from both direct and competitive binding assays that no significant recogniti

92 RNA immunoprecipitation (RIP) combined with competitive binding assays to identify novel primary tar

93 Competitive binding assays using a novel whole virus-cel

94 determined with high accuracy by two simple competitive binding assays using a scandium complex deri

95 Competitive binding assays using intact radiolabeled myc

96 Competitive binding assays using radiolabeled omega-atra

97 Competitive binding assays utilizing concanavalin A (Con

98 Competitive binding assays were performed under various

99 Saturation and competitive binding assays with B16F10 melanoma cells de

100 three other species, are designed as surface-competitive binding assays with fluorescence readouts.

101 This ligand was used in competitive binding assays with results comparable to th

102 These labeled ligands were used in competitive binding assays with results comparable to th

103 In competitive binding assays, CC-5079 competes with [(3)H]

104 gh the use of novel chimeric HA proteins and competitive binding assays, that sequential infection of

105 In vitro competitive binding assays, using PC-3 androgen-independ

106 receptor endocytosis assays and heterologous competitive binding assays.

107 The analogs were tested as antagonists of competitive binding at human A3 receptors, and K(i) valu

108 h also indicated a mechanism consistent with competitive binding at mAChRs.

109 er and repressor activities, possibly due to competitive binding at similar DNA binding sites.

110 ic cucurbit[n]uril congener toward guests by competitive binding at the ureidyl C horizontal lineO po

111 or to hydrogel systems or other matrixes for competitive-binding-based system, as they provide free m

112 the accurate characterization of binding and competitive binding behavior in biological systems.

113 e mutually exclusive, confirming their known competitive binding behavior.

114 Competitive binding between Ca(2+) and Mg(2+) to PIP2 is

115 ference in behavior can be attributed to the competitive binding between isocitrate and alphaKG, whic

116 d for detecting OSCS in heparin based on the competitive binding between OSCS and the adenosine-repea

117 or the mom-2 3'UTR reporter is determined by competitive binding between positive- and negative-actin

118 The assay is based on the competitive binding between PrP and a peptide-fluorophor

119 ignals that may be associated with potential competitive binding between Sox2 and Tcf3.

120 sor is fully reversible and specific through competitive binding between the dendrimer and glucose wi

121 he rate of reaction is controlled by initial competitive binding between the furylcarbinol and nitrog

122 hat is promoted by CN-Cbl, consistent with a competitive binding between the substrate and the colici

123 hibitor cross-competition kinetics indicated competitive binding between the transition state analogs

124 rylsulfonamides and benzodiazepines, but non-competitive binding between the transition state analogs

125 ant was tested against osanetant, indicating competitive binding between the two antagonists as well.

126 for which binding to eIF4G is RNA dependent, competitive binding by 100K protein is RNA independent.

127 Competitive binding by JQ1 displaces the BRD4 fusion onc

128 l-tRNA) as a specific target and demonstrate competitive binding by the unrelated natural products, d

129 rgy transfer based glucose sensor, wherein a competitive binding (CB) assay is encapsulated into poly

130 al assay configuration, the sensitivity of a competitive binding chemistry using ConA can be appropri

131 er DNA promoted more efficient binding under competitive binding conditions and was functionally impo

132 creen assay for a 384-well plate format in a competitive binding configuration for discovery of new i

133 Thus, the developed AlphaScreen assay in a competitive binding configuration offers several advanta

134 filaments, and a simple equilibrium model of competitive binding could explain these effects.

135 Competitive binding ELISA, native electrophoresis follow

136 Competitive binding ELISAs with N-terminal mutants and a

137 Lastly, a series of competitive binding enzyme-linked immunosorbent assay an

138 ause the presence of the cavitand leads to a competitive binding equilibrium in which the stronger bi

139 We couple dissociation to a competitive binding event so that dissociation can be dr

140 ulating the binding activity was tested by a competitive binding experiment that included the SL3-2 R

141 In a competitive binding experiment, EpCAM aptamer generated

142 Competitive binding experiments carried out in solutions

143 Molecular docking and TR-FRET GR competitive binding experiments demonstrated that ASI co

144 er (NET), and dopamine transporter (DAT)) in competitive binding experiments in vitro using cloned hu

145 Competitive binding experiments indicated that the radio

146 Here, de novo Rosetta modeling and competitive binding experiments show that the acidic tip

147 The results of competitive binding experiments suggest that a common ad

148 Competitive binding experiments suggest that Zn and Cd s

149 Competitive binding experiments using a series of ligand

150 Competitive binding experiments using unlabeled and 125I

151 Catch and release competitive binding experiments were done by NMR for the

152 The detection of vancomycin was achieved in competitive binding experiments with a horseradish perox

153 Next, we evaluated assay performance by competitive binding experiments with a series of known l

154 Competitive binding experiments with nonfluorescent RNC

155 The assay was tested in competitive binding experiments with substrates and prod

156 -permeable fluorescent tracers are used in a competitive binding format to quantify drug engagement w

157 This competitive binding has largely hindered the application

158 s were all shown to inhibit PCNA function by competitive binding in both human and S. pombe cells as

159 s slides, and fumonisin B1 was detected in a competitive binding inhibition assay using the antifumon

160 HEp-2 cell binding assays and in MAb and LRP competitive binding inhibition assays and based on the r

161 cant implications on the in vitro testing of competitive binding inhibitors and determines optimal in

162 Competitive binding inhibitors based on multivalent nano

163 functionally unique and did not result from competitive binding interactions.

164 at the resistance of the LacI-DNA complex to competitive binding is a function of both the operator s

165 In one example, using competitive binding, it was established that the mode of

166 r potency in three in vitro assays including competitive binding, Matrigel invasion and Galpha(i) cyc

167 A novel FRET competitive binding measurement developed to quantitate

168 e demonstrate that DHP has a unique two-site competitive binding mechanism in which the internal and

169 stranded DNA-binding site, suggesting that a competitive binding mechanism may regulate the formation

170 nding sites on hRPA70(1-326) suggests that a competitive binding mechanism mediates the formation of

171 viously, we and others discovered that via a competitive binding mechanism, the proteins WTX (AMER1),

172 eptor (AR)-FOXA1 and AR-HOXB13 complexes and competitive binding mechanisms.

173 apid kinetic, surface plasmon resonance, and competitive binding methods.

174 d displacement in a manner consistent with a competitive binding mode at the orthosteric site by TBPB

175 of their inhibitory kinetics revealed a non-competitive binding mode, with an IC50 value against ACE

176 tures demonstrated a canonical acetyl-lysine competitive binding mode.

177 illustrate that this provides support for a competitive binding model and adds new insight into a di

178 Consistent with a competitive binding model for TFAM repression of HSP2, t

179 We have explored a competitive binding model using specific mutations in th

180 domain, encompasses the cases treated by the competitive binding model, and provides a somewhat bette

181 We show in this paper that the pure competitive binding model, in which both S1 and caldesmo

182 ive exact analytical expressions for general competitive binding models which can also explain a comm

183 .929, 1.031, 1.052, 0.998, and 1.032 for the competitive binding of [1-(3)H]-, [2-(3)H]-, [3-(3)H]-,

184 igh-throughput screening method based on the competitive binding of a lumazine synthase inhibitor and

185 roach for antipsychotic drug screening where competitive binding of a novel APD and DA to a dopamine

186 Conversely, and very importantly, the competitive binding of a target DNA or protein with SWNT

187 ion effects point to nonspecific rather than competitive binding of alkali-metal ions.

188 A cantilever device based on competitive binding of an immobilized receptor to immobi

189 pertoires can be reached via the dynamics of competitive binding of antigens by receptors and selecti

190 tide conjugate was developed on the basis of competitive binding of AuNP-LHP and LH toward anti-LH.

191 e pituitary, through a combined mechanism of competitive binding of both ActRII and ALK4 by each subu

192 The competitive binding of calcium and the mobile segment of

193 te that chemokine cooperativity is caused by competitive binding of chemokines to GAGs.

194 The immunoassay scheme consists of the competitive binding of cocaine-specific antibodies to th

195 Force-jump kinetic investigations suggested competitive binding of cPDS and BG4 to the TERRA GQ.

196 cts of DOC on Cu uptake, possibly due to the competitive binding of Cu between the dissolved phase an

197 S-based multiplexing arises in balancing the competitive binding of different signal generating dyes

198 A sensitive assay for competitive binding of dinucleosome substrates revealed

199 I-[MePhe7]NKB as the radioligand, indicating competitive binding of either antagonist with regard to

200 The competitive binding of endogenous IQGAP1 by HA-Rac1(Val-

201 Competitive binding of ethanolamine and fluorescently la

202 ore, blockade of HepII-mediated signaling by competitive binding of fibulin-1 or tenascin-C represent

203 f the inactivation rates, suggesting partial competitive binding of hirudin-(54-65)(SO(3)(-)) and HCI

204 dulate JunD mRNA degradation by altering the competitive binding of HuR and AUF1 to the JunD 3'-UTR.

205 The 11-state mechanism accounts for competitive binding of inhibitors and activation by diff

206 our results do not support a model in which competitive binding of misfolded proteins causes dissoci

207 n of the BiP-ATF6 complex is a result of the competitive binding of misfolded proteins generated duri

208 The approach allows the competitive binding of multiple DNA sequences to the giv

209 s of the selectivity filter in which to test competitive binding of Na(+) These experiments disclosed

210 (c) Inhibition by excess olefin is caused by competitive binding of olefin and aryl starting material

211 the PNMT gene seems to be modulated through competitive binding of phosphorylated Sp1 and MAZ to the

212 spholipase C (PLC) beta activity, due to the competitive binding of RACK1, PI3K gamma, and PLC beta t

213 Competitive binding of radio-labeled proteins to western

214 calization of GFP-Kif17 to the cilia tip and competitive binding of RP2 and Arl3 with Kif17 complexes

215 NAs (ceRNAs), which regulate target genes by competitive binding of shared microRNAs.

216 Competitive binding of small guanosine triphosphatases t

217 These results suggest that competitive binding of Sp family proteins regulate betaM

218 Specifically, the competitive binding of streptavidin and goat anti-biotin

219 In this design, competitive binding of target to the aptamer causes the

220 The two complexes are formed by the competitive binding of Tec1 and Dig2 with Ste12, as Tec1

221 Disrupting AEG-1-Akt2 interaction by competitive binding of the Akt2-PH domain led to reduced

222 dynamics simulations revealed a Vroman-like competitive binding of the amphiphiles for the graphene

223 A model that partitions this trend into the competitive binding of the co-salt anion to the hydropho

224 xin 4 complexes are further regulated by the competitive binding of the double C2 domain protein Doc2

225 lexes at the mammalian cell surface involves competitive binding of the edema factor (EF) and lethal

226 the human mast cell receptor was analyzed by competitive binding of the fluorescent peptide 1 and the

227 Competitive binding of the human monoclonal antibody (mA

228 Mutual competitive binding of the mAbs indicated the presence o

229 todextrin utilization genes are regulated by competitive binding of the maltose repressor MalR and ca

230 concentrations, which most likely is due to competitive binding of the noncomplementary nucleotide t

231 The results corroborate our proposal that competitive binding of the transported ions to two (or m

232 nical signaling pathway and results from the competitive binding of the two sugars to hexose transpor

233 Competitive binding of this ryanoid to RyR2 implied a mi

234 ing complex immunoprecipitation demonstrates competitive binding of TRADD and RIP to TNFR1, whereas T

235 , thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii)

236 A mathematical model based on competitive binding of two antibodies for up to four ant

237 With this view, we investigate the effect of competitive binding on the dynamics of CaM binding partn

238 inhibitor binding by SPR without the use of competitive binding or antibodies.

239 Affinity Reagents (MegaSTAR) to identify non-competitive binding pairs of recombinant affinity reagen

240 dulate the PCSK9 extracellular activity as a competitive binding partner to the LDLR in HepG2 cells.

241 pad" for increasing the duration of the key competitive binding reaction and uses silver amplificati

242 ), which results in systematic shifts in the competitive binding response curve.

243 ryptophans in LDLR for both ligands, and the competitive binding results showed an involvement of the

244 phenol A, and acrolein) in human serum via a competitive binding scheme.

245 (2+), Cd(2+), and Hg(2+) revealed a mutually competitive binding site common to three metal ions and

246 and relative energies for hydration of these competitive binding sites at 133 K are obtained from the

247 hatic C-H donors are observed to function as competitive binding sites in solution and suggest that s

248 5.9 +/- 2.4 microM), but a novel, two-phased competitive binding strategy was necessary to ascertain

249 Competitive binding studied by isothermal titration calo

250 Competitive binding studies are consistent with a specif

251 Finally, competitive binding studies demonstrate that AGN 190730

252 Competitive binding studies demonstrated that soluble he

253 urther validated by binding, inhibition, and competitive binding studies of CvGal1 and ABH-specific m

254 Competitive binding studies of mixtures of the Fab-activ

255 Surprisingly, competitive binding studies reveal that Co(NH(3))(6)(3+)

256 Furthermore, competitive binding studies reveal that these chemically

257 Competitive binding studies showed a high affinity of th

258 ptide adopts the PPII conformation, however, competitive binding studies showed an order of magnitude

259 Competitive binding studies suggested that Ec-CDT and Hd

260 Competitive binding studies with a thrombin-specific chr

261 Competitive binding studies with excess trastuzumab befo

262 exhibited IC(50) values lower than 20 nM in competitive binding studies with GPR30-expressing human

263 Competitive binding studies with heparin pentasaccharide

264 Competitive binding studies with low-affinity heparin an

265 No product inhibition is observed, and competitive binding studies with nitro-containing additi

266 Competitive binding studies with P450eryF preloaded with

267 eries of peptides derived from beta-actin in competitive binding studies, we show that the domain nec

268 We propose that competitive binding to alpha2 by the ubiquitylation mach

269 Competitive binding to eIFiso4G was also observed betwee

270 information within a thermodynamic model of competitive binding to jointly learn a holistic view of

271 eIF4B and eIFiso4G exhibited competitive binding to PABP, supporting the overlapping

272 35Ab1 and the aforementioned proteins: 1) No competitive binding to rootworm BBMV was observed for co

273 combined with unlabeled Cry34Ab1, and 2) No competitive binding to rootworm BBMV was observed for un

274 dvantage to S. gordonii over S. sanguinis in competitive binding to sHA.

275 host defense against bacterial infection by competitive binding to target glycolipid molecules.

276 the cortisol level is detected based on its competitive binding to the aptamer by following signal f

277 Competitive binding to the Hsp90 N-terminal domain was o

278 are similar and have coevolved to facilitate competitive binding to the IL-1 receptor.

279 ufu and Spop oppose each other through their competitive binding to the N- and C-terminal regions of

280 w that these compounds display high affinity competitive binding to the PPARgamma-LBD (EC(50) of 215

281 ARA70 increases E2 competitive binding to the wtAR in the presence of low l

282 fering with cytoadhesion of infected RBCs by competitive binding to these receptors in vitro and redu

283 Competitive binding to VEGF between VEGFR and bevacizuma

284 p and apply a physical model of TF-chromatin competitive binding using chemical reaction rate theory

285 ligands to RXRalpha was demonstrated through competitive binding using ultrafiltration LC-MS/MS (liqu

286 nd only Cu(+) co-migrated with ZiaA(N) after competitive binding versus Zn(2+).

287 Competitive binding was verified using the same soil wit

288 ucted, and seven VHH clones were selected by competitive binding with 3-PBA.

289 Competitive binding with [(3)H]spiroperidol was used to

290 exhibiting length-dependent selectivity and competitive binding with alkali metals present in soluti

291 ined by change in capacitance after allowing competitive binding with CRP and complementary RNA (cRNA

292 Studies with poly(dGdC)2 and poly(dIdC)2 and competitive binding with distamycin demonstrate that com

293 verely compromised by background signals and competitive binding with extrinsic probes.

294 ta suggest that RRP1 is involved not only in competitive binding with fibrillarin to C1QBP on 90S but

295 y equilibrium binding of SC-(1-325) to ProT, competitive binding with native ProT, and SC domain inte

296 ptor was identified by (+)-[(3)H]pentazocine competitive binding with nonradioactive [(127)I]IAF, it

297 Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 a

298 s of AAV2 transduction influenced by Notch1, competitive binding with soluble heparin and Notch1 anti

299 een selected that demonstrate high-affinity, competitive binding with the duplex 22-mer binding site,

300 f IL12p70, IL12p40, and IL12(p40)2 and their competitive binding with the IL-12 receptor are essentia